{ "tool": "enrich_gene_set", "organism": "hsapiens", "input_genes": [ "TP53", "ATM", "ATR", "CHEK1", "CHEK2", "BRCA1", "BRCA2", "RAD51", "CDKN1A", "GADD45A", "MDM2" ], "n_input": 11, "n_mapped": 11, "n_unmapped": 0, "mapped_genes": { "TP53": [ "ENSG00000141510" ], "ATM": [ "ENSG00000149311" ], "ATR": [ "ENSG00000175054" ], "CHEK1": [ "ENSG00000149554" ], "CHEK2": [ "ENSG00000183765" ], "BRCA1": [ "ENSG00000012048" ], "BRCA2": [ "ENSG00000139618" ], "RAD51": [ "ENSG00000051180" ], "CDKN1A": [ "ENSG00000124762" ], "GADD45A": [ "ENSG00000116717" ], "MDM2": [ "ENSG00000135679" ] }, "unmapped_genes": [], "ambiguous_genes": {}, "duplicate_genes": [], "background_size": null, "domain_scope": "annotated", "sources": [ "GO:BP", "REAC" ], "correction_method": "fdr", "n_results": 891, "results": [ { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25697, "intersection_size": 10, "intersections": [ [ "IDA", "IMP", "IEA" ], [ "IDA" ], [ "IDA" ], [], [ "IEA" ], [ "IMP" ], [ "IMP" ], [ "IDA", "IMP", "IEA" ], [ "IMP", "IEA" ], [ "IMP" ], [ "IDA" ] ], "name": "cellular response to ionizing radiation", "native": "GO:0071479", "p_value": 1.1251507180209587e-21, "parents": [ "GO:0010212", "GO:0071478" ], "precision": 0.9090909090909091, "query": "query_1", "query_size": 11, "recall": 0.14285714285714285, "significant": true, "source": "GO:BP", "term_size": 70, "source_order": 15574, "group_id": 1 }, { "description": "\"A cascade of processes induced by the detection of DNA damage within a cell.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 19824, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IMP", "IBA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IMP", "IBA", "NAS" ], [ "NAS" ], [ "NAS" ], [ "IDA", "IMP" ], [ "IMP" ], [ "IDA", "IMP" ] ], "name": "signal transduction in response to DNA damage", "native": "GO:0042770", "p_value": 1.6589416220018213e-20, "parents": [ "GO:0006974", "GO:0035556" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.057291666666666664, "significant": true, "source": "GO:BP", "term_size": 192, "source_order": 9701, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.\" [PMID:12509526]", "effective_domain_size": 20972, "goshv": 13948, "intersection_size": 10, "intersections": [ [ "IDA", "IMP", "IEA" ], [ "IDA", "IEA" ], [ "IDA" ], [], [ "IEA" ], [ "IMP" ], [ "IMP", "IEA" ], [ "IDA", "IMP", "IEA" ], [ "IMP", "IEA" ], [ "IMP" ], [ "IDA" ] ], "name": "response to ionizing radiation", "native": "GO:0010212", "p_value": 3.7126397122310702e-19, "parents": [ "GO:0009314" ], "precision": 0.9090909090909091, "query": "query_1", "query_size": 11, "recall": 0.07407407407407407, "significant": true, "source": "GO:BP", "term_size": 135, "source_order": 3825, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an environmental stimulus.\" [GOC:dos]", "effective_domain_size": 20972, "goshv": 28078, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IEA" ], [ "IDA" ], [ "IDA", "IMP" ], [ "IEP" ], [ "IEA" ], [ "IMP" ], [ "IMP" ], [ "IDA", "IMP", "IEA" ], [ "IMP", "ISS", "IEA" ], [ "IMP", "IEP" ], [ "IDA" ] ], "name": "cellular response to environmental stimulus", "native": "GO:0104004", "p_value": 3.0205969370071543e-18, "parents": [ "GO:0051716" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.03303303303303303, "significant": true, "source": "GO:BP", "term_size": 333, "source_order": 17955, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25696, "intersection_size": 10, "intersections": [ [ "IDA", "IMP", "IEA" ], [ "IDA" ], [ "IDA", "IMP" ], [], [ "IEA" ], [ "IMP" ], [ "IMP" ], [ "IDA", "IMP", "IEA" ], [ "IMP", "ISS", "IEA" ], [ "IMP" ], [ "IDA" ] ], "name": "cellular response to radiation", "native": "GO:0071478", "p_value": 3.0205969370071543e-18, "parents": [ "GO:0009314", "GO:0071214" ], "precision": 0.9090909090909091, "query": "query_1", "query_size": 11, "recall": 0.05649717514124294, "significant": true, "source": "GO:BP", "term_size": 177, "source_order": 15573, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25465, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IEA" ], [ "IDA" ], [ "IDA", "IMP" ], [ "IEP" ], [ "IEA" ], [ "IMP" ], [ "IMP" ], [ "IDA", "IMP", "IEA" ], [ "IMP", "ISS", "IEA" ], [ "IMP", "IEP" ], [ "IDA" ] ], "name": "cellular response to abiotic stimulus", "native": "GO:0071214", "p_value": 3.0205969370071543e-18, "parents": [ "GO:0009628", "GO:0104004" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.03303303303303303, "significant": true, "source": "GO:BP", "term_size": 333, "source_order": 15342, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.\" [GOC:tair_curators]", "effective_domain_size": 20972, "goshv": 14017, "intersection_size": 8, "intersections": [ [ "IDA", "IMP", "IEA" ], [ "IDA" ], [ "IDA" ], [], [ "IEA" ], [], [ "IEA" ], [ "IEA" ], [ "IEA" ], [], [ "IDA" ] ], "name": "response to gamma radiation", "native": "GO:0010332", "p_value": 1.588938913964917e-17, "parents": [ "GO:0010212" ], "precision": 0.7272727272727273, "query": "query_1", "query_size": 11, "recall": 0.16, "significant": true, "source": "GO:BP", "term_size": 50, "source_order": 3894, "group_id": 1 }, { "description": "\"A signal transduction process that contributes to a DNA damage checkpoint.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 10150, "intersection_size": 9, "intersections": [ [ "IMP", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IBA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IMP", "IBA", "TAS", "IEA" ], [ "IMP", "IBA", "NAS" ], [ "NAS" ], [ "NAS" ], [ "IDA", "IMP" ], [], [] ], "name": "DNA damage checkpoint signaling", "native": "GO:0000077", "p_value": 2.5961663648522267e-17, "parents": [ "GO:0031570", "GO:0042770" ], "precision": 0.8181818181818182, "query": "query_1", "query_size": 11, "recall": 0.0782608695652174, "significant": true, "source": "GO:BP", "term_size": 115, "source_order": 27, "group_id": 1 }, { "description": "\"A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes.\" [GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 16884, "intersection_size": 9, "intersections": [ [ "IMP", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IBA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IMP", "IBA", "TAS", "IEA" ], [ "IMP", "IBA", "NAS" ], [ "NAS" ], [ "NAS" ], [ "IDA", "IMP" ], [], [] ], "name": "DNA integrity checkpoint signaling", "native": "GO:0031570", "p_value": 4.652860133303461e-17, "parents": [ "GO:0000075" ], "precision": 0.8181818181818182, "query": "query_1", "query_size": 11, "recall": 0.07258064516129033, "significant": true, "source": "GO:BP", "term_size": 124, "source_order": 6761, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25698, "intersection_size": 7, "intersections": [ [ "IDA", "IEA" ], [ "IDA" ], [ "IDA" ], [], [ "IEA" ], [], [], [ "IEA" ], [ "IEA" ], [], [ "IDA" ] ], "name": "cellular response to gamma radiation", "native": "GO:0071480", "p_value": 7.158170082376059e-17, "parents": [ "GO:0010332", "GO:0071479" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.2692307692307692, "significant": true, "source": "GO:BP", "term_size": 26, "source_order": 15575, "group_id": 1 }, { "description": "\"A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction.\" [GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 10148, "intersection_size": 9, "intersections": [ [ "IMP", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IBA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IMP", "IBA", "TAS", "IEA" ], [ "IMP", "IBA", "NAS", "IEA" ], [ "NAS" ], [ "NAS" ], [ "IDA", "IMP" ], [], [] ], "name": "cell cycle checkpoint signaling", "native": "GO:0000075", "p_value": 1.6097792317436696e-15, "parents": [ "GO:0035556", "GO:1901988" ], "precision": 0.8181818181818182, "query": "query_1", "query_size": 11, "recall": 0.04838709677419355, "significant": true, "source": "GO:BP", "term_size": 186, "source_order": 25, "group_id": 1 }, { "description": "\"The process by which normal somatic cells reach an irreversible stage of cell cycle arrest following multiple rounds of replication; this end stage is associated with marked changes in gene expression and function. This is a natural barrier to unlimited proliferation of somatic cells, and is believed to be contolled by telomere shortening.\" [PMID:17014937, PMID:23061726]", "effective_domain_size": 20972, "goshv": 27183, "intersection_size": 6, "intersections": [ [ "IMP" ], [ "IMP" ], [ "IMP" ], [ "NAS" ], [ "NAS" ], [], [], [], [ "IEA" ], [], [] ], "name": "replicative senescence", "native": "GO:0090399", "p_value": 3.048503629902262e-15, "parents": [ "GO:0022402" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.375, "significant": true, "source": "GO:BP", "term_size": 16, "source_order": 17060, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of cell cycle phase transition.\" [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]", "effective_domain_size": 20972, "goshv": 30567, "intersection_size": 10, "intersections": [ [ "IMP", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IBA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IMP", "IBA", "TAS", "IEA" ], [ "IMP", "IBA", "NAS", "IEA" ], [ "NAS" ], [ "NAS" ], [ "IDA", "IMP", "IGI", "IBA" ], [], [ "IEA" ] ], "name": "regulation of cell cycle phase transition", "native": "GO:1901987", "p_value": 1.1200188130720134e-14, "parents": [ "GO:0010564", "GO:0044770" ], "precision": 0.9090909090909091, "query": "query_1", "query_size": 11, "recall": 0.023148148148148147, "significant": true, "source": "GO:BP", "term_size": 432, "source_order": 20444, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.\" [GOC:jl, Wikipedia:Electromagnetic_radiation]", "effective_domain_size": 20972, "goshv": 13427, "intersection_size": 10, "intersections": [ [ "IDA", "IMP", "ISS", "IEA" ], [ "IDA", "IEA" ], [ "IDA", "IMP" ], [], [ "IEA" ], [ "IMP" ], [ "IMP", "IEA" ], [ "IDA", "IMP", "IEA" ], [ "IMP", "ISS", "IEA" ], [ "IMP" ], [ "IDA" ] ], "name": "response to radiation", "native": "GO:0009314", "p_value": 1.1200188130720134e-14, "parents": [ "GO:0009628" ], "precision": 0.9090909090909091, "query": "query_1", "query_size": 11, "recall": 0.023148148148148147, "significant": true, "source": "GO:BP", "term_size": 432, "source_order": 3304, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition.\" [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]", "effective_domain_size": 20972, "goshv": 30568, "intersection_size": 9, "intersections": [ [ "IMP", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IBA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IMP", "IBA", "TAS", "IEA" ], [ "IMP", "IBA", "NAS", "IEA" ], [ "NAS" ], [ "NAS" ], [ "IDA", "IMP", "IGI" ], [], [] ], "name": "negative regulation of cell cycle phase transition", "native": "GO:1901988", "p_value": 1.7050061756191306e-14, "parents": [ "GO:0010948", "GO:0044770", "GO:1901987" ], "precision": 0.8181818181818182, "query": "query_1", "query_size": 11, "recall": 0.03614457831325301, "significant": true, "source": "GO:BP", "term_size": 249, "source_order": 20445, "group_id": 1 }, { "description": "\"Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 14436, "intersection_size": 9, "intersections": [ [ "IDA", "IMP", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IBA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IMP", "IBA", "TAS", "IEA" ], [ "IMP", "IBA", "NAS", "IEA" ], [ "NAS" ], [ "NAS" ], [ "IDA", "IMP", "IGI" ], [], [] ], "name": "negative regulation of cell cycle process", "native": "GO:0010948", "p_value": 6.412220918735105e-14, "parents": [ "GO:0010564", "GO:0022402", "GO:0045786" ], "precision": 0.8181818181818182, "query": "query_1", "query_size": 11, "recall": 0.03103448275862069, "significant": true, "source": "GO:BP", "term_size": 290, "source_order": 4313, "group_id": 1 }, { "description": "\"The cell cycle process by which a cell commits to entering the next cell cycle phase.\" [GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 20518, "intersection_size": 10, "intersections": [ [ "IMP", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IBA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IMP", "IBA", "TAS", "IEA" ], [ "IMP", "IBA", "NAS", "IEA" ], [ "NAS" ], [ "NAS" ], [ "IDA", "IMP", "IGI", "IBA", "TAS" ], [], [ "IEA" ] ], "name": "cell cycle phase transition", "native": "GO:0044770", "p_value": 7.803252110234442e-14, "parents": [ "GO:0022402" ], "precision": 0.9090909090909091, "query": "query_1", "query_size": 11, "recall": 0.018726591760299626, "significant": true, "source": "GO:BP", "term_size": 534, "source_order": 10395, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 12593, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IMP", "TAS", "IEA" ], [ "IDA", "IMP" ] ], "name": "DNA damage response", "native": "GO:0006974", "p_value": 7.913668790524067e-14, "parents": [ "GO:0033554" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.011840688912809472, "significant": true, "source": "GO:BP", "term_size": 929, "source_order": 2470, "group_id": 1 }, { "description": "\"An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 26304, "intersection_size": 8, "intersections": [ [ "IDA", "IMP", "IEA" ], [ "IMP", "TAS" ], [ "IMP" ], [ "TAS" ], [ "TAS", "IEA" ], [], [ "IEA" ], [], [ "IEA" ], [], [ "IDA", "IMP", "TAS" ] ], "name": "signal transduction by p53 class mediator", "native": "GO:0072331", "p_value": 2.8635628862701413e-13, "parents": [ "GO:0035556" ], "precision": 0.7272727272727273, "query": "query_1", "query_size": 11, "recall": 0.04371584699453552, "significant": true, "source": "GO:BP", "term_size": 183, "source_order": 16181, "group_id": 1 }, { "description": "\"Any process that modulates the rate or extent of progression through the cell cycle.\" [GOC:ai, GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 23108, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IBA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "NAS", "IEA" ], [ "NAS", "IEA" ], [ "NAS" ], [ "IDA", "IMP", "IGI", "ISS", "IBA", "IEA" ], [ "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ] ], "name": "regulation of cell cycle", "native": "GO:0051726", "p_value": 4.084598097673197e-13, "parents": [ "GO:0007049", "GO:0050794" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.01011029411764706, "significant": true, "source": "GO:BP", "term_size": 1088, "source_order": 12985, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus.\" [GOC:hb]", "effective_domain_size": 20972, "goshv": 13515, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IEP", "ISS", "IEA" ], [ "IDA", "TAS", "IEA" ], [ "IDA", "IMP", "TAS" ], [ "IEP" ], [ "IEA" ], [ "IMP" ], [ "IMP", "IEA" ], [ "IDA", "IMP", "IEA" ], [ "IMP", "ISS", "IEA" ], [ "IMP", "IEP" ], [ "IDA", "IEP" ] ], "name": "response to abiotic stimulus", "native": "GO:0009628", "p_value": 4.700185670906787e-13, "parents": [ "GO:0050896" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.009927797833935019, "significant": true, "source": "GO:BP", "term_size": 1108, "source_order": 3392, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.\" [GOC:dph, GOC:go_curators, GOC:tb]", "effective_domain_size": 20972, "goshv": 20969, "intersection_size": 9, "intersections": [ [ "IDA", "IMP", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IBA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IMP", "IBA", "TAS", "IEA" ], [ "IMP", "IBA", "NAS", "IEA" ], [ "NAS" ], [ "NAS" ], [ "IDA", "IMP", "IGI" ], [], [] ], "name": "negative regulation of cell cycle", "native": "GO:0045786", "p_value": 4.700185670906787e-13, "parents": [ "GO:0007049", "GO:0048523", "GO:0051726" ], "precision": 0.8181818181818182, "query": "query_1", "query_size": 11, "recall": 0.02406417112299465, "significant": true, "source": "GO:BP", "term_size": 374, "source_order": 10846, "group_id": 1 }, { "description": "\"Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 14154, "intersection_size": 10, "intersections": [ [ "IDA", "IMP", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IBA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IMP", "IBA", "TAS", "IEA" ], [ "IMP", "IBA", "NAS", "IEA" ], [ "NAS", "IEA" ], [ "NAS" ], [ "IDA", "IMP", "IGI", "IBA" ], [], [ "IEA" ] ], "name": "regulation of cell cycle process", "native": "GO:0010564", "p_value": 1.2971703694932985e-12, "parents": [ "GO:0022402", "GO:0051726" ], "precision": 0.9090909090909091, "query": "query_1", "query_size": 11, "recall": 0.013736263736263736, "significant": true, "source": "GO:BP", "term_size": 728, "source_order": 4031, "group_id": 1 }, { "description": "\"A process that is part of the mitotic cell cycle.\" [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 31273, "intersection_size": 10, "intersections": [ [ "IMP", "IEA" ], [ "IMP" ], [ "IDA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IMP", "IBA" ], [ "IMP", "IBA", "NAS", "IEA" ], [ "IMP" ], [ "IEA" ], [ "IDA", "IMP", "IGI", "IBA", "TAS" ], [], [ "IEA" ] ], "name": "mitotic cell cycle process", "native": "GO:1903047", "p_value": 1.6096262671531728e-12, "parents": [ "GO:0000278", "GO:0022402" ], "precision": 0.9090909090909091, "query": "query_1", "query_size": 11, "recall": 0.013386880856760375, "significant": true, "source": "GO:BP", "term_size": 747, "source_order": 21150, "group_id": 1 }, { "description": "\"The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.\" [GOC:isa_complete, GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 16282, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IMP", "IBA", "NAS", "IEA" ], [ "IMP", "NAS", "IEA" ], [ "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IGI", "IBA", "TAS", "IEA" ], [ "IEA" ], [ "IEA" ] ], "name": "cell cycle process", "native": "GO:0022402", "p_value": 2.1442064535429783e-12, "parents": [ "GO:0007049", "GO:0009987" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.008527131782945736, "significant": true, "source": "GO:BP", "term_size": 1290, "source_order": 6159, "group_id": 1 }, { "description": "\"Any process that modulates the rate or extent of progress through the mitotic cell cycle.\" [GOC:dph, GOC:go_curators, GOC:tb]", "effective_domain_size": 20972, "goshv": 12842, "intersection_size": 9, "intersections": [ [ "IMP", "IEA" ], [ "IMP" ], [ "IDA" ], [ "IDA", "IMP", "IBA" ], [ "IMP", "IBA" ], [ "IMP", "IBA", "NAS", "IEA" ], [ "IEA" ], [], [ "IDA", "IMP", "IGI", "IBA", "IEA" ], [], [ "IMP", "IBA", "IEA" ] ], "name": "regulation of mitotic cell cycle", "native": "GO:0007346", "p_value": 4.498806384711376e-12, "parents": [ "GO:0000278", "GO:0051726" ], "precision": 0.8181818181818182, "query": "query_1", "query_size": 11, "recall": 0.018404907975460124, "significant": true, "source": "GO:BP", "term_size": 489, "source_order": 2719, "group_id": 1 }, { "description": "\"A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.\" [GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 12665, "intersection_size": 7, "intersections": [ [ "IMP", "IEA" ], [ "IMP" ], [ "IDA" ], [ "IDA", "IMP", "IBA" ], [ "IMP", "IBA" ], [ "IMP", "IBA", "NAS", "IEA" ], [], [], [ "IDA", "IMP" ], [], [] ], "name": "mitotic cell cycle checkpoint signaling", "native": "GO:0007093", "p_value": 6.084662130972819e-12, "parents": [ "GO:0000075", "GO:0045930", "GO:1903047" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.051094890510948905, "significant": true, "source": "GO:BP", "term_size": 137, "source_order": 2542, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).\" [GOC:dhl]", "effective_domain_size": 20972, "goshv": 26757, "intersection_size": 9, "intersections": [ [ "IEA" ], [ "IMP", "TAS", "IEA" ], [ "IMP", "TAS", "NAS", "IEA" ], [ "IDA" ], [ "IEA" ], [ "IMP", "NAS" ], [ "NAS" ], [ "IDA", "NAS" ], [], [], [ "IDA" ] ], "name": "regulation of cellular response to stress", "native": "GO:0080135", "p_value": 7.93254139423939e-12, "parents": [ "GO:0033554", "GO:0050794", "GO:0080134" ], "precision": 0.8181818181818182, "query": "query_1", "query_size": 11, "recall": 0.017142857142857144, "significant": true, "source": "GO:BP", "term_size": 525, "source_order": 16634, "group_id": 1 }, { "description": "\"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.\" [GOC:mah, ISBN:0815316194]", "effective_domain_size": 20972, "goshv": 10198, "intersection_size": 10, "intersections": [ [ "IMP", "IEA" ], [ "IMP" ], [ "IDA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IMP", "IBA" ], [ "IMP", "IBA", "NAS", "IEA" ], [ "IMP", "IEA" ], [ "IEA" ], [ "IDA", "IMP", "IGI", "IBA", "TAS", "IEA" ], [], [ "IMP", "IBA", "IEA" ] ], "name": "mitotic cell cycle", "native": "GO:0000278", "p_value": 7.967238988601209e-12, "parents": [ "GO:0007049" ], "precision": 0.9090909090909091, "query": "query_1", "query_size": 11, "recall": 0.011198208286674132, "significant": true, "source": "GO:BP", "term_size": 893, "source_order": 75, "group_id": 1 }, { "description": "\"The cell cycle process by which a cell in G2 phase commits to M phase.\" [GOC:jl, GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 20556, "intersection_size": 7, "intersections": [ [ "IMP" ], [ "IMP" ], [ "IDA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IMP" ], [ "IMP", "IBA", "NAS", "IEA" ], [], [], [ "IMP" ], [], [] ], "name": "cell cycle G2/M phase transition", "native": "GO:0044839", "p_value": 1.3812712765709219e-11, "parents": [ "GO:0044770" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.04487179487179487, "significant": true, "source": "GO:BP", "term_size": 156, "source_order": 10433, "group_id": 1 }, { "description": "\"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.\" [GOC:elh]", "effective_domain_size": 20972, "goshv": 12124, "intersection_size": 8, "intersections": [ [ "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "NAS" ], [ "IDA" ], [ "IMP", "TAS" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [], [], [] ], "name": "double-strand break repair", "native": "GO:0006302", "p_value": 1.694705127896206e-11, "parents": [ "GO:0006281" ], "precision": 0.7272727272727273, "query": "query_1", "query_size": 11, "recall": 0.024844720496894408, "significant": true, "source": "GO:BP", "term_size": 322, "source_order": 2001, "group_id": 1 }, { "description": "\"A signal transduction process involved in mitotic DNA damage checkpoint.\" [GOC:mtg_cell_cycle, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 20521, "intersection_size": 6, "intersections": [ [ "IMP", "IEA" ], [ "IMP" ], [], [ "IMP", "IBA" ], [ "IMP", "IBA" ], [ "IMP", "IBA" ], [], [], [ "IDA", "IMP" ], [], [] ], "name": "mitotic DNA damage checkpoint signaling", "native": "GO:0044773", "p_value": 2.021643782208058e-11, "parents": [ "GO:0000077", "GO:0044774" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.08450704225352113, "significant": true, "source": "GO:BP", "term_size": 71, "source_order": 10398, "group_id": 1 }, { "description": "\"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.\" [ISBN:0198506732]", "effective_domain_size": 20972, "goshv": 12094, "intersection_size": 10, "intersections": [ [ "IDA", "IMP", "IEA" ], [ "IDA", "IMP", "IGI", "ISS", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "TAS", "IEA" ], [ "IMP", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "TAS", "IEA" ], [ "IMP", "TAS", "IEA" ], [ "TAS" ], [] ], "name": "DNA metabolic process", "native": "GO:0006259", "p_value": 2.129313278196218e-11, "parents": [ "GO:0090304" ], "precision": 0.9090909090909091, "query": "query_1", "query_size": 11, "recall": 0.01002004008016032, "significant": true, "source": "GO:BP", "term_size": 998, "source_order": 1971, "group_id": 1 }, { "description": "\"The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.\" [GOC:go_curators, GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 12639, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "NAS", "IEA" ], [ "IMP", "NAS", "IEA" ], [ "ISS", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IGI", "ISS", "IBA", "TAS", "IEA" ], [ "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ] ], "name": "cell cycle", "native": "GO:0007049", "p_value": 2.612310096721122e-11, "parents": [ "GO:0009987" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.006594724220623501, "significant": true, "source": "GO:BP", "term_size": 1668, "source_order": 2516, "group_id": 1 }, { "description": "\"A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during mitosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction.\" [GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 20522, "intersection_size": 6, "intersections": [ [ "IMP", "IEA" ], [ "IMP" ], [], [ "IMP", "IBA" ], [ "IMP", "IBA" ], [ "IMP", "IBA" ], [], [], [ "IDA", "IMP" ], [], [] ], "name": "mitotic DNA integrity checkpoint signaling", "native": "GO:0044774", "p_value": 2.612310096721122e-11, "parents": [ "GO:0007093", "GO:0031570" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.08, "significant": true, "source": "GO:BP", "term_size": 75, "source_order": 10399, "group_id": 1 }, { "description": "\"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.\" [PMID:11563486]", "effective_domain_size": 20972, "goshv": 12111, "intersection_size": 9, "intersections": [ [ "IMP", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IEA" ], [ "IMP", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [], [ "TAS" ], [] ], "name": "DNA repair", "native": "GO:0006281", "p_value": 2.8440179343264584e-11, "parents": [ "GO:0006259", "GO:0006974" ], "precision": 0.8181818181818182, "query": "query_1", "query_size": 11, "recall": 0.014469453376205787, "significant": true, "source": "GO:BP", "term_size": 622, "source_order": 1988, "group_id": 1 }, { "description": "DNA Double-Strand Break Repair", "effective_domain_size": 11056, "goshv": 39787, "intersection_size": 8, "intersections": [ [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [] ], "name": "DNA Double-Strand Break Repair", "native": "REAC:R-HSA-5693532", "p_value": 4.9023835707218485e-11, "parents": [ "REAC:R-HSA-73894" ], "precision": 0.7272727272727273, "query": "query_1", "query_size": 11, "recall": 0.047058823529411764, "significant": true, "source": "REAC", "term_size": 170, "source_order": 463, "group_id": 28 }, { "description": "Presynaptic phase of homologous DNA pairing and strand exchange", "effective_domain_size": 11056, "goshv": 41190, "intersection_size": 6, "intersections": [ [], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [] ], "name": "Presynaptic phase of homologous DNA pairing and strand exchange", "native": "REAC:R-HSA-5693616", "p_value": 4.9023835707218485e-11, "parents": [ "REAC:R-HSA-5693579" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.15, "significant": true, "source": "REAC", "term_size": 40, "source_order": 1866, "group_id": 28 }, { "description": "Regulation of TP53 Activity through Phosphorylation", "effective_domain_size": 11056, "goshv": 41424, "intersection_size": 7, "intersections": [ [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [], [], [ "REAC" ] ], "name": "Regulation of TP53 Activity through Phosphorylation", "native": "REAC:R-HSA-6804756", "p_value": 4.9023835707218485e-11, "parents": [ "REAC:R-HSA-5633007" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.07608695652173914, "significant": true, "source": "REAC", "term_size": 92, "source_order": 2100, "group_id": 25 }, { "description": "Homologous DNA Pairing and Strand Exchange", "effective_domain_size": 11056, "goshv": 40503, "intersection_size": 6, "intersections": [ [], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [] ], "name": "Homologous DNA Pairing and Strand Exchange", "native": "REAC:R-HSA-5693579", "p_value": 5.726611557226973e-11, "parents": [ "REAC:R-HSA-5685942" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.13953488372093023, "significant": true, "source": "REAC", "term_size": 43, "source_order": 1179, "group_id": 28 }, { "description": "Transcriptional Regulation by TP53", "effective_domain_size": 11056, "goshv": 41968, "intersection_size": 9, "intersections": [ [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [ "REAC" ], [ "REAC" ], [ "REAC" ] ], "name": "Transcriptional Regulation by TP53", "native": "REAC:R-HSA-3700989", "p_value": 7.318866027144557e-11, "parents": [ "REAC:R-HSA-212436" ], "precision": 0.8181818181818182, "query": "query_1", "query_size": 11, "recall": 0.025280898876404494, "significant": true, "source": "REAC", "term_size": 356, "source_order": 2644, "group_id": 25 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17852, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IEP", "ISS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IMP", "TAS", "IEA" ], [ "IDA", "IMP", "IEP" ] ], "name": "cellular response to stress", "native": "GO:0033554", "p_value": 8.026913436866034e-11, "parents": [ "GO:0006950", "GO:0051716" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.005926724137931034, "significant": true, "source": "GO:BP", "term_size": 1856, "source_order": 7729, "group_id": 1 }, { "description": "\"The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase.\" [GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 20520, "intersection_size": 8, "intersections": [ [ "IMP", "IEA" ], [ "IMP" ], [ "IDA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IMP" ], [ "IMP", "IBA", "NAS", "IEA" ], [], [], [ "IDA", "IMP", "IGI", "IBA", "TAS" ], [], [ "IEA" ] ], "name": "mitotic cell cycle phase transition", "native": "GO:0044772", "p_value": 1.3080233242393762e-10, "parents": [ "GO:0044770", "GO:1903047" ], "precision": 0.7272727272727273, "query": "query_1", "query_size": 11, "recall": 0.018779342723004695, "significant": true, "source": "GO:BP", "term_size": 426, "source_order": 10397, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.\" [GOC:dph, GOC:go_curators, GOC:tb]", "effective_domain_size": 20972, "goshv": 21069, "intersection_size": 7, "intersections": [ [ "IMP", "IEA" ], [ "IMP" ], [ "IDA" ], [ "IDA", "IMP", "IBA" ], [ "IMP", "IBA" ], [ "IMP", "IBA", "NAS", "IEA" ], [], [], [ "IDA", "IMP", "IGI" ], [], [] ], "name": "negative regulation of mitotic cell cycle", "native": "GO:0045930", "p_value": 1.335657193585919e-10, "parents": [ "GO:0000278", "GO:0007346", "GO:0045786" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.03139013452914798, "significant": true, "source": "GO:BP", "term_size": 223, "source_order": 10946, "group_id": 1 }, { "description": "\"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.\" [GOC:go_curators, GOC:mtg_apoptosis]", "effective_domain_size": 20972, "goshv": 13201, "intersection_size": 6, "intersections": [ [ "IDA", "IMP", "IEA" ], [ "IBA", "IEA" ], [], [], [ "IDA", "IMP", "IEA" ], [ "IDA" ], [ "IEA" ], [], [ "IEA" ], [], [] ], "name": "intrinsic apoptotic signaling pathway in response to DNA damage", "native": "GO:0008630", "p_value": 2.0258394465995764e-10, "parents": [ "GO:0006974", "GO:0097193" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.056074766355140186, "significant": true, "source": "GO:BP", "term_size": 107, "source_order": 3078, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator.\" [GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 30430, "intersection_size": 6, "intersections": [ [ "IEA" ], [ "IMP", "TAS" ], [ "IMP" ], [ "TAS" ], [ "TAS" ], [], [], [], [], [], [ "IDA", "IMP", "TAS" ] ], "name": "regulation of signal transduction by p53 class mediator", "native": "GO:1901796", "p_value": 2.61368687412865e-10, "parents": [ "GO:0072331", "GO:1902531" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.05357142857142857, "significant": true, "source": "GO:BP", "term_size": 112, "source_order": 20307, "group_id": 1 }, { "description": "Cell Cycle", "effective_domain_size": 11056, "goshv": 39661, "intersection_size": 10, "intersections": [ [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [ "REAC" ] ], "name": "Cell Cycle", "native": "REAC:R-HSA-1640170", "p_value": 2.6348550063321756e-10, "parents": [ "REAC:0000000" ], "precision": 0.9090909090909091, "query": "query_1", "query_size": 11, "recall": 0.014705882352941176, "significant": true, "source": "REAC", "term_size": 680, "source_order": 337, "group_id": 27 }, { "description": "\"Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle.\" [GO_REF:0000058, GOC:jl, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 31056, "intersection_size": 6, "intersections": [ [ "IMP" ], [ "IMP" ], [ "IDA" ], [ "IDA", "IMP", "IBA" ], [], [ "IMP", "IBA", "NAS", "IEA" ], [], [], [ "IMP" ], [], [] ], "name": "regulation of cell cycle G2/M phase transition", "native": "GO:1902749", "p_value": 3.332097413466705e-10, "parents": [ "GO:0044839", "GO:1901987" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.05128205128205128, "significant": true, "source": "GO:BP", "term_size": 117, "source_order": 20933, "group_id": 1 }, { "description": "G1/S DNA Damage Checkpoints", "effective_domain_size": 11056, "goshv": 40371, "intersection_size": 6, "intersections": [ [ "REAC" ], [ "REAC" ], [], [ "REAC" ], [ "REAC" ], [], [], [], [ "REAC" ], [], [ "REAC" ] ], "name": "G1/S DNA Damage Checkpoints", "native": "REAC:R-HSA-69615", "p_value": 5.818149432964558e-10, "parents": [ "REAC:R-HSA-69620" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.08823529411764706, "significant": true, "source": "REAC", "term_size": 68, "source_order": 1047, "group_id": 27 }, { "description": "HDR through Homologous Recombination (HRR)", "effective_domain_size": 11056, "goshv": 40470, "intersection_size": 6, "intersections": [ [], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [] ], "name": "HDR through Homologous Recombination (HRR)", "native": "REAC:R-HSA-5685942", "p_value": 6.093700189071953e-10, "parents": [ "REAC:R-HSA-5693567" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.08571428571428572, "significant": true, "source": "REAC", "term_size": 70, "source_order": 1146, "group_id": 28 }, { "description": "Cell Cycle Checkpoints", "effective_domain_size": 11056, "goshv": 39662, "intersection_size": 8, "intersections": [ [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [ "REAC" ], [], [ "REAC" ] ], "name": "Cell Cycle Checkpoints", "native": "REAC:R-HSA-69620", "p_value": 7.090105124775999e-10, "parents": [ "REAC:R-HSA-1640170" ], "precision": 0.7272727272727273, "query": "query_1", "query_size": 11, "recall": 0.02768166089965398, "significant": true, "source": "REAC", "term_size": 289, "source_order": 338, "group_id": 27 }, { "description": "Regulation of TP53 Activity", "effective_domain_size": 11056, "goshv": 41420, "intersection_size": 7, "intersections": [ [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [], [], [ "REAC" ] ], "name": "Regulation of TP53 Activity", "native": "REAC:R-HSA-5633007", "p_value": 7.659079454845383e-10, "parents": [ "REAC:R-HSA-3700989" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.04375, "significant": true, "source": "REAC", "term_size": 160, "source_order": 2096, "group_id": 25 }, { "description": "\"The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.\" [GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 10156, "intersection_size": 6, "intersections": [ [], [ "IMP" ], [ "IDA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IMP" ], [ "IMP", "IBA", "NAS", "IEA" ], [], [], [ "IMP" ], [], [] ], "name": "G2/M transition of mitotic cell cycle", "native": "GO:0000086", "p_value": 9.302191152598345e-10, "parents": [ "GO:0044772", "GO:0044839" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.04316546762589928, "significant": true, "source": "GO:BP", "term_size": 139, "source_order": 33, "group_id": 1 }, { "description": "\"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 12095, "intersection_size": 7, "intersections": [ [ "IEA" ], [], [ "IMP", "ISS", "TAS" ], [ "TAS" ], [], [ "IDA", "NAS" ], [ "IMP", "IEA" ], [ "IDA", "IMP", "IEA" ], [ "TAS" ], [], [] ], "name": "DNA replication", "native": "GO:0006260", "p_value": 9.551242837124554e-10, "parents": [ "GO:0006259" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.023333333333333334, "significant": true, "source": "GO:BP", "term_size": 300, "source_order": 1972, "group_id": 1 }, { "description": "\"A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle.\" [GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 20544, "intersection_size": 5, "intersections": [ [], [ "IMP" ], [ "IDA" ], [ "IDA", "IMP", "IBA" ], [], [ "IMP", "IBA", "NAS", "IEA" ], [], [], [ "IMP" ], [], [] ], "name": "mitotic G2/M transition checkpoint", "native": "GO:0044818", "p_value": 1.1111094155788203e-9, "parents": [ "GO:0007093", "GO:0010972" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.09259259259259259, "significant": true, "source": "GO:BP", "term_size": 54, "source_order": 10421, "group_id": 1 }, { "description": "\"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).\" [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119]", "effective_domain_size": 20972, "goshv": 27439, "intersection_size": 7, "intersections": [ [ "IDA", "IMP", "ISS", "TAS", "IEA" ], [ "IBA", "IEA" ], [], [], [ "IDA", "IMP", "IEA" ], [ "IDA" ], [ "IEA" ], [], [ "TAS", "IEA" ], [], [ "IMP" ] ], "name": "intrinsic apoptotic signaling pathway", "native": "GO:0097193", "p_value": 1.375055187878651e-9, "parents": [ "GO:0035556", "GO:0097190" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.0220125786163522, "significant": true, "source": "GO:BP", "term_size": 318, "source_order": 17316, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition.\" [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]", "effective_domain_size": 20972, "goshv": 30570, "intersection_size": 7, "intersections": [ [ "IMP", "IEA" ], [ "IMP" ], [ "IDA" ], [ "IDA", "IMP", "IBA" ], [], [ "IMP", "IBA", "NAS", "IEA" ], [], [], [ "IDA", "IMP", "IGI", "IBA" ], [], [ "IEA" ] ], "name": "regulation of mitotic cell cycle phase transition", "native": "GO:1901990", "p_value": 1.6366801032451348e-9, "parents": [ "GO:0007346", "GO:0044772", "GO:1901987" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.021406727828746176, "significant": true, "source": "GO:BP", "term_size": 327, "source_order": 20447, "group_id": 1 }, { "description": "DNA Repair", "effective_domain_size": 11056, "goshv": 39788, "intersection_size": 8, "intersections": [ [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [] ], "name": "DNA Repair", "native": "REAC:R-HSA-73894", "p_value": 1.6398065737805686e-9, "parents": [ "REAC:0000000" ], "precision": 0.7272727272727273, "query": "query_1", "query_size": 11, "recall": 0.0243161094224924, "significant": true, "source": "REAC", "term_size": 329, "source_order": 464, "group_id": 28 }, { "description": "Impaired BRCA2 binding to RAD51", "effective_domain_size": 11056, "goshv": 40546, "intersection_size": 5, "intersections": [ [], [ "REAC" ], [ "REAC" ], [], [], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [] ], "name": "Impaired BRCA2 binding to RAD51", "native": "REAC:R-HSA-9709570", "p_value": 1.8736159439890538e-9, "parents": [ "REAC:R-HSA-9701190" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.14285714285714285, "significant": true, "source": "REAC", "term_size": 35, "source_order": 1222, "group_id": 26 }, { "description": "G2/M DNA damage checkpoint", "effective_domain_size": 11056, "goshv": 40376, "intersection_size": 6, "intersections": [ [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [], [], [] ], "name": "G2/M DNA damage checkpoint", "native": "REAC:R-HSA-69473", "p_value": 2.3069966397856873e-9, "parents": [ "REAC:R-HSA-69481" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.06382978723404255, "significant": true, "source": "REAC", "term_size": 94, "source_order": 1052, "group_id": 27 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition.\" [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]", "effective_domain_size": 20972, "goshv": 30571, "intersection_size": 6, "intersections": [ [ "IMP", "IEA" ], [ "IMP" ], [ "IDA" ], [ "IDA", "IMP", "IBA" ], [], [ "IMP", "IBA", "NAS", "IEA" ], [], [], [ "IDA", "IMP", "IGI" ], [], [] ], "name": "negative regulation of mitotic cell cycle phase transition", "native": "GO:1901991", "p_value": 3.1434058248509676e-9, "parents": [ "GO:0044772", "GO:0045930", "GO:1901988", "GO:1901990" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.03468208092485549, "significant": true, "source": "GO:BP", "term_size": 173, "source_order": 20448, "group_id": 1 }, { "description": "Diseases of DNA Double-Strand Break Repair", "effective_domain_size": 11056, "goshv": 40119, "intersection_size": 5, "intersections": [ [], [ "REAC" ], [ "REAC" ], [], [], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [] ], "name": "Diseases of DNA Double-Strand Break Repair", "native": "REAC:R-HSA-9675136", "p_value": 3.4507225476025728e-9, "parents": [ "REAC:R-HSA-9675135" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.12195121951219512, "significant": true, "source": "REAC", "term_size": 41, "source_order": 795, "group_id": 26 }, { "description": "Defective homologous recombination repair (HRR) due to BRCA2 loss of function", "effective_domain_size": 11056, "goshv": 40042, "intersection_size": 5, "intersections": [ [], [ "REAC" ], [ "REAC" ], [], [], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [] ], "name": "Defective homologous recombination repair (HRR) due to BRCA2 loss of function", "native": "REAC:R-HSA-9701190", "p_value": 3.4507225476025728e-9, "parents": [ "REAC:R-HSA-9675136" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.12195121951219512, "significant": true, "source": "REAC", "term_size": 41, "source_order": 718, "group_id": 26 }, { "description": "\"Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.\" [GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 14457, "intersection_size": 5, "intersections": [ [], [ "IMP" ], [ "IDA" ], [ "IDA", "IMP", "IBA" ], [], [ "IMP", "IBA", "NAS", "IEA" ], [], [], [ "IMP" ], [], [] ], "name": "negative regulation of G2/M transition of mitotic cell cycle", "native": "GO:0010972", "p_value": 3.6132129663443414e-9, "parents": [ "GO:0000086", "GO:0010389", "GO:1901991", "GO:1902750" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.07246376811594203, "significant": true, "source": "GO:BP", "term_size": 69, "source_order": 4334, "group_id": 1 }, { "description": "\"Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle.\" [GO_REF:0000058, GOC:jl, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 31057, "intersection_size": 5, "intersections": [ [], [ "IMP" ], [ "IDA" ], [ "IDA", "IMP", "IBA" ], [], [ "IMP", "IBA", "NAS", "IEA" ], [], [], [ "IMP" ], [], [] ], "name": "negative regulation of cell cycle G2/M phase transition", "native": "GO:1902750", "p_value": 4.1002573832031725e-9, "parents": [ "GO:0044839", "GO:1901988", "GO:1902749" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.07042253521126761, "significant": true, "source": "GO:BP", "term_size": 71, "source_order": 20934, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of a DNA damage checkpoint.\" [GOC:obol]", "effective_domain_size": 20972, "goshv": 33637, "intersection_size": 4, "intersections": [ [], [], [], [], [ "IEA" ], [ "NAS" ], [ "NAS" ], [ "NAS" ], [], [], [] ], "name": "regulation of DNA damage checkpoint", "native": "GO:2000001", "p_value": 8.277318141741616e-9, "parents": [ "GO:0000077", "GO:0080135", "GO:1901976" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.17391304347826086, "significant": true, "source": "GO:BP", "term_size": 23, "source_order": 23514, "group_id": 1 }, { "description": "Diseases of DNA repair", "effective_domain_size": 11056, "goshv": 40120, "intersection_size": 5, "intersections": [ [], [ "REAC" ], [ "REAC" ], [], [], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [] ], "name": "Diseases of DNA repair", "native": "REAC:R-HSA-9675135", "p_value": 9.109134432820094e-9, "parents": [ "REAC:R-HSA-1643685" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.1, "significant": true, "source": "REAC", "term_size": 50, "source_order": 796, "group_id": 26 }, { "description": "\"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered.\" [GOC:mah, GOC:mtg_apoptosis]", "effective_domain_size": 20972, "goshv": 26305, "intersection_size": 5, "intersections": [ [ "IDA", "IMP", "IEA" ], [], [], [], [ "IEA" ], [], [ "IEA" ], [], [ "IEA" ], [], [ "IMP" ] ], "name": "intrinsic apoptotic signaling pathway by p53 class mediator", "native": "GO:0072332", "p_value": 9.319336471950034e-9, "parents": [ "GO:0072331", "GO:0097193" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.05952380952380952, "significant": true, "source": "GO:BP", "term_size": 84, "source_order": 16182, "group_id": 1 }, { "description": "\"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.\" [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]", "effective_domain_size": 20972, "goshv": 18628, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IEP", "ISS", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "NAS", "IEA" ], [ "NAS", "IEA" ], [ "NAS" ], [ "IDA", "IMP", "IEP", "TAS", "IEA" ], [ "IDA", "IMP" ], [ "IDA", "IMP", "TAS" ] ], "name": "intracellular signal transduction", "native": "GO:0035556", "p_value": 9.727202021174442e-9, "parents": [ "GO:0007165" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.003712453594330071, "significant": true, "source": "GO:BP", "term_size": 2963, "source_order": 8505, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of intracellular signal transduction.\" [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 30937, "intersection_size": 10, "intersections": [ [ "IMP", "ISS", "IEA" ], [ "IMP", "IBA", "TAS", "IEA" ], [ "IMP" ], [ "TAS" ], [ "TAS", "IEA" ], [ "IMP", "NAS" ], [ "NAS" ], [ "NAS" ], [], [ "IDA" ], [ "IDA", "IMP", "TAS" ] ], "name": "regulation of intracellular signal transduction", "native": "GO:1902531", "p_value": 1.0064317601513752e-8, "parents": [ "GO:0009966", "GO:0035556" ], "precision": 0.9090909090909091, "query": "query_1", "query_size": 11, "recall": 0.005141388174807198, "significant": true, "source": "GO:BP", "term_size": 1945, "source_order": 20814, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz).\" [GOC:sm, Wikipedia:X-ray]", "effective_domain_size": 20972, "goshv": 13920, "intersection_size": 4, "intersections": [ [ "IEA" ], [ "IDA" ], [], [], [], [], [ "IEA" ], [ "IEA" ], [], [], [] ], "name": "response to X-ray", "native": "GO:0010165", "p_value": 1.2947965991654003e-8, "parents": [ "GO:0010212" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.15384615384615385, "significant": true, "source": "GO:BP", "term_size": 26, "source_order": 3797, "group_id": 1 }, { "description": "HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)", "effective_domain_size": 11056, "goshv": 40471, "intersection_size": 6, "intersections": [ [], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [] ], "name": "HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)", "native": "REAC:R-HSA-5693567", "p_value": 1.5311326352092705e-8, "parents": [ "REAC:R-HSA-5693538" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.04477611940298507, "significant": true, "source": "REAC", "term_size": 134, "source_order": 1147, "group_id": 28 }, { "description": "Homology Directed Repair", "effective_domain_size": 11056, "goshv": 40504, "intersection_size": 6, "intersections": [ [], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [] ], "name": "Homology Directed Repair", "native": "REAC:R-HSA-5693538", "p_value": 1.8855991530316496e-8, "parents": [ "REAC:R-HSA-5693532" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.04285714285714286, "significant": true, "source": "REAC", "term_size": 140, "source_order": 1180, "group_id": 28 }, { "description": "TP53 Regulates Transcription of DNA Repair Genes", 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cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.\" [GOC:mtg_cell_cycle, PMID:17329565]", "effective_domain_size": 20972, "goshv": 14051, "intersection_size": 5, "intersections": [ [], [ "IMP" ], [ "IDA" ], [ "IDA", "IMP", "IBA" ], [], [ "IMP", "IBA", "NAS", "IEA" ], [], [], [ "IMP" ], [], [] ], "name": "regulation of G2/M transition of mitotic cell cycle", "native": "GO:0010389", "p_value": 2.520469943181169e-8, "parents": [ "GO:0000086", "GO:1901990", "GO:1902749" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.04807692307692308, "significant": true, "source": "GO:BP", "term_size": 104, "source_order": 3928, "group_id": 1 }, { "description": "p53-Dependent G1 DNA Damage Response", "effective_domain_size": 11056, "goshv": 42139, "intersection_size": 5, "intersections": [ [ "REAC" ], [ "REAC" ], [], [], [ "REAC" ], [], [], [], [ "REAC" ], [], [ "REAC" ] ], "name": "p53-Dependent G1 DNA 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[], [ "REAC" ], [], [], [], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [] ], "name": "Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "native": "REAC:R-HSA-9704646", "p_value": 4.783907237020509e-8, "parents": [ "REAC:R-HSA-9701193" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.16, "significant": true, "source": "REAC", "term_size": 25, "source_order": 585, "group_id": 26 }, { "description": "RNA Polymerase II Transcription", "effective_domain_size": 11056, "goshv": 41287, "intersection_size": 10, "intersections": [ [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ] ], "name": "RNA Polymerase II Transcription", "native": "REAC:R-HSA-73857", "p_value": 4.950569664013243e-8, "parents": [ "REAC:R-HSA-74160" ], "precision": 0.9090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0073964497041420114, "significant": true, "source": "REAC", "term_size": 1352, "source_order": 1963, "group_id": 25 }, { "description": "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "effective_domain_size": 11056, "goshv": 41486, "intersection_size": 4, "intersections": [ [], [ "REAC" ], [], [], [], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [] ], "name": "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "native": "REAC:R-HSA-5693554", "p_value": 6.202473443303767e-8, "parents": [ "REAC:R-HSA-5693537" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.14814814814814814, "significant": true, "source": "REAC", "term_size": 27, "source_order": 2162, "group_id": 28 }, { "description": "\"Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 20189, "intersection_size": 4, "intersections": [ [ "IEA" ], [ "IMP" ], [ "IMP" ], [], [], [], [], [], [], [], [ "IDA" ] ], "name": "regulation of DNA damage response, signal transduction by p53 class mediator", "native": "GO:0043516", "p_value": 7.228448509638342e-8, "parents": [ "GO:0030330", "GO:0080135", "GO:1901796" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.1, "significant": true, "source": "GO:BP", "term_size": 40, "source_order": 10066, "group_id": 1 }, { "description": "\"The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.\" [GOC:mtg_apoptosis]", "effective_domain_size": 20972, "goshv": 27436, "intersection_size": 7, "intersections": [ [ "IDA", "IMP", "ISS", "TAS", "IEA" ], [ "IBA", "IEA" ], [], [], [ "IDA", "IMP", "IEA" ], [ "IDA", "IMP" ], [ "IEA" ], [], [ "TAS", "IEA" ], [], [ "IMP" ] ], "name": "apoptotic signaling pathway", "native": "GO:0097190", "p_value": 9.95927715126811e-8, "parents": [ "GO:0006915", "GO:0007165" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.011437908496732025, "significant": true, "source": "GO:BP", "term_size": 612, "source_order": 17313, "group_id": 1 }, { "description": "\"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.\" [GOC:go_curators, GOC:mtg_apoptosis]", "effective_domain_size": 20972, "goshv": 19825, "intersection_size": 4, "intersections": [ [ "IDA", "IMP", "IEA" ], [], [], [], [ "IEA" ], [], [ "IEA" ], [], [ "IEA" ], [], [] ], "name": "intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator", "native": "GO:0042771", "p_value": 1.3627076010720652e-7, "parents": [ "GO:0008630", "GO:0072332" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.0851063829787234, "significant": true, "source": "GO:BP", "term_size": 47, "source_order": 9702, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of cell cycle checkpoint.\" [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116]", "effective_domain_size": 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Junction Intermediates", "native": "REAC:R-HSA-5693568", "p_value": 1.8894648942308587e-7, "parents": [ "REAC:R-HSA-5693537" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.1111111111111111, "significant": true, "source": "REAC", "term_size": 36, "source_order": 2161, "group_id": 28 }, { "description": "\"Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 15397, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "NAS", "IEA" ], [ "IMP", "IGI", "ISS", "IEA" ], [ "IMP", "ISS", "NAS" ], [ "IDA" ], [ "IDA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IBA" ], [ "IDA" ], [ "IMP", "TAS", "IEA" ], [ "IMP" ], [ "IDA", "IMP" ] ], "name": "regulation of nucleobase-containing compound metabolic process", "native": "GO:0019219", 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"group_id": 25 }, { "description": "\"The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes.\" [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542]", "effective_domain_size": 20972, "goshv": 16789, "intersection_size": 4, "intersections": [ [], [], [ "ISS" ], [], [], [ "NAS" ], [ "IMP", "IEA" ], [ "IDA", "IMP", "IEA" ], [], [], [] ], "name": "replication fork processing", "native": "GO:0031297", "p_value": 1.9702392559269216e-7, "parents": [ "GO:0045005" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.07692307692307693, "significant": true, "source": "GO:BP", "term_size": 52, "source_order": 6666, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 12574, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IEP", "ISS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IMP", "TAS", "IEA" ], [ "IDA", "IMP", "IEP" ] ], "name": "response to stress", "native": "GO:0006950", "p_value": 2.038236409990816e-7, "parents": [ "GO:0050896" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.0027610441767068274, "significant": true, "source": "GO:BP", "term_size": 3984, "source_order": 2451, "group_id": 1 }, { "description": "\"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.\" [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]", "effective_domain_size": 20972, "goshv": 10322, "intersection_size": 5, "intersections": [ [ "IDA" ], [ "IMP", "IGI", "ISS", "IBA", "IEA" ], [ "ISS", "IBA" ], [], [], [], [ "IEA" ], [ "ISS", "IEA" ], [], [], [] ], "name": "telomere maintenance", "native": "GO:0000723", "p_value": 2.1366814881230831e-7, "parents": [ "GO:0006259", "GO:0032200" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.03048780487804878, "significant": true, "source": "GO:BP", "term_size": 164, "source_order": 199, "group_id": 1 }, { "description": "Meiosis", "effective_domain_size": 11056, "goshv": 40796, "intersection_size": 5, "intersections": [ [], [ "REAC" ], [ "REAC" ], [], [], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [] ], "name": "Meiosis", "native": "REAC:R-HSA-1500620", "p_value": 3.07076259492914e-7, "parents": [ "REAC:R-HSA-1474165", "REAC:R-HSA-1640170" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.0423728813559322, "significant": true, "source": "REAC", "term_size": 118, "source_order": 1472, "group_id": 27 }, { "description": "\"A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair.\" [GOC:mah, GOC:vw]", "effective_domain_size": 20972, "goshv": 20587, "intersection_size": 4, "intersections": [ [], [], [ "ISS" ], [], [], [ "NAS" ], [ "IMP", "IEA" ], [ "IDA", "IMP", "IEA" ], [], [], [] ], "name": "DNA-templated DNA replication maintenance of fidelity", "native": "GO:0045005", "p_value": 3.15261947268248e-7, "parents": [ "GO:0006259", "GO:0006261" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.06779661016949153, "significant": true, "source": "GO:BP", "term_size": 59, "source_order": 10464, "group_id": 1 }, { "description": "\"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.\" [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]", "effective_domain_size": 20972, "goshv": 12556, "intersection_size": 9, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "TAS", "IEA" ], [ "IMP", "IBA", "TAS", "IEA" ], [], [ "IDA", "IEA" ], [ "IDA", "IMP", "IEA" ], [ "IDA", "IMP" ], [ "IEA" ], [], [ "TAS", "IEA" ], [ "IDA", "TAS" ], [ "IDA", "IMP", "IBA", "IEA" ] ], "name": "apoptotic process", "native": "GO:0006915", "p_value": 3.15261947268248e-7, "parents": [ "GO:0012501" ], "precision": 0.8181818181818182, "query": "query_1", "query_size": 11, "recall": 0.004741833508956797, "significant": true, "source": "GO:BP", "term_size": 1898, "source_order": 2433, "group_id": 1 }, { "description": "\"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.\" [GOC:elh, PMID:10357855]", "effective_domain_size": 20972, "goshv": 10323, "intersection_size": 5, "intersections": [ [], [ "IDA", "IEA" ], [], [ "IDA" ], [], [ "IDA", "IBA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [], [], [] ], "name": "double-strand break repair via homologous recombination", "native": "GO:0000724", "p_value": 3.9502379429118706e-7, "parents": [ "GO:0000725", "GO:0006302" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.026737967914438502, "significant": true, "source": "GO:BP", "term_size": 187, "source_order": 200, "group_id": 1 }, { "description": "\"A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.\" [GOC:lr, GOC:mtg_apoptosis]", "effective_domain_size": 20972, "goshv": 14479, "intersection_size": 9, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "TAS", "IEA" ], [ "IMP", "IBA", "TAS", "IEA" ], [], [ "IDA", "IEA" ], [ "IDA", "IMP", "IEA" ], [ "IDA", "IMP" ], [ "IEA" ], [], [ "TAS", "IEA" ], [ "IDA", "TAS" ], [ "IDA", "IMP", "IBA", "IEA" ] ], "name": "programmed cell death", "native": "GO:0012501", "p_value": 4.0339246552102475e-7, "parents": [ "GO:0008219" ], "precision": 0.8181818181818182, "query": "query_1", "query_size": 11, "recall": 0.004596527068437181, "significant": true, "source": "GO:BP", "term_size": 1958, "source_order": 4356, "group_id": 1 }, { "description": "\"Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).\" [GOC:mah, GOC:mtg_apoptosis, PMID:25236395]", "effective_domain_size": 20972, "goshv": 13129, "intersection_size": 9, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "TAS", "IEA" ], [ "IMP", "IBA", "TAS", "IEA" ], [], [ "IDA", "IEA" ], [ "IDA", "IMP", "IEA" ], [ "IDA", "IMP" ], [ "IEA" ], [], [ "TAS", "IEA" ], [ "IDA", "TAS" ], [ "IDA", "IMP", "IBA", "IEA" ] ], "name": "cell death", "native": "GO:0008219", "p_value": 4.050271735710898e-7, "parents": [ "GO:0009987" ], "precision": 0.8181818181818182, "query": "query_1", "query_size": 11, "recall": 0.0045871559633027525, "significant": true, "source": "GO:BP", "term_size": 1962, "source_order": 3006, "group_id": 1 }, { "description": "\"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins.\" [GOC:dph, GOC:jl, GOC:mah]", "effective_domain_size": 20972, "goshv": 17030, "intersection_size": 5, "intersections": [ [ "IDA" ], [ "IMP", "IGI", "ISS", "IBA", "IEA" ], [ "ISS", "IBA" ], [], [], [], [ "IEA" ], [ "ISS", "IEA" ], [], [], [] ], "name": "telomere organization", "native": "GO:0032200", "p_value": 4.2114781973704187e-7, "parents": [ "GO:0051276" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.02617801047120419, "significant": true, "source": "GO:BP", "term_size": 191, "source_order": 6907, "group_id": 1 }, { "description": "\"A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region.\" [GOC:elh]", "effective_domain_size": 20972, "goshv": 10324, "intersection_size": 5, "intersections": [ [], [ "IDA", "IEA" ], [], [ "IDA" ], [], [ "IDA", "IBA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [], [], [] ], "name": "recombinational repair", "native": "GO:0000725", "p_value": 4.264627287619373e-7, "parents": [ "GO:0006281", "GO:0006310" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.026041666666666668, "significant": true, "source": "GO:BP", "term_size": 192, "source_order": 201, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of signal transduction.\" [GOC:sm]", "effective_domain_size": 20972, "goshv": 13766, "intersection_size": 10, "intersections": [ [ "IMP", "ISS", "IEA" ], [ "IMP", "IBA", "TAS", "IEA" ], [ "IMP" ], [ "TAS" ], [ "TAS", "IEA" ], [ "IMP", "NAS" ], [ "NAS" ], [ "NAS" ], [], [ "IDA", "IMP" ], [ "IDA", "IMP", "TAS" ] ], "name": "regulation of signal transduction", "native": "GO:0009966", "p_value": 5.854196090158336e-7, "parents": [ "GO:0007165", "GO:0010646", "GO:0023051", "GO:0048583" ], "precision": 0.9090909090909091, "query": "query_1", "query_size": 11, "recall": 0.003299241174529858, "significant": true, "source": "GO:BP", "term_size": 3031, "source_order": 3643, "group_id": 1 }, { "description": "\"A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 16461, "intersection_size": 4, "intersections": [ [ "IDA", "IMP", "IEA" ], [ "IMP" ], [ "IMP" ], [], [], [], [], [], [], [], [ "IDA", "IMP" ] ], "name": "DNA damage response, signal transduction by p53 class mediator", "native": "GO:0030330", "p_value": 6.286603508294978e-7, "parents": [ "GO:0042770", "GO:0072331" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.05555555555555555, "significant": true, "source": "GO:BP", "term_size": 72, "source_order": 6338, "group_id": 1 }, { "description": "\"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 14360, "intersection_size": 4, "intersections": [ [ "IDA" ], [ "IMP", "IGI", "ISS", "IEA" ], [ "ISS" ], [], [], [], [], [ "ISS", "IEA" ], [], [], [] ], "name": "telomere maintenance via telomere lengthening", "native": "GO:0010833", "p_value": 6.286603508294978e-7, "parents": [ "GO:0000723" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.05555555555555555, "significant": true, "source": "GO:BP", "term_size": 72, "source_order": 4237, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of DNA repair.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 12112, "intersection_size": 5, "intersections": [ [], [ "IMP" ], [ "NAS" ], [ "IDA" ], [], [ "IMP", "NAS" ], [], [ "IDA" ], [], [], [] ], "name": "regulation of DNA repair", "native": "GO:0006282", "p_value": 9.761986187574676e-7, "parents": [ "GO:0006281", "GO:0051052", "GO:0080135" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.021834061135371178, "significant": true, "source": "GO:BP", "term_size": 229, "source_order": 1989, "group_id": 1 }, { "description": "Stabilization of p53", "effective_domain_size": 11056, "goshv": 41772, "intersection_size": 4, "intersections": [ [ "REAC" ], [ "REAC" ], [], [], [ "REAC" ], [], [], [], [], [], [ "REAC" ] ], "name": "Stabilization of p53", "native": "REAC:R-HSA-69541", "p_value": 0.0000010928893512315076, "parents": [ "REAC:R-HSA-69563" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.07017543859649122, "significant": true, "source": "REAC", "term_size": 57, "source_order": 2448, "group_id": 27 }, { "description": "Reproduction", "effective_domain_size": 11056, "goshv": 41472, "intersection_size": 5, "intersections": [ [], [ "REAC" ], [ "REAC" ], [], [], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [] ], "name": "Reproduction", "native": "REAC:R-HSA-1474165", "p_value": 0.0000011825539085592438, "parents": [ "REAC:0000000" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.03205128205128205, "significant": true, "source": "REAC", "term_size": 156, "source_order": 2148, "group_id": 27 }, { "description": "\"Any process that modulates the frequency, rate or extent of DNA biosynthetic process.\" [GOC:obol]", "effective_domain_size": 20972, "goshv": 33859, "intersection_size": 4, "intersections": [ [ "IDA" ], [ "IGI", "ISS", "IEA" ], [ "ISS" ], [], [], [], [], [], [ "IMP", "IEA" ], [], [] ], "name": "regulation of DNA biosynthetic process", "native": "GO:2000278", "p_value": 0.0000012017680040095722, "parents": [ "GO:0010556", "GO:0051052", "GO:0071897" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.047058823529411764, "significant": true, "source": "GO:BP", "term_size": 85, "source_order": 23736, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of a signaling process.\" [GOC:mtg_signal]", "effective_domain_size": 20972, "goshv": 16327, "intersection_size": 10, "intersections": [ [ "IMP", "ISS", "IEA" ], [ "IMP", "IBA", "TAS", "IEA" ], [ "IMP" ], [ "TAS" ], [ "TAS", "IEA" ], [ "IMP", "NAS" ], [ "NAS" ], [ "NAS" ], [], [ "IDA", "IMP" ], [ "IDA", "IMP", "TAS" ] ], "name": "regulation of signaling", "native": "GO:0023051", "p_value": 0.000002083787324125428, "parents": [ "GO:0023052", "GO:0050789" ], "precision": 0.9090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0028793550244745176, "significant": true, "source": "GO:BP", "term_size": 3473, "source_order": 6204, "group_id": 1 }, { "description": "\"A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.\" [GOC:BHF, PMID:28682291]", "effective_domain_size": 20972, "goshv": 27182, "intersection_size": 4, "intersections": [ [ "IDA", "IMP", "ISS", "IEA" ], [ "TAS" ], [], [], [], [], [ "IEA" ], [], [ "IMP", "TAS", "IEA" ], [], [] ], "name": "cellular senescence", "native": "GO:0090398", "p_value": 0.000002083787324125428, "parents": [ "GO:0009987", "GO:0033554" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.04081632653061224, "significant": true, "source": "GO:BP", "term_size": 98, "source_order": 17059, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 14228, "intersection_size": 10, "intersections": [ [ "IMP", "ISS", "IEA" ], [ "IMP", "IBA", "TAS", "IEA" ], [ "IMP" ], [ "TAS" ], [ "TAS", "IEA" ], [ "IMP", "NAS" ], [ "NAS" ], [ "NAS" ], [], [ "IDA", "IMP" ], [ "IDA", "IMP", "TAS" ] ], "name": "regulation of cell communication", "native": "GO:0010646", "p_value": 0.0000020875591580240147, "parents": [ "GO:0007154", "GO:0050794" ], "precision": 0.9090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0028735632183908046, "significant": true, "source": "GO:BP", "term_size": 3480, "source_order": 4105, "group_id": 1 }, { "description": "\"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.\" [GOC:ai, GOC:dph, GOC:jl, GOC:mah]", "effective_domain_size": 20972, "goshv": 22838, "intersection_size": 6, "intersections": [ [ "IDA", "IEA" ], [ "IMP", "IGI", "ISS", "IBA", "IEA" ], [ "ISS", "IBA" ], [], [ "IMP" ], [], [ "IEA" ], [ "ISS", "IBA", "IEA" ], [], [], [] ], "name": "chromosome organization", "native": "GO:0051276", "p_value": 0.0000023977284325745193, "parents": [ "GO:0006996" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.010434782608695653, "significant": true, "source": "GO:BP", "term_size": 575, "source_order": 12715, "group_id": 1 }, { "description": "\"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.\" [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]", "effective_domain_size": 20972, "goshv": 12141, "intersection_size": 7, "intersections": [ [ "IDA" ], [ "IEA" ], [ "IEA" ], [ "ISS", "IEA" ], [ "IEA" ], [ "IMP", "IBA", "TAS", "IEA" ], [ "IEA" ], [], [], [], [] ], "name": "chromatin remodeling", "native": "GO:0006338", "p_value": 0.0000030785844356110293, "parents": [ "GO:0006325" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.006622516556291391, "significant": true, "source": "GO:BP", "term_size": 1057, "source_order": 2018, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.\" [PMID:19211694]", "effective_domain_size": 20972, "goshv": 26740, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "NAS", "IEA" ], [ "IMP", "IGI", "ISS", "IEA" ], [ "IMP", "ISS", "NAS" ], [ "IDA" ], [ "IDA", "IMP" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IBA" ], [ "IDA" ], [ "IDA", "IMP", "TAS", "IEA" ], [ "IMP", "TAS" ], [ "IDA", "IMP" ] ], "name": "regulation of primary metabolic process", "native": "GO:0080090", "p_value": 0.0000030785844356110293, "parents": [ "GO:0019222", "GO:0044238" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.002109300095877277, "significant": true, "source": "GO:BP", "term_size": 5215, "source_order": 16617, "group_id": 1 }, { "description": "\"The aggregation, arrangement and bonding together of a set of components to form a telomerase catalytic core complex.\" [GO_REF:0000079, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]", "effective_domain_size": 20972, "goshv": 32555, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [ "IMP" ], [], [], [], [], [], [], [], [] ], "name": "telomerase catalytic core complex assembly", "native": "GO:1904868", "p_value": 0.000003215719545163273, "parents": [ "GO:1905323" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 1, "significant": true, "source": "GO:BP", "term_size": 2, "source_order": 22432, "group_id": 1 }, { "description": "\"Any maintenance of fidelity that is involved in cell cycle DNA replication.\" [GOC:mtg_cell_cycle, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 30801, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [ "IMP" ], [ "IEA" ], [], [], [] ], "name": "cell cycle DNA replication maintenance of fidelity", "native": "GO:1902298", "p_value": 0.000003215719545163273, "parents": [ "GO:0022402", "GO:0044786", "GO:0045005" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 1, "significant": true, "source": "GO:BP", "term_size": 2, "source_order": 20678, "group_id": 1 }, { "description": "\"Any maintenance of fidelity that is involved in mitotic cell cycle DNA replication.\" [PMID:19185548]", "effective_domain_size": 20972, "goshv": 33465, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [ "IMP" ], [ "IEA" ], [], [], [] ], "name": "mitotic DNA replication maintenance of fidelity", "native": "GO:1990505", "p_value": 0.000003215719545163273, "parents": [ "GO:1902298", "GO:1902969", "GO:1903047" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 1, "significant": true, "source": "GO:BP", "term_size": 2, "source_order": 23342, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of telomerase catalytic core complex assembly.\" [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]", "effective_domain_size": 20972, "goshv": 32568, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [ "IMP" ], [], [], [], [], [], [], [], [] ], "name": "positive regulation of telomerase catalytic core complex assembly", "native": "GO:1904884", "p_value": 0.000003215719545163273, "parents": [ "GO:0031334", "GO:1904868", "GO:1904882" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 1, "significant": true, "source": "GO:BP", "term_size": 2, "source_order": 22445, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of telomerase catalytic core complex assembly.\" [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433]", "effective_domain_size": 20972, "goshv": 32566, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [ "IMP" ], [], [], [], [], [], [], [], [] ], "name": "regulation of telomerase catalytic core complex assembly", "native": "GO:1904882", "p_value": 0.000003215719545163273, "parents": [ "GO:0043254", "GO:1904868" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 1, "significant": true, "source": "GO:BP", "term_size": 2, "source_order": 22443, "group_id": 1 }, { "description": "\"Replication fork processing that includes recombination between DNA near the arrested fork and homologous sequences. Proteins involved in homologous recombination are required for replication restart.\" [GOC:mah, PMID:23093942]", "effective_domain_size": 20972, "goshv": 33441, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [ "IMP" ], [ "IEA" ], [], [], [] ], "name": "mitotic recombination-dependent replication fork processing", "native": "GO:1990426", "p_value": 0.000003215719545163273, "parents": [ "GO:0031297", "GO:1990505" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 1, "significant": true, "source": "GO:BP", "term_size": 2, "source_order": 23318, "group_id": 1 }, { "description": "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "effective_domain_size": 11056, "goshv": 41346, "intersection_size": 4, "intersections": [ [ "REAC" ], [ "REAC" ], [], [], [ "REAC" ], [ "REAC" ], [], [], [], [], [] ], "name": "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "native": "REAC:R-HSA-5693565", "p_value": 0.0000035254758873861986, "parents": [ "REAC:R-HSA-5693606" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.05194805194805195, "significant": true, "source": "REAC", "term_size": 77, "source_order": 2022, "group_id": 28 }, { "description": "DNA Double Strand Break Response", "effective_domain_size": 11056, "goshv": 39786, "intersection_size": 4, "intersections": [ [ "REAC" ], [ "REAC" ], [], [], [ "REAC" ], [ "REAC" ], [], [], [], [], [] ], "name": "DNA Double Strand Break Response", "native": "REAC:R-HSA-5693606", "p_value": 0.0000036257195980036914, "parents": [ "REAC:R-HSA-5693532" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.05128205128205128, "significant": true, "source": "REAC", "term_size": 78, "source_order": 462, "group_id": 28 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.\" [GOC:jid]", "effective_domain_size": 20972, "goshv": 22080, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IMP", "IBA" ], [ "IDA", "IMP", "ISS", "IBA", "TAS", "IEA" ], [ "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "NAS", "IEA" ], [ "IDA", "NAS" ], [ "NAS" ], [ "IDA", "IMP", "IGI", "IEA" ], [ "IMP", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ] ], "name": "negative regulation of cellular process", "native": "GO:0048523", "p_value": 0.000005197908255293947, "parents": [ "GO:0009987", "GO:0048519", "GO:0050794" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.001996370235934664, "significant": true, "source": "GO:BP", "term_size": 5510, "source_order": 11957, "group_id": 1 }, { "description": "\"The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.\" [GOC:mtg_sensu]", "effective_domain_size": 20972, "goshv": 19939, "intersection_size": 6, "intersections": [ [ "IEA" ], [ "IEA" ], [], [ "IEA" ], [], [ "IBA", "IEA" ], [ "IEA" ], [], [ "IEA" ], [], [] ], "name": "chordate embryonic development", "native": "GO:0043009", "p_value": 0.000005224010067255076, "parents": [ "GO:0009792" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.008968609865470852, "significant": true, "source": "GO:BP", "term_size": 669, "source_order": 9816, "group_id": 1 }, { "description": "Meiotic recombination", "effective_domain_size": 11056, "goshv": 40797, "intersection_size": 4, "intersections": [ [], [ "REAC" ], [], [], [], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [] ], "name": "Meiotic recombination", "native": "REAC:R-HSA-912446", "p_value": 0.0000057600157384278914, "parents": [ "REAC:R-HSA-1500620" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.045454545454545456, "significant": true, "source": "REAC", "term_size": 88, "source_order": 1473, "group_id": 27 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22715, "intersection_size": 4, "intersections": [ [ "IDA", "IEA" ], [ "IMP" ], [ "IMP" ], [], [], [], [], [], [ "IMP" ], [], [] ], "name": "negative regulation of DNA metabolic process", "native": "GO:0051053", "p_value": 0.000005772873544409997, "parents": [ "GO:0006259", "GO:0010605", "GO:0045934", "GO:0051052" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.030534351145038167, "significant": true, "source": "GO:BP", "term_size": 131, "source_order": 12592, "group_id": 1 }, { "description": "\"The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.\" [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]", "effective_domain_size": 20972, "goshv": 13642, "intersection_size": 6, "intersections": [ [ "IEA" ], [ "IEA" ], [], [ "IEA" ], [], [ "IBA", "IEA" ], [ "IEA" ], [], [ "IEA" ], [], [] ], "name": "embryo development ending in birth or egg hatching", "native": "GO:0009792", "p_value": 0.000005978116284793822, "parents": [ "GO:0009790" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.008733624454148471, "significant": true, "source": "GO:BP", "term_size": 687, "source_order": 3519, "group_id": 1 }, { "description": "\"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.\" [ISBN:0198506732]", "effective_domain_size": 20972, "goshv": 12130, "intersection_size": 5, "intersections": [ [], [ "IDA", "TAS", "IEA" ], [], [ "IDA" ], [], [ "IDA", "IBA", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "TAS", "IEA" ], [], [], [] ], "name": "DNA recombination", "native": "GO:0006310", "p_value": 0.000006341489407785185, "parents": [ "GO:0006259" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.014367816091954023, "significant": true, "source": "GO:BP", "term_size": 348, "source_order": 2007, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.\" [GOC:jid]", "effective_domain_size": 20972, "goshv": 22128, "intersection_size": 10, "intersections": [ [ "IMP", "ISS", "IEA" ], [ "IMP", "IBA", "TAS", "IEA" ], [ "IMP", "TAS", "NAS", "IEA" ], [ "IDA", "TAS" ], [ "TAS", "IEA" ], [ "IMP", "NAS" ], [ "NAS" ], [ "IDA", "NAS" ], [], [ "IDA", "IMP" ], [ "IDA", "IMP", "TAS" ] ], "name": "regulation of response to stimulus", "native": "GO:0048583", "p_value": 0.000006808930050008355, "parents": [ "GO:0050789", "GO:0050896" ], "precision": 0.9090909090909091, "query": "query_1", "query_size": 11, "recall": 0.002504382669671926, "significant": true, "source": "GO:BP", "term_size": 3993, "source_order": 12005, "group_id": 1 }, { "description": "\"The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.\" [PMID:20404130]", "effective_domain_size": 20972, "goshv": 12137, "intersection_size": 7, "intersections": [ [ "IDA" ], [ "IEA" ], [ "IEA" ], [ "ISS", "IEA" ], [ "IEA" ], [ "IMP", "IBA", "TAS", "IEA" ], [ "IEA" ], [], [], [], [] ], "name": "chromatin organization", "native": "GO:0006325", "p_value": 0.00000694412569514385, "parents": [ "GO:0016043" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.005756578947368421, "significant": true, "source": "GO:BP", "term_size": 1216, "source_order": 2014, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 33935, "intersection_size": 4, "intersections": [ [ "IMP", "IEA" ], [], [], [], [], [ "IMP" ], [], [], [ "IMP", "IEA" ], [ "IMP" ], [] ], "name": "regulation of reactive oxygen species metabolic process", "native": "GO:2000377", "p_value": 0.00000695171944593685, "parents": [ "GO:0019222", "GO:0072593" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.02877697841726619, "significant": true, "source": "GO:BP", "term_size": 139, "source_order": 23812, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.\" [GOC:jid]", "effective_domain_size": 20972, "goshv": 22076, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IMP", "IBA" ], [ "IDA", "IMP", "ISS", "IBA", "TAS", "IEA" ], [ "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "NAS", "IEA" ], [ "IDA", "NAS" ], [ "NAS" ], [ "IDA", "IMP", "IGI", "ISS", "IEA" ], [ "IMP", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ] ], "name": "negative regulation of biological process", "native": "GO:0048519", "p_value": 0.000007690778438699247, "parents": [ "GO:0008150", "GO:0050789" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.0019120458891013384, "significant": true, "source": "GO:BP", "term_size": 5753, "source_order": 11953, "group_id": 1 }, { "description": "\"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.\" [ISBN:0815316194]", "effective_domain_size": 20972, "goshv": 12670, "intersection_size": 4, "intersections": [ [], [], [], [ "IDA" ], [], [ "NAS", "IEA" ], [ "IMP" ], [], [], [ "IEA" ], [] ], "name": "centrosome cycle", "native": "GO:0007098", "p_value": 0.00000785012163264769, "parents": [ "GO:0022402", "GO:0031023" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.027777777777777776, "significant": true, "source": "GO:BP", "term_size": 144, "source_order": 2547, "group_id": 1 }, { "description": "Processing of DNA double-strand break ends", "effective_domain_size": 11056, "goshv": 41195, "intersection_size": 4, "intersections": [ [], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [ "REAC" ], [], [], [], [], [] ], "name": "Processing of DNA double-strand break ends", "native": "REAC:R-HSA-5693607", "p_value": 0.000008325764126179217, "parents": [ "REAC:R-HSA-5693567" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.041237113402061855, "significant": true, "source": "REAC", "term_size": 97, "source_order": 1871, "group_id": 28 }, { "description": "\"Any process that modulates the frequency, rate or extent of double-strand break repair.\" [GOC:BHF]", "effective_domain_size": 20972, "goshv": 34254, "intersection_size": 4, "intersections": [ [], [ "IMP" ], [ "NAS" ], [ "IDA" ], [], [], [], [ "IDA" ], [], [], [] ], "name": "regulation of double-strand break repair", "native": "GO:2000779", "p_value": 0.000008358478579708503, "parents": [ "GO:0006282", "GO:0006302" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.027210884353741496, "significant": true, "source": "GO:BP", "term_size": 147, "source_order": 24131, "group_id": 1 }, { "description": "\"The directed movement of RNA to a specific location in the telomeric region of a chromosome.\" [GOC:BHF, GOC:BHF_telomere, GOC:rph, PMID:26586433]", "effective_domain_size": 20972, "goshv": 27615, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [ "IMP" ], [], [], [], [], [], [], [], [] ], "name": "establishment of RNA localization to telomere", "native": "GO:0097694", "p_value": 0.000008358478579708503, "parents": [ "GO:0051236" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.6666666666666666, "significant": true, "source": "GO:BP", "term_size": 3, "source_order": 17492, "group_id": 2 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an actinomycin D stimulus.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 26471, "intersection_size": 2, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [], [], [], [ "IDA" ] ], "name": "cellular response to actinomycin D", "native": "GO:0072717", "p_value": 0.000008358478579708503, "parents": [ "GO:0071236", "GO:0072716", "GO:1901699", "GO:1901701" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.6666666666666666, "significant": true, "source": "GO:BP", "term_size": 3, "source_order": 16348, "group_id": 1 }, { "description": "\"The directed movement of a protein-containing macromolecular complex to a specific location in the telomeric region of a chromosome.\" [GOC:BHF, GOC:BHF_telomere, GOC:rph, PMID:26586433]", "effective_domain_size": 20972, "goshv": 27616, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [ "IC" ], [], [], [], [], [], [], [], [] ], "name": "establishment of protein-containing complex localization to telomere", "native": "GO:0097695", "p_value": 0.000008358478579708503, "parents": [ "GO:0033036", "GO:0051234" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.6666666666666666, "significant": true, "source": "GO:BP", "term_size": 3, "source_order": 17493, "group_id": 2 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.\" [GOC:hb]", "effective_domain_size": 20972, "goshv": 13443, "intersection_size": 4, "intersections": [ [ "IDA", "IEA" ], [], [ "IMP" ], [], [], [], [ "IEA" ], [], [ "ISS", "IEA" ], [], [] ], "name": "response to UV", "native": "GO:0009411", "p_value": 0.000009044545416097521, "parents": [ "GO:0009416" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.026490066225165563, "significant": true, "source": "GO:BP", "term_size": 151, "source_order": 3320, "group_id": 1 }, { "description": "\"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow.\" [GOC:dph, GOC:jl, GOC:mah]", "effective_domain_size": 20972, "goshv": 16673, "intersection_size": 4, "intersections": [ [], [], [], [ "IDA" ], [], [ "NAS", "IEA" ], [ "IMP" ], [], [], [ "IEA" ], [] ], "name": "microtubule organizing center organization", "native": "GO:0031023", "p_value": 0.000010470569562355095, "parents": [ "GO:0000226", "GO:0007017", "GO:0016043" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.025477707006369428, "significant": true, "source": "GO:BP", "term_size": 157, "source_order": 6550, "group_id": 1 }, { "description": "\"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.\" [GOC:mah, ISBN:0198506732]", "effective_domain_size": 20972, "goshv": 12096, "intersection_size": 4, "intersections": [ [], [], [ "ISS" ], [], [], [ "NAS" ], [ "IMP", "IEA" ], [ "IDA", "IMP", "IEA" ], [], [], [] ], "name": "DNA-templated DNA replication", "native": "GO:0006261", "p_value": 0.000011757881018035757, "parents": [ "GO:0006260" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.024691358024691357, "significant": true, "source": "GO:BP", "term_size": 162, "source_order": 1973, "group_id": 1 }, { "description": "\"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.\" [GOC:go_curators, GOC:mtg_signaling_feb11]", "effective_domain_size": 20972, "goshv": 12718, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IGI", "IEP", "ISS", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "NAS", "IEA" ], [ "NAS", "IEA" ], [ "NAS" ], [ "IDA", "IMP", "IEP", "TAS", "IEA" ], [ "IDA", "IMP" ], [ "IDA", "IMP", "TAS" ] ], "name": "signal transduction", "native": "GO:0007165", "p_value": 0.000012459921089964006, "parents": [ "GO:0007154", "GO:0009987", "GO:0023052", "GO:0050794", "GO:0051716" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.001814283358073561, "significant": true, "source": "GO:BP", "term_size": 6063, "source_order": 2595, "group_id": 1 }, { "description": "\"The biosynthetic process resulting in the formation of DNA.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25948, "intersection_size": 4, "intersections": [ [ "IDA" ], [ "IGI", "ISS", "IEA" ], [ "ISS" ], [], [], [], [], [], [ "IMP", "IEA" ], [], [] ], "name": "DNA biosynthetic process", "native": "GO:0071897", "p_value": 0.000012459921089964006, "parents": [ "GO:0006259", "GO:0141187" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.024242424242424242, "significant": true, "source": "GO:BP", "term_size": 165, "source_order": 15825, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17040, "intersection_size": 3, "intersections": [ [ "IDA" ], [ "IGI", "ISS", "IEA" ], [ "ISS" ], [], [], [], [], [], [], [], [] ], "name": "regulation of telomere maintenance via telomerase", "native": "GO:0032210", "p_value": 0.000015721934621338087, "parents": [ "GO:0007004", "GO:1904356", "GO:2000278" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.06666666666666667, "significant": true, "source": "GO:BP", "term_size": 45, "source_order": 6917, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an actinomycin D stimulus.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 26470, "intersection_size": 2, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [], [], [], [ "IDA" ] ], "name": "response to actinomycin D", "native": "GO:0072716", "p_value": 0.000015721934621338087, "parents": [ "GO:0046677", "GO:1901698", "GO:1901700" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.5, "significant": true, "source": "GO:BP", "term_size": 4, "source_order": 16347, "group_id": 1 }, { "description": "\"The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 10200, "intersection_size": 5, "intersections": [ [], [ "IMP", "TAS", "IEA" ], [], [ "IDA" ], [ "IMP" ], [], [ "IEA" ], [ "IBA", "TAS", "IEA" ], [], [], [] ], "name": "nuclear division", "native": "GO:0000280", "p_value": 0.000019129031236361224, "parents": [ "GO:0048285" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.011111111111111112, "significant": true, "source": "GO:BP", "term_size": 450, "source_order": 77, "group_id": 1 }, { "description": "Transcriptional Regulation by E2F6", "effective_domain_size": 11056, "goshv": 41965, "intersection_size": 3, "intersections": [ [], [], [], [ "REAC" ], [], [ "REAC" ], [], [ "REAC" ], [], [], [] ], "name": "Transcriptional Regulation by E2F6", "native": "REAC:R-HSA-8953750", "p_value": 0.000020024886289724167, "parents": [ "REAC:R-HSA-212436" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.08823529411764706, "significant": true, "source": "REAC", "term_size": 34, "source_order": 2641, "group_id": 25 }, { "description": "\"Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 19973, "intersection_size": 7, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IEA" ], [ "IMP", "TAS", "IEA" ], [], [], [ "IEA" ], [ "IMP" ], [], [], [ "IEA" ], [ "IDA" ], [ "IMP", "IBA", "IEA" ] ], "name": "regulation of programmed cell death", "native": "GO:0043067", "p_value": 0.00002130525763245168, "parents": [ "GO:0012501", "GO:0050794" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.004771642808452625, "significant": true, "source": "GO:BP", "term_size": 1467, "source_order": 9850, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 23610, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "NAS", "IEA" ], [ "IDA", "IMP", "IGI", "ISS", "IEA" ], [ "IMP", "ISS", "NAS" ], [ "IDA", "ISS", "IEA" ], [ "IDA", "IMP" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IBA" ], [ "IDA" ], [ "IDA", "IMP", "TAS", "IEA" ], [ "IMP", "TAS" ], [ "IDA", "IMP", "IEA" ] ], "name": "regulation of macromolecule metabolic process", "native": "GO:0060255", "p_value": 0.00002132329527212949, "parents": [ "GO:0019222", "GO:0043170" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.00172090112640801, "significant": true, "source": "GO:BP", "term_size": 6392, "source_order": 13487, "group_id": 1 }, { "description": "Transcriptional activation of cell cycle inhibitor p21 ", "effective_domain_size": 11056, "goshv": 41964, "intersection_size": 2, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [ "REAC" ], [], [] ], "name": "Transcriptional activation of cell cycle inhibitor p21 ", "native": "REAC:R-HSA-69895", "p_value": 0.000023986340664771325, "parents": [ "REAC:R-HSA-69560" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.5, "significant": true, "source": "REAC", "term_size": 4, "source_order": 2640, "group_id": 27 }, { "description": "Transcriptional activation of p53 responsive genes ", "effective_domain_size": 11056, "goshv": 41971, "intersection_size": 2, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [ "REAC" ], [], [] ], "name": "Transcriptional activation of p53 responsive genes ", "native": "REAC:R-HSA-69560", "p_value": 0.000023986340664771325, "parents": [ "REAC:R-HSA-69563" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.5, "significant": true, "source": "REAC", "term_size": 4, "source_order": 2647, "group_id": 27 }, { "description": "\"Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 21073, "intersection_size": 7, "intersections": [ [ "IDA", "IMP", "ISS", "NAS", "IEA" ], [ "IMP" ], [ "IMP" ], [], [], [ "IDA" ], [], [], [ "IMP" ], [ "IMP" ], [ "IDA", "IMP" ] ], "name": "negative regulation of nucleobase-containing compound metabolic process", "native": "GO:0045934", "p_value": 0.00002544643485908349, "parents": [ "GO:0006139", "GO:0009892", "GO:0019219" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.004635761589403974, "significant": true, "source": "GO:BP", "term_size": 1510, "source_order": 10950, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening.\" [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]", "effective_domain_size": 20972, "goshv": 32167, "intersection_size": 3, "intersections": [ [ "IDA" ], [ "IMP", "IGI", "ISS", "IEA" ], [ "ISS" ], [], [], [], [], [], [], [], [] ], "name": "regulation of telomere maintenance via telomere lengthening", "native": "GO:1904356", "p_value": 0.000026239643281840994, "parents": [ "GO:0010833", "GO:0032204" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.05555555555555555, "significant": true, "source": "GO:BP", "term_size": 54, "source_order": 22044, "group_id": 1 }, { "description": "\"The increase in size or mass of an entire organism, a part of an organism or a cell.\" [GOC:bf, GOC:ma]", "effective_domain_size": 20972, "goshv": 19384, "intersection_size": 6, "intersections": [ [ "IMP", "IEA" ], [ "IEA" ], [], [ "IEA" ], [], [ "IMP" ], [ "IEA" ], [], [ "IDA", "ISS", "IEA" ], [], [] ], "name": "growth", "native": "GO:0040007", "p_value": 0.000026575670629743767, "parents": [ "GO:0008150" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.006521739130434782, "significant": true, "source": "GO:BP", "term_size": 920, "source_order": 9261, "group_id": 1 }, { "description": "\"The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.\" [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]", "effective_domain_size": 20972, "goshv": 16328, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IGI", "IEP", "ISS", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "NAS", "IEA" ], [ "NAS", "IEA" ], [ "NAS" ], [ "IDA", "IMP", "IEP", "TAS", "IEA" ], [ "IDA", "IMP" ], [ "IDA", "IMP", "TAS" ] ], "name": "signaling", "native": "GO:0023052", "p_value": 0.00002732631050358316, "parents": [ "GO:0050789" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.0016773406526379995, "significant": true, "source": "GO:BP", "term_size": 6558, "source_order": 6205, "group_id": 1 }, { "description": "\"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 12707, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IGI", "IEP", "ISS", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "NAS", "IEA" ], [ "NAS", "IEA" ], [ "NAS" ], [ "IDA", "IMP", "IEP", "TAS", "IEA" ], [ "IDA", "IMP" ], [ "IDA", "IMP", "TAS" ] ], "name": "cell communication", "native": "GO:0007154", "p_value": 0.000028735223692749977, "parents": [ "GO:0009987" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.0016671718702637162, "significant": true, "source": "GO:BP", "term_size": 6598, "source_order": 2584, "group_id": 1 }, { "description": "\"The alteration of an amino acid residue in a peptide.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 15219, "intersection_size": 5, "intersections": [ [], [ "IDA", "IMP" ], [ "IDA" ], [ "IDA" ], [], [], [], [], [], [ "IMP" ], [ "TAS" ] ], "name": "peptidyl-amino acid modification", "native": "GO:0018193", "p_value": 0.000028735223692749977, "parents": [ "GO:0036211" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.010101010101010102, "significant": true, "source": "GO:BP", "term_size": 495, "source_order": 5096, "group_id": 1 }, { "description": "\"The creation of two or more organelles by division of one organelle.\" [GOC:jid]", "effective_domain_size": 20972, "goshv": 21905, "intersection_size": 5, "intersections": [ [], [ "IMP", "TAS", "IEA" ], [], [ "IDA" ], [ "IMP" ], [], [ "IEA" ], [ "IBA", "TAS", "IEA" ], [], [], [] ], "name": "organelle fission", "native": "GO:0048285", "p_value": 0.0000288471422064688, "parents": [ "GO:0006996" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.01006036217303823, "significant": true, "source": "GO:BP", "term_size": 497, "source_order": 11782, "group_id": 1 }, { "description": "\"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).\" [GOC:bf, GOC:jl]", "effective_domain_size": 20972, "goshv": 19001, "intersection_size": 8, "intersections": [ [], [ "IDA", "IMP" ], [ "IDA" ], [ "IDA", "IEA" ], [ "IDA", "IEA" ], [ "IDA", "IEA" ], [], [], [ "IDA", "IMP", "TAS" ], [ "IMP", "TAS" ], [ "IDA", "IMP", "TAS" ] ], "name": "protein modification process", "native": "GO:0036211", "p_value": 0.000029152913866778738, "parents": [ "GO:0019538", "GO:0043412" ], "precision": 0.7272727272727273, "query": "query_1", "query_size": 11, "recall": 0.003389830508474576, "significant": true, "source": "GO:BP", "term_size": 2360, "source_order": 8878, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 13715, "intersection_size": 9, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IEA" ], [ "IMP", "ISS", "IEA" ], [ "ISS" ], [], [ "IDA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA" ], [], [ "IDA", "IMP", "TAS", "IEA" ], [ "IMP" ], [ "IDA" ] ], "name": "positive regulation of metabolic process", "native": "GO:0009893", "p_value": 0.000029808536225428382, "parents": [ "GO:0008152", "GO:0019222", "GO:0048522" ], "precision": 0.8181818181818182, "query": "query_1", "query_size": 11, "recall": 0.0026392961876832845, "significant": true, "source": "GO:BP", "term_size": 3410, "source_order": 3592, "group_id": 1 }, { "description": "\"The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase.\" [GOC:elh]", "effective_domain_size": 20972, "goshv": 12606, "intersection_size": 3, "intersections": [ [ "IDA" ], [ "IGI", "ISS", "IEA" ], [ "ISS" ], [], [], [], [], [], [], [], [] ], "name": "telomere maintenance via telomerase", "native": "GO:0007004", "p_value": 0.00003214353300742446, "parents": [ "GO:0006278", "GO:0010833" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.05084745762711865, "significant": true, "source": "GO:BP", "term_size": 59, "source_order": 2483, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoside stimulus.\" [GO_REF:0000071, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:12027881, PMID:16243970]", "effective_domain_size": 20972, "goshv": 31508, "intersection_size": 2, "intersections": [ [], [], [], [], [ "IEA" ], [], [], [ "IEA" ], [], [], [] ], "name": "response to glycoside", "native": "GO:1903416", "p_value": 0.000034797108220295964, "parents": [ "GO:1901700" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.3333333333333333, "significant": true, "source": "GO:BP", "term_size": 6, "source_order": 21385, "group_id": 1 }, { "description": "\"The process of introducing a phosphate group on to a protein.\" [GOC:hb]", "effective_domain_size": 20972, "goshv": 12221, "intersection_size": 6, "intersections": [ [], [ "IDA", "IMP" ], [ "IDA" ], [ "IDA", "IEA" ], [ "IDA", "IEA" ], [], [], [], [ "IDA", "IMP", "TAS" ], [ "IMP", "TAS" ], [] ], "name": "protein phosphorylation", "native": "GO:0006468", "p_value": 0.00003607843545234609, "parents": [ "GO:0016310", "GO:0036211" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.006109979633401222, "significant": true, "source": "GO:BP", "term_size": 982, "source_order": 2098, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 19974, "intersection_size": 5, "intersections": [ [ "IDA", "IMP", "ISS", "IEA" ], [ "IMP", "IEA" ], [], [], [ "IEA" ], [], [], [], [ "IEA" ], [ "IDA" ], [] ], "name": "positive regulation of programmed cell death", "native": "GO:0043068", "p_value": 0.000036632161114581594, "parents": [ "GO:0012501", "GO:0043067", "GO:0048522" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.009487666034155597, "significant": true, "source": "GO:BP", "term_size": 527, "source_order": 9851, "group_id": 1 }, { "description": "\"A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand.\" [GOC:mah, ISBN:0198506732]", "effective_domain_size": 20972, "goshv": 12109, "intersection_size": 3, "intersections": [ [ "IDA" ], [ "IGI", "ISS", "IEA" ], [ "ISS" ], [], [], [], [], [], [], [], [] ], "name": "RNA-templated DNA biosynthetic process", "native": "GO:0006278", "p_value": 0.000038003486432009075, "parents": [ "GO:0071897" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.047619047619047616, "significant": true, "source": "GO:BP", "term_size": 63, "source_order": 1986, "group_id": 1 }, { "description": "\"The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 26401, "intersection_size": 4, "intersections": [ [ "IMP", "IEA" ], [], [], [], [], [ "IMP" ], [], [], [ "IMP", "IEA" ], [ "IMP" ], [] ], "name": "reactive oxygen species metabolic process", "native": "GO:0072593", "p_value": 0.00003806318080251119, "parents": [ "GO:0008152" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.017543859649122806, "significant": true, "source": "GO:BP", "term_size": 228, "source_order": 16278, "group_id": 1 }, { "description": "\"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 12601, "intersection_size": 9, "intersections": [ [ "IDA", "IEA" ], [ "IMP", "IGI", "ISS", "IBA", "TAS", "IC", "IEA" ], [ "IDA", "ISS", "IBA" ], [ "IDA", "IEA" ], [ "IDA", "IMP" ], [ "NAS", "IEA" ], [ "IMP", "IEA" ], [ "ISS", "IBA", "TAS", "IEA" ], [], [ "IEA" ], [] ], "name": "organelle organization", "native": "GO:0006996", "p_value": 0.000042274257390447953, "parents": [ "GO:0016043" ], "precision": 0.8181818181818182, "query": "query_1", "query_size": 11, "recall": 0.0025188916876574307, "significant": true, "source": "GO:BP", "term_size": 3573, "source_order": 2478, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 33937, "intersection_size": 3, "intersections": [ [ "IMP" ], [], [], [], [], [], [], [], [ "IMP", "IEA" ], [ "IMP" ], [] ], "name": "positive regulation of reactive oxygen species metabolic process", "native": "GO:2000379", "p_value": 0.00004276033738912744, "parents": [ "GO:0009893", "GO:0072593", "GO:2000377" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.045454545454545456, "significant": true, "source": "GO:BP", "term_size": 66, "source_order": 23814, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 15399, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "NAS", "IEA" ], [ "IDA", "IMP", "IGI", "ISS", "IEA" ], [ "IMP", "ISS", "NAS" ], [ "IDA", "ISS", "IEA" ], [ "IDA", "IMP" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IBA" ], [ "IDA" ], [ "IDA", "IMP", "TAS", "IEA" ], [ "IMP", "TAS" ], [ "IDA", "IMP", "IEA" ] ], "name": "regulation of metabolic process", "native": "GO:0019222", "p_value": 0.00004278696690510868, "parents": [ "GO:0008152", "GO:0050794" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.0015942028985507246, "significant": true, "source": "GO:BP", "term_size": 6900, "source_order": 5276, "group_id": 1 }, { "description": "\"A DNA recombination process that results in the exchange of an equal amount of genetic material between highly homologous DNA molecules.\" [GOC:mah, PMID:11139492, PMID:17304215]", "effective_domain_size": 20972, "goshv": 18799, "intersection_size": 3, "intersections": [ [], [ "TAS" ], [], [], [], [ "NAS" ], [], [ "IBA", "TAS", "IEA" ], [], [], [] ], "name": "homologous recombination", "native": "GO:0035825", "p_value": 0.0000440839651659815, "parents": [ "GO:0006310" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.04477611940298507, "significant": true, "source": "GO:BP", "term_size": 67, "source_order": 8676, "group_id": 1 }, { "description": "\"The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 20131, "intersection_size": 8, "intersections": [ [], [ "IDA", "IMP" ], [ "IDA" ], [ "IDA", "IEA" ], [ "IDA", "IEA" ], [ "IDA", "IEA" ], [], [], [ "IDA", "IMP", "TAS" ], [ "IMP", "TAS" ], [ "IDA", "IMP", "TAS" ] ], "name": "macromolecule modification", "native": "GO:0043412", "p_value": 0.000047651794848689697, "parents": [ "GO:0043170" ], "precision": 0.7272727272727273, "query": "query_1", "query_size": 11, "recall": 0.0031409501374165686, "significant": true, "source": "GO:BP", "term_size": 2547, "source_order": 10008, "group_id": 1 }, { "description": "TP53 Regulates Transcription of Cell Cycle Genes", "effective_domain_size": 11056, "goshv": 41875, "intersection_size": 3, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [ "REAC" ], [ "REAC" ], [] ], "name": "TP53 Regulates Transcription of Cell Cycle Genes", "native": "REAC:R-HSA-6791312", "p_value": 0.00005733127357741196, "parents": [ "REAC:R-HSA-3700989" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.061224489795918366, "significant": true, "source": "REAC", "term_size": 49, "source_order": 2551, "group_id": 25 }, { "description": "\"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.\" [ISBN:0198506732]", "effective_domain_size": 20972, "goshv": 15069, "intersection_size": 6, "intersections": [ [], [ "IDA", "IMP" ], [ "IDA" ], [ "IDA", "IEA" ], [ "IDA", "IEA" ], [], [], [], [ "IDA", "IMP", "TAS" ], [ "IMP", "TAS" ], [] ], "name": "phosphorylation", "native": "GO:0016310", "p_value": 0.00005753818741097842, "parents": [ "GO:0006796" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.005571030640668524, "significant": true, "source": "GO:BP", "term_size": 1077, "source_order": 4946, "group_id": 1 }, { "description": "\"A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays.\" [GOC:BHF]", "effective_domain_size": 20972, "goshv": 27184, "intersection_size": 2, "intersections": [ [ "IMP" ], [], [], [], [], [], [], [], [ "TAS" ], [], [] ], "name": "stress-induced premature senescence", "native": "GO:0090400", "p_value": 0.00005927244276793956, "parents": [ "GO:0090398" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.25, "significant": true, "source": "GO:BP", "term_size": 8, "source_order": 17061, "group_id": 1 }, { "description": "\"The aggregation, arrangement and bonding together of a set of components to form a telomerase holoenzyme complex.\" [GO_REF:0000079, GOC:TermGenie, PMID:26305931]", "effective_domain_size": 20972, "goshv": 32889, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [ "IMP" ], [], [], [], [], [], [], [], [] ], "name": "telomerase holoenzyme complex assembly", "native": "GO:1905323", "p_value": 0.00005927244276793956, "parents": [ "GO:0022618" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.25, "significant": true, "source": "GO:BP", "term_size": 8, "source_order": 22766, "group_id": 1 }, { "description": "\"The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.\" [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]", "effective_domain_size": 20972, "goshv": 13640, "intersection_size": 6, "intersections": [ [ "IEA" ], [ "IEA" ], [], [ "IEA" ], [], [ "IBA", "IEA" ], [ "IEA" ], [], [ "IEA" ], [], [] ], "name": "embryo development", "native": "GO:0009790", "p_value": 0.00007280228991584973, "parents": [ "GO:0007275" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.0053285968028419185, "significant": true, "source": "GO:BP", "term_size": 1126, "source_order": 3517, "group_id": 1 }, { "description": "\"The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.\" [GOC:mah, UBERON:0001009]", "effective_domain_size": 20972, "goshv": 26320, "intersection_size": 6, "intersections": [ [ "IEA" ], [ "IEA" ], [], [], [], [ "IMP" ], [], [], [ "ISS", "IEA" ], [ "IEA" ], [ "IEA" ] ], "name": "circulatory system development", "native": "GO:0072359", "p_value": 0.00007568131637778441, "parents": [ "GO:0048731" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.0052863436123348016, "significant": true, "source": "GO:BP", "term_size": 1135, "source_order": 16197, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22716, "intersection_size": 4, "intersections": [ [], [ "IMP", "ISS", "IEA" ], [ "ISS" ], [], [], [ "IMP" ], [], [], [ "TAS" ], [], [] ], "name": "positive regulation of DNA metabolic process", "native": "GO:0051054", "p_value": 0.00007910230114288091, "parents": [ "GO:0006259", "GO:0010604", "GO:0051052" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.014285714285714285, "significant": true, "source": "GO:BP", "term_size": 280, "source_order": 12593, "group_id": 1 }, { "description": "RUNX3 regulates CDKN1A transcription", "effective_domain_size": 11056, "goshv": 41330, "intersection_size": 2, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [ "REAC" ], [], [] ], "name": "RUNX3 regulates CDKN1A transcription", "native": "REAC:R-HSA-8941855", "p_value": 0.00008039451800867399, "parents": [ "REAC:R-HSA-8878159" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.2857142857142857, "significant": true, "source": "REAC", "term_size": 7, "source_order": 2006, "group_id": 25 }, { "description": "\"Any cellular metabolic process involving nucleic acids.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 27105, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "NAS", "IEA" ], [ "IDA", "IMP", "IGI", "ISS", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "TAS", "IEA" ], [ "IDA", "IMP", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "TAS", "IEA" ], [ "IMP", "TAS", "IEA" ], [ "IMP", "TAS" ], [ "IDA", "IMP" ] ], "name": "nucleic acid metabolic process", "native": "GO:0090304", "p_value": 0.00008668896448491398, "parents": [ "GO:0006139", "GO:0043170" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.0014862856370760709, "significant": true, "source": "GO:BP", "term_size": 7401, "source_order": 16982, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17605, "intersection_size": 6, "intersections": [ [ "IDA" ], [ "IMP", "IGI", "ISS", "IC", "IEA" ], [ "ISS" ], [ "IDA" ], [ "IDA" ], [ "NAS" ], [], [], [], [], [] ], "name": "regulation of organelle organization", "native": "GO:0033043", "p_value": 0.00008698030450914774, "parents": [ "GO:0006996", "GO:0051128" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.005141388174807198, "significant": true, "source": "GO:BP", "term_size": 1167, "source_order": 7482, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.\" [GOC:bf, GOC:jl]", "effective_domain_size": 20972, "goshv": 23106, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IGI", "IEP", "ISS", "TAS", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IEP", "ISS", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IEP", "ISS", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IEP", "TAS", "IEA" ], [ "IDA", "IMP", "IEP", "TAS" ] ], "name": "cellular response to stimulus", "native": "GO:0051716", "p_value": 0.00008858632820378894, "parents": [ "GO:0009987", "GO:0050896" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.0014814814814814814, "significant": true, "source": "GO:BP", "term_size": 7425, "source_order": 12983, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 18253, "intersection_size": 3, "intersections": [ [ "IDA", "IEA" ], [], [ "IMP" ], [], [], [], [], [], [ "ISS", "IEA" ], [], [] ], "name": "cellular response to UV", "native": "GO:0034644", "p_value": 0.00008962574982581733, "parents": [ "GO:0009411", "GO:0071482" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.034482758620689655, "significant": true, "source": "GO:BP", "term_size": 87, "source_order": 8130, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25487, "intersection_size": 2, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [], [], [], [ "IDA" ] ], "name": "cellular response to antibiotic", "native": "GO:0071236", "p_value": 0.00008998807885520057, "parents": [ "GO:0046677", "GO:0070887" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.2, "significant": true, "source": "GO:BP", "term_size": 10, "source_order": 15364, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus.\" [GOC:pr, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 30361, "intersection_size": 6, "intersections": [ [ "IDA" ], [ "IDA", "ISS", "IEA" ], [], [], [ "IEA" ], [ "IDA" ], [], [ "IDA" ], [], [], [ "IDA" ] ], "name": "cellular response to oxygen-containing compound", "native": "GO:1901701", "p_value": 0.0000958773274090045, "parents": [ "GO:0070887", "GO:1901700" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.005025125628140704, "significant": true, "source": "GO:BP", "term_size": 1194, "source_order": 20238, "group_id": 1 }, { "description": "\"The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 22134, "intersection_size": 5, "intersections": [ [ "IEA" ], [ "IEA" ], [], [ "IEA" ], [], [], [ "IEA" ], [], [ "ISS", "IEA" ], [], [] ], "name": "developmental growth", "native": "GO:0048589", "p_value": 0.0000958773274090045, "parents": [ "GO:0032502", "GO:0040007" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.007564296520423601, "significant": true, "source": "GO:BP", "term_size": 661, "source_order": 12011, "group_id": 1 }, { "description": "\"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 10183, "intersection_size": 5, "intersections": [ [], [], [], [ "IDA" ], [ "IMP" ], [ "NAS", "IEA" ], [ "IMP" ], [], [], [ "IEA" ], [] ], "name": "microtubule cytoskeleton organization", "native": "GO:0000226", "p_value": 0.00010968841835187935, "parents": [ "GO:0007010", "GO:0007017" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.007342143906020558, "significant": true, "source": "GO:BP", "term_size": 681, "source_order": 60, "group_id": 1 }, { "description": "Cellular Senescence", "effective_domain_size": 11056, "goshv": 39672, "intersection_size": 4, "intersections": [ [ "REAC" ], [ "REAC" ], [], [], [], [], [], [], [ "REAC" ], [], [ "REAC" ] ], "name": "Cellular Senescence", "native": "REAC:R-HSA-2559583", "p_value": 0.00011513080804902784, "parents": [ "REAC:R-HSA-2262752" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.020618556701030927, "significant": true, "source": "REAC", "term_size": 194, "source_order": 348, "group_id": 29 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.\" [GOC:go_curators, ISBN:0582227089]", "effective_domain_size": 20972, "goshv": 13447, "intersection_size": 4, "intersections": [ [ "IDA", "ISS", "IEA" ], [], [ "IMP" ], [], [], [], [ "IEA" ], [], [ "ISS", "IEA" ], [], [] ], "name": "response to light stimulus", "native": "GO:0009416", "p_value": 0.00012428877547316839, "parents": [ "GO:0009314" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.012539184952978056, "significant": true, "source": "GO:BP", "term_size": 319, "source_order": 3324, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm.\" [GOC:tb]", "effective_domain_size": 20972, "goshv": 13959, "intersection_size": 2, "intersections": [ [ "IEA" ], [], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "response to UV-C", "native": "GO:0010225", "p_value": 0.0001274196073413427, "parents": [ "GO:0009411" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.16666666666666666, "significant": true, "source": "GO:BP", "term_size": 12, "source_order": 3836, "group_id": 1 }, { "description": "\"Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 14146, "intersection_size": 10, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "NAS", "IEA" ], [ "IDA", "IMP", "IGI", "ISS", "IEA" ], [ "ISS" ], [ "ISS", "IEA" ], [ "IDA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IBA" ], [], [ "IMP", "IEA" ], [ "IMP" ], [ "IDA", "IMP", "IEA" ] ], "name": "regulation of macromolecule biosynthetic process", "native": "GO:0010556", "p_value": 0.0001274196073413427, "parents": [ "GO:0009059", "GO:0009889", "GO:0060255" ], "precision": 0.9090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0017708517797060386, "significant": true, "source": "GO:BP", "term_size": 5647, "source_order": 4023, "group_id": 1 }, { "description": "\"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.\" [RESID:AA0037]", "effective_domain_size": 20972, "goshv": 15192, "intersection_size": 3, "intersections": [ [], [ "IDA", "IMP" ], [ "IDA" ], [], [], [], [], [], [], [ "IMP" ], [] ], "name": "peptidyl-serine phosphorylation", "native": "GO:0018105", "p_value": 0.000133010622840779, "parents": [ "GO:0006468", "GO:0018209" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.0297029702970297, "significant": true, "source": "GO:BP", "term_size": 101, "source_order": 5069, "group_id": 1 }, { "description": "\"The modification of peptidyl-serine.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 15234, "intersection_size": 3, "intersections": [ [], [ "IDA", "IMP" ], [ "IDA" ], [], [], [], [], [], [], [ "IMP" ], [] ], "name": "peptidyl-serine modification", "native": "GO:0018209", "p_value": 0.0001401555188546082, "parents": [ "GO:0018193" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.02912621359223301, "significant": true, "source": "GO:BP", "term_size": 103, "source_order": 5111, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.\" [GOC:jid]", "effective_domain_size": 20972, "goshv": 22079, "intersection_size": 10, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IEA" ], [ "IMP", "ISS", "IEA" ], [ "IMP", "ISS" ], [ "IDA" ], [ "IDA", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IEA" ], [], [ "IDA", "IMP", "TAS", "IEA" ], [ "IDA", "IMP" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ] ], "name": "positive regulation of cellular process", "native": "GO:0048522", "p_value": 0.00014611288325126417, "parents": [ "GO:0009987", "GO:0048518", "GO:0050794" ], "precision": 0.9090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0017424638438752395, "significant": true, "source": "GO:BP", "term_size": 5739, "source_order": 11956, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 13711, "intersection_size": 10, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "NAS", "IEA" ], [ "IDA", "IMP", "IGI", "ISS", "IEA" ], [ "ISS" ], [ "ISS", "IEA" ], [ "IDA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IBA" ], [], [ "IMP", "IEA" ], [ "IMP" ], [ "IDA", "IMP", "IEA" ] ], "name": "regulation of biosynthetic process", "native": "GO:0009889", "p_value": 0.00016653191067331332, "parents": [ "GO:0009058", "GO:0019222" ], "precision": 0.9090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0017179178835251675, "significant": true, "source": "GO:BP", "term_size": 5821, "source_order": 3588, "group_id": 1 }, { "description": "\"Any process that activates or increases the rate or extent of progression through the cell cycle.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 20970, "intersection_size": 4, "intersections": [ [], [], [], [ "IDA" ], [ "IEA" ], [], [ "IEA" ], [], [], [], [ "IMP", "IBA", "IEA" ] ], "name": "positive regulation of cell cycle", "native": "GO:0045787", "p_value": 0.00016902720878346857, "parents": [ "GO:0007049", "GO:0048522", "GO:0051726" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.011461318051575931, "significant": true, "source": "GO:BP", "term_size": 349, "source_order": 10847, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17034, "intersection_size": 3, "intersections": [ [ "IDA" ], [ "IMP", "IGI", "ISS", "IEA" ], [ "ISS" ], [], [], [], [], [], [], [], [] ], "name": "regulation of telomere maintenance", "native": "GO:0032204", "p_value": 0.00017094680698296683, "parents": [ "GO:0000723", "GO:0033044", "GO:0051052" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.02702702702702703, "significant": true, "source": "GO:BP", "term_size": 111, "source_order": 6911, "group_id": 1 }, { "description": "\"Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 14189, "intersection_size": 8, "intersections": [ [ "IDA", "IMP", "ISS", "NAS", "IEA" ], [ "IDA", "IMP" ], [ "IMP" ], [ "ISS", "IEA" ], [], [ "IDA", "IMP", "IEA" ], [], [], [ "IMP", "IEA" ], [ "IMP" ], [ "IDA", "IMP" ] ], "name": "negative regulation of macromolecule metabolic process", "native": "GO:0010605", "p_value": 0.0001716816108263756, "parents": [ "GO:0009892", "GO:0043170", "GO:0060255" ], "precision": 0.7272727272727273, "query": "query_1", "query_size": 11, "recall": 0.0025974025974025974, "significant": true, "source": "GO:BP", "term_size": 3080, "source_order": 4066, "group_id": 1 }, { "description": "\"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 12005, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "NAS", "IEA" ], [ "IDA", "IMP", "IGI", "ISS", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "TAS", "IEA" ], [ "IDA", "IMP", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "TAS", "IEA" ], [ "IMP", "TAS", "IEA" ], [ "IMP", "TAS" ], [ "IDA", "IMP" ] ], "name": "nucleobase-containing compound metabolic process", "native": "GO:0006139", "p_value": 0.00017242882189923768, "parents": [ "GO:0044238" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.0013812154696132596, "significant": true, "source": "GO:BP", "term_size": 7964, "source_order": 1882, "group_id": 1 }, { "description": "\"Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 14221, "intersection_size": 4, "intersections": [ [ "IDA" ], [ "IMP" ], [], [ "IDA" ], [], [ "NAS" ], [], [], [], [], [] ], "name": "negative regulation of organelle organization", "native": "GO:0010639", "p_value": 0.0001801493405187478, "parents": [ "GO:0006996", "GO:0033043", "GO:0051129" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.011204481792717087, "significant": true, "source": "GO:BP", "term_size": 357, "source_order": 4098, "group_id": 1 }, { "description": "Cellular responses to stress", "effective_domain_size": 11056, "goshv": 39681, "intersection_size": 6, "intersections": [ [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [ "REAC" ], [], [], [ "REAC" ], [], [ "REAC" ] ], "name": "Cellular responses to stress", "native": "REAC:R-HSA-2262752", "p_value": 0.00018369111563018494, "parents": [ "REAC:R-HSA-8953897" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.007575757575757576, "significant": true, "source": "REAC", "term_size": 792, "source_order": 357, "group_id": 29 }, { "description": "\"The proliferation of cells in the inner cell mass.\" [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771]", "effective_domain_size": 20972, "goshv": 10600, "intersection_size": 2, "intersections": [ [], [], [], [ "IEA" ], [], [], [ "IEA" ], [], [], [], [] ], "name": "inner cell mass cell proliferation", "native": "GO:0001833", "p_value": 0.00018780433815361548, "parents": [ "GO:0001832", "GO:0008283" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.13333333333333333, "significant": true, "source": "GO:BP", "term_size": 15, "source_order": 477, "group_id": 1 }, { "description": "\"Any recombinational process that contributes to the maintenance of proper telomeric length.\" [GOC:elh, PMID:11850777]", "effective_domain_size": 20972, "goshv": 10321, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [ "IEA" ], [ "ISS", "IEA" ], [], [], [] ], "name": "telomere maintenance via recombination", "native": "GO:0000722", "p_value": 0.00018780433815361548, "parents": [ "GO:0000723", "GO:0006312" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.13333333333333333, "significant": true, "source": "GO:BP", "term_size": 15, "source_order": 198, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of DNA replication.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 12106, "intersection_size": 3, "intersections": [ [ "IEA" ], [], [ "IMP" ], [], [], [], [], [], [ "TAS" ], [], [] ], "name": "regulation of DNA replication", "native": "GO:0006275", "p_value": 0.00019280863778272452, "parents": [ "GO:0006260", "GO:0051052" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.02564102564102564, "significant": true, "source": "GO:BP", "term_size": 117, "source_order": 1983, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25700, "intersection_size": 3, "intersections": [ [ "IDA", "IEA" ], [], [ "IMP" ], [], [], [], [], [], [ "ISS", "IEA" ], [], [] ], "name": "cellular response to light stimulus", "native": "GO:0071482", "p_value": 0.00019580594748324297, "parents": [ "GO:0009416", "GO:0071478" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.025423728813559324, "significant": true, "source": "GO:BP", "term_size": 118, "source_order": 15577, "group_id": 1 }, { "description": "\"Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 14188, "intersection_size": 8, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IEA" ], [ "IMP", "ISS", "IEA" ], [ "ISS" ], [], [ "IDA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA" ], [], [ "IDA", "TAS" ], [], [ "IDA" ] ], "name": "positive regulation of macromolecule metabolic process", "native": "GO:0010604", "p_value": 0.00019580594748324297, "parents": [ "GO:0009893", "GO:0043170", "GO:0060255" ], "precision": 0.7272727272727273, "query": "query_1", "query_size": 11, "recall": 0.0025380710659898475, "significant": true, "source": "GO:BP", "term_size": 3152, "source_order": 4065, "group_id": 1 }, { "description": "Cellular responses to stimuli", "effective_domain_size": 11056, "goshv": 39680, "intersection_size": 6, "intersections": [ [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [ "REAC" ], [], [], [ "REAC" ], [], [ "REAC" ] ], "name": "Cellular responses to stimuli", "native": "REAC:R-HSA-8953897", "p_value": 0.00019904873690149003, "parents": [ "REAC:0000000" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.007444168734491315, "significant": true, "source": "REAC", "term_size": 806, "source_order": 356, "group_id": 29 }, { "description": "\"A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint.\" [GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 16885, "intersection_size": 2, "intersections": [ [ "IMP", "IEA" ], [], [], [], [], [], [], [], [ "IDA" ], [], [] ], "name": "mitotic G1 DNA damage checkpoint signaling", "native": "GO:0031571", "p_value": 0.00020818604282581577, "parents": [ "GO:0044773", "GO:0044819" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.125, "significant": true, "source": "GO:BP", "term_size": 16, "source_order": 6762, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of cellular response to heat.\" [GOC:TermGenie, GOC:yaf]", "effective_domain_size": 20972, "goshv": 29239, "intersection_size": 2, "intersections": [ [], [ "TAS" ], [ "TAS" ], [], [], [], [], [], [], [], [] ], "name": "regulation of cellular response to heat", "native": "GO:1900034", "p_value": 0.00020818604282581577, "parents": [ "GO:0034605", "GO:0080135" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.125, "significant": true, "source": "GO:BP", "term_size": 16, "source_order": 19116, "group_id": 1 }, { "description": "\"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 12477, "intersection_size": 7, "intersections": [ [ "IMP" ], [ "IDA", "IMP", "IEA" ], [ "IDA" ], [ "IDA", "IEA" ], [ "IDA", "IEA" ], [], [], [], [ "IDA", "IMP", "TAS" ], [ "IMP", "TAS" ], [] ], "name": "phosphate-containing compound metabolic process", "native": "GO:0006796", "p_value": 0.0002133125519683753, "parents": [ "GO:0006793" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.0031876138433515485, "significant": true, "source": "GO:BP", "term_size": 2196, "source_order": 2354, "group_id": 1 }, { "description": "\"The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 12474, "intersection_size": 7, "intersections": [ [ "IMP" ], [ "IDA", "IMP", "IEA" ], [ "IDA" ], [ "IDA", "IEA" ], [ "IDA", "IEA" ], [], [], [], [ "IDA", "IMP", "TAS" ], [ "IMP", "TAS" ], [] ], "name": "phosphorus metabolic process", "native": "GO:0006793", "p_value": 0.00021397941606035004, "parents": [ "GO:0008152" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.0031832651205093224, "significant": true, "source": "GO:BP", "term_size": 2199, "source_order": 2351, "group_id": 1 }, { "description": "DNA Damage/Telomere Stress Induced Senescence", "effective_domain_size": 11056, "goshv": 39785, "intersection_size": 3, "intersections": [ [ "REAC" ], [ "REAC" ], [], [], [], [], [], [], [ "REAC" ], [], [] ], "name": "DNA Damage/Telomere Stress Induced Senescence", "native": "REAC:R-HSA-2559586", "p_value": 0.00021925238441252484, "parents": [ "REAC:R-HSA-2559583" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.0379746835443038, "significant": true, "source": "REAC", "term_size": 79, "source_order": 461, "group_id": 29 }, { "description": "\"The chemical reactions and pathways involving a protein. Includes protein modification.\" [GOC:ma]", "effective_domain_size": 20972, "goshv": 15622, "intersection_size": 9, "intersections": [ [ "IEA" ], [ "IDA", "IMP", "IEA" ], [ "IDA" ], [ "IDA", "IEA" ], [ "IDA", "IMP", "IEA" ], [ "IDA", "IEA" ], [], [], [ "IDA", "IMP", "TAS" ], [ "IMP", "TAS" ], [ "IDA", "IMP", "IGI", "IBA", "TAS", "IEA" ] ], "name": "protein metabolic process", "native": "GO:0019538", "p_value": 0.00022074741274318523, "parents": [ "GO:0043170", "GO:0044238" ], "precision": 0.8181818181818182, "query": "query_1", "query_size": 11, "recall": 0.0020147750167897917, "significant": true, "source": "GO:BP", "term_size": 4467, "source_order": 5499, "group_id": 1 }, { "description": "\"A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase as part of a mitotic cell cycle.\" [GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 20545, "intersection_size": 2, "intersections": [ [ "IMP", "IEA" ], [], [], [], [], [], [], [], [ "IDA" ], [], [] ], "name": "mitotic G1/S transition checkpoint signaling", "native": "GO:0044819", "p_value": 0.00022774299447665718, "parents": [ "GO:0007093", "GO:2000134" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.11764705882352941, "significant": true, "source": "GO:BP", "term_size": 17, "source_order": 10422, "group_id": 1 }, { "description": "\"Any process that modulates the occurrence or rate of cell death by apoptotic process.\" [GOC:jl, GOC:mtg_apoptosis]", "effective_domain_size": 20972, "goshv": 19927, "intersection_size": 6, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IEA" ], [ "IMP", "TAS", "IEA" ], [], [], [ "IEA" ], [ "IMP" ], [], [], [], [ "IDA" ], [ "IMP", "IBA", "IEA" ] ], "name": "regulation of apoptotic process", "native": "GO:0042981", "p_value": 0.00022774299447665718, "parents": [ "GO:0006915", "GO:0043067" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.004207573632538569, "significant": true, "source": "GO:BP", "term_size": 1426, "source_order": 9804, "group_id": 1 }, { "description": "\"Any nuclear DNA replication that is involved in a mitotic cell cycle.\" [GO_REF:0000060, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 31213, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [ "IMP" ], [ "IEA" ], [], [], [] ], "name": "mitotic DNA replication", "native": "GO:1902969", "p_value": 0.00022774299447665718, "parents": [ "GO:0033260", "GO:1903047" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.11764705882352941, "significant": true, "source": "GO:BP", "term_size": 17, "source_order": 21090, "group_id": 1 }, { "description": "TP53 Regulates Transcription of Caspase Activators and Caspases", "effective_domain_size": 11056, "goshv": 41874, "intersection_size": 2, "intersections": [ [ "REAC" ], [ "REAC" ], [], [], [], [], [], [], [], [], [] ], "name": "TP53 Regulates Transcription of Caspase Activators and Caspases", "native": "REAC:R-HSA-6803207", "p_value": 0.0002286516945824555, "parents": [ "REAC:R-HSA-5633008" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.16666666666666666, "significant": true, "source": "REAC", "term_size": 12, "source_order": 2550, "group_id": 25 }, { "description": "Disease", "effective_domain_size": 11056, "goshv": 40109, "intersection_size": 8, "intersections": [ [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [], [ "REAC" ], [ "REAC" ], [ "REAC" ], [ "REAC" ], [], [ "REAC" ] ], "name": "Disease", "native": "REAC:R-HSA-1643685", "p_value": 0.00023353089561004408, "parents": [ "REAC:0000000" ], "precision": 0.7272727272727273, "query": "query_1", "query_size": 11, "recall": 0.004329004329004329, "significant": true, "source": "REAC", "term_size": 1848, "source_order": 785, "group_id": 26 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 13714, "intersection_size": 8, "intersections": [ [ "IDA", "IMP", "ISS", "NAS", "IEA" ], [ "IDA", "IMP" ], [ "IMP" ], [ "ISS", "IEA" ], [], [ "IDA", "IMP", "IEA" ], [], [], [ "IDA", "IMP", "IEA" ], [ "IMP" ], [ "IDA", "IMP" ] ], "name": "negative regulation of metabolic process", "native": "GO:0009892", "p_value": 0.0002472889429263923, "parents": [ "GO:0008152", "GO:0019222", "GO:0048523" ], "precision": 0.7272727272727273, "query": "query_1", "query_size": 11, "recall": 0.002442002442002442, "significant": true, "source": "GO:BP", "term_size": 3276, "source_order": 3591, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.\" [GOC:jl, GOC:krc]", "effective_domain_size": 20972, "goshv": 13442, "intersection_size": 4, "intersections": [ [ "IEP", "IEA" ], [], [ "IEA" ], [], [ "IEA" ], [], [], [ "IEA" ], [], [], [] ], "name": "response to xenobiotic stimulus", "native": "GO:0009410", "p_value": 0.0002472889429263923, "parents": [ "GO:0042221" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.010101010101010102, "significant": true, "source": "GO:BP", "term_size": 396, "source_order": 3319, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.\" [GOC:jid]", "effective_domain_size": 20972, "goshv": 22075, "intersection_size": 10, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IEA" ], [ "IMP", "ISS", "IEA" ], [ "IMP", "ISS" ], [ "IDA" ], [ "IDA", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IEA" ], [], [ "IDA", "IMP", "TAS", "IEA" ], [ "IDA", "IMP" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ] ], "name": "positive regulation of biological process", "native": "GO:0048518", "p_value": 0.0002495969723820835, "parents": [ "GO:0008150", "GO:0050789" ], "precision": 0.9090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0016260162601626016, "significant": true, "source": "GO:BP", "term_size": 6150, "source_order": 11952, "group_id": 1 }, { "description": "\"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.\" [GOC:ai, GOC:jl, GOC:mah]", "effective_domain_size": 20972, "goshv": 14958, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IEA" ], [ "IMP", "IGI", "ISS", "IBA", "TAS", "IC", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "IEA" ], [ "IDA", "ISS", "IEA" ], [ "IDA", "IMP", "IEA" ], [ "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IMP", "IEA" ], [ "IMP", "ISS", "IBA", "TAS", "IEA" ], [ "IDA" ], [ "IEA" ], [ "IDA", "IMP", "IEA" ] ], "name": "cellular component organization", "native": "GO:0016043", "p_value": 0.00025247763345179555, "parents": [ "GO:0071840" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.0013213213213213214, "significant": true, "source": "GO:BP", "term_size": 8325, "source_order": 4835, "group_id": 1 }, { "description": "\"The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei.\" [GOC:dph, GOC:jl, GOC:mtg_cell_cycle, PMID:9334324]", "effective_domain_size": 20972, "goshv": 12687, "intersection_size": 3, "intersections": [ [], [ "TAS", "IEA" ], [], [], [], [], [ "IEA" ], [ "IBA", "TAS", "IEA" ], [], [], [] ], "name": "meiosis I", "native": "GO:0007127", "p_value": 0.0002533352561145587, "parents": [ "GO:0061982", "GO:0140013" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.022727272727272728, "significant": true, "source": "GO:BP", "term_size": 132, "source_order": 2564, "group_id": 1 }, { "description": "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "effective_domain_size": 11056, "goshv": 39688, "intersection_size": 2, "intersections": [ [], [], [], [ "REAC" ], [ "REAC" ], [], [], [], [], [], [] ], "name": "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "native": "REAC:R-HSA-75035", "p_value": 0.00026043241008026505, "parents": [ "REAC:R-HSA-69473" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.15384615384615385, "significant": true, "source": "REAC", "term_size": 13, "source_order": 364, "group_id": 27 }, { "description": "\"The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.\" [GOC:go_curators, GOC:mtg_sensu]", "effective_domain_size": 20972, "goshv": 10503, "intersection_size": 4, "intersections": [ [ "IEA" ], [], [], [ "IEA" ], [], [], [ "IEA" ], [], [ "IEA" ], [], [] ], "name": "in utero embryonic development", "native": "GO:0001701", "p_value": 0.0002639826615048494, "parents": [ "GO:0043009" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.009876543209876543, "significant": true, "source": "GO:BP", "term_size": 405, "source_order": 380, "group_id": 1 }, { "description": "\"Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 20190, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [ "IMP" ], [], [], [], [], [], [], [], [] ], "name": "positive regulation of DNA damage response, signal transduction by p53 class mediator", "native": "GO:0043517", "p_value": 0.00027512138140196575, "parents": [ "GO:0030330", "GO:0043516", "GO:1901798" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.10526315789473684, "significant": true, "source": "GO:BP", "term_size": 19, "source_order": 10067, "group_id": 1 }, { "description": "Signaling by ALK fusions and activated point mutants", "effective_domain_size": 11056, "goshv": 41639, "intersection_size": 3, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [ "REAC" ], [], [ "REAC" ] ], "name": "Signaling by ALK fusions and activated point mutants", "native": "REAC:R-HSA-9725370", "p_value": 0.0002834280324589799, "parents": [ "REAC:R-HSA-9700206" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.033707865168539325, "significant": true, "source": "REAC", "term_size": 89, "source_order": 2315, "group_id": 26 }, { "description": "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "effective_domain_size": 11056, "goshv": 41880, "intersection_size": 2, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [ "REAC" ], [], [] ], "name": "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "native": "REAC:R-HSA-6804116", "p_value": 0.0002834280324589799, "parents": [ "REAC:R-HSA-6791312" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.14285714285714285, "significant": true, "source": "REAC", "term_size": 14, "source_order": 2556, "group_id": 25 }, { "description": "Signaling by ALK in cancer", "effective_domain_size": 11056, "goshv": 41640, "intersection_size": 3, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [ "REAC" ], [], [ "REAC" ] ], "name": "Signaling by ALK in cancer", "native": "REAC:R-HSA-9700206", "p_value": 0.0002834280324589799, "parents": [ "REAC:R-HSA-5663202" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.033707865168539325, "significant": true, "source": "REAC", "term_size": 89, "source_order": 2316, "group_id": 26 }, { "description": "AKT phosphorylates targets in the cytosol", "effective_domain_size": 11056, "goshv": 39337, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [], [], [ "REAC" ], [], [ "REAC" ] ], "name": "AKT phosphorylates targets in the cytosol", "native": "REAC:R-HSA-198323", "p_value": 0.0002834280324589799, "parents": [ "REAC:R-HSA-1257604" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.14285714285714285, "significant": true, "source": "REAC", "term_size": 14, "source_order": 13, "group_id": 30 }, { "description": "\"A process that contributes to the first meiotic division. The first meiotic division is the reductive division resulting in the separation of homologous chromosome pairs.\" [PMID:29385397]", "effective_domain_size": 20972, "goshv": 24788, "intersection_size": 3, "intersections": [ [], [ "TAS", "IEA" ], [], [], [], [], [ "IEA" ], [ "IBA", "TAS", "IEA" ], [], [], [] ], "name": "meiosis I cell cycle process", "native": "GO:0061982", "p_value": 0.00030979770261231696, "parents": [ "GO:1903046" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.02112676056338028, "significant": true, "source": "GO:BP", "term_size": 142, "source_order": 14665, "group_id": 1 }, { "description": "\"A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25919, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IEA" ], [ "IMP", "IGI", "ISS", "IBA", "TAS", "IC", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "IEA" ], [ "IDA", "ISS", "IEA" ], [ "IDA", "IMP", "IEA" ], [ "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IMP", "IEA" ], [ "IMP", "ISS", "IBA", "TAS", "IEA" ], [ "IDA" ], [ "IEA" ], [ "IDA", "IMP", "IEA" ] ], "name": "cellular component organization or biogenesis", "native": "GO:0071840", "p_value": 0.00032430560383776776, "parents": [ "GO:0009987" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.0012883579292574372, "significant": true, "source": "GO:BP", "term_size": 8538, "source_order": 15796, "group_id": 1 }, { "description": "Transcriptional regulation by RUNX3", "effective_domain_size": 11056, "goshv": 41976, "intersection_size": 3, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [ "REAC" ], [], [ "REAC" ] ], "name": "Transcriptional regulation by RUNX3", "native": "REAC:R-HSA-8878159", "p_value": 0.00033054301405623885, "parents": [ "REAC:R-HSA-212436" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.031578947368421054, "significant": true, "source": "REAC", "term_size": 95, "source_order": 2652, "group_id": 25 }, { "description": "\"Any apoptotic process in a thymocyte, an immature T cell located in the thymus.\" [CL:0000893, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]", "effective_domain_size": 20972, "goshv": 25028, "intersection_size": 2, "intersections": [ [ "ISS", "IEA" ], [], [], [], [ "IEA" ], [], [], [], [], [], [] ], "name": "thymocyte apoptotic process", "native": "GO:0070242", "p_value": 0.0003321694757217865, "parents": [ "GO:0070231" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.09523809523809523, "significant": true, "source": "GO:BP", "term_size": 21, "source_order": 14905, "group_id": 1 }, { "description": "\"Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.\" [GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 33678, "intersection_size": 3, "intersections": [ [ "IMP", "IEA" ], [], [], [], [], [], [], [], [ "IDA", "IGI", "IBA" ], [], [ "IEA" ] ], "name": "regulation of G1/S transition of mitotic cell cycle", "native": "GO:2000045", "p_value": 0.0003588266050422898, "parents": [ "GO:0000082", "GO:1901990", "GO:1902806" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.02, "significant": true, "source": "GO:BP", "term_size": 150, "source_order": 23555, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22750, "intersection_size": 7, "intersections": [ [ "IDA", "IMP" ], [ "IMP", "IGI", "ISS", "IC", "IEA" ], [ "IMP", "ISS" ], [ "IDA" ], [ "IDA" ], [ "IMP", "NAS" ], [], [], [ "IDA" ], [], [] ], "name": "regulation of cellular component organization", "native": "GO:0051128", "p_value": 0.0003744743452206218, "parents": [ "GO:0016043", "GO:0050794" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.00288421920065925, "significant": true, "source": "GO:BP", "term_size": 2427, "source_order": 12627, "group_id": 1 }, { "description": "\"An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation.\" [GOC:dph, ISBN:0124020607, ISBN:0198542771]", "effective_domain_size": 20972, "goshv": 10599, "intersection_size": 2, "intersections": [ [], [], [], [ "IEA" ], [], [], [ "IEA" ], [], [], [], [] ], "name": "blastocyst growth", "native": "GO:0001832", "p_value": 0.0003914464534468252, "parents": [ "GO:0001824", "GO:0048589" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.08695652173913043, "significant": true, "source": "GO:BP", "term_size": 23, "source_order": 476, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17042, "intersection_size": 2, "intersections": [ [], [ "ISS", "IEA" ], [ "ISS" ], [], [], [], [], [], [], [], [] ], "name": "positive regulation of telomere maintenance via telomerase", "native": "GO:0032212", "p_value": 0.0003914464534468252, "parents": [ "GO:0007004", "GO:0032210", "GO:1904358", "GO:2000573" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.08695652173913043, "significant": true, "source": "GO:BP", "term_size": 23, "source_order": 6919, "group_id": 1 }, { "description": "\"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).\" [ISBN:0198506732]", "effective_domain_size": 20972, "goshv": 21648, "intersection_size": 3, "intersections": [ [], [ "IDA", "IMP" ], [ "IDA" ], [], [ "IDA" ], [], [], [], [], [], [] ], "name": "protein autophosphorylation", "native": "GO:0046777", "p_value": 0.000402289593389477, "parents": [ "GO:0006468" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.01910828025477707, "significant": true, "source": "GO:BP", "term_size": 157, "source_order": 11525, "group_id": 1 }, { "description": "FOXO-mediated transcription of cell cycle genes", "effective_domain_size": 11056, "goshv": 40289, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [], [], [ "REAC" ], [ "REAC" ], [] ], "name": "FOXO-mediated transcription of cell cycle genes", "native": "REAC:R-HSA-9617828", "p_value": 0.0004092535887159628, "parents": [ "REAC:R-HSA-9614085" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.11764705882352941, "significant": true, "source": "REAC", "term_size": 17, "source_order": 965, "group_id": 25 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 13111, "intersection_size": 2, "intersections": [ [ "IEA" ], [], [ "IMP" ], [], [], [], [], [], [], [], [] ], "name": "negative regulation of DNA replication", "native": "GO:0008156", "p_value": 0.0004224165182645738, "parents": [ "GO:0006260", "GO:0006275", "GO:0051053" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.08333333333333333, "significant": true, "source": "GO:BP", "term_size": 24, "source_order": 2988, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus.\" [GOC:pr, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 30360, "intersection_size": 6, "intersections": [ [ "IDA" ], [ "IDA", "ISS", "IEA" ], [], [], [ "IEA" ], [ "IDA" ], [], [ "IDA", "IEA" ], [], [], [ "IDA" ] ], "name": "response to oxygen-containing compound", "native": "GO:1901700", "p_value": 0.00044225491280419253, "parents": [ "GO:0042221" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.003676470588235294, "significant": true, "source": "GO:BP", "term_size": 1632, "source_order": 20237, "group_id": 1 }, { "description": "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "effective_domain_size": 11056, "goshv": 41881, "intersection_size": 2, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [], [ "REAC" ], [] ], "name": "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "native": "REAC:R-HSA-6804114", "p_value": 0.0004457803699987456, "parents": [ "REAC:R-HSA-6791312" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.1111111111111111, "significant": true, "source": "REAC", "term_size": 18, "source_order": 2557, "group_id": 25 }, { "description": "SUMOylation of transcription factors", "effective_domain_size": 11056, "goshv": 41597, "intersection_size": 2, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [], [], [ "REAC" ] ], "name": "SUMOylation of transcription factors", "native": "REAC:R-HSA-3232118", "p_value": 0.0004457803699987456, "parents": [ "REAC:R-HSA-3108232" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.1111111111111111, "significant": true, "source": "REAC", "term_size": 18, "source_order": 2273, "group_id": 31 }, { "description": "\"Any process that modulates the frequency, rate or extent of cell proliferation.\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 19463, "intersection_size": 6, "intersections": [ [ "IDA", "IMP", "ISS", "IEA" ], [ "IMP" ], [], [ "IEA" ], [], [], [ "IDA" ], [], [ "IDA", "IMP", "IEA" ], [], [ "TAS" ] ], "name": "regulation of cell population proliferation", "native": "GO:0042127", "p_value": 0.0004507265833642844, "parents": [ "GO:0008283", "GO:0050794" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.0036607687614399025, "significant": true, "source": "GO:BP", "term_size": 1639, "source_order": 9340, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening.\" [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]", "effective_domain_size": 20972, "goshv": 32169, "intersection_size": 2, "intersections": [ [], [ "IMP", "ISS", "IEA" ], [ "ISS" ], [], [], [], [], [], [], [], [] ], "name": "positive regulation of telomere maintenance via telomere lengthening", "native": "GO:1904358", "p_value": 0.0004868761312250423, "parents": [ "GO:0010833", "GO:0032206", "GO:1904356" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.07692307692307693, "significant": true, "source": "GO:BP", "term_size": 26, "source_order": 22046, "group_id": 1 }, { "description": "\"The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous DNA region that occurs during mitotic cell cycles.\" [GOC:elh]", "effective_domain_size": 20972, "goshv": 12132, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [ "IEA" ], [ "ISS", "IBA", "TAS", "IEA" ], [], [], [] ], "name": "mitotic recombination", "native": "GO:0006312", "p_value": 0.0004868761312250423, "parents": [ "GO:0006310" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.07692307692307693, "significant": true, "source": "GO:BP", "term_size": 26, "source_order": 2009, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 16446, "intersection_size": 3, "intersections": [ [ "IMP" ], [], [], [], [], [ "IMP" ], [], [], [ "IDA" ], [], [] ], "name": "negative regulation of cell growth", "native": "GO:0030308", "p_value": 0.000493894679997805, "parents": [ "GO:0001558", "GO:0016049", "GO:0045926", "GO:0048523" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.01764705882352941, "significant": true, "source": "GO:BP", "term_size": 170, "source_order": 6323, "group_id": 1 }, { "description": "\"Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.\" [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 31099, "intersection_size": 3, "intersections": [ [ "IMP", "IEA" ], [], [], [], [], [], [], [], [ "IDA", "IMP", "IGI", "IBA" ], [], [ "IEA" ] ], "name": "regulation of cell cycle G1/S phase transition", "native": "GO:1902806", "p_value": 0.0005355228019189789, "parents": [ "GO:0044843", "GO:1901987" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.017142857142857144, "significant": true, "source": "GO:BP", "term_size": 175, "source_order": 20976, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 20335, "intersection_size": 5, "intersections": [ [ "IDA" ], [ "IMP", "IC" ], [ "IMP" ], [], [ "IDA" ], [ "NAS" ], [], [], [], [], [] ], "name": "regulation of cellular component biogenesis", "native": "GO:0044087", "p_value": 0.0005414516041970835, "parents": [ "GO:0044085", "GO:0050794" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.004970178926441352, "significant": true, "source": "GO:BP", "term_size": 1006, "source_order": 10212, "group_id": 1 }, { "description": "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "effective_domain_size": 11056, "goshv": 41879, "intersection_size": 2, "intersections": [ [ "REAC" ], [ "REAC" ], [], [], [], [], [], [], [], [], [] ], "name": "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "native": "REAC:R-HSA-6803204", "p_value": 0.0005444752463138947, "parents": [ "REAC:R-HSA-5633008" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.1, "significant": true, "source": "REAC", "term_size": 20, "source_order": 2555, "group_id": 25 }, { "description": "\"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 12615, "intersection_size": 5, "intersections": [ [], [], [], [ "IDA" ], [ "IMP" ], [ "NAS", "IEA" ], [ "IMP" ], [], [], [ "IEA" ], [] ], "name": "microtubule-based process", "native": "GO:0007017", "p_value": 0.0005620494116845464, "parents": [ "GO:0009987" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.0049261083743842365, "significant": true, "source": "GO:BP", "term_size": 1015, "source_order": 2492, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.\" [GOC:ai, GOC:bf]", "effective_domain_size": 20972, "goshv": 22599, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IGI", "IEP", "ISS", "TAS", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IEP", "ISS", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IEP", "ISS", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IEP", "TAS", "IEA" ], [ "IDA", "IMP", "IEP", "TAS" ] ], "name": "response to stimulus", "native": "GO:0050896", "p_value": 0.0005668337726608991, "parents": [ "GO:0008150" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.0012153353220638603, "significant": true, "source": "GO:BP", "term_size": 9051, "source_order": 12476, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.\" [GOC:jl, GOC:mtg_apoptosis]", "effective_domain_size": 20972, "goshv": 19971, "intersection_size": 4, "intersections": [ [ "IDA", "IMP", "ISS", "IEA" ], [ "IMP", "IEA" ], [], [], [ "IEA" ], [], [], [], [], [ "IDA" ], [] ], "name": "positive regulation of apoptotic process", "native": "GO:0043065", "p_value": 0.0005913644118537621, "parents": [ "GO:0006915", "GO:0042981", "GO:0043068" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.0078125, "significant": true, "source": "GO:BP", "term_size": 512, "source_order": 9848, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process.\" [GOC:obol]", "effective_domain_size": 20972, "goshv": 33860, "intersection_size": 2, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [], [ "IMP" ], [], [] ], "name": "negative regulation of DNA biosynthetic process", "native": "GO:2000279", "p_value": 0.0006282506344480245, "parents": [ "GO:0010558", "GO:0051053", "GO:0071897", "GO:2000278" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.06666666666666667, "significant": true, "source": "GO:BP", "term_size": 30, "source_order": 23737, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator.\" [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871]", "effective_domain_size": 20972, "goshv": 30770, "intersection_size": 2, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [ "IMP" ] ], "name": "regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "native": "GO:1902253", "p_value": 0.0007123960210218516, "parents": [ "GO:0072332", "GO:1901796", "GO:2001242" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.0625, "significant": true, "source": "GO:BP", "term_size": 32, "source_order": 20647, "group_id": 1 }, { "description": "\"Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 14148, "intersection_size": 7, "intersections": [ [ "IDA", "IMP", "ISS", "NAS", "IEA" ], [ "IDA" ], [], [ "ISS", "IEA" ], [], [ "IDA", "IMP", "IEA" ], [], [], [ "IMP", "IEA" ], [ "IMP" ], [ "IDA", "IMP" ] ], "name": "negative regulation of macromolecule biosynthetic process", "native": "GO:0010558", "p_value": 0.0007449976968151887, "parents": [ "GO:0009059", "GO:0009890", "GO:0010556", "GO:0010605" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.002561287961946579, "significant": true, "source": "GO:BP", "term_size": 2733, "source_order": 4025, "group_id": 1 }, { "description": "\"One of the two nuclear divisions that occur as part of the meiotic cell cycle.\" [PMID:9334324]", "effective_domain_size": 20972, "goshv": 28485, "intersection_size": 3, "intersections": [ [], [ "TAS", "IEA" ], [], [], [], [], [ "IEA" ], [ "IBA", "TAS", "IEA" ], [], [], [] ], "name": "meiotic nuclear division", "native": "GO:0140013", "p_value": 0.0007492695377813982, "parents": [ "GO:0000280", "GO:1903046" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.01507537688442211, "significant": true, "source": "GO:BP", "term_size": 199, "source_order": 18362, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator.\" [GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 30432, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [ "IMP" ], [], [], [], [], [], [], [], [] ], "name": "positive regulation of signal transduction by p53 class mediator", "native": "GO:1901798", "p_value": 0.0007492695377813982, "parents": [ "GO:0072331", "GO:1901796", "GO:1902533" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.06060606060606061, "significant": true, "source": "GO:BP", "term_size": 33, "source_order": 20309, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of protein complex assembly.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 16795, "intersection_size": 3, "intersections": [ [ "IDA" ], [ "IMP" ], [ "IMP" ], [], [], [], [], [], [], [], [] ], "name": "positive regulation of protein-containing complex assembly", "native": "GO:0031334", "p_value": 0.000802405779743893, "parents": [ "GO:0043254", "GO:0044089", "GO:0051130", "GO:0065003" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.014705882352941176, "significant": true, "source": "GO:BP", "term_size": 204, "source_order": 6672, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.\" [GOC:ai, GOC:ef]", "effective_domain_size": 20972, "goshv": 21593, "intersection_size": 2, "intersections": [ [ "IDA", "IEP" ], [], [], [], [], [], [], [], [], [], [ "IDA", "IEP" ] ], "name": "response to antibiotic", "native": "GO:0046677", "p_value": 0.0008332301209600276, "parents": [ "GO:0042221" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.05714285714285714, "significant": true, "source": "GO:BP", "term_size": 35, "source_order": 11470, "group_id": 1 }, { "description": "Constitutive Signaling by AKT1 E17K in Cancer", "effective_domain_size": 11056, "goshv": 39740, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [], [], [ "REAC" ], [], [ "REAC" ] ], "name": "Constitutive Signaling by AKT1 E17K in Cancer", "native": "REAC:R-HSA-5674400", "p_value": 0.0008443767124331502, "parents": [ "REAC:R-HSA-2219528" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.08, "significant": true, "source": "REAC", "term_size": 25, "source_order": 416, "group_id": 26 }, { "description": "\"Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 13712, "intersection_size": 7, "intersections": [ [ "IDA", "IMP", "ISS", "NAS", "IEA" ], [ "IDA" ], [], [ "ISS", "IEA" ], [], [ "IDA", "IMP", "IEA" ], [], [], [ "IMP", "IEA" ], [ "IMP" ], [ "IDA", "IMP" ] ], "name": "negative regulation of biosynthetic process", "native": "GO:0009890", "p_value": 0.0008547819649678342, "parents": [ "GO:0009058", "GO:0009889", "GO:0009892" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.0024982155603140615, "significant": true, "source": "GO:BP", "term_size": 2802, "source_order": 3589, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 21074, "intersection_size": 3, "intersections": [ [ "IMP" ], [], [], [], [], [], [], [], [ "IDA", "IMP" ], [ "IMP" ], [] ], "name": "negative regulation of phosphate metabolic process", "native": "GO:0045936", "p_value": 0.0008575209467410072, "parents": [ "GO:0006796", "GO:0010563" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.014285714285714285, "significant": true, "source": "GO:BP", "term_size": 210, "source_order": 10951, "group_id": 1 }, { "description": "\"Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 14153, "intersection_size": 3, "intersections": [ [ "IMP" ], [], [], [], [], [], [], [], [ "IDA", "IMP" ], [ "IMP" ], [] ], "name": "negative regulation of phosphorus metabolic process", "native": "GO:0010563", "p_value": 0.0008575209467410072, "parents": [ "GO:0006793", "GO:0009892", "GO:0051174" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.014285714285714285, "significant": true, "source": "GO:BP", "term_size": 210, "source_order": 4030, "group_id": 1 }, { "description": "\"The pathways that regulate the duration of the adult phase of the life-cycle of an animal.\" [PMID:25561524, PMID:273723695, PMID:3424805]", "effective_domain_size": 20972, "goshv": 13150, "intersection_size": 2, "intersections": [ [ "ISS", "IEA" ], [ "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "determination of adult lifespan", "native": "GO:0008340", "p_value": 0.0008652710152441667, "parents": [ "GO:0032501" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.05555555555555555, "significant": true, "source": "GO:BP", "term_size": 36, "source_order": 3027, "group_id": 1 }, { "description": "\"The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.\" [GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 10153, "intersection_size": 3, "intersections": [ [ "IMP", "IEA" ], [], [], [], [], [], [], [], [ "IDA", "IGI", "IBA", "TAS" ], [], [ "IEA" ] ], "name": "G1/S transition of mitotic cell cycle", "native": "GO:0000082", "p_value": 0.0008735491026763536, "parents": [ "GO:0044772", "GO:0044843" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.014150943396226415, "significant": true, "source": "GO:BP", "term_size": 212, "source_order": 30, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.\" [GOC:hb]", "effective_domain_size": 20972, "goshv": 13506, "intersection_size": 3, "intersections": [ [], [], [ "IDA" ], [ "IEP" ], [], [], [], [], [], [ "IEP" ], [] ], "name": "response to mechanical stimulus", "native": "GO:0009612", "p_value": 0.0008938932389968771, "parents": [ "GO:0009605", "GO:0009628" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.014018691588785047, "significant": true, "source": "GO:BP", "term_size": 214, "source_order": 3383, "group_id": 1 }, { "description": "\"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.\" [GOC:jid, UBERON:0000948]", "effective_domain_size": 20972, "goshv": 12980, "intersection_size": 4, "intersections": [ [ "IEA" ], [ "IEA" ], [], [], [], [], [], [], [ "ISS", "IEA" ], [], [ "IEA" ] ], "name": "heart development", "native": "GO:0007507", "p_value": 0.0009618703877272636, "parents": [ "GO:0048513", "GO:0072359" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.00676818950930626, "significant": true, "source": "GO:BP", "term_size": 591, "source_order": 2857, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 21066, "intersection_size": 3, "intersections": [ [ "IMP" ], [], [], [], [], [ "IMP" ], [], [], [ "IDA", "ISS", "IEA" ], [], [] ], "name": "negative regulation of growth", "native": "GO:0045926", "p_value": 0.0009738299264984522, "parents": [ "GO:0040007", "GO:0040008", "GO:0048519" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.013574660633484163, "significant": true, "source": "GO:BP", "term_size": 221, "source_order": 10943, "group_id": 1 }, { "description": "\"A process that is part of the meiotic cell cycle.\" [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 31272, "intersection_size": 3, "intersections": [ [], [ "TAS", "IEA" ], [], [], [], [], [ "IEA" ], [ "IBA", "TAS", "IEA" ], [], [], [] ], "name": "meiotic cell cycle process", "native": "GO:1903046", "p_value": 0.0009823175165723467, "parents": [ "GO:0022402", "GO:0022414", "GO:0051321" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.013513513513513514, "significant": true, "source": "GO:BP", "term_size": 222, "source_order": 21149, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17035, "intersection_size": 2, "intersections": [ [ "IDA" ], [ "IMP" ], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of telomere maintenance", "native": "GO:0032205", "p_value": 0.0009841990450631948, "parents": [ "GO:0000723", "GO:0032204", "GO:0051053", "GO:2001251" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.05128205128205128, "significant": true, "source": "GO:BP", "term_size": 39, "source_order": 6912, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 33936, "intersection_size": 2, "intersections": [ [ "IEA" ], [], [], [], [], [ "IMP" ], [], [], [], [], [] ], "name": "negative regulation of reactive oxygen species metabolic process", "native": "GO:2000378", "p_value": 0.0009841990450631948, "parents": [ "GO:0009892", "GO:0072593", "GO:2000377" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.05128205128205128, "significant": true, "source": "GO:BP", "term_size": 39, "source_order": 23813, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.\" [GOC:ai, GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 22814, "intersection_size": 7, "intersections": [ [ "IEA" ], [ "IMP" ], [], [], [], [ "IMP" ], [ "IDA" ], [], [ "IEA" ], [ "IEA" ], [ "IEA" ] ], "name": "regulation of multicellular organismal process", "native": "GO:0051239", "p_value": 0.0010672057626768389, "parents": [ "GO:0032501", "GO:0050789" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.0023947998631542937, "significant": true, "source": "GO:BP", "term_size": 2923, "source_order": 12691, "group_id": 1 }, { "description": "\"The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle.\" [GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 17698, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [ "IMP" ], [ "IEA" ], [], [], [] ], "name": "nuclear DNA replication", "native": "GO:0033260", "p_value": 0.0010688913069425707, "parents": [ "GO:0044786" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.04878048780487805, "significant": true, "source": "GO:BP", "term_size": 41, "source_order": 7575, "group_id": 1 }, { "description": "\"The multiplication or reproduction of cells, resulting in the expansion of a cell population.\" [GOC:mah, GOC:mb]", "effective_domain_size": 20972, "goshv": 13133, "intersection_size": 6, "intersections": [ [ "IDA", "IMP", "ISS", "IEA" ], [ "IMP" ], [], [ "IEA" ], [], [], [ "IDA", "IEA" ], [], [ "IDA", "IMP", "IEA" ], [], [ "TAS" ] ], "name": "cell population proliferation", "native": "GO:0008283", "p_value": 0.0010688913069425707, "parents": [ "GO:0009987" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.0030596634370219276, "significant": true, "source": "GO:BP", "term_size": 1961, "source_order": 3010, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).\" [GOC:txnOH-2018]", "effective_domain_size": 20972, "goshv": 14100, "intersection_size": 9, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "NAS", "IEA" ], [ "IDA", "IMP", "ISS", "IEA" ], [], [ "ISS", "IEA" ], [ "IDA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IBA" ], [], [ "IEA" ], [ "IMP" ], [ "IDA", "IMP", "IEA" ] ], "name": "regulation of gene expression", "native": "GO:0010468", "p_value": 0.0010688913069425707, "parents": [ "GO:0010467", "GO:0010556" ], "precision": 0.8181818181818182, "query": "query_1", "query_size": 11, "recall": 0.0016219138583528565, "significant": true, "source": "GO:BP", "term_size": 5549, "source_order": 3977, "group_id": 1 }, { "description": "\"Any process that stops or reduces the activity of an enzyme.\" [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]", "effective_domain_size": 20972, "goshv": 19978, "intersection_size": 3, "intersections": [ [ "TAS" ], [], [], [], [], [], [], [], [ "IMP" ], [ "IMP" ], [] ], "name": "negative regulation of catalytic activity", "native": "GO:0043086", "p_value": 0.0010972758429802496, "parents": [ "GO:0044092", "GO:0050790" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.012875536480686695, "significant": true, "source": "GO:BP", "term_size": 233, "source_order": 9855, "group_id": 1 }, { "description": "\"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication.\" [GOC:vw, PMID:16464006, PMID:22064477]", "effective_domain_size": 20972, "goshv": 19048, "intersection_size": 2, "intersections": [ [], [], [ "TAS" ], [], [], [], [], [ "IMP" ], [], [], [] ], "name": "interstrand cross-link repair", "native": "GO:0036297", "p_value": 0.0011119967588015727, "parents": [ "GO:0006281" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.047619047619047616, "significant": true, "source": "GO:BP", "term_size": 42, "source_order": 8925, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of organelle assembly.\" [GOC:pr, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 30664, "intersection_size": 3, "intersections": [ [], [ "IC" ], [], [], [ "IDA" ], [ "NAS" ], [], [], [], [], [] ], "name": "regulation of organelle assembly", "native": "GO:1902115", "p_value": 0.0011576984137697756, "parents": [ "GO:0033043", "GO:0044087", "GO:0070925" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.012605042016806723, "significant": true, "source": "GO:BP", "term_size": 238, "source_order": 20541, "group_id": 1 }, { "description": "\"The cell cycle process by which a cell in G1 phase commits to S phase.\" [GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 20557, "intersection_size": 3, "intersections": [ [ "IMP", "IEA" ], [], [], [], [], [], [], [], [ "IDA", "IMP", "IGI", "IBA", "TAS" ], [], [ "IEA" ] ], "name": "cell cycle G1/S phase transition", "native": "GO:0044843", "p_value": 0.001166891776504221, "parents": [ "GO:0044770" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.012552301255230125, "significant": true, "source": "GO:BP", "term_size": 239, "source_order": 10434, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17606, "intersection_size": 3, "intersections": [ [ "IDA" ], [ "IMP", "IGI", "ISS", "IEA" ], [ "ISS" ], [], [], [], [], [], [], [], [] ], "name": "regulation of chromosome organization", "native": "GO:0033044", "p_value": 0.001190601604672337, "parents": [ "GO:0033043", "GO:0051276" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.012448132780082987, "significant": true, "source": "GO:BP", "term_size": 241, "source_order": 7483, "group_id": 1 }, { "description": "\"The DNA-dependent DNA replication that takes place as part of the cell cycle.\" [GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 20530, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [ "IMP" ], [ "IEA" ], [], [], [] ], "name": "cell cycle DNA replication", "native": "GO:0044786", "p_value": 0.0012550929769944183, "parents": [ "GO:0006261", "GO:0022402" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.044444444444444446, "significant": true, "source": "GO:BP", "term_size": 45, "source_order": 10407, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process.\" [GOC:obol]", "effective_domain_size": 20972, "goshv": 34110, "intersection_size": 2, "intersections": [ [], [ "ISS", "IEA" ], [ "ISS" ], [], [], [], [], [], [], [], [] ], "name": "positive regulation of DNA biosynthetic process", "native": "GO:2000573", "p_value": 0.0013060389844469624, "parents": [ "GO:0010557", "GO:0051054", "GO:0071897", "GO:2000278" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.043478260869565216, "significant": true, "source": "GO:BP", "term_size": 46, "source_order": 23987, "group_id": 1 }, { "description": "Oncogene Induced Senescence", "effective_domain_size": 11056, "goshv": 41032, "intersection_size": 2, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [], [], [ "REAC" ] ], "name": "Oncogene Induced Senescence", "native": "REAC:R-HSA-2559585", "p_value": 0.0014575776673315854, "parents": [ "REAC:R-HSA-2559583" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.06060606060606061, "significant": true, "source": "REAC", "term_size": 33, "source_order": 1708, "group_id": 29 }, { "description": "\"Any process that modulates the frequency, rate or extent of autophagosome assembly.\" [GOC:autophagy, GOC:BHF]", "effective_domain_size": 20972, "goshv": 34260, "intersection_size": 2, "intersections": [ [], [ "IC" ], [], [], [ "IDA" ], [], [], [], [], [], [] ], "name": "regulation of autophagosome assembly", "native": "GO:2000785", "p_value": 0.0014762432429203916, "parents": [ "GO:0000045", "GO:0044088", "GO:1902115" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.04081632653061224, "significant": true, "source": "GO:BP", "term_size": 49, "source_order": 24137, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus.\" [GOC:pr, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 30359, "intersection_size": 4, "intersections": [ [ "IDA" ], [], [], [], [], [ "IDA" ], [], [ "IDA", "IEA" ], [], [], [ "IDA" ] ], "name": "cellular response to nitrogen compound", "native": "GO:1901699", "p_value": 0.0014923590389905098, "parents": [ "GO:0070887", "GO:1901698" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.005917159763313609, "significant": true, "source": "GO:BP", "term_size": 676, "source_order": 20236, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction.\" [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 30938, "intersection_size": 4, "intersections": [ [], [ "IMP", "IBA", "IEA" ], [], [], [ "IEA" ], [ "IMP" ], [], [], [], [], [ "IDA", "IMP", "TAS" ] ], "name": "negative regulation of intracellular signal transduction", "native": "GO:1902532", "p_value": 0.0015283968611298354, "parents": [ "GO:0009968", "GO:0035556", "GO:1902531" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.005873715124816446, "significant": true, "source": "GO:BP", "term_size": 681, "source_order": 20815, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the rate or extent of cell proliferation.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 13135, "intersection_size": 4, "intersections": [ [ "IDA", "IMP", "ISS", "IEA" ], [ "IMP" ], [], [], [], [], [ "IDA" ], [], [ "IDA", "IMP", "IEA" ], [], [] ], "name": "negative regulation of cell population proliferation", "native": "GO:0008285", "p_value": 0.0015649947171695877, "parents": [ "GO:0008283", "GO:0042127", "GO:0048523" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.0058309037900874635, "significant": true, "source": "GO:BP", "term_size": 686, "source_order": 3012, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22751, "intersection_size": 4, "intersections": [ [ "IDA" ], [ "IMP" ], [], [ "IDA" ], [], [ "NAS" ], [], [], [], [], [] ], "name": "negative regulation of cellular component organization", "native": "GO:0051129", "p_value": 0.0016378738756306147, "parents": [ "GO:0016043", "GO:0048523", "GO:0051128" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.0057553956834532375, "significant": true, "source": "GO:BP", "term_size": 695, "source_order": 12628, "group_id": 1 }, { "description": "SUMO E3 ligases SUMOylate target proteins", "effective_domain_size": 11056, "goshv": 41582, "intersection_size": 3, "intersections": [ [ "REAC" ], [], [], [], [], [ "REAC" ], [], [], [], [], [ "REAC" ] ], "name": "SUMO E3 ligases SUMOylate target proteins", "native": "REAC:R-HSA-3108232", "p_value": 0.0017117716199551679, "parents": [ "REAC:R-HSA-2990846" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.01744186046511628, "significant": true, "source": "REAC", "term_size": 172, "source_order": 2258, "group_id": 31 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.\" [GOC:sm]", "effective_domain_size": 20972, "goshv": 13768, "intersection_size": 5, "intersections": [ [ "IEA" ], [ "IMP", "IBA", "IEA" ], [], [], [ "IEA" ], [ "IMP" ], [], [], [], [], [ "IDA", "IMP", "TAS" ] ], "name": "negative regulation of signal transduction", "native": "GO:0009968", "p_value": 0.0017622818331677012, "parents": [ "GO:0007165", "GO:0009966", "GO:0010648", "GO:0023057", "GO:0048585" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.0037285607755406414, "significant": true, "source": "GO:BP", "term_size": 1341, "source_order": 3645, "group_id": 1 }, { "description": "Activation of ATR in response to replication stress", "effective_domain_size": 11056, "goshv": 39405, "intersection_size": 2, "intersections": [ [], [], [ "REAC" ], [ "REAC" ], [], [], [], [], [], [], [] ], "name": "Activation of ATR in response to replication stress", "native": "REAC:R-HSA-176187", "p_value": 0.0017813717324601643, "parents": [ "REAC:R-HSA-69481" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.05405405405405406, "significant": true, "source": "REAC", "term_size": 37, "source_order": 81, "group_id": 27 }, { "description": "\"A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.\" [ISBN:0198547684]", "effective_domain_size": 20972, "goshv": 28486, "intersection_size": 3, "intersections": [ [], [ "IMP" ], [], [ "IDA" ], [ "IMP" ], [], [], [], [], [], [] ], "name": "mitotic nuclear division", "native": "GO:0140014", "p_value": 0.0018354840095075355, "parents": [ "GO:0000280", "GO:1903047" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.01060070671378092, "significant": true, "source": "GO:BP", "term_size": 283, "source_order": 18363, "group_id": 1 }, { "description": "SUMOylation", "effective_domain_size": 11056, "goshv": 41586, "intersection_size": 3, "intersections": [ [ "REAC" ], [], [], [], [], [ "REAC" ], [], [], [], [], [ "REAC" ] ], "name": "SUMOylation", "native": "REAC:R-HSA-2990846", "p_value": 0.0018380851250790829, "parents": [ "REAC:R-HSA-597592" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.016853932584269662, "significant": true, "source": "REAC", "term_size": 178, "source_order": 2262, "group_id": 31 }, { "description": "\"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline.\" [GOC:dph, GOC:mah, GOC:vw]", "effective_domain_size": 20972, "goshv": 12700, "intersection_size": 2, "intersections": [ [], [ "IEA" ], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "male meiotic nuclear division", "native": "GO:0007140", "p_value": 0.0018715131483996344, "parents": [ "GO:0048232", "GO:0140013" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.03571428571428571, "significant": true, "source": "GO:BP", "term_size": 56, "source_order": 2577, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25354, "intersection_size": 6, "intersections": [ [ "IDA", "IMP", "IEP", "IEA" ], [ "IDA", "ISS", "IEA" ], [], [], [ "IEA" ], [ "IDA", "IMP" ], [], [ "IDA", "IEA" ], [], [], [ "IDA", "IEP" ] ], "name": "cellular response to chemical stimulus", "native": "GO:0070887", "p_value": 0.0018715131483996344, "parents": [ "GO:0042221", "GO:0051716" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.002728512960436562, "significant": true, "source": "GO:BP", "term_size": 2199, "source_order": 15231, "group_id": 1 }, { "description": "\"The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.\" [GOC:mgi_curators, ISBN:0781735149]", "effective_domain_size": 20972, "goshv": 19455, "intersection_size": 3, "intersections": [ [ "IEA" ], [ "IMP", "ISS", "IEA" ], [], [], [], [], [], [], [ "IEA" ], [], [] ], "name": "B cell activation", "native": "GO:0042113", "p_value": 0.0018715131483996344, "parents": [ "GO:0046649" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.01048951048951049, "significant": true, "source": "GO:BP", "term_size": 286, "source_order": 9332, "group_id": 1 }, { "description": "\"Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.\" [GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 33750, "intersection_size": 2, "intersections": [ [ "IMP", "IEA" ], [], [], [], [], [], [], [], [ "IDA", "IGI" ], [], [] ], "name": "negative regulation of G1/S transition of mitotic cell cycle", "native": "GO:2000134", "p_value": 0.0019156045255553711, "parents": [ "GO:0000082", "GO:1901991", "GO:1902807", "GO:2000045" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.03508771929824561, "significant": true, "source": "GO:BP", "term_size": 57, "source_order": 23627, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.\" [GOC:go_curators, GOC:mtg_apoptosis]", "effective_domain_size": 20972, "goshv": 20197, "intersection_size": 2, "intersections": [ [ "IEA" ], [ "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "positive regulation of neuron apoptotic process", "native": "GO:0043525", "p_value": 0.001975221216016513, "parents": [ "GO:0043065", "GO:0043523", "GO:0051402" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.034482758620689655, "significant": true, "source": "GO:BP", "term_size": 58, "source_order": 10074, "group_id": 1 }, { "description": "\"The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 22140, "intersection_size": 2, "intersections": [ [], [ "IEA" ], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "oocyte development", "native": "GO:0048599", "p_value": 0.0019942918238004845, "parents": [ "GO:0007281", "GO:0009994" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.03389830508474576, "significant": true, "source": "GO:BP", "term_size": 59, "source_order": 12017, "group_id": 1 }, { "description": "\"The expansion of a lymphocyte population by cell division.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 21572, "intersection_size": 3, "intersections": [ [ "IEA" ], [ "IMP" ], [], [], [], [], [], [], [ "IEA" ], [], [] ], "name": "lymphocyte proliferation", "native": "GO:0046651", "p_value": 0.0019942918238004845, "parents": [ "GO:0032943", "GO:0046649" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.010169491525423728, "significant": true, "source": "GO:BP", "term_size": 295, "source_order": 11449, "group_id": 1 }, { "description": "\"Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22869, "intersection_size": 3, "intersections": [ [], [ "TAS", "IEA" ], [], [], [], [], [ "IEA" ], [ "ISS", "IBA", "TAS", "IEA" ], [], [], [] ], "name": "meiotic cell cycle", "native": "GO:0051321", "p_value": 0.0019942918238004845, "parents": [ "GO:0007049", "GO:0019953", "GO:0022414" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.010169491525423728, "significant": true, "source": "GO:BP", "term_size": 295, "source_order": 12746, "group_id": 1 }, { "description": "\"A DNA recombination process that results in the bidirectional exchange of genetic material between highly homologous DNA molecules.\" [PMID:17846636]", "effective_domain_size": 20972, "goshv": 28687, "intersection_size": 2, "intersections": [ [], [ "TAS" ], [], [], [], [], [], [ "IBA", "TAS", "IEA" ], [], [], [] ], "name": "reciprocal homologous recombination", "native": "GO:0140527", "p_value": 0.0019942918238004845, "parents": [ "GO:0035825" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.03389830508474576, "significant": true, "source": "GO:BP", "term_size": 59, "source_order": 18564, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.\" [GOC:dph, GOC:go_curators, GOC:tb]", "effective_domain_size": 20972, "goshv": 21005, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [], [ "IDA" ], [], [], [], [], [], [], [] ], "name": "negative regulation of mitotic nuclear division", "native": "GO:0045839", "p_value": 0.0019942918238004845, "parents": [ "GO:0007088", "GO:0010948", "GO:0045930", "GO:0051784", "GO:0140014" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.03389830508474576, "significant": true, "source": "GO:BP", "term_size": 59, "source_order": 10882, "group_id": 1 }, { "description": "\"The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.\" [PMID:2087779]", "effective_domain_size": 20972, "goshv": 12691, "intersection_size": 2, "intersections": [ [], [ "TAS" ], [], [], [], [], [], [ "IBA", "TAS", "IEA" ], [], [], [] ], "name": "reciprocal meiotic recombination", "native": "GO:0007131", "p_value": 0.0019942918238004845, "parents": [ "GO:0007127", "GO:0140527", "GO:1903046" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.03389830508474576, "significant": true, "source": "GO:BP", "term_size": 59, "source_order": 2568, "group_id": 1 }, { "description": "\"A process that modulates the frequency, rate or extent of gene expression through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine methylation of DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal.\" [PMID:10521337, PMID:11498582, PMID:22243696, PMID:34414474]", "effective_domain_size": 20972, "goshv": 19405, "intersection_size": 3, "intersections": [ [ "IDA" ], [], [], [ "ISS", "IEA" ], [], [ "IMP", "IBA", "IEA" ], [], [], [], [], [] ], "name": "epigenetic regulation of gene expression", "native": "GO:0040029", "p_value": 0.002011823480258298, "parents": [ "GO:0006338", "GO:0010468" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.010101010101010102, "significant": true, "source": "GO:BP", "term_size": 297, "source_order": 9282, "group_id": 1 }, { "description": "\"Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.\" [CL:0000084, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]", "effective_domain_size": 20972, "goshv": 25017, "intersection_size": 2, "intersections": [ [ "ISS", "IEA" ], [], [], [], [ "IEA" ], [], [], [], [], [], [] ], "name": "T cell apoptotic process", "native": "GO:0070231", "p_value": 0.002045904197978476, "parents": [ "GO:0070227" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.03333333333333333, "significant": true, "source": "GO:BP", "term_size": 60, "source_order": 14894, "group_id": 1 }, { "description": "\"The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form.\" [GOC:add]", "effective_domain_size": 20972, "goshv": 17539, "intersection_size": 3, "intersections": [ [ "IEA" ], [ "IMP" ], [], [], [], [], [], [], [ "IEA" ], [], [] ], "name": "mononuclear cell proliferation", "native": "GO:0032943", "p_value": 0.002095565202366984, "parents": [ "GO:0070661" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.009933774834437087, "significant": true, "source": "GO:BP", "term_size": 302, "source_order": 7416, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.\" [GOC:jl, GOC:mah]", "effective_domain_size": 20972, "goshv": 20336, "intersection_size": 2, "intersections": [ [], [ "IC" ], [], [], [ "IDA" ], [], [], [], [], [], [] ], "name": "regulation of vacuole organization", "native": "GO:0044088", "p_value": 0.002097801850840704, "parents": [ "GO:0007033", "GO:0033043" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.03278688524590164, "significant": true, "source": "GO:BP", "term_size": 61, "source_order": 10213, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 18233, "intersection_size": 2, "intersections": [ [], [ "TAS" ], [ "TAS" ], [], [], [], [], [], [], [], [] ], "name": "cellular response to heat", "native": "GO:0034605", "p_value": 0.002149977057150955, "parents": [ "GO:0009408", "GO:0033554" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.03225806451612903, "significant": true, "source": "GO:BP", "term_size": 62, "source_order": 8110, "group_id": 1 }, { "description": "\"Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.\" [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 31100, "intersection_size": 2, "intersections": [ [ "IMP", "IEA" ], [], [], [], [], [], [], [], [ "IDA", "IGI" ], [], [] ], "name": "negative regulation of cell cycle G1/S phase transition", "native": "GO:1902807", "p_value": 0.002149977057150955, "parents": [ "GO:0044843", "GO:1901988", "GO:1902806" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.03225806451612903, "significant": true, "source": "GO:BP", "term_size": 62, "source_order": 20977, "group_id": 1 }, { "description": "\"The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete.\" [GOC:go_curators, GOC:mtg_sensu]", "effective_domain_size": 20972, "goshv": 13777, "intersection_size": 2, "intersections": [ [], [ "IEA" ], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "oocyte differentiation", "native": "GO:0009994", "p_value": 0.0022110932886555794, "parents": [ "GO:0003006", "GO:0030154", "GO:0048477" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.031746031746031744, "significant": true, "source": "GO:BP", "term_size": 63, "source_order": 3654, "group_id": 1 }, { "description": "\"Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 14230, "intersection_size": 5, "intersections": [ [ "IEA" ], [ "IMP", "IBA", "IEA" ], [], [], [ "IEA" ], [ "IMP" ], [], [], [], [], [ "IDA", "IMP", "TAS" ] ], "name": "negative regulation of cell communication", "native": "GO:0010648", "p_value": 0.002319371148061795, "parents": [ "GO:0007154", "GO:0010646", "GO:0048523" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.003450655624568668, "significant": true, "source": "GO:BP", "term_size": 1449, "source_order": 4107, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 23127, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [], [ "IDA" ], [], [], [], [], [], [], [] ], "name": "negative regulation of nuclear division", "native": "GO:0051784", "p_value": 0.002319371148061795, "parents": [ "GO:0000280", "GO:0010639", "GO:0051783" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.03076923076923077, "significant": true, "source": "GO:BP", "term_size": 65, "source_order": 13004, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.\" [GOC:go_curators, GOC:txnOH]", "effective_domain_size": 20972, "goshv": 12147, "intersection_size": 7, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "NAS", "IEA" ], [ "ISS", "IEA" ], [], [], [ "IDA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IBA" ], [], [], [ "IMP" ], [ "IDA", "IMP" ] ], "name": "regulation of DNA-templated transcription", "native": "GO:0006355", "p_value": 0.002319371148061795, "parents": [ "GO:0006351", "GO:0010468", "GO:2001141" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.00206794682422452, "significant": true, "source": "GO:BP", "term_size": 3385, "source_order": 2024, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.\" [GOC:mtg_signal]", "effective_domain_size": 20972, "goshv": 16330, "intersection_size": 5, "intersections": [ [ "IEA" ], [ "IMP", "IBA", "IEA" ], [], [], [ "IEA" ], [ "IMP" ], [], [], [], [], [ "IDA", "IMP", "TAS" ] ], "name": "negative regulation of signaling", "native": "GO:0023057", "p_value": 0.002319371148061795, "parents": [ "GO:0023051", "GO:0023052", "GO:0048519" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.003450655624568668, "significant": true, "source": "GO:BP", "term_size": 1449, "source_order": 6207, "group_id": 1 }, { "description": "\"A process in which a protein transports or maintains the localization of another protein to the nucleus.\" [GOC:ecd]", "effective_domain_size": 20972, "goshv": 18219, "intersection_size": 3, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [ "IEA" ], [], [ "IDA" ] ], "name": "protein localization to nucleus", "native": "GO:0034504", "p_value": 0.002334474181953766, "parents": [ "GO:0033365" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.009404388714733543, "significant": true, "source": "GO:BP", "term_size": 319, "source_order": 8096, "group_id": 2 }, { "description": "\"Any process that modulates the frequency, rate or extent of RNA biosynthetic process.\" [GOC:dph]", "effective_domain_size": 20972, "goshv": 34540, "intersection_size": 7, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "NAS", "IEA" ], [ "ISS", "IEA" ], [], [], [ "IDA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IBA" ], [], [], [ "IMP" ], [ "IDA", "IMP" ] ], "name": "regulation of RNA biosynthetic process", "native": "GO:2001141", "p_value": 0.002334474181953766, "parents": [ "GO:0010556", "GO:0032774", "GO:0051252" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.0020606417427141595, "significant": true, "source": "GO:BP", "term_size": 3397, "source_order": 24417, "group_id": 1 }, { "description": "\"A process of chromosome organization that is involved in a meiotic cell cycle.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 24992, "intersection_size": 2, "intersections": [ [], [ "IEA" ], [], [], [], [], [], [ "IBA", "IEA" ], [], [], [] ], "name": "chromosome organization involved in meiotic cell cycle", "native": "GO:0070192", "p_value": 0.002334474181953766, "parents": [ "GO:0051276", "GO:1903046" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.030303030303030304, "significant": true, "source": "GO:BP", "term_size": 66, "source_order": 14869, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of G1 to G0 transition.\" [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24088570]", "effective_domain_size": 20972, "goshv": 31538, "intersection_size": 1, "intersections": [ [ "IDA", "IMP" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of G1 to G0 transition", "native": "GO:1903451", "p_value": 0.002334474181953766, "parents": [ "GO:0010948", "GO:0070314", "GO:1903450" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 1, "significant": true, "source": "GO:BP", "term_size": 1, "source_order": 21415, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucoside stimulus.\" [GO_REF:0000071, GOC:TermGenie, PMID:16842873]", "effective_domain_size": 20972, "goshv": 32366, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [ "IEA" ], [], [], [] ], "name": "response to glucoside", "native": "GO:1904631", "p_value": 0.002334474181953766, "parents": [ "GO:1903416" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 1, "significant": true, "source": "GO:BP", "term_size": 1, "source_order": 22243, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17652, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [ "IMP" ], [] ], "name": "negative regulation of peptidyl-serine phosphorylation of STAT protein", "native": "GO:0033140", "p_value": 0.002334474181953766, "parents": [ "GO:0033137", "GO:0033139", "GO:0042501" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 1, "significant": true, "source": "GO:BP", "term_size": 1, "source_order": 7529, "group_id": 1 }, { "description": "\"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).\" [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]", "effective_domain_size": 20972, "goshv": 12789, "intersection_size": 8, "intersections": [ [ "IMP", "IEA" ], [ "IEA" ], [], [ "IEA" ], [], [ "IMP", "IBA", "IEA" ], [ "IEA" ], [], [ "ISS", "IEA" ], [ "IEA" ], [ "IEA" ] ], "name": "multicellular organism development", "native": "GO:0007275", "p_value": 0.00234071810496529, "parents": [ "GO:0032501", "GO:0048856" ], "precision": 0.7272727272727273, "query": "query_1", "query_size": 11, "recall": 0.0017057569296375266, "significant": true, "source": "GO:BP", "term_size": 4690, "source_order": 2666, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of B cell proliferation.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 16629, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [ "IEA" ], [], [] ], "name": "regulation of B cell proliferation", "native": "GO:0030888", "p_value": 0.002378586276446772, "parents": [ "GO:0042100", "GO:0050670", "GO:0050864" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.029850746268656716, "significant": true, "source": "GO:BP", "term_size": 67, "source_order": 6506, "group_id": 1 }, { "description": "\"The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.\" [ISBN:0721662544]", "effective_domain_size": 20972, "goshv": 10535, "intersection_size": 2, "intersections": [ [ "IEA" ], [ "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "somitogenesis", "native": "GO:0001756", "p_value": 0.002378586276446772, "parents": [ "GO:0009952", "GO:0035282", "GO:0043009", "GO:0048646", "GO:0061053" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.029850746268656716, "significant": true, "source": "GO:BP", "term_size": 67, "source_order": 412, "group_id": 1 }, { "description": "TP53 Regulates Transcription of Cell Death Genes", "effective_domain_size": 11056, "goshv": 41876, "intersection_size": 2, "intersections": [ [ "REAC" ], [ "REAC" ], [], [], [], [], [], [], [], [], [] ], "name": "TP53 Regulates Transcription of Cell Death Genes", "native": "REAC:R-HSA-5633008", "p_value": 0.00244969304440557, "parents": [ "REAC:R-HSA-3700989" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.045454545454545456, "significant": true, "source": "REAC", "term_size": 44, "source_order": 2552, "group_id": 25 }, { "description": "\"Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.\" [GOC:go_curators, GOC:pr]", "effective_domain_size": 20972, "goshv": 10151, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [], [], [ "TAS" ], [ "TAS" ], [] ], "name": "regulation of cyclin-dependent protein serine/threonine kinase activity", "native": "GO:0000079", "p_value": 0.002586133470586085, "parents": [ "GO:0071900" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.02857142857142857, "significant": true, "source": "GO:BP", "term_size": 70, "source_order": 28, "group_id": 1 }, { "description": "\"The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart.\" [GOC:dph, GOC:mtg_heart]", "effective_domain_size": 20972, "goshv": 23740, "intersection_size": 2, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [ "IEA" ] ], "name": "cardiac septum morphogenesis", "native": "GO:0060411", "p_value": 0.0026504427592228498, "parents": [ "GO:0003206", "GO:0003279", "GO:0009653" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.028169014084507043, "significant": true, "source": "GO:BP", "term_size": 71, "source_order": 13617, "group_id": 1 }, { "description": "\"The expansion of a leukocyte population by cell division.\" [GOC:add]", "effective_domain_size": 20972, "goshv": 25242, "intersection_size": 3, "intersections": [ [ "IEA" ], [ "IMP" ], [], [], [], [], [], [], [ "IEA" ], [], [] ], "name": "leukocyte proliferation", "native": "GO:0070661", "p_value": 0.002708305058720651, "parents": [ "GO:0008283" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.008849557522123894, "significant": true, "source": "GO:BP", "term_size": 339, "source_order": 15119, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25507, "intersection_size": 2, "intersections": [ [], [], [], [ "IEP" ], [], [], [], [], [], [ "IEP" ], [] ], "name": "cellular response to mechanical stimulus", "native": "GO:0071260", "p_value": 0.002708305058720651, "parents": [ "GO:0009612", "GO:0071214", "GO:0071496" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.027777777777777776, "significant": true, "source": "GO:BP", "term_size": 72, "source_order": 15384, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25714, "intersection_size": 2, "intersections": [ [], [], [], [ "IEP" ], [], [], [], [], [], [ "IEP" ], [] ], "name": "cellular response to external stimulus", "native": "GO:0071496", "p_value": 0.002770462127849794, "parents": [ "GO:0009605" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.0273972602739726, "significant": true, "source": "GO:BP", "term_size": 73, "source_order": 15591, "group_id": 1 }, { "description": "\"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.\" [GOC:dph, GOC:jl, GOC:mah]", "effective_domain_size": 20972, "goshv": 12612, "intersection_size": 5, "intersections": [ [], [], [], [ "IDA" ], [ "IMP" ], [ "NAS", "IEA" ], [ "IMP" ], [], [], [ "IEA" ], [] ], "name": "cytoskeleton organization", "native": "GO:0007010", "p_value": 0.0028155508392466114, "parents": [ "GO:0006996" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.003259452411994785, "significant": true, "source": "GO:BP", "term_size": 1534, "source_order": 2489, "group_id": 1 }, { "description": "\"The synthesis of an RNA transcript from a DNA template.\" [GOC:jl, GOC:txnOH]", "effective_domain_size": 20972, "goshv": 12143, "intersection_size": 7, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "NAS", "IEA" ], [ "ISS", "IEA" ], [], [], [ "IDA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IBA" ], [], [], [ "IMP" ], [ "IDA", "IMP" ] ], "name": "DNA-templated transcription", "native": "GO:0006351", "p_value": 0.0028155508392466114, "parents": [ "GO:0010467", "GO:0032774" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.0019869429463525404, "significant": true, "source": "GO:BP", "term_size": 3523, "source_order": 2020, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17036, "intersection_size": 2, "intersections": [ [], [ "IMP", "ISS", "IEA" ], [ "ISS" ], [], [], [], [], [], [], [], [] ], "name": "positive regulation of telomere maintenance", "native": "GO:0032206", "p_value": 0.0028155508392466114, "parents": [ "GO:0000723", "GO:0032204", "GO:0051054", "GO:2001252" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.02702702702702703, "significant": true, "source": "GO:BP", "term_size": 74, "source_order": 6913, "group_id": 1 }, { "description": "Loss of function of TP53 in cancer due to loss of tetramerization ability", "effective_domain_size": 11056, "goshv": 40712, "intersection_size": 1, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [], [], [] ], "name": "Loss of function of TP53 in cancer due to loss of tetramerization ability", "native": "REAC:R-HSA-9723905", "p_value": 0.0028485121820656235, "parents": [ "REAC:R-HSA-9723907" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 1, "significant": true, "source": "REAC", "term_size": 1, "source_order": 1388, "group_id": 32 }, { "description": "Loss of Function of TP53 in Cancer", "effective_domain_size": 11056, "goshv": 40706, "intersection_size": 1, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [], [], [] ], "name": "Loss of Function of TP53 in Cancer", "native": "REAC:R-HSA-9723907", "p_value": 0.0028485121820656235, "parents": [ "REAC:R-HSA-9734009" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 1, "significant": true, "source": "REAC", "term_size": 1, "source_order": 1382, "group_id": 32 }, { "description": "\"The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 23148, "intersection_size": 2, "intersections": [ [], [], [], [], [], [ "IDA", "IEA" ], [], [], [], [], [ "IMP" ] ], "name": "protein autoubiquitination", "native": "GO:0051865", "p_value": 0.0029584123454066812, "parents": [ "GO:0016567" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.02631578947368421, "significant": true, "source": "GO:BP", "term_size": 76, "source_order": 13025, "group_id": 16 }, { "description": "\"Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.\" [GO:jl]", "effective_domain_size": 20972, "goshv": 20340, "intersection_size": 3, "intersections": [ [ "TAS" ], [], [], [], [], [], [], [], [ "IMP" ], [ "IMP" ], [] ], "name": "negative regulation of molecular function", "native": "GO:0044092", "p_value": 0.003030021807113303, "parents": [ "GO:0065009" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.008450704225352112, "significant": true, "source": "GO:BP", "term_size": 355, "source_order": 10217, "group_id": 1 }, { "description": "\"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22851, "intersection_size": 2, "intersections": [ [], [], [], [], [], [ "NAS" ], [ "IMP" ], [], [], [], [] ], "name": "centrosome duplication", "native": "GO:0051298", "p_value": 0.0030930355354365576, "parents": [ "GO:0007098", "GO:0022402" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.02564102564102564, "significant": true, "source": "GO:BP", "term_size": 78, "source_order": 12728, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22818, "intersection_size": 5, "intersections": [ [ "IEA" ], [], [], [], [ "IMP" ], [], [], [], [ "IDA", "IMP", "TAS" ], [ "IMP", "TAS" ], [ "IDA" ] ], "name": "regulation of protein metabolic process", "native": "GO:0051246", "p_value": 0.003122702740550169, "parents": [ "GO:0019538", "GO:0060255", "GO:0080090" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.0031766200762388818, "significant": true, "source": "GO:BP", "term_size": 1574, "source_order": 12695, "group_id": 1 }, { "description": "Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "effective_domain_size": 11056, "goshv": 42038, "intersection_size": 2, "intersections": [ [], [], [], [ "REAC" ], [ "REAC" ], [], [], [], [], [], [] ], "name": "Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "native": "REAC:R-HSA-69601", "p_value": 0.0031939087034866713, "parents": [ "REAC:R-HSA-69613" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.038461538461538464, "significant": true, "source": "REAC", "term_size": 52, "source_order": 2714, "group_id": 27 }, { "description": "Autodegradation of the E3 ubiquitin ligase COP1", "effective_domain_size": 11056, "goshv": 39525, "intersection_size": 2, "intersections": [ [ "REAC" ], [ "REAC" ], [], [], [], [], [], [], [], [], [] ], "name": "Autodegradation of the E3 ubiquitin ligase COP1", "native": "REAC:R-HSA-349425", "p_value": 0.0031939087034866713, "parents": [ "REAC:R-HSA-69541" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.038461538461538464, "significant": true, "source": "REAC", "term_size": 52, "source_order": 201, "group_id": 27 }, { "description": "p53-Independent G1/S DNA Damage Checkpoint", "effective_domain_size": 11056, "goshv": 42141, "intersection_size": 2, "intersections": [ [], [], [], [ "REAC" ], [ "REAC" ], [], [], [], [], [], [] ], "name": "p53-Independent G1/S DNA Damage Checkpoint", "native": "REAC:R-HSA-69613", "p_value": 0.0031939087034866713, "parents": [ "REAC:R-HSA-69615" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.038461538461538464, "significant": true, "source": "REAC", "term_size": 52, "source_order": 2817, "group_id": 27 }, { "description": "\"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).\" [PMID:10197977]", "effective_domain_size": 20972, "goshv": 12117, "intersection_size": 2, "intersections": [ [ "IMP" ], [], [], [], [], [], [ "IMP" ], [], [], [], [] ], "name": "nucleotide-excision repair", "native": "GO:0006289", "p_value": 0.003426072871846247, "parents": [ "GO:0006281" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.024096385542168676, "significant": true, "source": "GO:BP", "term_size": 83, "source_order": 1994, "group_id": 1 }, { "description": "\"Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.\" [CL:0000542, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]", "effective_domain_size": 20972, "goshv": 25013, "intersection_size": 2, "intersections": [ [ "ISS", "IEA" ], [], [], [], [ "IEA" ], [], [], [], [], [], [] ], "name": "lymphocyte apoptotic process", "native": "GO:0070227", "p_value": 0.003426072871846247, "parents": [ "GO:0071887" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.024096385542168676, "significant": true, "source": "GO:BP", "term_size": 83, "source_order": 14890, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22824, "intersection_size": 7, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "NAS", "IEA" ], [ "ISS", "IEA" ], [], [], [ "IDA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IBA" ], [], [], [ "IMP" ], [ "IDA", "IMP" ] ], "name": "regulation of RNA metabolic process", "native": "GO:0051252", "p_value": 0.003426072871846247, "parents": [ "GO:0016070", "GO:0019219", "GO:0060255" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.0019157088122605363, "significant": true, "source": "GO:BP", "term_size": 3654, "source_order": 12701, "group_id": 1 }, { "description": "\"A process in which a protein is transported to, or maintained in, a location within an organelle.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17759, "intersection_size": 4, "intersections": [ [ "IEA" ], [], [ "IMP" ], [], [], [], [], [], [ "IEA" ], [], [ "IDA" ] ], "name": "protein localization to organelle", "native": "GO:0033365", "p_value": 0.003426072871846247, "parents": [ "GO:0008104" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.004509582863585118, "significant": true, "source": "GO:BP", "term_size": 887, "source_order": 7636, "group_id": 2 }, { "description": "\"Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.\" [GOC:dph, GOC:jp, GOC:tb]", "effective_domain_size": 20972, "goshv": 14159, "intersection_size": 2, "intersections": [ [], [], [], [ "IDA" ], [], [], [], [ "IDA" ], [], [], [] ], "name": "regulation of double-strand break repair via homologous recombination", "native": "GO:0010569", "p_value": 0.003426072871846247, "parents": [ "GO:0000018", "GO:0000724", "GO:2000779" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.024096385542168676, "significant": true, "source": "GO:BP", "term_size": 83, "source_order": 4036, "group_id": 1 }, { "description": "\"Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 14147, "intersection_size": 6, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IEA" ], [ "IMP", "ISS", "IEA" ], [ "ISS" ], [], [ "IDA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA" ], [], [], [], [] ], "name": "positive regulation of macromolecule biosynthetic process", "native": "GO:0010557", "p_value": 0.0034416192290534567, "parents": [ "GO:0009059", "GO:0009891", "GO:0010556", "GO:0010604" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.002364066193853428, "significant": true, "source": "GO:BP", "term_size": 2538, "source_order": 4024, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of apoptotic signaling pathway.\" [GOC:mtg_apoptosis]", "effective_domain_size": 20972, "goshv": 34597, "intersection_size": 3, "intersections": [ [ "IMP", "ISS", "IEA" ], [], [], [], [], [ "IMP" ], [], [], [], [], [ "IMP" ] ], "name": "regulation of apoptotic signaling pathway", "native": "GO:2001233", "p_value": 0.00346749783925544, "parents": [ "GO:0009966", "GO:0042981", "GO:0097190" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.007978723404255319, "significant": true, "source": "GO:BP", "term_size": 376, "source_order": 24474, "group_id": 1 }, { "description": "\"The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.\" [GOC:dph]", "effective_domain_size": 20972, "goshv": 24238, "intersection_size": 2, "intersections": [ [ "IEA" ], [ "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "somite development", "native": "GO:0061053", "p_value": 0.003550692072452474, "parents": [ "GO:0009790", "GO:0060429" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.023529411764705882, "significant": true, "source": "GO:BP", "term_size": 85, "source_order": 14115, "group_id": 1 }, { "description": "\"The autophagic process that proceeds via the formation of an autophagosome.\" [PMID:24366339]", "effective_domain_size": 20972, "goshv": 15054, "intersection_size": 3, "intersections": [ [ "IEA" ], [ "IDA", "IC" ], [], [], [ "IDA" ], [], [], [], [], [], [] ], "name": "macroautophagy", "native": "GO:0016236", "p_value": 0.003550692072452474, "parents": [ "GO:0006914" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.007894736842105263, "significant": true, "source": "GO:BP", "term_size": 380, "source_order": 4931, "group_id": 1 }, { "description": "\"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.\" [GOC:dph, GOC:mah, GOC:tb]", "effective_domain_size": 20972, "goshv": 16917, "intersection_size": 3, "intersections": [ [ "IEA" ], [], [], [], [ "IDA" ], [], [], [], [], [], [ "IDA", "IMP" ] ], "name": "regulation of protein stability", "native": "GO:0031647", "p_value": 0.0036750050798457683, "parents": [ "GO:0065008" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.007792207792207792, "significant": true, "source": "GO:BP", "term_size": 385, "source_order": 6794, "group_id": 4 }, { "description": "\"Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells.\" [GOC:jid]", "effective_domain_size": 20972, "goshv": 21824, "intersection_size": 2, "intersections": [ [ "IMP", "IEA" ], [], [], [], [], [], [], [], [ "IMP" ], [], [] ], "name": "regulation of fibroblast proliferation", "native": "GO:0048145", "p_value": 0.0037688211929995086, "parents": [ "GO:0042127", "GO:0048144" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.022727272727272728, "significant": true, "source": "GO:BP", "term_size": 88, "source_order": 11701, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.\" [GOC:go_curators, GOC:txnOH]", "effective_domain_size": 20972, "goshv": 21039, "intersection_size": 5, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IEA" ], [ "ISS", "IEA" ], [], [], [ "IDA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA" ], [], [], [], [] ], "name": "positive regulation of DNA-templated transcription", "native": "GO:0045893", "p_value": 0.003952121513037751, "parents": [ "GO:0006351", "GO:0006355", "GO:1902680" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.0029904306220095694, "significant": true, "source": "GO:BP", "term_size": 1672, "source_order": 10916, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process.\" [GO:jl, GO_REF:0000058, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 31018, "intersection_size": 5, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IEA" ], [ "ISS", "IEA" ], [], [], [ "IDA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA" ], [], [], [], [] ], "name": "positive regulation of RNA biosynthetic process", "native": "GO:1902680", "p_value": 0.003960226742533141, "parents": [ "GO:0010557", "GO:0032774", "GO:0051254", "GO:2001141" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.002986857825567503, "significant": true, "source": "GO:BP", "term_size": 1674, "source_order": 20895, "group_id": 1 }, { "description": "\"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).\" [GOC:txnOH-2018]", "effective_domain_size": 20972, "goshv": 14211, "intersection_size": 5, "intersections": [ [ "IEA" ], [ "IDA" ], [], [ "ISS", "IEA" ], [], [ "IMP", "IEA" ], [], [], [ "IEA" ], [], [] ], "name": "negative regulation of gene expression", "native": "GO:0010629", "p_value": 0.003990112816255285, "parents": [ "GO:0010467", "GO:0010468", "GO:0010558" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.0029797377830750892, "significant": true, "source": "GO:BP", "term_size": 1678, "source_order": 4088, "group_id": 1 }, { "description": "\"The biosynthetic process resulting in the formation of a nucleic acid.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 28948, "intersection_size": 9, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "NAS", "IEA" ], [ "IGI", "ISS", "IEA" ], [ "ISS" ], [], [ "IDA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IBA" ], [], [ "IMP", "IEA" ], [ "IMP" ], [ "IDA", "IMP" ] ], "name": "nucleic acid biosynthetic process", "native": "GO:0141187", "p_value": 0.00400101218908473, "parents": [ "GO:0009059", "GO:0034654", "GO:0090304" ], "precision": 0.8181818181818182, "query": "query_1", "query_size": 11, "recall": 0.0013363028953229399, "significant": true, "source": "GO:BP", "term_size": 6735, "source_order": 18825, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate, extent or direction of cell growth.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 10459, "intersection_size": 3, "intersections": [ [ "IMP" ], [], [], [], [], [ "IMP" ], [], [], [ "IDA" ], [], [] ], "name": "regulation of cell growth", "native": "GO:0001558", "p_value": 0.00400101218908473, "parents": [ "GO:0016049", "GO:0040008", "GO:0051128" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.007518796992481203, "significant": true, "source": "GO:BP", "term_size": 399, "source_order": 336, "group_id": 1 }, { "description": "\"Any process that stops or reduces the activity of a helicase.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22737, "intersection_size": 1, "intersections": [ [ "TAS" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of helicase activity", "native": "GO:0051097", "p_value": 0.004023141386579548, "parents": [ "GO:0032780", "GO:0043086" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.5, "significant": true, "source": "GO:BP", "term_size": 2, "source_order": 12614, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of glucose catabolic process to lactate via pyruvate.\" [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:20935145]", "effective_domain_size": 20972, "goshv": 31938, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of glucose catabolic process to lactate via pyruvate", "native": "GO:1904024", "p_value": 0.004023141386579548, "parents": [ "GO:0009895", "GO:0019661", "GO:0045912", "GO:0062014", "GO:1901003", "GO:1904023" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.5, "significant": true, "source": "GO:BP", "term_size": 2, "source_order": 21815, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.\" [GOC:jid]", "effective_domain_size": 20972, "goshv": 22130, "intersection_size": 5, "intersections": [ [ "IEA" ], [ "IMP", "IBA", "IEA" ], [], [], [ "IEA" ], [ "IMP" ], [], [], [], [], [ "IDA", "IMP", "TAS" ] ], "name": "negative regulation of response to stimulus", "native": "GO:0048585", "p_value": 0.004023141386579548, "parents": [ "GO:0048519", "GO:0048583", "GO:0050896" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.0029533372711163615, "significant": true, "source": "GO:BP", "term_size": 1693, "source_order": 12007, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of pentose-phosphate shunt.\" [GO_REF:0000058, GOC:TermGenie, PMID:19015259]", "effective_domain_size": 20972, "goshv": 33259, "intersection_size": 1, "intersections": [ [ "IMP" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of pentose-phosphate shunt", "native": "GO:1905856", "p_value": 0.004023141386579548, "parents": [ "GO:0006098", "GO:0043456", "GO:1900543" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.5, "significant": true, "source": "GO:BP", "term_size": 2, "source_order": 23136, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 13713, "intersection_size": 6, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IEA" ], [ "IMP", "ISS", "IEA" ], [ "ISS" ], [], [ "IDA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA" ], [], [], [], [] ], "name": "positive regulation of biosynthetic process", "native": "GO:0009891", "p_value": 0.004023141386579548, "parents": [ "GO:0009058", "GO:0009889", "GO:0009893" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.002268431001890359, "significant": true, "source": "GO:BP", "term_size": 2645, "source_order": 3590, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell-matrix adhesion.\" [GOC:sl, PMID:11425869]", "effective_domain_size": 20972, "goshv": 25678, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "IMP" ], [], [] ], "name": "cellular response to cell-matrix adhesion", "native": "GO:0071460", "p_value": 0.004023141386579548, "parents": [ "GO:0051716" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.5, "significant": true, "source": "GO:BP", "term_size": 2, "source_order": 15555, "group_id": 1 }, { "description": "\"The expansion of a B cell population by cell division. Follows B cell activation.\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 19450, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [ "IEA" ], [], [] ], "name": "B cell proliferation", "native": "GO:0042100", "p_value": 0.004023141386579548, "parents": [ "GO:0042113", "GO:0046651" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.021739130434782608, "significant": true, "source": "GO:BP", "term_size": 92, "source_order": 9327, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus.\" [GOC:pr, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 30358, "intersection_size": 4, "intersections": [ [ "IDA" ], [], [], [], [], [ "IDA" ], [], [ "IDA", "IEA" ], [], [], [ "IDA" ] ], "name": "response to nitrogen compound", "native": "GO:1901698", "p_value": 0.004023141386579548, "parents": [ "GO:0042221" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.004250797024442083, "significant": true, "source": "GO:BP", "term_size": 941, "source_order": 20235, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle tissue regeneration.\" [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23222520]", "effective_domain_size": 20972, "goshv": 32788, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "ISS", "IEA" ], [], [] ], "name": "negative regulation of cardiac muscle tissue regeneration", "native": "GO:1905179", "p_value": 0.004023141386579548, "parents": [ "GO:0048640", "GO:0061026", "GO:1905178" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.5, "significant": true, "source": "GO:BP", "term_size": 2, "source_order": 22665, "group_id": 5 }, { "description": "\"Any process that modulates the frequency, rate or extent of cardiac muscle tissue regeneration.\" [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23222520]", "effective_domain_size": 20972, "goshv": 32787, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "ISS", "IEA" ], [], [] ], "name": "regulation of cardiac muscle tissue regeneration", "native": "GO:1905178", "p_value": 0.004023141386579548, "parents": [ "GO:0048638", "GO:0061026" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.5, "significant": true, "source": "GO:BP", "term_size": 2, "source_order": 22664, "group_id": 5 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization.\" [GOC:obol]", "effective_domain_size": 20972, "goshv": 34615, "intersection_size": 2, "intersections": [ [ "IDA" ], [ "IMP" ], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of chromosome organization", "native": "GO:2001251", "p_value": 0.004305021932887815, "parents": [ "GO:0010639", "GO:0033044", "GO:0051276" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.020618556701030927, "significant": true, "source": "GO:BP", "term_size": 97, "source_order": 24492, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.\" [GOC:lr]", "effective_domain_size": 20972, "goshv": 13440, "intersection_size": 2, "intersections": [ [], [ "TAS" ], [ "TAS" ], [], [], [], [], [], [], [], [] ], "name": "response to heat", "native": "GO:0009408", "p_value": 0.004305021932887815, "parents": [ "GO:0006950", "GO:0009266" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.020618556701030927, "significant": true, "source": "GO:BP", "term_size": 97, "source_order": 3317, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus.\" [GOC:pr]", "effective_domain_size": 20972, "goshv": 27487, "intersection_size": 2, "intersections": [ [], [], [], [], [], [ "IDA" ], [], [ "IDA" ], [], [], [] ], "name": "cellular response to alcohol", "native": "GO:0097306", "p_value": 0.004305021932887815, "parents": [ "GO:0097305", "GO:1901701" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.020618556701030927, "significant": true, "source": "GO:BP", "term_size": 97, "source_order": 17364, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 19523, "intersection_size": 7, "intersections": [ [ "IDA", "IMP", "IGI", "IEP", "IEA" ], [ "IDA", "ISS", "IEA" ], [ "IEA" ], [], [ "IEA" ], [ "IDA", "IMP" ], [], [ "IDA", "IEA" ], [], [], [ "IDA", "IEP" ] ], "name": "response to chemical", "native": "GO:0042221", "p_value": 0.004451673174372418, "parents": [ "GO:0050896" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.0018120631633445508, "significant": true, "source": "GO:BP", "term_size": 3863, "source_order": 9400, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of protein complex assembly.\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 20043, "intersection_size": 3, "intersections": [ [ "IDA" ], [ "IMP" ], [ "IMP" ], [], [], [], [], [], [], [], [] ], "name": "regulation of protein-containing complex assembly", "native": "GO:0043254", "p_value": 0.004466982685448811, "parents": [ "GO:0044087", "GO:0051128", "GO:0065003" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.0071090047393364926, "significant": true, "source": "GO:BP", "term_size": 422, "source_order": 9920, "group_id": 1 }, { "description": "\"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.\" [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]", "effective_domain_size": 20972, "goshv": 12648, "intersection_size": 3, "intersections": [ [], [ "IMP", "IEA" ], [], [], [ "IMP" ], [ "IMP" ], [], [], [], [], [] ], "name": "chromosome segregation", "native": "GO:0007059", "p_value": 0.0047637452838352684, "parents": [ "GO:0022402" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.006944444444444444, "significant": true, "source": "GO:BP", "term_size": 432, "source_order": 2525, "group_id": 1 }, { "description": "PIP3 activates AKT signaling", "effective_domain_size": 11056, "goshv": 41072, "intersection_size": 3, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [ "REAC" ], [], [ "REAC" ] ], "name": "PIP3 activates AKT signaling", "native": "REAC:R-HSA-1257604", "p_value": 0.0048418303771785446, "parents": [ "REAC:R-HSA-9006925" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.011673151750972763, "significant": true, "source": "REAC", "term_size": 257, "source_order": 1748, "group_id": 30 }, { "description": "\"The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation.\" [GOC:add, GOC:rl, ISBN:0781735149]", "effective_domain_size": 20972, "goshv": 22089, "intersection_size": 2, "intersections": [ [ "IMP" ], [ "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "hematopoietic or lymphoid organ development", "native": "GO:0048534", "p_value": 0.004847905006901471, "parents": [ "GO:0002520", "GO:0048513" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.019230769230769232, "significant": true, "source": "GO:BP", "term_size": 104, "source_order": 11966, "group_id": 1 }, { "description": "\"The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis.\" [PMID:10611687, PMID:9706689]", "effective_domain_size": 20972, "goshv": 18485, "intersection_size": 2, "intersections": [ [ "IEA" ], [ "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "segmentation", "native": "GO:0035282", "p_value": 0.004847905006901471, "parents": [ "GO:0003002" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.019230769230769232, "significant": true, "source": "GO:BP", "term_size": 104, "source_order": 8362, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of chromosome organization.\" [GOC:obol]", "effective_domain_size": 20972, "goshv": 34616, "intersection_size": 2, "intersections": [ [], [ "IMP", "ISS", "IEA" ], [ "ISS" ], [], [], [], [], [], [], [], [] ], "name": "positive regulation of chromosome organization", "native": "GO:2001252", "p_value": 0.004847905006901471, "parents": [ "GO:0010638", "GO:0033044", "GO:0051276" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.019230769230769232, "significant": true, "source": "GO:BP", "term_size": 104, "source_order": 24493, "group_id": 1 }, { "description": "Nonhomologous End-Joining (NHEJ)", "effective_domain_size": 11056, "goshv": 40993, "intersection_size": 2, "intersections": [ [], [ "REAC" ], [], [], [], [ "REAC" ], [], [], [], [], [] ], "name": "Nonhomologous End-Joining (NHEJ)", "native": "REAC:R-HSA-5693571", "p_value": 0.004890525664009826, "parents": [ "REAC:R-HSA-5693532" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.029411764705882353, "significant": true, "source": "REAC", "term_size": 68, "source_order": 1669, "group_id": 28 }, { "description": "FOXO-mediated transcription", "effective_domain_size": 11056, "goshv": 40288, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [], [], [ "REAC" ], [ "REAC" ], [] ], "name": "FOXO-mediated transcription", "native": "REAC:R-HSA-9614085", "p_value": 0.004890525664009826, "parents": [ "REAC:R-HSA-212436" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.030303030303030304, "significant": true, "source": "REAC", "term_size": 66, "source_order": 964, "group_id": 25 }, { "description": "Regulation of HSF1-mediated heat shock response", "effective_domain_size": 11056, "goshv": 41381, "intersection_size": 2, "intersections": [ [], [ "REAC" ], [ "REAC" ], [], [], [], [], [], [], [], [] ], "name": "Regulation of HSF1-mediated heat shock response", "native": "REAC:R-HSA-3371453", "p_value": 0.004890525664009826, "parents": [ "REAC:R-HSA-3371556" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.029850746268656716, "significant": true, "source": "REAC", "term_size": 67, "source_order": 2057, "group_id": 29 }, { "description": "Defective DNA double strand break response due to BRCA1 loss of function", "effective_domain_size": 11056, "goshv": 39877, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "REAC" ], [], [], [], [], [] ], "name": "Defective DNA double strand break response due to BRCA1 loss of function", "native": "REAC:R-HSA-9663199", "p_value": 0.004890525664009826, "parents": [ "REAC:R-HSA-9675136" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.5, "significant": true, "source": "REAC", "term_size": 2, "source_order": 553, "group_id": 26 }, { "description": "Defective DNA double strand break response due to BARD1 loss of function", "effective_domain_size": 11056, "goshv": 39876, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "REAC" ], [], [], [], [], [] ], "name": "Defective DNA double strand break response due to BARD1 loss of function", "native": "REAC:R-HSA-9699150", "p_value": 0.004890525664009826, "parents": [ "REAC:R-HSA-9675136" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.5, "significant": true, "source": "REAC", "term_size": 2, "source_order": 552, "group_id": 26 }, { "description": "Regulation of TP53 Expression", "effective_domain_size": 11056, "goshv": 41426, "intersection_size": 1, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [], [], [] ], "name": "Regulation of TP53 Expression", "native": "REAC:R-HSA-6804754", "p_value": 0.004890525664009826, "parents": [ "REAC:R-HSA-6806003" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.5, "significant": true, "source": "REAC", "term_size": 2, "source_order": 2102, "group_id": 25 }, { "description": "Impaired BRCA2 binding to SEM1 (DSS1)", "effective_domain_size": 11056, "goshv": 40547, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [ "REAC" ], [], [], [], [] ], "name": "Impaired BRCA2 binding to SEM1 (DSS1)", "native": "REAC:R-HSA-9763198", "p_value": 0.004890525664009826, "parents": [ "REAC:R-HSA-9701190" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.5, "significant": true, "source": "REAC", "term_size": 2, "source_order": 1223, "group_id": 26 }, { "description": "Impaired BRCA2 translocation to the nucleus", "effective_domain_size": 11056, "goshv": 40548, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [ "REAC" ], [], [], [], [] ], "name": "Impaired BRCA2 translocation to the nucleus", "native": "REAC:R-HSA-9709275", "p_value": 0.004890525664009826, "parents": [ "REAC:R-HSA-9701190" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.5, "significant": true, "source": "REAC", "term_size": 2, "source_order": 1224, "group_id": 26 }, { "description": "\"The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.\" [GOC:dph, GOC:jid, GOC:tb]", "effective_domain_size": 20972, "goshv": 13179, "intersection_size": 2, "intersections": [ [], [ "IEA" ], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "female gonad development", "native": "GO:0008585", "p_value": 0.0049249405713834545, "parents": [ "GO:0008406", "GO:0046545" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.01904761904761905, "significant": true, "source": "GO:BP", "term_size": 105, "source_order": 3056, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process.\" [GOC:vw]", "effective_domain_size": 20972, "goshv": 24804, "intersection_size": 2, "intersections": [ [ "IMP", "IEA" ], [], [], [], [], [ "IMP" ], [], [], [], [], [] ], "name": "negative regulation of small molecule metabolic process", "native": "GO:0062014", "p_value": 0.005080082195122946, "parents": [ "GO:0009892", "GO:0044281", "GO:0062012" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.018691588785046728, "significant": true, "source": "GO:BP", "term_size": 107, "source_order": 14681, "group_id": 1 }, { "description": "\"The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population.\" [GOC:jid]", "effective_domain_size": 20972, "goshv": 21823, "intersection_size": 2, "intersections": [ [ "IMP", "IEA" ], [], [], [], [], [], [], [], [ "IMP", "IEA" ], [], [] ], "name": "fibroblast proliferation", "native": "GO:0048144", "p_value": 0.005080082195122946, "parents": [ "GO:0008283" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.018691588785046728, "significant": true, "source": "GO:BP", "term_size": 107, "source_order": 11700, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22826, "intersection_size": 5, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IEA" ], [ "ISS", "IEA" ], [], [], [ "IDA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA" ], [], [], [], [] ], "name": "positive regulation of RNA metabolic process", "native": "GO:0051254", "p_value": 0.005116531931708398, "parents": [ "GO:0010604", "GO:0016070", "GO:0051252" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.002771618625277162, "significant": true, "source": "GO:BP", "term_size": 1804, "source_order": 12703, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 12222, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [], [], [ "IMP" ], [ "IMP" ], [] ], "name": "negative regulation of protein kinase activity", "native": "GO:0006469", "p_value": 0.005142010190886691, "parents": [ "GO:0001933", "GO:0033673", "GO:0045859" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.018518518518518517, "significant": true, "source": "GO:BP", "term_size": 108, "source_order": 2099, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 13716, "intersection_size": 4, "intersections": [ [ "IMP", "IEA" ], [ "IMP", "IEA" ], [], [], [ "IMP" ], [], [], [], [], [], [ "IDA" ] ], "name": "regulation of catabolic process", "native": "GO:0009894", "p_value": 0.005172643124945, "parents": [ "GO:0009056", "GO:0019222" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.00390625, "significant": true, "source": "GO:BP", "term_size": 1024, "source_order": 3593, "group_id": 1 }, { "description": "\"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.\" [GOC:kmv, GOC:mtg_sensu, GOC:pr]", "effective_domain_size": 20972, "goshv": 22046, "intersection_size": 2, "intersections": [ [], [ "IEA" ], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "oogenesis", "native": "GO:0048477", "p_value": 0.005187835410630995, "parents": [ "GO:0007281", "GO:0007292" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.01834862385321101, "significant": true, "source": "GO:BP", "term_size": 109, "source_order": 11923, "group_id": 1 }, { "description": "\"The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 21516, "intersection_size": 2, "intersections": [ [], [ "IEA" ], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "development of primary female sexual characteristics", "native": "GO:0046545", "p_value": 0.005187835410630995, "parents": [ "GO:0045137", "GO:0046660" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.01834862385321101, "significant": true, "source": "GO:BP", "term_size": 109, "source_order": 11393, "group_id": 1 }, { "description": "\"The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 18257, "intersection_size": 9, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "NAS", "IEA" ], [ "IGI", "ISS", "IEA" ], [ "ISS" ], [], [ "IDA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IBA" ], [], [ "IMP", "IEA" ], [ "IMP" ], [ "IDA", "IMP" ] ], "name": "nucleobase-containing compound biosynthetic process", "native": "GO:0034654", "p_value": 0.005217327590556184, "parents": [ "GO:0006139", "GO:0009058" ], "precision": 0.8181818181818182, "query": "query_1", "query_size": 11, "recall": 0.001279317697228145, "significant": true, "source": "GO:BP", "term_size": 7035, "source_order": 8134, "group_id": 1 }, { "description": "\"The progression of a cardiac septum over time, from its initial formation to the mature structure.\" [GOC:mtg_heart]", "effective_domain_size": 20972, "goshv": 11760, "intersection_size": 2, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [ "IEA" ] ], "name": "cardiac septum development", "native": "GO:0003279", "p_value": 0.005249787264452184, "parents": [ "GO:0003205", "GO:0048856" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.01818181818181818, "significant": true, "source": "GO:BP", "term_size": 110, "source_order": 1637, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of cell cycle phase transition.\" [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]", "effective_domain_size": 20972, "goshv": 30569, "intersection_size": 2, "intersections": [ [], [], [], [], [ "IEA" ], [], [], [], [], [], [ "IEA" ] ], "name": "positive regulation of cell cycle phase transition", "native": "GO:1901989", "p_value": 0.005423462255456928, "parents": [ "GO:0044770", "GO:0090068", "GO:1901987" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.017857142857142856, "significant": true, "source": "GO:BP", "term_size": 112, "source_order": 20446, "group_id": 1 }, { "description": "\"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.\" [GOC:dph, GOC:jid]", "effective_domain_size": 20972, "goshv": 22261, "intersection_size": 7, "intersections": [ [ "IMP", "IEA" ], [ "IEA" ], [], [], [], [ "IMP" ], [ "IEA" ], [], [ "ISS", "IEA" ], [ "IEA" ], [ "IEA" ] ], "name": "system development", "native": "GO:0048731", "p_value": 0.0054326771455219915, "parents": [ "GO:0007275", "GO:0048856" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.0017399950285856326, "significant": true, "source": "GO:BP", "term_size": 4023, "source_order": 12138, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25712, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "cellular response to UV-C", "native": "GO:0071494", "p_value": 0.005476632036413576, "parents": [ "GO:0010225", "GO:0034644" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.3333333333333333, "significant": true, "source": "GO:BP", "term_size": 3, "source_order": 15589, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17910, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [], [], [ "IMP" ], [ "IMP" ], [] ], "name": "negative regulation of kinase activity", "native": "GO:0033673", "p_value": 0.005476632036413576, "parents": [ "GO:0042326", "GO:0043086", "GO:0043549" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.017543859649122806, "significant": true, "source": "GO:BP", "term_size": 114, "source_order": 7787, "group_id": 1 }, { "description": "\"The process of introducing a phosphate group to a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.\" [GOC:jl, PMID:10918594]", "effective_domain_size": 20972, "goshv": 19694, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [ "IMP" ], [] ], "name": "serine phosphorylation of STAT protein", "native": "GO:0042501", "p_value": 0.005476632036413576, "parents": [ "GO:0018105", "GO:0046425" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.3333333333333333, "significant": true, "source": "GO:BP", "term_size": 3, "source_order": 9571, "group_id": 1 }, { "description": "\"The expansion of a T cell population by cell division as part of an immune response.\" [GOC:add, ISBN:0781735149]", "effective_domain_size": 20972, "goshv": 10929, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "T cell proliferation involved in immune response", "native": "GO:0002309", "p_value": 0.005476632036413576, "parents": [ "GO:0002286", "GO:0042098" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.3333333333333333, "significant": true, "source": "GO:BP", "term_size": 3, "source_order": 806, "group_id": 17 }, { "description": "\"Any process that modulates the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17651, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [ "IMP" ], [] ], "name": "regulation of peptidyl-serine phosphorylation of STAT protein", "native": "GO:0033139", "p_value": 0.005476632036413576, "parents": [ "GO:0033135", "GO:0042501" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.3333333333333333, "significant": true, "source": "GO:BP", "term_size": 3, "source_order": 7528, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of glucose catabolic process to lactate via pyruvate.\" [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:20935145]", "effective_domain_size": 20972, "goshv": 31937, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of glucose catabolic process to lactate via pyruvate", "native": "GO:1904023", "p_value": 0.005476632036413576, "parents": [ "GO:0010906", "GO:0019661", "GO:0043465", "GO:0043470" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.3333333333333333, "significant": true, "source": "GO:BP", "term_size": 3, "source_order": 21814, "group_id": 1 }, { "description": "\"The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, via canonical glycolysis, yielding energy in the form of adenosine triphosphate (ATP).\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 15706, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "homolactic fermentation", "native": "GO:0019661", "p_value": 0.005476632036413576, "parents": [ "GO:0019659" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.3333333333333333, "significant": true, "source": "GO:BP", "term_size": 3, "source_order": 5583, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of a DNA damage checkpoint.\" [GOC:BHF, GOC:obol]", "effective_domain_size": 20972, "goshv": 33638, "intersection_size": 1, "intersections": [ [], [], [], [], [ "IEA" ], [], [], [], [], [], [] ], "name": "negative regulation of DNA damage checkpoint", "native": "GO:2000002", "p_value": 0.005476632036413576, "parents": [ "GO:0000077", "GO:1901977", "GO:2000001" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.3333333333333333, "significant": true, "source": "GO:BP", "term_size": 3, "source_order": 23515, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of fermentation.\" [GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 29911, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of fermentation", "native": "GO:1901003", "p_value": 0.005476632036413576, "parents": [ "GO:0006113", "GO:0009892", "GO:0043465" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.3333333333333333, "significant": true, "source": "GO:BP", "term_size": 3, "source_order": 19788, "group_id": 1 }, { "description": "\"The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, and possibly ethanol, yielding energy in the form of adenosine triphosphate (ATP).\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 15704, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "glucose catabolic process to lactate", "native": "GO:0019659", "p_value": 0.005476632036413576, "parents": [ "GO:0006007", "GO:0006089", "GO:0006113" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.3333333333333333, "significant": true, "source": "GO:BP", "term_size": 3, "source_order": 5581, "group_id": 1 }, { "description": "\"Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.\" [CL:0000738, GOC:BHF, GOC:mah, GOC:mtg_apoptosis]", "effective_domain_size": 20972, "goshv": 25943, "intersection_size": 2, "intersections": [ [ "ISS", "IEA" ], [], [], [], [ "IEA" ], [], [], [], [], [], [] ], "name": "leukocyte apoptotic process", "native": "GO:0071887", "p_value": 0.005684925232620138, "parents": [ "GO:0006915" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.017094017094017096, "significant": true, "source": "GO:BP", "term_size": 117, "source_order": 15820, "group_id": 1 }, { "description": "\"An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal.\" [GOC:bf]", "effective_domain_size": 20972, "goshv": 12780, "intersection_size": 2, "intersections": [ [ "IEP" ], [], [], [], [], [], [], [], [ "IEP" ], [], [] ], "name": "Ras protein signal transduction", "native": "GO:0007265", "p_value": 0.005684925232620138, "parents": [ "GO:0007264" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.017094017094017096, "significant": true, "source": "GO:BP", "term_size": 117, "source_order": 2657, "group_id": 8 }, { "description": "\"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.\" [GOC:autophagy, PMID:9412464]", "effective_domain_size": 20972, "goshv": 10139, "intersection_size": 2, "intersections": [ [], [ "IC" ], [], [], [ "IDA" ], [], [], [], [], [], [] ], "name": "autophagosome assembly", "native": "GO:0000045", "p_value": 0.005764232671680561, "parents": [ "GO:0070925", "GO:1905037" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.01694915254237288, "significant": true, "source": "GO:BP", "term_size": 118, "source_order": 16, "group_id": 1 }, { "description": "\"The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. The blastula follows the morula and precedes the gastrula in the developmental sequence.\" [GOC:dph, ISBN:0124020607, ISBN:0198542771]", "effective_domain_size": 20972, "goshv": 10591, "intersection_size": 2, "intersections": [ [], [], [], [ "IEA" ], [], [], [ "IEA" ], [], [], [], [] ], "name": "blastocyst development", "native": "GO:0001824", "p_value": 0.005826713265688482, "parents": [ "GO:0001701", "GO:0048856" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.01680672268907563, "significant": true, "source": "GO:BP", "term_size": 119, "source_order": 468, "group_id": 1 }, { "description": "\"The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 14962, "intersection_size": 3, "intersections": [ [ "IMP" ], [], [], [], [], [ "IMP" ], [], [], [ "IDA" ], [], [] ], "name": "cell growth", "native": "GO:0016049", "p_value": 0.005826713265688482, "parents": [ "GO:0009987", "GO:0040007" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.006276150627615063, "significant": true, "source": "GO:BP", "term_size": 478, "source_order": 4839, "group_id": 1 }, { "description": "Meiotic synapsis", "effective_domain_size": 11056, "goshv": 40798, "intersection_size": 2, "intersections": [ [], [], [ "REAC" ], [], [], [ "REAC" ], [], [], [], [], [] ], "name": "Meiotic synapsis", "native": "REAC:R-HSA-1221632", "p_value": 0.005987977103850513, "parents": [ "REAC:R-HSA-1500620" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.02631578947368421, "significant": true, "source": "REAC", "term_size": 76, "source_order": 1474, "group_id": 27 }, { "description": "\"Any process that modulates the frequency, rate or extent of mitosis.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 12662, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [], [ "IDA" ], [], [], [], [], [], [], [] ], "name": "regulation of mitotic nuclear division", "native": "GO:0007088", "p_value": 0.006004004628171176, "parents": [ "GO:0007346", "GO:0010564", "GO:0051783", "GO:0140014" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.01652892561983471, "significant": true, "source": "GO:BP", "term_size": 121, "source_order": 2539, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22816, "intersection_size": 4, "intersections": [ [ "IEA" ], [ "IMP" ], [], [], [], [], [ "IDA" ], [], [], [ "IEA" ], [] ], "name": "negative regulation of multicellular organismal process", "native": "GO:0051241", "p_value": 0.006106843321757214, "parents": [ "GO:0032501", "GO:0048519", "GO:0051239" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.0036663611365719525, "significant": true, "source": "GO:BP", "term_size": 1091, "source_order": 12693, "group_id": 1 }, { "description": "\"Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.\" [GOC:dph, GOC:go_curators, GOC:tb]", "effective_domain_size": 20972, "goshv": 21070, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [ "IEA" ], [], [], [], [ "IMP", "IBA", "IEA" ] ], "name": "positive regulation of mitotic cell cycle", "native": "GO:0045931", "p_value": 0.006165360260485911, "parents": [ "GO:0000278", "GO:0007346", "GO:0045787" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.016260162601626018, "significant": true, "source": "GO:BP", "term_size": 123, "source_order": 10947, "group_id": 1 }, { "description": "\"The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.\" [GOC:mtg_kidney_jan10]", "effective_domain_size": 20972, "goshv": 26091, "intersection_size": 2, "intersections": [ [ "IEA" ], [], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "stem cell proliferation", "native": "GO:0072089", "p_value": 0.006346233012682603, "parents": [ "GO:0008283" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.016, "significant": true, "source": "GO:BP", "term_size": 125, "source_order": 15968, "group_id": 1 }, { "description": "The role of GTSE1 in G2/M progression after G2 checkpoint", "effective_domain_size": 11056, "goshv": 41925, "intersection_size": 2, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [ "REAC" ], [], [] ], "name": "The role of GTSE1 in G2/M progression after G2 checkpoint", "native": "REAC:R-HSA-8852276", "p_value": 0.006388498917591823, "parents": [ "REAC:R-HSA-69275" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.02531645569620253, "significant": true, "source": "REAC", "term_size": 79, "source_order": 2601, "group_id": 33 }, { "description": "\"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome.\" [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22186024]", "effective_domain_size": 20972, "goshv": 32688, "intersection_size": 2, "intersections": [ [], [ "IC" ], [], [], [ "IDA" ], [], [], [], [], [], [] ], "name": "autophagosome organization", "native": "GO:1905037", "p_value": 0.006391171196650752, "parents": [ "GO:0007033", "GO:0016236" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.015873015873015872, "significant": true, "source": "GO:BP", "term_size": 126, "source_order": 22565, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of intracellular signal transduction.\" [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 30939, "intersection_size": 4, "intersections": [ [ "IMP", "ISS" ], [ "IMP" ], [ "IMP" ], [], [], [], [], [], [], [ "IDA" ], [] ], "name": "positive regulation of intracellular signal transduction", "native": "GO:1902533", "p_value": 0.006391171196650752, "parents": [ "GO:0009967", "GO:0035556", "GO:1902531" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.0036101083032490976, "significant": true, "source": "GO:BP", "term_size": 1108, "source_order": 20816, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 20337, "intersection_size": 3, "intersections": [ [ "IDA" ], [ "IMP" ], [ "IMP" ], [], [], [], [], [], [], [], [] ], "name": "positive regulation of cellular component biogenesis", "native": "GO:0044089", "p_value": 0.006391171196650752, "parents": [ "GO:0044085", "GO:0044087", "GO:0048522" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.006036217303822937, "significant": true, "source": "GO:BP", "term_size": 497, "source_order": 10214, "group_id": 1 }, { "description": "Intracellular signaling by second messengers", "effective_domain_size": 11056, "goshv": 40641, "intersection_size": 3, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [ "REAC" ], [], [ "REAC" ] ], "name": "Intracellular signaling by second messengers", "native": "REAC:R-HSA-9006925", "p_value": 0.006395871195232722, "parents": [ "REAC:R-HSA-162582" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.010101010101010102, "significant": true, "source": "REAC", "term_size": 297, "source_order": 1317, "group_id": 30 }, { "description": "Deubiquitination", "effective_domain_size": 11056, "goshv": 40087, "intersection_size": 3, "intersections": [ [ "REAC" ], [], [], [], [], [ "REAC" ], [], [], [], [], [ "REAC" ] ], "name": "Deubiquitination", "native": "REAC:R-HSA-5688426", "p_value": 0.006395871195232722, "parents": [ "REAC:R-HSA-597592" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.010067114093959731, "significant": true, "source": "REAC", "term_size": 298, "source_order": 763, "group_id": 35 }, { "description": "\"Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 14220, "intersection_size": 3, "intersections": [ [ "IDA" ], [ "IMP", "ISS", "IEA" ], [ "ISS" ], [], [], [], [], [], [], [], [] ], "name": "positive regulation of organelle organization", "native": "GO:0010638", "p_value": 0.006423053371380372, "parents": [ "GO:0006996", "GO:0033043", "GO:0051130" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.006012024048096192, "significant": true, "source": "GO:BP", "term_size": 499, "source_order": 4097, "group_id": 1 }, { "description": "\"The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.\" [GOC:mtg_heart]", "effective_domain_size": 20972, "goshv": 11700, "intersection_size": 2, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [ "IEA" ] ], "name": "cardiac chamber morphogenesis", "native": "GO:0003206", "p_value": 0.006454477399360518, "parents": [ "GO:0003007", "GO:0003205", "GO:0009653" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.015748031496062992, "significant": true, "source": "GO:BP", "term_size": 127, "source_order": 1577, "group_id": 1 }, { "description": "\"The establishment of the sex of a female organism by physical differentiation.\" [GOC:bf]", "effective_domain_size": 20972, "goshv": 21578, "intersection_size": 2, "intersections": [ [], [ "IEA" ], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "female sex differentiation", "native": "GO:0046660", "p_value": 0.006637413563027163, "parents": [ "GO:0007275", "GO:0007548" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.015503875968992248, "significant": true, "source": "GO:BP", "term_size": 129, "source_order": 11455, "group_id": 1 }, { "description": "\"The aggregation, arrangement and bonding together of a set of components to form a DNA repair complex.\" [GOC:pg, PMID:27113759, PMID:27233470]", "effective_domain_size": 20972, "goshv": 27342, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [ "IMP", "IBA" ], [], [], [] ], "name": "DNA repair complex assembly", "native": "GO:0090735", "p_value": 0.006683777183164204, "parents": [ "GO:0065003" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.25, "significant": true, "source": "GO:BP", "term_size": 4, "source_order": 17219, "group_id": 1 }, { "description": "\"Expression of a single heavy chain allele during pre-B cell differentiation.\" [GOC:add, GOC:jal, ISBN:0781735149]", "effective_domain_size": 20972, "goshv": 10947, "intersection_size": 1, "intersections": [ [], [ "ISS", "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "pre-B cell allelic exclusion", "native": "GO:0002331", "p_value": 0.006683777183164204, "parents": [ "GO:0002329", "GO:0010468" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.25, "significant": true, "source": "GO:BP", "term_size": 4, "source_order": 824, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 26473, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [ "IEA" ], [], [], [] ], "name": "cellular response to cisplatin", "native": "GO:0072719", "p_value": 0.006683777183164204, "parents": [ "GO:0070887", "GO:0072718" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.25, "significant": true, "source": "GO:BP", "term_size": 4, "source_order": 16350, "group_id": 1 }, { "description": "\"A cell cycle process by which a cell commits to entering S phase via a positive feedback mechanism between the regulation of transcription and G1 CDK activity.\" [GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 12663, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [], [ "IEA" ] ], "name": "traversing start control point of mitotic cell cycle", "native": "GO:0007089", "p_value": 0.006683777183164204, "parents": [ "GO:1900087" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.25, "significant": true, "source": "GO:BP", "term_size": 4, "source_order": 2540, "group_id": 1 }, { "description": "\"A cellular senescence process associated with the dismantling of a cell as a response to oxidative stress, e.g. high levels of reactive oxygen species, such as superoxide anions, hydrogen peroxide, and hydroxyl radicals.\" [GOC:BHF]", "effective_domain_size": 20972, "goshv": 27186, "intersection_size": 1, "intersections": [ [ "IMP" ], [], [], [], [], [], [], [], [], [], [] ], "name": "oxidative stress-induced premature senescence", "native": "GO:0090403", "p_value": 0.006683777183164204, "parents": [ "GO:0034599", "GO:0090400" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.25, "significant": true, "source": "GO:BP", "term_size": 4, "source_order": 17063, "group_id": 1 }, { "description": "\"The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA.\" [PMID:10357855]", "effective_domain_size": 20972, "goshv": 10327, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [ "IMP", "IBA" ], [], [], [] ], "name": "DNA recombinase assembly", "native": "GO:0000730", "p_value": 0.006683777183164204, "parents": [ "GO:0045003", "GO:0065004", "GO:0090735" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.25, "significant": true, "source": "GO:BP", "term_size": 4, "source_order": 204, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of fermentation, the anaerobic enzymatic conversion of organic compounds, especially carbohydrates, to other compounds, especially to ethyl alcohol, resulting in energy in the form of adenosine triphosphate (ATP).\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 20160, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of fermentation", "native": "GO:0043465", "p_value": 0.006683777183164204, "parents": [ "GO:0006113", "GO:0043467" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.25, "significant": true, "source": "GO:BP", "term_size": 4, "source_order": 10037, "group_id": 1 }, { "description": "\"The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 20023, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "NAS", "IEA" ], [ "IDA", "IMP", "IGI", "ISS", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "ISS", "TAS", "IEA" ], [ "IDA", "IMP", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "TAS", "IEA" ], [ "IMP", "TAS" ], [ "IDA", "IMP", "IGI", "IBA", "TAS", "IEA" ] ], "name": "macromolecule metabolic process", "native": "GO:0043170", "p_value": 0.006683777183164204, "parents": [ "GO:0008152" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.0009211187405794674, "significant": true, "source": "GO:BP", "term_size": 11942, "source_order": 9900, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 26508, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [ "IDA" ], [], [], [] ], "name": "cellular response to camptothecin", "native": "GO:0072757", "p_value": 0.006683777183164204, "parents": [ "GO:0071312", "GO:0097306", "GO:1901563" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.25, "significant": true, "source": "GO:BP", "term_size": 4, "source_order": 16385, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bisphenol A stimulus.\" [GO_REF:0000071, GOC:TermGenie, PMID:22957036]", "effective_domain_size": 20972, "goshv": 31871, "intersection_size": 1, "intersections": [ [], [], [], [], [ "IEA" ], [], [], [], [], [], [] ], "name": "cellular response to bisphenol A", "native": "GO:1903926", "p_value": 0.006683777183164204, "parents": [ "GO:1901701", "GO:1903925" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.25, "significant": true, "source": "GO:BP", "term_size": 4, "source_order": 21748, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bisphenol A stimulus.\" [GO_REF:0000071, GOC:TermGenie, PMID:22957036]", "effective_domain_size": 20972, "goshv": 31870, "intersection_size": 1, "intersections": [ [], [], [], [], [ "IEA" ], [], [], [], [], [], [] ], "name": "response to bisphenol A", "native": "GO:1903925", "p_value": 0.006683777183164204, "parents": [ "GO:1901700" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.25, "significant": true, "source": "GO:BP", "term_size": 4, "source_order": 21747, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 22524, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IGI", "IEP", "ISS", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IGI", "ISS", "IBA", "TAS", "IC", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IBA", "NAS", "IEA" ], [ "IDA", "NAS" ], [ "IDA", "IMP", "IGI", "IEP", "ISS", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ] ], "name": "regulation of cellular process", "native": "GO:0050794", "p_value": 0.006683777183164204, "parents": [ "GO:0009987", "GO:0050789" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.000919578665774954, "significant": true, "source": "GO:BP", "term_size": 11962, "source_order": 12401, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the rate or extent of mammary gland epithelial cell proliferation.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17872, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [ "IDA" ], [], [], [], [] ], "name": "negative regulation of mammary gland epithelial cell proliferation", "native": "GO:0033600", "p_value": 0.006683777183164204, "parents": [ "GO:0033598", "GO:0033599", "GO:0050680", "GO:0051241" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.25, "significant": true, "source": "GO:BP", "term_size": 4, "source_order": 7749, "group_id": 1 }, { "description": "\"Any apoptotic process in an oligodendrocyte. Oligodendrocytes belong to a class of large neuroglial (macroglial) cells in the central nervous system, where they form the insulating myelin sheath of axons.\" [CL:0000128, GOC:mtg_apoptosis, GOC:yaf, PMID:16723520]", "effective_domain_size": 20972, "goshv": 27462, "intersection_size": 1, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "oligodendrocyte apoptotic process", "native": "GO:0097252", "p_value": 0.006683777183164204, "parents": [ "GO:0034349" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.25, "significant": true, "source": "GO:BP", "term_size": 4, "source_order": 17339, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus.\" [GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 30286, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [ "IDA" ], [], [], [] ], "name": "response to camptothecin", "native": "GO:1901563", "p_value": 0.006683777183164204, "parents": [ "GO:0043279", "GO:0097305" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.25, "significant": true, "source": "GO:BP", "term_size": 4, "source_order": 20163, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 21043, "intersection_size": 1, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "positive regulation of RNA polymerase II transcription preinitiation complex assembly", "native": "GO:0045899", "p_value": 0.006683777183164204, "parents": [ "GO:0031334", "GO:0045898", "GO:0051123", "GO:0060261" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.25, "significant": true, "source": "GO:BP", "term_size": 4, "source_order": 10920, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of B cell activation.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22572, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [ "IEA" ], [], [] ], "name": "regulation of B cell activation", "native": "GO:0050864", "p_value": 0.00672336941243888, "parents": [ "GO:0042113", "GO:0051249" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.015037593984962405, "significant": true, "source": "GO:BP", "term_size": 133, "source_order": 12449, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25675, "intersection_size": 2, "intersections": [ [ "IEP", "IEA" ], [], [], [], [], [], [], [], [], [], [ "IEP" ] ], "name": "cellular response to hypoxia", "native": "GO:0071456", "p_value": 0.006905146142490153, "parents": [ "GO:0001666", "GO:0033554", "GO:0036294" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.014814814814814815, "significant": true, "source": "GO:BP", "term_size": 135, "source_order": 15552, "group_id": 1 }, { "description": "\"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.\" [ISBN:0471245208]", "effective_domain_size": 20972, "goshv": 13710, "intersection_size": 5, "intersections": [ [ "IMP", "IEA" ], [ "IEA" ], [], [], [], [], [ "IDA" ], [], [ "IEA" ], [], [ "IEA" ] ], "name": "tissue development", "native": "GO:0009888", "p_value": 0.007233396423058005, "parents": [ "GO:0048856" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.0024826216484607746, "significant": true, "source": "GO:BP", "term_size": 2014, "source_order": 3587, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of DNA repair.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 20933, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [], [], [], [ "IMP" ], [], [], [], [], [] ], "name": "positive regulation of DNA repair", "native": "GO:0045739", "p_value": 0.007377483300212822, "parents": [ "GO:0006281", "GO:0006282", "GO:0048584", "GO:0051054" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.014285714285714285, "significant": true, "source": "GO:BP", "term_size": 140, "source_order": 10810, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents.\" [GOC:go_curators, ISBN:0198506732]", "effective_domain_size": 20972, "goshv": 10128, "intersection_size": 2, "intersections": [ [], [], [], [ "IDA" ], [], [], [], [ "IDA" ], [], [], [] ], "name": "regulation of DNA recombination", "native": "GO:0000018", "p_value": 0.007461381474145134, "parents": [ "GO:0006310", "GO:0051052" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.014184397163120567, "significant": true, "source": "GO:BP", "term_size": 141, "source_order": 5, "group_id": 1 }, { "description": "Cellular response to heat stress", "effective_domain_size": 11056, "goshv": 39675, "intersection_size": 2, "intersections": [ [], [ "REAC" ], [ "REAC" ], [], [], [], [], [], [], [], [] ], "name": "Cellular response to heat stress", "native": "REAC:R-HSA-3371556", "p_value": 0.007465954668116491, "parents": [ "REAC:R-HSA-2262752" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.022988505747126436, "significant": true, "source": "REAC", "term_size": 87, "source_order": 351, "group_id": 29 }, { "description": "\"The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.\" [GO_REF:0000022, GOC:mah]", "effective_domain_size": 20972, "goshv": 16388, "intersection_size": 2, "intersections": [ [ "IEA" ], [ "ISS", "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "B cell differentiation", "native": "GO:0030183", "p_value": 0.007545523719388972, "parents": [ "GO:0030098", "GO:0042113" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.014084507042253521, "significant": true, "source": "GO:BP", "term_size": 142, "source_order": 6265, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.\" [GOC:al]", "effective_domain_size": 20972, "goshv": 19045, "intersection_size": 2, "intersections": [ [ "IEP", "IEA" ], [], [], [], [], [], [], [], [], [], [ "IEP" ] ], "name": "cellular response to decreased oxygen levels", "native": "GO:0036294", "p_value": 0.007629907458706829, "parents": [ "GO:0036293", "GO:0071453" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.013986013986013986, "significant": true, "source": "GO:BP", "term_size": 143, "source_order": 8922, "group_id": 1 }, { "description": "\"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.\" [GOC:dph, GOC:jid, GOC:tb]", "effective_domain_size": 20972, "goshv": 22178, "intersection_size": 4, "intersections": [ [ "IEA" ], [ "IEA" ], [], [], [], [ "IMP" ], [], [], [], [ "IEA" ], [] ], "name": "anatomical structure formation involved in morphogenesis", "native": "GO:0048646", "p_value": 0.007696767050274192, "parents": [ "GO:0009653", "GO:0032502" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.0033613445378151263, "significant": true, "source": "GO:BP", "term_size": 1190, "source_order": 12055, "group_id": 1 }, { "description": "\"The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 20359, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "NAS", "IEA" ], [ "IDA", "IMP", "IGI", "ISS", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "TAS", "IEA" ], [ "IDA", "IMP", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "TAS", "IEA" ], [ "IMP", "TAS" ], [ "IDA", "IMP", "IGI", "IBA", "TAS", "IEA" ] ], "name": "primary metabolic process", "native": "GO:0044238", "p_value": 0.007804263216776353, "parents": [ "GO:0008152" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.0009038619556285949, "significant": true, "source": "GO:BP", "term_size": 12170, "source_order": 10236, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 23126, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [], [ "IDA" ], [], [], [], [], [], [], [] ], "name": "regulation of nuclear division", "native": "GO:0051783", "p_value": 0.007982947485320208, "parents": [ "GO:0000280", "GO:0033043" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.013605442176870748, "significant": true, "source": "GO:BP", "term_size": 147, "source_order": 13003, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.\" [GOC:hjd]", "effective_domain_size": 20972, "goshv": 10657, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [], [], [ "IMP" ], [ "IMP" ], [] ], "name": "negative regulation of protein phosphorylation", "native": "GO:0001933", "p_value": 0.007982947485320208, "parents": [ "GO:0001932", "GO:0006468", "GO:0031400", "GO:0042326" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.013513513513513514, "significant": true, "source": "GO:BP", "term_size": 148, "source_order": 534, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of thymocyte death by apoptotic process.\" [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]", "effective_domain_size": 20972, "goshv": 25031, "intersection_size": 1, "intersections": [ [ "ISS", "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "positive regulation of thymocyte apoptotic process", "native": "GO:0070245", "p_value": 0.007982947485320208, "parents": [ "GO:0070234", "GO:0070242", "GO:0070243" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.2, "significant": true, "source": "GO:BP", "term_size": 5, "source_order": 14908, "group_id": 1 }, { "description": "\"The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 13218, "intersection_size": 10, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "NAS", "IEA" ], [ "IDA", "IMP", "IGI", "ISS", "IEA" ], [ "ISS" ], [ "ISS", "IEA" ], [ "IDA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IBA" ], [], [ "IMP", "IEA" ], [ "IMP" ], [ "IDA", "IMP", "IEA" ] ], "name": "macromolecule biosynthetic process", "native": "GO:0009059", "p_value": 0.007982947485320208, "parents": [ "GO:0009058", "GO:0043170" ], "precision": 0.9090909090909091, "query": "query_1", "query_size": 11, "recall": 0.001041124414367517, "significant": true, "source": "GO:BP", "term_size": 9605, "source_order": 3095, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus.\" [GOC:mah, GOC:yaf]", "effective_domain_size": 20972, "goshv": 25836, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "IDA" ], [], [], [], [], [] ], "name": "cellular response to indole-3-methanol", "native": "GO:0071681", "p_value": 0.007982947485320208, "parents": [ "GO:0071680", "GO:0097306", "GO:1901699" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.2, "significant": true, "source": "GO:BP", "term_size": 5, "source_order": 15713, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus.\" [GOC:mah, GOC:yaf]", "effective_domain_size": 20972, "goshv": 25835, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "IDA" ], [], [], [], [], [] ], "name": "response to indole-3-methanol", "native": "GO:0071680", "p_value": 0.007982947485320208, "parents": [ "GO:0097305", "GO:1901698" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.2, "significant": true, "source": "GO:BP", "term_size": 5, "source_order": 15712, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of G1 to G0 transition.\" [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24088570]", "effective_domain_size": 20972, "goshv": 31537, "intersection_size": 1, "intersections": [ [ "IDA", "IMP" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of G1 to G0 transition", "native": "GO:1903450", "p_value": 0.007982947485320208, "parents": [ "GO:0010564", "GO:0070314" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.2, "significant": true, "source": "GO:BP", "term_size": 5, "source_order": 21414, "group_id": 1 }, { "description": "\"The metabolic process that uses oxidation-reduction reactions of organic compounds and substrate-level phosphorylation for the generation of adenosine triphosphate (ATP), without consuming oxygen and is independent of electron transport chains.\" [PMID:25617754, PMID:38821505]", "effective_domain_size": 20972, "goshv": 11994, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "fermentation", "native": "GO:0006113", "p_value": 0.007982947485320208, "parents": [ "GO:0015980" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.2, "significant": true, "source": "GO:BP", "term_size": 5, "source_order": 1871, "group_id": 1 }, { "description": "\"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.\" [GOC:dph, GOC:ems, GOC:jl, GOC:mah]", "effective_domain_size": 20972, "goshv": 12602, "intersection_size": 2, "intersections": [ [], [], [ "IDA" ], [ "IEA" ], [], [], [], [], [], [], [] ], "name": "nucleus organization", "native": "GO:0006997", "p_value": 0.008444062393470243, "parents": [ "GO:0006996" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.013071895424836602, "significant": true, "source": "GO:BP", "term_size": 153, "source_order": 2479, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22820, "intersection_size": 3, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [ "IMP" ], [ "IMP" ], [] ], "name": "negative regulation of protein metabolic process", "native": "GO:0051248", "p_value": 0.008444062393470243, "parents": [ "GO:0010605", "GO:0019538", "GO:0051246" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.005272407732864675, "significant": true, "source": "GO:BP", "term_size": 569, "source_order": 12697, "group_id": 1 }, { "description": "\"The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.\" [GOC:dph, GOC:mtg_lung]", "effective_domain_size": 20972, "goshv": 23755, "intersection_size": 4, "intersections": [ [ "IEA" ], [ "IEA" ], [], [], [], [], [ "IDA" ], [], [ "IEA" ], [], [] ], "name": "epithelium development", "native": "GO:0060429", "p_value": 0.008521153667251962, "parents": [ "GO:0009888" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.0032414910858995136, "significant": true, "source": "GO:BP", "term_size": 1234, "source_order": 13632, "group_id": 1 }, { "description": "\"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.\" [GO_REF:0000021]", "effective_domain_size": 20972, "goshv": 22370, "intersection_size": 8, "intersections": [ [ "IMP", "IEA" ], [ "ISS", "IEA" ], [], [ "IEA" ], [], [ "IMP", "IBA", "IEA" ], [ "IDA", "IEA" ], [], [ "ISS", "IEA" ], [ "IEA" ], [ "IEA" ] ], "name": "anatomical structure development", "native": "GO:0048856", "p_value": 0.008730245218321357, "parents": [ "GO:0032502" ], "precision": 0.7272727272727273, "query": "query_1", "query_size": 11, "recall": 0.0013449899125756557, "significant": true, "source": "GO:BP", "term_size": 5948, "source_order": 12247, "group_id": 1 }, { "description": "PI3K/AKT Signaling in Cancer", "effective_domain_size": 11056, "goshv": 41067, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [], [], [ "REAC" ], [], [ "REAC" ] ], "name": "PI3K/AKT Signaling in Cancer", "native": "REAC:R-HSA-2219528", "p_value": 0.008956567902787635, "parents": [ "REAC:R-HSA-5663202" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.020833333333333332, "significant": true, "source": "REAC", "term_size": 96, "source_order": 1743, "group_id": 26 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25672, "intersection_size": 2, "intersections": [ [ "IEP", "IEA" ], [], [], [], [], [], [], [], [], [], [ "IEP" ] ], "name": "cellular response to oxygen levels", "native": "GO:0071453", "p_value": 0.00903405549600249, "parents": [ "GO:0070482", "GO:0070887" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.012578616352201259, "significant": true, "source": "GO:BP", "term_size": 159, "source_order": 15549, "group_id": 1 }, { "description": "\"The directed movement of RNA to a specific location.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22812, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [ "IMP" ], [], [], [], [], [], [], [], [] ], "name": "establishment of RNA localization", "native": "GO:0051236", "p_value": 0.00911021565143626, "parents": [ "GO:0006403", "GO:0051234" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.012269938650306749, "significant": true, "source": "GO:BP", "term_size": 163, "source_order": 12689, "group_id": 2 }, { "description": "\"Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.\" [GOC:ai, GOC:go_curators]", "effective_domain_size": 20972, "goshv": 22520, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IGI", "IEP", "ISS", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IGI", "ISS", "IBA", "TAS", "IC", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IBA", "NAS", "IEA" ], [ "IDA", "NAS" ], [ "IDA", "IMP", "IGI", "IEP", "ISS", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ] ], "name": "regulation of biological process", "native": "GO:0050789", "p_value": 0.00911021565143626, "parents": [ "GO:0008150", "GO:0065007" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.0008873114463176575, "significant": true, "source": "GO:BP", "term_size": 12397, "source_order": 12397, "group_id": 1 }, { "description": "\"The regrowth of cardiac muscle tissue to repair injured or damaged muscle fibers in the postnatal stage.\" [GOC:dph]", "effective_domain_size": 20972, "goshv": 24212, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "ISS", "IEA" ], [], [] ], "name": "cardiac muscle tissue regeneration", "native": "GO:0061026", "p_value": 0.00911021565143626, "parents": [ "GO:0042246" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.16666666666666666, "significant": true, "source": "GO:BP", "term_size": 6, "source_order": 14089, "group_id": 5 }, { "description": "\"The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules.\" [GOC:elh, PMID:10357855]", "effective_domain_size": 20972, "goshv": 19472, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [ "IBA" ], [], [], [] ], "name": "DNA strand invasion", "native": "GO:0042148", "p_value": 0.00911021565143626, "parents": [ "GO:0006259", "GO:0006310" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.16666666666666666, "significant": true, "source": "GO:BP", "term_size": 6, "source_order": 9349, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 26472, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [ "IEA" ], [], [], [] ], "name": "response to cisplatin", "native": "GO:0072718", "p_value": 0.00911021565143626, "parents": [ "GO:0042221" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.16666666666666666, "significant": true, "source": "GO:BP", "term_size": 6, "source_order": 16349, "group_id": 1 }, { "description": "\"The process in which a lymphoid progenitor cell becomes committed to become any type of B cell.\" [GOC:add, ISBN:0781735149]", "effective_domain_size": 20972, "goshv": 10942, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "B cell lineage commitment", "native": "GO:0002326", "p_value": 0.00911021565143626, "parents": [ "GO:0030183", "GO:0045165" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.16666666666666666, "significant": true, "source": "GO:BP", "term_size": 6, "source_order": 819, "group_id": 1 }, { "description": "\"A cellular senescence process associated with the dismantling of a cell as a response to oncogenic stress, such as the activation of the Ras oncogenic family.\" [GOC:BHF]", "effective_domain_size": 20972, "goshv": 27185, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "IEA" ], [], [] ], "name": "oncogene-induced cell senescence", "native": "GO:0090402", "p_value": 0.00911021565143626, "parents": [ "GO:0090398" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.16666666666666666, "significant": true, "source": "GO:BP", "term_size": 6, "source_order": 17062, "group_id": 1 }, { "description": "\"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 26402, "intersection_size": 3, "intersections": [ [ "IEA" ], [], [], [], [], [], [ "IDA", "IEA" ], [], [ "IEA" ], [], [] ], "name": "establishment of protein localization to organelle", "native": "GO:0072594", "p_value": 0.00911021565143626, "parents": [ "GO:0045184" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.005110732538330494, "significant": true, "source": "GO:BP", "term_size": 587, "source_order": 16279, "group_id": 2 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25718, "intersection_size": 1, "intersections": [ [], [ "IDA" ], [], [], [], [], [], [], [], [], [] ], "name": "cellular response to nitrosative stress", "native": "GO:0071500", "p_value": 0.00911021565143626, "parents": [ "GO:0051409", "GO:0062197" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.16666666666666666, "significant": true, "source": "GO:BP", "term_size": 6, "source_order": 15595, "group_id": 1 }, { "description": "\"The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments.\" [GOC:jal, ISBN:0781735149]", "effective_domain_size": 20972, "goshv": 10945, "intersection_size": 1, "intersections": [ [], [ "ISS", "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "pre-B cell differentiation", "native": "GO:0002329", "p_value": 0.00911021565143626, "parents": [ "GO:0002327" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.16666666666666666, "significant": true, "source": "GO:BP", "term_size": 6, "source_order": 822, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.\" [GOC:ems, GOC:mah]", "effective_domain_size": 20972, "goshv": 19385, "intersection_size": 3, "intersections": [ [ "IMP" ], [], [], [], [], [ "IMP" ], [], [], [ "IDA", "ISS", "IEA" ], [], [] ], "name": "regulation of growth", "native": "GO:0040008", "p_value": 0.00911021565143626, "parents": [ "GO:0040007", "GO:0050789" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.005084745762711864, "significant": true, "source": "GO:BP", "term_size": 590, "source_order": 9262, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 21042, "intersection_size": 1, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of RNA polymerase II transcription preinitiation complex assembly", "native": "GO:0045898", "p_value": 0.00911021565143626, "parents": [ "GO:0043254", "GO:0051123", "GO:0060260" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.16666666666666666, "significant": true, "source": "GO:BP", "term_size": 6, "source_order": 10919, "group_id": 1 }, { "description": "\"A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25072, "intersection_size": 1, "intersections": [ [], [], [], [ "TAS" ], [], [], [], [], [], [], [] ], "name": "negative regulation of G0 to G1 transition", "native": "GO:0070317", "p_value": 0.00911021565143626, "parents": [ "GO:0010948", "GO:0045023", "GO:0070316" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.16666666666666666, "significant": true, "source": "GO:BP", "term_size": 6, "source_order": 14949, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process in which glucose is oxidized, coupled to NADPH synthesis.\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 20154, "intersection_size": 1, "intersections": [ [ "IMP" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of pentose-phosphate shunt", "native": "GO:0043456", "p_value": 0.00911021565143626, "parents": [ "GO:0006098", "GO:0043467", "GO:0043470", "GO:1902031" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.16666666666666666, "significant": true, "source": "GO:BP", "term_size": 6, "source_order": 10031, "group_id": 1 }, { "description": "\"The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks.\" [GOC:rb, PMID:12820977, PMID:16888651]", "effective_domain_size": 20972, "goshv": 33437, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [ "IEA" ], [], [], [] ], "name": "replication-born double-strand break repair via sister chromatid exchange", "native": "GO:1990414", "p_value": 0.00911021565143626, "parents": [ "GO:0000724" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.16666666666666666, "significant": true, "source": "GO:BP", "term_size": 6, "source_order": 23314, "group_id": 1 }, { "description": "\"Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule.\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 19568, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [], [], [ "IDA", "IMP" ], [ "IMP" ], [] ], "name": "negative regulation of phosphorylation", "native": "GO:0042326", "p_value": 0.00911021565143626, "parents": [ "GO:0016310", "GO:0042325", "GO:0045936" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.012269938650306749, "significant": true, "source": "GO:BP", "term_size": 163, "source_order": 9445, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.\" [GOC:go_curators, GOC:txnOH]", "effective_domain_size": 20972, "goshv": 21038, "intersection_size": 4, "intersections": [ [ "IDA", "IMP", "ISS", "NAS", "IEA" ], [], [], [], [], [ "IDA" ], [], [], [], [ "IMP" ], [ "IDA", "IMP" ] ], "name": "negative regulation of DNA-templated transcription", "native": "GO:0045892", "p_value": 0.009153864187436647, "parents": [ "GO:0006351", "GO:0006355", "GO:1902679" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.003137254901960784, "significant": true, "source": "GO:BP", "term_size": 1275, "source_order": 10915, "group_id": 1 }, { "description": "\"A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway.\" [PMID:21997368, PMID:22966490, PMID:28596378]", "effective_domain_size": 20972, "goshv": 24747, "intersection_size": 3, "intersections": [ [ "IMP", "IEA" ], [ "IDA", "IMP", "IC", "IEA" ], [], [], [ "IDA" ], [], [], [], [], [], [] ], "name": "process utilizing autophagic mechanism", "native": "GO:0061919", "p_value": 0.009242057086865723, "parents": [ "GO:0009987" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.005008347245409015, "significant": true, "source": "GO:BP", "term_size": 599, "source_order": 14624, "group_id": 1 }, { "description": "\"The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation.\" [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]", "effective_domain_size": 20972, "goshv": 12555, "intersection_size": 3, "intersections": [ [ "IMP", "IEA" ], [ "IDA", "IMP", "IC", "IEA" ], [], [], [ "IDA" ], [], [], [], [], [], [] ], "name": "autophagy", "native": "GO:0006914", "p_value": 0.009242057086865723, "parents": [ "GO:0009056", "GO:0061919" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.005008347245409015, "significant": true, "source": "GO:BP", "term_size": 599, "source_order": 2432, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process.\" [GO:jl, GO_REF:0000058, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 31017, "intersection_size": 4, "intersections": [ [ "IDA", "IMP", "ISS", "NAS", "IEA" ], [], [], [], [], [ "IDA" ], [], [], [], [ "IMP" ], [ "IDA", "IMP" ] ], "name": "negative regulation of RNA biosynthetic process", "native": "GO:1902679", "p_value": 0.009323062845807632, "parents": [ "GO:0010558", "GO:0032774", "GO:0051253", "GO:2001141" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.003115264797507788, "significant": true, "source": "GO:BP", "term_size": 1284, "source_order": 20894, "group_id": 1 }, { "description": "\"The directed movement of a protein from the cytoplasm to the nucleus.\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 12327, "intersection_size": 2, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [ "IEA" ], [], [] ], "name": "protein import into nucleus", "native": "GO:0006606", "p_value": 0.009326451295444743, "parents": [ "GO:0006886", "GO:0034504", "GO:0051170", "GO:0072594" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.012048192771084338, "significant": true, "source": "GO:BP", "term_size": 166, "source_order": 2204, "group_id": 2 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.\" [GOC:hb]", "effective_domain_size": 20972, "goshv": 13398, "intersection_size": 2, "intersections": [ [], [ "TAS" ], [ "TAS" ], [], [], [], [], [], [], [], [] ], "name": "response to temperature stimulus", "native": "GO:0009266", "p_value": 0.009413837956655244, "parents": [ "GO:0009628" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.011976047904191617, "significant": true, "source": "GO:BP", "term_size": 167, "source_order": 3275, "group_id": 1 }, { "description": "\"Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction.\" [GOC:dph, ISBN:0198506732]", "effective_domain_size": 20972, "goshv": 12805, "intersection_size": 2, "intersections": [ [], [ "IEA" ], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "female gamete generation", "native": "GO:0007292", "p_value": 0.009501414136917978, "parents": [ "GO:0007276" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.011904761904761904, "significant": true, "source": "GO:BP", "term_size": 168, "source_order": 2682, "group_id": 1 }, { "description": "\"The increase in size or mass of an entire multicellular organism, as opposed to cell growth.\" [GOC:bf, GOC:curators, GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 18474, "intersection_size": 2, "intersections": [ [ "IEA" ], [ "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "multicellular organism growth", "native": "GO:0035264", "p_value": 0.00970055865806227, "parents": [ "GO:0032501", "GO:0048589" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.011764705882352941, "significant": true, "source": "GO:BP", "term_size": 170, "source_order": 8351, "group_id": 1 }, { "description": "\"The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.\" [GOC:mtg_heart]", "effective_domain_size": 20972, "goshv": 11699, "intersection_size": 2, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [ "IEA" ] ], "name": "cardiac chamber development", "native": "GO:0003205", "p_value": 0.009788848181062347, "parents": [ "GO:0007507", "GO:0048856" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.011695906432748537, "significant": true, "source": "GO:BP", "term_size": 171, "source_order": 1576, "group_id": 1 }, { "description": "\"The directed movement of substances into the nucleus.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22785, "intersection_size": 2, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [ "IMP", "IEA" ], [], [] ], "name": "import into nucleus", "native": "GO:0051170", "p_value": 0.009877319304536562, "parents": [ "GO:0006913" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.011627906976744186, "significant": true, "source": "GO:BP", "term_size": 172, "source_order": 12662, "group_id": 2 }, { "description": "\"Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway.\" [GOC:mtg_apoptosis]", "effective_domain_size": 20972, "goshv": 34606, "intersection_size": 2, "intersections": [ [ "IMP", "ISS", "IEA" ], [], [], [], [], [], [], [], [], [], [ "IMP" ] ], "name": "regulation of intrinsic apoptotic signaling pathway", "native": "GO:2001242", "p_value": 0.010192572087220261, "parents": [ "GO:0097193", "GO:1902531", "GO:2001233" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.011428571428571429, "significant": true, "source": "GO:BP", "term_size": 175, "source_order": 24483, "group_id": 1 }, { "description": "\"The process of restoring mitochondrial DNA after damage.\" [PMID:12565799, PMID:15189144, PMID:16050976]", "effective_domain_size": 20972, "goshv": 20185, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "mitochondrial DNA repair", "native": "GO:0043504", "p_value": 0.010237677305150726, "parents": [ "GO:0006281", "GO:0032042" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.14285714285714285, "significant": true, "source": "GO:BP", "term_size": 7, "source_order": 10062, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of anoikis.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 33801, "intersection_size": 1, "intersections": [ [], [], [], [], [ "IEA" ], [], [], [], [], [], [] ], "name": "positive regulation of anoikis", "native": "GO:2000210", "p_value": 0.010237677305150726, "parents": [ "GO:0043065", "GO:0043276", "GO:2000209" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.14285714285714285, "significant": true, "source": "GO:BP", "term_size": 7, "source_order": 23678, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of centriole replication.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 21535, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "NAS" ], [], [], [], [], [] ], "name": "negative regulation of centriole replication", "native": "GO:0046600", "p_value": 0.010237677305150726, "parents": [ "GO:0007099", "GO:0010826", "GO:0046599", "GO:1902116" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.14285714285714285, "significant": true, "source": "GO:BP", "term_size": 7, "source_order": 11412, "group_id": 1 }, { "description": "\"The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling.\" [GOC:ebc]", "effective_domain_size": 20972, "goshv": 22293, "intersection_size": 2, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [ "IEA" ] ], "name": "tissue remodeling", "native": "GO:0048771", "p_value": 0.010436647064270015, "parents": [ "GO:0032501" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.011235955056179775, "significant": true, "source": "GO:BP", "term_size": 178, "source_order": 12170, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 13399, "intersection_size": 2, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [], [ "IMP", "IEA" ], [], [] ], "name": "cellular response to starvation", "native": "GO:0009267", "p_value": 0.01110857179657535, "parents": [ "GO:0031669", "GO:0033554", "GO:0042594" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.010869565217391304, "significant": true, "source": "GO:BP", "term_size": 184, "source_order": 3276, "group_id": 1 }, { "description": "Activation of NOXA and translocation to mitochondria", "effective_domain_size": 11056, "goshv": 39420, "intersection_size": 1, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [], [], [] ], "name": "Activation of NOXA and translocation to mitochondria", "native": "REAC:R-HSA-111448", "p_value": 0.011159435547844416, "parents": [ "REAC:R-HSA-114452" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.2, "significant": true, "source": "REAC", "term_size": 5, "source_order": 96, "group_id": 34 }, { "description": "TFAP2 (AP-2) family regulates transcription of cell cycle factors", "effective_domain_size": 11056, "goshv": 41845, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "REAC" ], [], [] ], "name": "TFAP2 (AP-2) family regulates transcription of cell cycle factors", "native": "REAC:R-HSA-8866911", "p_value": 0.011159435547844416, "parents": [ "REAC:R-HSA-8864260" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.2, "significant": true, "source": "REAC", "term_size": 5, "source_order": 2521, "group_id": 38 }, { "description": "\"SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break.\" [PMID:10357855]", "effective_domain_size": 20972, "goshv": 20585, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [ "IMP", "IBA" ], [], [], [] ], "name": "double-strand break repair via synthesis-dependent strand annealing", "native": "GO:0045003", "p_value": 0.011478258524511892, "parents": [ "GO:0000724" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.125, "significant": true, "source": "GO:BP", "term_size": 8, "source_order": 10462, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of NADP metabolic process.\" [GOC:TermGenie, PMID:23334421]", "effective_domain_size": 20972, "goshv": 30598, "intersection_size": 1, "intersections": [ [ "IMP" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of NADP metabolic process", "native": "GO:1902031", "p_value": 0.011478258524511892, "parents": [ "GO:0006739", "GO:1900542" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.125, "significant": true, "source": "GO:BP", "term_size": 8, "source_order": 20475, "group_id": 1 }, { "description": "\"Any process that increases the frequency, rate or extent of programmed necrotic cell death.\" [GOC:aruk, GOC:rph, PMID:27258785]", "effective_domain_size": 20972, "goshv": 24840, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "positive regulation of programmed necrotic cell death", "native": "GO:0062100", "p_value": 0.011478258524511892, "parents": [ "GO:0043068", "GO:0062098", "GO:0097300" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.125, "significant": true, "source": "GO:BP", "term_size": 8, "source_order": 14717, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of telomere capping.\" [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]", "effective_domain_size": 20972, "goshv": 32165, "intersection_size": 1, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of telomere capping", "native": "GO:1904354", "p_value": 0.011478258524511892, "parents": [ "GO:0016233", "GO:0032205", "GO:1904353" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.125, "significant": true, "source": "GO:BP", "term_size": 8, "source_order": 22042, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle checkpoint.\" [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116]", "effective_domain_size": 20972, "goshv": 30561, "intersection_size": 1, "intersections": [ [], [], [], [], [ "IEA" ], [], [], [], [], [], [] ], "name": "negative regulation of cell cycle checkpoint", "native": "GO:1901977", "p_value": 0.011478258524511892, "parents": [ "GO:0000075", "GO:1901976", "GO:1901989", "GO:1902532" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.125, "significant": true, "source": "GO:BP", "term_size": 8, "source_order": 20438, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of microRNA processing.\" [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]", "effective_domain_size": 20972, "goshv": 31776, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of miRNA processing", "native": "GO:1903799", "p_value": 0.011478258524511892, "parents": [ "GO:0010629", "GO:0035196", "GO:0060965", "GO:1903798" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.125, "significant": true, "source": "GO:BP", "term_size": 8, "source_order": 21653, "group_id": 1 }, { "description": "Interleukin-4 and Interleukin-13 signaling", "effective_domain_size": 11056, "goshv": 40627, "intersection_size": 2, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [ "REAC" ], [], [] ], "name": "Interleukin-4 and Interleukin-13 signaling", "native": "REAC:R-HSA-6785807", "p_value": 0.01151435037930236, "parents": [ "REAC:R-HSA-449147" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.018018018018018018, "significant": true, "source": "REAC", "term_size": 111, "source_order": 1303, "group_id": 39 }, { "description": "\"Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.\" [GOC:jid]", "effective_domain_size": 20972, "goshv": 22129, "intersection_size": 5, "intersections": [ [ "IMP", "ISS" ], [ "IMP" ], [ "IMP" ], [], [], [ "IMP" ], [], [], [], [ "IDA" ], [] ], "name": "positive regulation of response to stimulus", "native": "GO:0048584", "p_value": 0.011732242735707254, "parents": [ "GO:0048518", "GO:0048583", "GO:0050896" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.0021551724137931034, "significant": true, "source": "GO:BP", "term_size": 2320, "source_order": 12006, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22825, "intersection_size": 4, "intersections": [ [ "IDA", "IMP", "ISS", "NAS", "IEA" ], [], [], [], [], [ "IDA" ], [], [], [], [ "IMP" ], [ "IDA", "IMP" ] ], "name": "negative regulation of RNA metabolic process", "native": "GO:0051253", "p_value": 0.011827162818884764, "parents": [ "GO:0010605", "GO:0016070", "GO:0045934", "GO:0051252" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.0028797696184305254, "significant": true, "source": "GO:BP", "term_size": 1389, "source_order": 12702, "group_id": 1 }, { "description": "\"Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25949, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [], [], [ "TAS" ], [ "IMP", "TAS" ], [] ], "name": "regulation of protein serine/threonine kinase activity", "native": "GO:0071900", "p_value": 0.011910617318657758, "parents": [ "GO:0045859" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.010362694300518135, "significant": true, "source": "GO:BP", "term_size": 193, "source_order": 15826, "group_id": 1 }, { "description": "\"Any process that modulates a measurable attribute of any biological process, quality or function.\" [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]", "effective_domain_size": 20972, "goshv": 24907, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IGI", "IEP", "ISS", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IGI", "ISS", "IBA", "TAS", "IC", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IBA", "NAS", "IEA" ], [ "IDA", "NAS" ], [ "IDA", "IMP", "IGI", "IEP", "ISS", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ] ], "name": "biological regulation", "native": "GO:0065007", "p_value": 0.011910617318657758, "parents": [ "GO:0008150" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.000859106529209622, "significant": true, "source": "GO:BP", "term_size": 12804, "source_order": 14784, "group_id": 1 }, { "description": "\"The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.\" [GOC:ai, GOC:jl]", "effective_domain_size": 20972, "goshv": 10146, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [], [], [ "IMP" ], [], [], [], [], [], [] ], "name": "mitotic sister chromatid segregation", "native": "GO:0000070", "p_value": 0.011975671640317405, "parents": [ "GO:0000819", "GO:0140014", "GO:1903047" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.010309278350515464, "significant": true, "source": "GO:BP", "term_size": 194, "source_order": 23, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.\" [GOC:krc, GOC:mah]", "effective_domain_size": 20972, "goshv": 25684, "intersection_size": 2, "intersections": [ [ "IEP" ], [], [], [], [ "IEA" ], [], [], [], [], [], [] ], "name": "cellular response to xenobiotic stimulus", "native": "GO:0071466", "p_value": 0.011975671640317405, "parents": [ "GO:0009410", "GO:0070887" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.010309278350515464, "significant": true, "source": "GO:BP", "term_size": 194, "source_order": 15561, "group_id": 1 }, { "description": "\"An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation.\" [PMID:22243696]", "effective_domain_size": 20972, "goshv": 20987, "intersection_size": 2, "intersections": [ [], [], [], [ "ISS", "IEA" ], [], [ "IMP", "IEA" ], [], [], [], [], [] ], "name": "negative regulation of gene expression, epigenetic", "native": "GO:0045814", "p_value": 0.012068438518618033, "parents": [ "GO:0010629", "GO:0040029" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.010256410256410256, "significant": true, "source": "GO:BP", "term_size": 195, "source_order": 10864, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25595, "intersection_size": 2, "intersections": [ [ "IGI" ], [], [], [], [], [ "IMP" ], [], [], [], [], [] ], "name": "cellular response to tumor necrosis factor", "native": "GO:0071356", "p_value": 0.012404344845151844, "parents": [ "GO:0034612", "GO:0071345" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.010101010101010102, "significant": true, "source": "GO:BP", "term_size": 198, "source_order": 15472, "group_id": 9 }, { "description": "\"The aggregation, arrangement and bonding together of a cellular component.\" [GOC:isa_complete]", "effective_domain_size": 20972, "goshv": 16303, "intersection_size": 7, "intersections": [ [ "IDA", "IEA" ], [ "IMP", "IC" ], [ "IMP" ], [], [ "IDA", "IMP" ], [ "NAS", "IEA" ], [], [ "IMP", "IBA" ], [], [], [ "IDA" ] ], "name": "cellular component assembly", "native": "GO:0022607", "p_value": 0.012420199945428246, "parents": [ "GO:0016043", "GO:0044085" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.0014492753623188406, "significant": true, "source": "GO:BP", "term_size": 4830, "source_order": 6180, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 21537, "intersection_size": 1, "intersections": [ [], [], [], [ "IDA" ], [], [], [], [], [], [], [] ], "name": "regulation of mitotic centrosome separation", "native": "GO:0046602", "p_value": 0.012500122985799961, "parents": [ "GO:0007100", "GO:0010564" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.1111111111111111, "significant": true, "source": "GO:BP", "term_size": 9, "source_order": 11414, "group_id": 1 }, { "description": "\"The phosphorylation by a protein of one or more of its own serine amino acid residues, or a serine residue on an identical protein.\" [GOC:pm]", "effective_domain_size": 20972, "goshv": 19042, "intersection_size": 1, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [], [], [] ], "name": "peptidyl-serine autophosphorylation", "native": "GO:0036289", "p_value": 0.012500122985799961, "parents": [ "GO:0018105", "GO:0046777" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.1111111111111111, "significant": true, "source": "GO:BP", "term_size": 9, "source_order": 8919, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz).\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25699, "intersection_size": 1, "intersections": [ [], [ "IDA" ], [], [], [], [], [], [], [], [], [] ], "name": "cellular response to X-ray", "native": "GO:0071481", "p_value": 0.012500122985799961, "parents": [ "GO:0010165", "GO:0071479" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.1111111111111111, "significant": true, "source": "GO:BP", "term_size": 9, "source_order": 15576, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17649, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [ "IMP" ], [] ], "name": "negative regulation of peptidyl-serine phosphorylation", "native": "GO:0033137", "p_value": 0.012500122985799961, "parents": [ "GO:0001933", "GO:0018105", "GO:0033135" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.1111111111111111, "significant": true, "source": "GO:BP", "term_size": 9, "source_order": 7526, "group_id": 1 }, { "description": "\"The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure.\" [GOC:add, ISBN:0781735149]", "effective_domain_size": 20972, "goshv": 22094, "intersection_size": 1, "intersections": [ [ "IMP" ], [], [], [], [], [], [], [], [], [], [] ], "name": "bone marrow development", "native": "GO:0048539", "p_value": 0.012500122985799961, "parents": [ "GO:0009888", "GO:0048534", "GO:0060348" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.1111111111111111, "significant": true, "source": "GO:BP", "term_size": 9, "source_order": 11971, "group_id": 1 }, { "description": "\"A process in which RNA is transported to, or maintained in, a specific location.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 12179, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [ "IMP" ], [], [], [], [], [], [], [], [] ], "name": "RNA localization", "native": "GO:0006403", "p_value": 0.012570792508238683, "parents": [ "GO:0033036" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.009950248756218905, "significant": true, "source": "GO:BP", "term_size": 201, "source_order": 2056, "group_id": 2 }, { "description": "\"The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.\" [GOC:add, GOC:dph]", "effective_domain_size": 20972, "goshv": 11123, "intersection_size": 2, "intersections": [ [ "IMP" ], [ "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "immune system development", "native": "GO:0002520", "p_value": 0.013032931576109647, "parents": [ "GO:0002376", "GO:0048731" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.00975609756097561, "significant": true, "source": "GO:BP", "term_size": 205, "source_order": 1000, "group_id": 1 }, { "description": "Sensing of DNA Double Strand Breaks", "effective_domain_size": 11056, "goshv": 41616, "intersection_size": 1, "intersections": [ [], [ "REAC" ], [], [], [], [], [], [], [], [], [] ], "name": "Sensing of DNA Double Strand Breaks", "native": "REAC:R-HSA-5693548", "p_value": 0.013103473051434646, "parents": [ "REAC:R-HSA-5693606" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.16666666666666666, "significant": true, "source": "REAC", "term_size": 6, "source_order": 2292, "group_id": 28 }, { "description": "\"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22786, "intersection_size": 3, "intersections": [ [ "IMP" ], [], [], [], [], [], [], [], [ "IDA", "IMP", "TAS" ], [ "IMP", "TAS" ], [] ], "name": "regulation of phosphorus metabolic process", "native": "GO:0051174", "p_value": 0.013278305165137283, "parents": [ "GO:0006793", "GO:0019222" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.004273504273504274, "significant": true, "source": "GO:BP", "term_size": 702, "source_order": 12663, "group_id": 1 }, { "description": "Oxidative Stress Induced Senescence", "effective_domain_size": 11056, "goshv": 41045, "intersection_size": 2, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [], [], [ "REAC" ] ], "name": "Oxidative Stress Induced Senescence", "native": "REAC:R-HSA-2559580", "p_value": 0.01354977878372859, "parents": [ "REAC:R-HSA-2559583" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.01639344262295082, "significant": true, "source": "REAC", "term_size": 122, "source_order": 1721, "group_id": 29 }, { "description": "\"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hypoxia (lowered oxygen tension). Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. The pathway ends when the execution phase of apoptosis is triggered.\" [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, PMID:20436456]", "effective_domain_size": 20972, "goshv": 33374, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "intrinsic apoptotic signaling pathway in response to hypoxia", "native": "GO:1990144", "p_value": 0.013668751018815341, "parents": [ "GO:0071456", "GO:0097193" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.1, "significant": true, "source": "GO:BP", "term_size": 10, "source_order": 23251, "group_id": 1 }, { "description": "\"The 5' to 3' exonucleolytic resection of DNA at the site of a stalled replication fork that contributes to replication fork processing.\" [GOC:mah, PMID:28475874]", "effective_domain_size": 20972, "goshv": 28217, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "NAS" ], [], [], [], [], [] ], "name": "DNA strand resection involved in replication fork processing", "native": "GO:0110025", "p_value": 0.013668751018815341, "parents": [ "GO:0006259", "GO:0031297" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.1, "significant": true, "source": "GO:BP", "term_size": 10, "source_order": 18094, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.\" [PMID:15925705]", "effective_domain_size": 20972, "goshv": 22909, "intersection_size": 1, "intersections": [ [], [ "IDA" ], [], [], [], [], [], [], [], [], [] ], "name": "response to nitrosative stress", "native": "GO:0051409", "p_value": 0.013668751018815341, "parents": [ "GO:0006950" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.1, "significant": true, "source": "GO:BP", "term_size": 10, "source_order": 12786, "group_id": 1 }, { "description": "\"The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.\" [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]", "effective_domain_size": 20972, "goshv": 13752, "intersection_size": 2, "intersections": [ [ "IEA" ], [ "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "anterior/posterior pattern specification", "native": "GO:0009952", "p_value": 0.013668751018815341, "parents": [ "GO:0003002" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.009478672985781991, "significant": true, "source": "GO:BP", "term_size": 211, "source_order": 3629, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 22523, "intersection_size": 5, "intersections": [ [ "IEA" ], [], [], [], [], [ "IMP" ], [], [], [ "ISS", "IEA" ], [ "IEA" ], [ "IEA" ] ], "name": "regulation of developmental process", "native": "GO:0050793", "p_value": 0.013730059100028695, "parents": [ "GO:0032502", "GO:0050789" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.0020567667626491155, "significant": true, "source": "GO:BP", "term_size": 2431, "source_order": 12400, "group_id": 1 }, { "description": "\"The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex.\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 24905, "intersection_size": 2, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [ "IMP", "IBA" ], [], [], [] ], "name": "protein-DNA complex assembly", "native": "GO:0065004", "p_value": 0.01382199232844272, "parents": [ "GO:0065003", "GO:0071824" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.009389671361502348, "significant": true, "source": "GO:BP", "term_size": 213, "source_order": 14782, "group_id": 1 }, { "description": "KEAP1-NFE2L2 pathway", "effective_domain_size": 11056, "goshv": 40657, "intersection_size": 2, "intersections": [ [], [], [], [], [], [ "REAC" ], [], [], [ "REAC" ], [], [] ], "name": "KEAP1-NFE2L2 pathway", "native": "REAC:R-HSA-9755511", "p_value": 0.013840181340094512, "parents": [ "REAC:R-HSA-9711123" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.016129032258064516, "significant": true, "source": "REAC", "term_size": 124, "source_order": 1333, "group_id": 29 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 18238, "intersection_size": 2, "intersections": [ [ "IGI" ], [], [], [], [], [ "IMP" ], [], [], [], [], [] ], "name": "response to tumor necrosis factor", "native": "GO:0034612", "p_value": 0.014171328818370788, "parents": [ "GO:0034097" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.009259259259259259, "significant": true, "source": "GO:BP", "term_size": 216, "source_order": 8115, "group_id": 9 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 19723, "intersection_size": 2, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [], [ "IMP", "IEA" ], [], [] ], "name": "response to starvation", "native": "GO:0042594", "p_value": 0.014267428103492626, "parents": [ "GO:0006950", "GO:0031667" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.009216589861751152, "significant": true, "source": "GO:BP", "term_size": 217, "source_order": 9600, "group_id": 1 }, { "description": "\"The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.\" [GOC:hjd, UBERON:0001981]", "effective_domain_size": 20972, "goshv": 10464, "intersection_size": 3, "intersections": [ [], [], [], [], [], [ "IMP" ], [], [], [], [ "IEA" ], [ "IEA" ] ], "name": "blood vessel development", "native": "GO:0001568", "p_value": 0.014336743167145186, "parents": [ "GO:0001944", "GO:0048856" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.0041265474552957355, "significant": true, "source": "GO:BP", "term_size": 727, "source_order": 341, "group_id": 1 }, { "description": "\"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.\" [GOC:isa_complete]", "effective_domain_size": 20972, "goshv": 17240, "intersection_size": 8, "intersections": [ [ "IMP", "IEA" ], [ "ISS", "IEA" ], [], [ "IEA" ], [], [ "IMP", "IBA", "IEA" ], [ "IDA", "IEA" ], [], [ "ISS", "IEA" ], [ "IEA" ], [ "IEA" ] ], "name": "developmental process", "native": "GO:0032502", "p_value": 0.014336743167145186, "parents": [ "GO:0008150" ], "precision": 0.7272727272727273, "query": "query_1", "query_size": 11, "recall": 0.001224177505738332, "significant": true, "source": "GO:BP", "term_size": 6535, "source_order": 7117, "group_id": 1 }, { "description": "\"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix that contributes to reciprocal meiotic recombination.\" [GOC:mah, PMID:15238514]", "effective_domain_size": 20972, "goshv": 33611, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [ "IEA" ], [], [], [] ], "name": "double-strand break repair involved in meiotic recombination", "native": "GO:1990918", "p_value": 0.014639902552719308, "parents": [ "GO:0006302", "GO:0007131", "GO:1903046" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.09090909090909091, "significant": true, "source": "GO:BP", "term_size": 11, "source_order": 23488, "group_id": 1 }, { "description": "\"The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA).\" [GOC:dgf, GOC:krc, PMID:17179095, PMID:17855393]", "effective_domain_size": 20972, "goshv": 25433, "intersection_size": 1, "intersections": [ [], [ "IDA" ], [], [], [], [], [], [], [], [], [] ], "name": "histone mRNA catabolic process", "native": "GO:0071044", "p_value": 0.014639902552719308, "parents": [ "GO:0000956", "GO:0008334" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.09090909090909091, "significant": true, "source": "GO:BP", "term_size": 11, "source_order": 15310, "group_id": 10 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 26465, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [ "IEA" ], [], [], [] ], "name": "cellular response to hydroxyurea", "native": "GO:0072711", "p_value": 0.014639902552719308, "parents": [ "GO:0072710", "GO:1901699" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.09090909090909091, "significant": true, "source": "GO:BP", "term_size": 11, "source_order": 16342, "group_id": 1 }, { "description": "\"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).\" [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]", "effective_domain_size": 20972, "goshv": 12902, "intersection_size": 3, "intersections": [ [ "IEA" ], [ "IEA" ], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "brain development", "native": "GO:0007420", "p_value": 0.014639902552719308, "parents": [ "GO:0007417", "GO:0048513", "GO:0060322" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.004076086956521739, "significant": true, "source": "GO:BP", "term_size": 736, "source_order": 2779, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 12890, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of neuroblast proliferation", "native": "GO:0007406", "p_value": 0.014639902552719308, "parents": [ "GO:0007405", "GO:0050768", "GO:1902692", "GO:2000178" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.09090909090909091, "significant": true, "source": "GO:BP", "term_size": 11, "source_order": 2767, "group_id": 1 }, { "description": "\"The series of molecular signals initiated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB.\" [PMID:10390516]", "effective_domain_size": 20972, "goshv": 12596, "intersection_size": 1, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "ER overload response", "native": "GO:0006983", "p_value": 0.014639902552719308, "parents": [ "GO:0006984", "GO:0034976", "GO:0071216" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.09090909090909091, "significant": true, "source": "GO:BP", "term_size": 11, "source_order": 2473, "group_id": 1 }, { "description": "\"The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.\" [GOC:ems, ISBN:0198506732]", "effective_domain_size": 20972, "goshv": 13170, "intersection_size": 2, "intersections": [ [], [ "IEA" ], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "gonad development", "native": "GO:0008406", "p_value": 0.015267270064303696, "parents": [ "GO:0045137", "GO:0048513", "GO:0048608" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.00881057268722467, "significant": true, "source": "GO:BP", "term_size": 227, "source_order": 3047, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.\" [GOC:mtg_apoptosis]", "effective_domain_size": 20972, "goshv": 34598, "intersection_size": 2, "intersections": [ [], [], [], [], [], [ "IMP" ], [], [], [], [], [ "IMP" ] ], "name": "negative regulation of apoptotic signaling pathway", "native": "GO:2001234", "p_value": 0.015364643357950777, "parents": [ "GO:0009968", "GO:0043066", "GO:0097190", "GO:2001233" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.008771929824561403, "significant": true, "source": "GO:BP", "term_size": 228, "source_order": 24475, "group_id": 1 }, { "description": "\"The cell cycle process in which the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in progression through meiosis and precedes synapsis.\" [GOC:vw, PMID:10690419]", "effective_domain_size": 20972, "goshv": 20660, "intersection_size": 1, "intersections": [ [], [ "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "meiotic telomere clustering", "native": "GO:0045141", "p_value": 0.015365729111640958, "parents": [ "GO:0034397", "GO:0070192", "GO:0090220" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.08333333333333333, "significant": true, "source": "GO:BP", "term_size": 12, "source_order": 10537, "group_id": 1 }, { "description": "\"Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.\" [GOC:dph, GOC:mtg_apoptosis, GOC:tb]", "effective_domain_size": 20972, "goshv": 14247, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "positive regulation of cardiac muscle cell apoptotic process", "native": "GO:0010666", "p_value": 0.015365729111640958, "parents": [ "GO:0010659", "GO:0010663", "GO:0010665" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.08333333333333333, "significant": true, "source": "GO:BP", "term_size": 12, "source_order": 4124, "group_id": 1 }, { "description": "\"Any process that decreases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 14353, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "NAS" ], [], [], [], [], [] ], "name": "negative regulation of centrosome duplication", "native": "GO:0010826", "p_value": 0.015365729111640958, "parents": [ "GO:0010824", "GO:0046606", "GO:0051298" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.08333333333333333, "significant": true, "source": "GO:BP", "term_size": 12, "source_order": 4230, "group_id": 1 }, { "description": "\"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22544, "intersection_size": 2, "intersections": [ [ "IEA" ], [], [], [], [ "IDA" ], [], [], [], [], [], [] ], "name": "protein stabilization", "native": "GO:0050821", "p_value": 0.015365729111640958, "parents": [ "GO:0031647" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.008695652173913044, "significant": true, "source": "GO:BP", "term_size": 230, "source_order": 12421, "group_id": 4 }, { "description": "\"The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 20658, "intersection_size": 2, "intersections": [ [], [ "IEA" ], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "development of primary sexual characteristics", "native": "GO:0045137", "p_value": 0.015365729111640958, "parents": [ "GO:0003006", "GO:0007275", "GO:0007548" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.008620689655172414, "significant": true, "source": "GO:BP", "term_size": 232, "source_order": 10535, "group_id": 1 }, { "description": "\"The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.\" [GOC:dph, UBERON:0002409]", "effective_domain_size": 20972, "goshv": 10665, "intersection_size": 3, "intersections": [ [], [], [], [], [], [ "IMP" ], [], [], [], [ "IEA" ], [ "IEA" ] ], "name": "vasculature development", "native": "GO:0001944", "p_value": 0.015365729111640958, "parents": [ "GO:0048731", "GO:0072359" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.00395778364116095, "significant": true, "source": "GO:BP", "term_size": 758, "source_order": 542, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 26464, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [ "IEA" ], [], [], [] ], "name": "response to hydroxyurea", "native": "GO:0072710", "p_value": 0.015365729111640958, "parents": [ "GO:1901698" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.08333333333333333, "significant": true, "source": "GO:BP", "term_size": 12, "source_order": 16341, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25711, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "ISS", "IEA" ], [], [] ], "name": "cellular response to UV-B", "native": "GO:0071493", "p_value": 0.015365729111640958, "parents": [ "GO:0010224", "GO:0034644" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.08333333333333333, "significant": true, "source": "GO:BP", "term_size": 12, "source_order": 15588, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of mitophagy.\" [GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 30258, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of mitophagy", "native": "GO:1901525", "p_value": 0.015365729111640958, "parents": [ "GO:0000423", "GO:0016242", "GO:1901524", "GO:1903147" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.08333333333333333, "significant": true, "source": "GO:BP", "term_size": 12, "source_order": 20135, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrion degradation by autophagy.\" [GO_REF:0000058, GOC:autophagy, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24600391]", "effective_domain_size": 20972, "goshv": 31338, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of autophagy of mitochondrion", "native": "GO:1903147", "p_value": 0.015365729111640958, "parents": [ "GO:0000422", "GO:0010507", "GO:1903146" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.08333333333333333, "significant": true, "source": "GO:BP", "term_size": 12, "source_order": 21215, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of the centrosome cycle.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 21541, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "NAS" ], [], [], [], [], [] ], "name": "negative regulation of centrosome cycle", "native": "GO:0046606", "p_value": 0.015365729111640958, "parents": [ "GO:0007098", "GO:0010948", "GO:0046605", "GO:0051494" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.08333333333333333, "significant": true, "source": "GO:BP", "term_size": 12, "source_order": 11418, "group_id": 1 }, { "description": "\"The controlled breakdown of the nuclear membranes, for example during cellular division.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22730, "intersection_size": 1, "intersections": [ [], [], [ "IDA" ], [], [], [], [], [], [], [], [] ], "name": "nuclear membrane disassembly", "native": "GO:0051081", "p_value": 0.015365729111640958, "parents": [ "GO:0030397", "GO:0071763" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.08333333333333333, "significant": true, "source": "GO:BP", "term_size": 12, "source_order": 12607, "group_id": 1 }, { "description": "\"Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.\" [GOC:dph, GOC:mtg_apoptosis, GOC:tb]", "effective_domain_size": 20972, "goshv": 14244, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "positive regulation of striated muscle cell apoptotic process", "native": "GO:0010663", "p_value": 0.015365729111640958, "parents": [ "GO:0010658", "GO:0010661", "GO:0010662" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.08333333333333333, "significant": true, "source": "GO:BP", "term_size": 12, "source_order": 4121, "group_id": 1 }, { "description": "\"The directed movement of a protein to a specific location in the telomeric region of a chromosome.\" [GOC:BHF, GOC:mah]", "effective_domain_size": 20972, "goshv": 24999, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [ "IDA", "IEA" ], [], [], [], [] ], "name": "establishment of protein localization to telomere", "native": "GO:0070200", "p_value": 0.015365729111640958, "parents": [ "GO:0070199" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.08333333333333333, "significant": true, "source": "GO:BP", "term_size": 12, "source_order": 14876, "group_id": 2 }, { "description": "\"The directed movement of a chromosome to the nuclear envelope that contributes to homologous chromosome segregation and precedes synapsis.\" [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:19913287]", "effective_domain_size": 20972, "goshv": 27039, "intersection_size": 1, "intersections": [ [], [ "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "chromosome localization to nuclear envelope involved in homologous chromosome segregation", "native": "GO:0090220", "p_value": 0.015365729111640958, "parents": [ "GO:0045143", "GO:0050000" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.08333333333333333, "significant": true, "source": "GO:BP", "term_size": 12, "source_order": 16916, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of cellular senescence.\" [GOC:BHF]", "effective_domain_size": 20972, "goshv": 34253, "intersection_size": 1, "intersections": [ [ "IDA", "ISS", "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "positive regulation of cellular senescence", "native": "GO:2000774", "p_value": 0.015365729111640958, "parents": [ "GO:0048522", "GO:0090398", "GO:2000772" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.08333333333333333, "significant": true, "source": "GO:BP", "term_size": 12, "source_order": 24130, "group_id": 1 }, { "description": "\"Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25907, "intersection_size": 2, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [ "IMP", "IBA" ], [], [], [] ], "name": "protein-DNA complex organization", "native": "GO:0071824", "p_value": 0.01540218797204171, "parents": [ "GO:0043933" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.008583690987124463, "significant": true, "source": "GO:BP", "term_size": 233, "source_order": 15784, "group_id": 1 }, { "description": "\"A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.\" [GOC:jl, GOC:mah]", "effective_domain_size": 20972, "goshv": 20334, "intersection_size": 7, "intersections": [ [ "IDA", "IEA" ], [ "IMP", "IC" ], [ "IMP" ], [], [ "IDA", "IMP" ], [ "NAS", "IEA" ], [], [ "IMP", "IBA" ], [], [], [ "IDA" ] ], "name": "cellular component biogenesis", "native": "GO:0044085", "p_value": 0.01540218797204171, "parents": [ "GO:0071840" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.00137524557956778, "significant": true, "source": "GO:BP", "term_size": 5090, "source_order": 10211, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 18232, "intersection_size": 2, "intersections": [ [ "IMP" ], [ "IDA" ], [], [], [], [], [], [], [], [], [] ], "name": "cellular response to oxidative stress", "native": "GO:0034599", "p_value": 0.01540218797204171, "parents": [ "GO:0006979", "GO:0062197" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.008583690987124463, "significant": true, "source": "GO:BP", "term_size": 233, "source_order": 8109, "group_id": 1 }, { "description": "\"The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.\" [GOC:ai, GOC:elh]", "effective_domain_size": 20972, "goshv": 10352, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [], [], [ "IMP" ], [], [], [], [], [], [] ], "name": "sister chromatid segregation", "native": "GO:0000819", "p_value": 0.015616029087222575, "parents": [ "GO:0051276", "GO:0098813" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.00851063829787234, "significant": true, "source": "GO:BP", "term_size": 235, "source_order": 229, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus.\" [GOC:pr, PMID:24014527]", "effective_domain_size": 20972, "goshv": 27486, "intersection_size": 2, "intersections": [ [], [], [], [], [], [ "IDA" ], [], [ "IDA" ], [], [], [] ], "name": "response to alcohol", "native": "GO:0097305", "p_value": 0.01593826665347271, "parents": [ "GO:1901700" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.008403361344537815, "significant": true, "source": "GO:BP", "term_size": 238, "source_order": 17363, "group_id": 1 }, { "description": "\"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 12628, "intersection_size": 2, "intersections": [ [], [ "IC" ], [], [], [ "IDA" ], [], [], [], [], [], [] ], "name": "vacuole organization", "native": "GO:0007033", "p_value": 0.01593826665347271, "parents": [ "GO:0006996" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.008403361344537815, "significant": true, "source": "GO:BP", "term_size": 238, "source_order": 2505, "group_id": 1 }, { "description": "\"Any process that modulates the activity of an enzyme.\" [GOC:ai, GOC:ebc, GOC:vw]", "effective_domain_size": 20972, "goshv": 22521, "intersection_size": 3, "intersections": [ [ "TAS" ], [], [], [], [], [], [], [], [ "IDA", "IMP", "TAS" ], [ "IMP", "TAS" ], [] ], "name": "regulation of catalytic activity", "native": "GO:0050790", "p_value": 0.01596244487315486, "parents": [ "GO:0065009" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.003875968992248062, "significant": true, "source": "GO:BP", "term_size": 774, "source_order": 12398, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of lymphocyte proliferation.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22468, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [ "IEA" ], [], [] ], "name": "regulation of lymphocyte proliferation", "native": "GO:0050670", "p_value": 0.016002044575750808, "parents": [ "GO:0032944", "GO:0046651", "GO:0051249" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.008368200836820083, "significant": true, "source": "GO:BP", "term_size": 239, "source_order": 12345, "group_id": 1 }, { "description": "\"A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.\" [GOC:curators, ISBN:0198547684]", "effective_domain_size": 20972, "goshv": 13217, "intersection_size": 10, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "NAS", "IEA" ], [ "IDA", "IMP", "IGI", "ISS", "IEA" ], [ "ISS" ], [ "ISS", "IEA" ], [ "IDA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IBA" ], [], [ "IMP", "IEA" ], [ "IMP" ], [ "IDA", "IMP", "IEA" ] ], "name": "biosynthetic process", "native": "GO:0009058", "p_value": 0.016046173420995086, "parents": [ "GO:0008152" ], "precision": 0.9090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0009399379640943697, "significant": true, "source": "GO:BP", "term_size": 10639, "source_order": 3094, "group_id": 1 }, { "description": "\"Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons.\" [GOC:go_curators, GOC:mtg_apoptosis]", "effective_domain_size": 20972, "goshv": 20195, "intersection_size": 2, "intersections": [ [ "IEA" ], [ "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "regulation of neuron apoptotic process", "native": "GO:0043523", "p_value": 0.016065784899330252, "parents": [ "GO:0042981", "GO:0051402" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.008333333333333333, "significant": true, "source": "GO:BP", "term_size": 240, "source_order": 10072, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of signal transduction.\" [GOC:sm]", "effective_domain_size": 20972, "goshv": 13767, "intersection_size": 4, "intersections": [ [ "IMP", "ISS" ], [ "IMP" ], [ "IMP" ], [], [], [], [], [], [], [ "IDA" ], [] ], "name": "positive regulation of signal transduction", "native": "GO:0009967", "p_value": 0.01607540757979377, "parents": [ "GO:0007165", "GO:0009966", "GO:0010647", "GO:0023056", "GO:0048584" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.0025493945188017845, "significant": true, "source": "GO:BP", "term_size": 1569, "source_order": 3644, "group_id": 1 }, { "description": "\"Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on either the paternal or maternal X-chromosome in the XX sex.\" [GOC:dph, GOC:sdb_2009, GOC:tb, PMID:32189388]", "effective_domain_size": 20972, "goshv": 24055, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "IEA" ], [], [], [], [], [] ], "name": "random inactivation of X chromosome", "native": "GO:0060816", "p_value": 0.016168680091227888, "parents": [ "GO:0009048" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.07692307692307693, "significant": true, "source": "GO:BP", "term_size": 13, "source_order": 13932, "group_id": 1 }, { "description": "\"Any process in which a telomere is transported to, and/or maintained in, a specific location.\" [GOC:mah, GOC:vw]", "effective_domain_size": 20972, "goshv": 18165, "intersection_size": 1, "intersections": [ [], [ "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "telomere localization", "native": "GO:0034397", "p_value": 0.016168680091227888, "parents": [ "GO:0050000" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.07692307692307693, "significant": true, "source": "GO:BP", "term_size": 13, "source_order": 8042, "group_id": 1 }, { "description": "\"The controlled breakdown of any cell membrane in the context of a normal process such as autophagy.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 16472, "intersection_size": 1, "intersections": [ [], [], [ "IDA" ], [], [], [], [], [], [], [], [] ], "name": "membrane disassembly", "native": "GO:0030397", "p_value": 0.016168680091227888, "parents": [ "GO:0022411", "GO:0061024" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.07692307692307693, "significant": true, "source": "GO:BP", "term_size": 13, "source_order": 6349, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of mononuclear cell proliferation.\" [GOC:add]", "effective_domain_size": 20972, "goshv": 17540, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [ "IEA" ], [], [] ], "name": "regulation of mononuclear cell proliferation", "native": "GO:0032944", "p_value": 0.016289755631966142, "parents": [ "GO:0032943", "GO:0070663" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.00823045267489712, "significant": true, "source": "GO:BP", "term_size": 243, "source_order": 7417, "group_id": 1 }, { "description": "\"The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body.\" [GOC:dph]", "effective_domain_size": 20972, "goshv": 23667, "intersection_size": 3, "intersections": [ [ "IEA" ], [ "IEA" ], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "head development", "native": "GO:0060322", "p_value": 0.01641363274631344, "parents": [ "GO:0048856" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.0038119440914866584, "significant": true, "source": "GO:BP", "term_size": 787, "source_order": 13544, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.\" [GOC:mah, GOC:tb]", "effective_domain_size": 20972, "goshv": 16823, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [], [], [ "IMP" ], [ "IMP" ], [] ], "name": "negative regulation of protein modification process", "native": "GO:0031400", "p_value": 0.01661357379293572, "parents": [ "GO:0031399", "GO:0036211", "GO:0051248" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.008130081300813009, "significant": true, "source": "GO:BP", "term_size": 246, "source_order": 6700, "group_id": 1 }, { "description": "\"The process in which a precursor cell type acquires the specialized features of an immature B cell.\" [GOC:jal, ISBN:0781735149, PMID:16551251]", "effective_domain_size": 20972, "goshv": 10943, "intersection_size": 1, "intersections": [ [], [ "ISS", "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "immature B cell differentiation", "native": "GO:0002327", "p_value": 0.017095552031688145, "parents": [ "GO:0030183" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.07142857142857142, "significant": true, "source": "GO:BP", "term_size": 14, "source_order": 820, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 16932, "intersection_size": 2, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [], [ "IMP", "IEA" ], [], [] ], "name": "cellular response to nutrient levels", "native": "GO:0031669", "p_value": 0.017095552031688145, "parents": [ "GO:0031667", "GO:0051716" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.008, "significant": true, "source": "GO:BP", "term_size": 250, "source_order": 6809, "group_id": 1 }, { "description": "\"Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.\" [ISBN:0815316194]", "effective_domain_size": 20972, "goshv": 12672, "intersection_size": 1, "intersections": [ [], [], [], [ "IDA" ], [], [], [], [], [], [], [] ], "name": "mitotic centrosome separation", "native": "GO:0007100", "p_value": 0.017095552031688145, "parents": [ "GO:0051299", "GO:0140014", "GO:1903047" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.07142857142857142, "significant": true, "source": "GO:BP", "term_size": 14, "source_order": 2549, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17658, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "IMP" ], [], [], [], [], [] ], "name": "negative regulation of intracellular estrogen receptor signaling pathway", "native": "GO:0033147", "p_value": 0.017095552031688145, "parents": [ "GO:0030520", "GO:0033144", "GO:0033146" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.07142857142857142, "significant": true, "source": "GO:BP", "term_size": 14, "source_order": 7535, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of telomere capping.\" [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]", "effective_domain_size": 20972, "goshv": 32164, "intersection_size": 1, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [], [], [] ], "name": "regulation of telomere capping", "native": "GO:1904353", "p_value": 0.017095552031688145, "parents": [ "GO:0016233", "GO:0032204" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.07142857142857142, "significant": true, "source": "GO:BP", "term_size": 14, "source_order": 22041, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of microRNA processing.\" [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]", "effective_domain_size": 20972, "goshv": 31775, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of miRNA processing", "native": "GO:1903798", "p_value": 0.017095552031688145, "parents": [ "GO:0035196", "GO:0070920" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.07142857142857142, "significant": true, "source": "GO:BP", "term_size": 14, "source_order": 21652, "group_id": 1 }, { "description": "\"A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.\" [GOC:mgi_curators, ISBN:0781735149]", "effective_domain_size": 20972, "goshv": 21571, "intersection_size": 3, "intersections": [ [ "IEA" ], [ "IMP", "ISS", "IEA" ], [], [], [], [], [], [], [ "IEA" ], [], [] ], "name": "lymphocyte activation", "native": "GO:0046649", "p_value": 0.017554530114360943, "parents": [ "GO:0045321" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.0036991368680641184, "significant": true, "source": "GO:BP", "term_size": 811, "source_order": 11448, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of regulatory non-coding RNA processing.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25366, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of regulatory ncRNA processing", "native": "GO:0070920", "p_value": 0.017918870174528458, "parents": [ "GO:0060966", "GO:0070918", "GO:0080090" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.06666666666666667, "significant": true, "source": "GO:BP", "term_size": 15, "source_order": 15243, "group_id": 1 }, { "description": "\"The chemical reactions and pathways involving lactate, the anion of lactic acid.\" [ISBN:0198547684]", "effective_domain_size": 20972, "goshv": 11974, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "lactate metabolic process", "native": "GO:0006089", "p_value": 0.017918870174528458, "parents": [ "GO:0032787" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.06666666666666667, "significant": true, "source": "GO:BP", "term_size": 15, "source_order": 1851, "group_id": 1 }, { "description": "\"Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome.\" [GOC:BHF, GOC:mah]", "effective_domain_size": 20972, "goshv": 24997, "intersection_size": 1, "intersections": [ [], [], [ "IMP" ], [], [], [], [], [], [], [], [] ], "name": "protein localization to chromosome, telomeric region", "native": "GO:0070198", "p_value": 0.017918870174528458, "parents": [ "GO:0034502" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.06666666666666667, "significant": true, "source": "GO:BP", "term_size": 15, "source_order": 14874, "group_id": 18 }, { "description": "\"A process that decreases the rate, frequency, or extent of gene silencing by a microRNA (miRNA).\" [GOC:aruk, GOC:bc, GOC:dph, GOC:rl, GOC:tb, PMID:23985560, PMID:28379604]", "effective_domain_size": 20972, "goshv": 24165, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of miRNA-mediated gene silencing", "native": "GO:0060965", "p_value": 0.017918870174528458, "parents": [ "GO:0035195", "GO:0060964", "GO:1900369" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.06666666666666667, "significant": true, "source": "GO:BP", "term_size": 15, "source_order": 14042, "group_id": 1 }, { "description": "\"Any process that stops or decreases the rate or extent of glial cell proliferation.\" [GOC:dph, GOC:sl, GOC:tb]", "effective_domain_size": 20972, "goshv": 23608, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of glial cell proliferation", "native": "GO:0060253", "p_value": 0.017918870174528458, "parents": [ "GO:0008285", "GO:0014009", "GO:0014014", "GO:0060251" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.06666666666666667, "significant": true, "source": "GO:BP", "term_size": 15, "source_order": 13485, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 20191, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [], [ "IDA" ] ], "name": "negative regulation of DNA damage response, signal transduction by p53 class mediator", "native": "GO:0043518", "p_value": 0.017918870174528458, "parents": [ "GO:0030330", "GO:0043516", "GO:1901797" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.06666666666666667, "significant": true, "source": "GO:BP", "term_size": 15, "source_order": 10068, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process.\" [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]", "effective_domain_size": 20972, "goshv": 25020, "intersection_size": 1, "intersections": [ [ "ISS", "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "positive regulation of T cell apoptotic process", "native": "GO:0070234", "p_value": 0.017918870174528458, "parents": [ "GO:0070230", "GO:0070231", "GO:0070232" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.06666666666666667, "significant": true, "source": "GO:BP", "term_size": 15, "source_order": 14897, "group_id": 1 }, { "description": "\"Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 26925, "intersection_size": 2, "intersections": [ [], [], [], [], [ "IEA" ], [], [], [], [], [], [ "IEA" ] ], "name": "positive regulation of cell cycle process", "native": "GO:0090068", "p_value": 0.017918870174528458, "parents": [ "GO:0010564", "GO:0022402", "GO:0045787" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.007722007722007722, "significant": true, "source": "GO:BP", "term_size": 259, "source_order": 16802, "group_id": 1 }, { "description": "\"The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.\" [ISBN:0198506732]", "effective_domain_size": 20972, "goshv": 19478, "intersection_size": 1, "intersections": [ [], [ "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "lipoprotein catabolic process", "native": "GO:0042159", "p_value": 0.017918870174528458, "parents": [ "GO:0030163", "GO:0042157" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.06666666666666667, "significant": true, "source": "GO:BP", "term_size": 15, "source_order": 9355, "group_id": 1 }, { "description": "\"Any process that modulates the occurrence or rate of thymocyte death by apoptotic process.\" [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]", "effective_domain_size": 20972, "goshv": 25029, "intersection_size": 1, "intersections": [ [ "ISS", "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of thymocyte apoptotic process", "native": "GO:0070243", "p_value": 0.017918870174528458, "parents": [ "GO:0070232", "GO:0070242" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.06666666666666667, "significant": true, "source": "GO:BP", "term_size": 15, "source_order": 14906, "group_id": 1 }, { "description": "\"The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.\" [GOC:dph, GOC:isa_complete]", "effective_domain_size": 20972, "goshv": 11532, "intersection_size": 2, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [ "IEA" ] ], "name": "heart morphogenesis", "native": "GO:0003007", "p_value": 0.018238720784134944, "parents": [ "GO:0007507", "GO:0009887" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.0076045627376425855, "significant": true, "source": "GO:BP", "term_size": 263, "source_order": 1409, "group_id": 1 }, { "description": "Diseases of signal transduction by growth factor receptors and second messengers", "effective_domain_size": 11056, "goshv": 40135, "intersection_size": 3, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [ "REAC" ], [], [ "REAC" ] ], "name": "Diseases of signal transduction by growth factor receptors and second messengers", "native": "REAC:R-HSA-5663202", "p_value": 0.018346959195291602, "parents": [ "REAC:R-HSA-1643685" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.0066815144766146995, "significant": true, "source": "REAC", "term_size": 449, "source_order": 811, "group_id": 26 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of post-transcriptional gene silencing by RNA.\" [GOC:kmv, GOC:TermGenie, PMID:22412382]", "effective_domain_size": 20972, "goshv": 29484, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of post-transcriptional gene silencing by regulatory ncRNA", "native": "GO:1900369", "p_value": 0.01849482157713229, "parents": [ "GO:0035194", "GO:0060149", "GO:0060967", "GO:1900368" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0625, "significant": true, "source": "GO:BP", "term_size": 16, "source_order": 19361, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of leukocyte proliferation.\" [GOC:add, GOC:mah]", "effective_domain_size": 20972, "goshv": 25244, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [ "IEA" ], [], [] ], "name": "regulation of leukocyte proliferation", "native": "GO:0070663", "p_value": 0.01849482157713229, "parents": [ "GO:0042127", "GO:0070661" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.007434944237918215, "significant": true, "source": "GO:BP", "term_size": 269, "source_order": 15121, "group_id": 1 }, { "description": "\"Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system.\" [CL:0000125, GOC:mtg_apoptosis, GOC:sart]", "effective_domain_size": 20972, "goshv": 18135, "intersection_size": 1, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "glial cell apoptotic process", "native": "GO:0034349", "p_value": 0.01849482157713229, "parents": [ "GO:0006915" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0625, "significant": true, "source": "GO:BP", "term_size": 16, "source_order": 8012, "group_id": 1 }, { "description": "\"An epigenetic gene regulation mechanism that negatively regulates gene expression by methylation of cytosine residues in chromosomal CpG islands. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide associated with the transcription start site of genes.\" [PMID:11898023, Wikipedia:Cpg_island]", "effective_domain_size": 20972, "goshv": 20313, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "IMP", "IEA" ], [], [], [], [], [] ], "name": "negative regulation of gene expression via chromosomal CpG island methylation", "native": "GO:0044027", "p_value": 0.01849482157713229, "parents": [ "GO:0045814" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0625, "significant": true, "source": "GO:BP", "term_size": 16, "source_order": 10190, "group_id": 1 }, { "description": "\"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is added to a protein. K6-linked ubiquitination is involved in DNA repair.\" [GOC:sp]", "effective_domain_size": 20972, "goshv": 26811, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "IDA", "IEA" ], [], [], [], [], [] ], "name": "protein K6-linked ubiquitination", "native": "GO:0085020", "p_value": 0.01849482157713229, "parents": [ "GO:0000209" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0625, "significant": true, "source": "GO:BP", "term_size": 16, "source_order": 16688, "group_id": 11 }, { "description": "\"Any process that stops or reduces the rate of an ATP-dependent activity.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17438, "intersection_size": 1, "intersections": [ [ "TAS" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of ATP-dependent activity", "native": "GO:0032780", "p_value": 0.01849482157713229, "parents": [ "GO:0043462", "GO:0044092" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0625, "significant": true, "source": "GO:BP", "term_size": 16, "source_order": 7315, "group_id": 1 }, { "description": "\"Any process that decreases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism.\" [GOC:dph]", "effective_domain_size": 20972, "goshv": 23533, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of post-transcriptional gene silencing", "native": "GO:0060149", "p_value": 0.01849482157713229, "parents": [ "GO:0010628", "GO:0016441", "GO:0048519", "GO:0060147" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0625, "significant": true, "source": "GO:BP", "term_size": 16, "source_order": 13410, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of cyclin-dependent protein kinase activity.\" [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22995177]", "effective_domain_size": 20972, "goshv": 31943, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "IMP" ], [], [] ], "name": "negative regulation of cyclin-dependent protein kinase activity", "native": "GO:1904030", "p_value": 0.01849482157713229, "parents": [ "GO:0006469" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0625, "significant": true, "source": "GO:BP", "term_size": 16, "source_order": 21820, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.\" [GOC:go_curators, GOC:txnOH]", "effective_domain_size": 20972, "goshv": 12149, "intersection_size": 5, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "IEA" ], [ "ISS", "IEA" ], [], [], [], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [], [], [], [ "IMP" ], [ "IDA" ] ], "name": "regulation of transcription by RNA polymerase II", "native": "GO:0006357", "p_value": 0.01849482157713229, "parents": [ "GO:0006355", "GO:0006366" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.0018601190476190475, "significant": true, "source": "GO:BP", "term_size": 2688, "source_order": 2026, "group_id": 1 }, { "description": "\"The process in which peroxisomes are delivered to a type of vacuole and degraded in response to changing nutrient conditions.\" [GOC:autophagy, PMID:10547367, PMID:20083110]", "effective_domain_size": 20972, "goshv": 16423, "intersection_size": 1, "intersections": [ [], [ "IDA" ], [], [], [], [], [], [], [], [], [] ], "name": "autophagy of peroxisome", "native": "GO:0030242", "p_value": 0.01849482157713229, "parents": [ "GO:0006914" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0625, "significant": true, "source": "GO:BP", "term_size": 16, "source_order": 6300, "group_id": 1 }, { "description": "\"The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22852, "intersection_size": 1, "intersections": [ [], [], [], [ "IDA" ], [], [], [], [], [], [], [] ], "name": "centrosome separation", "native": "GO:0051299", "p_value": 0.01849482157713229, "parents": [ "GO:0007098", "GO:0022402" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0625, "significant": true, "source": "GO:BP", "term_size": 16, "source_order": 12729, "group_id": 1 }, { "description": "\"Any process that decreases the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 24167, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of gene silencing by regulatory ncRNA", "native": "GO:0060967", "p_value": 0.01849482157713229, "parents": [ "GO:0010628", "GO:0031047", "GO:0048519", "GO:0060966" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0625, "significant": true, "source": "GO:BP", "term_size": 16, "source_order": 14044, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17871, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [ "IDA" ], [], [], [], [] ], "name": "regulation of mammary gland epithelial cell proliferation", "native": "GO:0033599", "p_value": 0.01849482157713229, "parents": [ "GO:0033598", "GO:0050678" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0625, "significant": true, "source": "GO:BP", "term_size": 16, "source_order": 7748, "group_id": 1 }, { "description": "\"The selective autophagy process in which a peroxisome is degraded by macroautophagy.\" [GOC:autophagy, PMID:12914914, PMID:16973210]", "effective_domain_size": 20972, "goshv": 10251, "intersection_size": 1, "intersections": [ [], [ "IDA" ], [], [], [], [], [], [], [], [], [] ], "name": "pexophagy", "native": "GO:0000425", "p_value": 0.01849482157713229, "parents": [ "GO:0016236", "GO:0030242" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0625, "significant": true, "source": "GO:BP", "term_size": 16, "source_order": 128, "group_id": 1 }, { "description": "\"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.\" [PMID:26906419]", "effective_domain_size": 20972, "goshv": 10181, "intersection_size": 2, "intersections": [ [], [], [], [], [], [ "IDA", "IEA" ], [], [], [], [], [ "TAS" ] ], "name": "protein polyubiquitination", "native": "GO:0000209", "p_value": 0.01849482157713229, "parents": [ "GO:0016567" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.007518796992481203, "significant": true, "source": "GO:BP", "term_size": 266, "source_order": 58, "group_id": 11 }, { "description": "\"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.\" [GOC:go_curators, ISBN:0521436125]", "effective_domain_size": 20972, "goshv": 13537, "intersection_size": 5, "intersections": [ [ "IEA" ], [ "IEA" ], [], [], [], [ "IMP" ], [], [], [], [ "IEA" ], [ "IEA" ] ], "name": "anatomical structure morphogenesis", "native": "GO:0009653", "p_value": 0.01849482157713229, "parents": [ "GO:0032502", "GO:0048856" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.001852537977028529, "significant": true, "source": "GO:BP", "term_size": 2699, "source_order": 3414, "group_id": 1 }, { "description": "PI5P Regulates TP53 Acetylation", "effective_domain_size": 11056, "goshv": 41069, "intersection_size": 1, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [], [], [] ], "name": "PI5P Regulates TP53 Acetylation", "native": "REAC:R-HSA-6811555", "p_value": 0.018647138568387803, "parents": [ "REAC:R-HSA-6804758" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.1111111111111111, "significant": true, "source": "REAC", "term_size": 9, "source_order": 1745, "group_id": 25 }, { "description": "Activation of PUMA and translocation to mitochondria", "effective_domain_size": 11056, "goshv": 39423, "intersection_size": 1, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [], [], [] ], "name": "Activation of PUMA and translocation to mitochondria", "native": "REAC:R-HSA-139915", "p_value": 0.018647138568387803, "parents": [ "REAC:R-HSA-114452" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.1111111111111111, "significant": true, "source": "REAC", "term_size": 9, "source_order": 99, "group_id": 34 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.\" [GOC:jl, GOC:mtg_apoptosis]", "effective_domain_size": 20972, "goshv": 19972, "intersection_size": 3, "intersections": [ [ "IDA", "IMP", "IGI", "IEA" ], [], [], [], [], [ "IMP" ], [], [], [], [], [ "IMP", "IBA", "IEA" ] ], "name": "negative regulation of apoptotic process", "native": "GO:0043066", "p_value": 0.019301139688484265, "parents": [ "GO:0006915", "GO:0042981", "GO:0043069" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.0035046728971962616, "significant": true, "source": "GO:BP", "term_size": 856, "source_order": 9849, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.\" [GOC:hjd]", "effective_domain_size": 20972, "goshv": 10487, "intersection_size": 2, "intersections": [ [ "IEP", "IEA" ], [], [], [], [], [], [], [], [], [], [ "IEP" ] ], "name": "response to hypoxia", "native": "GO:0001666", "p_value": 0.01949728742119635, "parents": [ "GO:0006950", "GO:0036293" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.007194244604316547, "significant": true, "source": "GO:BP", "term_size": 278, "source_order": 364, "group_id": 1 }, { "description": "\"The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).\" [GOC:add, ISBN:0781700221, ISBN:0781735149]", "effective_domain_size": 20972, "goshv": 17660, "intersection_size": 1, "intersections": [ [], [ "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "V(D)J recombination", "native": "GO:0033151", "p_value": 0.01949728742119635, "parents": [ "GO:0002562" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.058823529411764705, "significant": true, "source": "GO:BP", "term_size": 17, "source_order": 7537, "group_id": 19 }, { "description": "\"A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.\" [GOC:vw]", "effective_domain_size": 20972, "goshv": 16886, "intersection_size": 1, "intersections": [ [], [], [], [], [ "IMP" ], [], [], [], [], [], [] ], "name": "mitotic intra-S DNA damage checkpoint signaling", "native": "GO:0031573", "p_value": 0.01949728742119635, "parents": [ "GO:0044773" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.058823529411764705, "significant": true, "source": "GO:BP", "term_size": 17, "source_order": 6763, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the rate or extent of B cell proliferation.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 16630, "intersection_size": 1, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of B cell proliferation", "native": "GO:0030889", "p_value": 0.01949728742119635, "parents": [ "GO:0030888", "GO:0042100", "GO:0050672", "GO:0050869" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.058823529411764705, "significant": true, "source": "GO:BP", "term_size": 17, "source_order": 6507, "group_id": 1 }, { "description": "STAT5 activation downstream of FLT3 ITD mutants", "effective_domain_size": 11056, "goshv": 41579, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "REAC" ], [], [] ], "name": "STAT5 activation downstream of FLT3 ITD mutants", "native": "REAC:R-HSA-9702518", "p_value": 0.020504632433761938, "parents": [ "REAC:R-HSA-9703648" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.1, "significant": true, "source": "REAC", "term_size": 10, "source_order": 2255, "group_id": 26 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process.\" [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]", "effective_domain_size": 20972, "goshv": 25016, "intersection_size": 1, "intersections": [ [ "ISS", "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "positive regulation of lymphocyte apoptotic process", "native": "GO:0070230", "p_value": 0.02056352645648865, "parents": [ "GO:0070227", "GO:0070228", "GO:2000108" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.05555555555555555, "significant": true, "source": "GO:BP", "term_size": 18, "source_order": 14893, "group_id": 1 }, { "description": "\"The establishment of the sex of an organism by physical differentiation.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 13013, "intersection_size": 2, "intersections": [ [], [ "IEA" ], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "sex differentiation", "native": "GO:0007548", "p_value": 0.020790166241824573, "parents": [ "GO:0003006" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.006944444444444444, "significant": true, "source": "GO:BP", "term_size": 288, "source_order": 2890, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 19975, "intersection_size": 3, "intersections": [ [ "IDA", "IMP", "IGI", "IEA" ], [], [], [], [], [ "IMP" ], [], [], [], [], [ "IMP", "IBA", "IEA" ] ], "name": "negative regulation of programmed cell death", "native": "GO:0043069", "p_value": 0.02099004795827716, "parents": [ "GO:0012501", "GO:0043067", "GO:0048523" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.0033821871476888386, "significant": true, "source": "GO:BP", "term_size": 887, "source_order": 9852, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.\" [GOC:al]", "effective_domain_size": 20972, "goshv": 19044, "intersection_size": 2, "intersections": [ [ "IEP", "IEA" ], [], [], [], [], [], [], [], [], [], [ "IEP" ] ], "name": "response to decreased oxygen levels", "native": "GO:0036293", "p_value": 0.02099004795827716, "parents": [ "GO:0070482" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.006896551724137931, "significant": true, "source": "GO:BP", "term_size": 290, "source_order": 8921, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of angiogenesis.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 20952, "intersection_size": 2, "intersections": [ [], [], [], [], [], [ "IMP" ], [], [], [], [ "IEA" ], [] ], "name": "regulation of angiogenesis", "native": "GO:0045765", "p_value": 0.021229435222642236, "parents": [ "GO:0001525", "GO:0022603", "GO:1901342" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.00684931506849315, "significant": true, "source": "GO:BP", "term_size": 292, "source_order": 10829, "group_id": 1 }, { "description": "\"Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.\" [CL:0000540, GOC:mtg_apoptosis]", "effective_domain_size": 20972, "goshv": 22907, "intersection_size": 2, "intersections": [ [ "IEA" ], [ "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "neuron apoptotic process", "native": "GO:0051402", "p_value": 0.021329654822384442, "parents": [ "GO:0006915" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.006825938566552901, "significant": true, "source": "GO:BP", "term_size": 293, "source_order": 12784, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of fibroblast apoptotic process.\" [GOC:mtg_apoptosis, GOC:obol, GOC:yaf]", "effective_domain_size": 20972, "goshv": 33853, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of fibroblast apoptotic process", "native": "GO:2000269", "p_value": 0.021341753417092095, "parents": [ "GO:0042981", "GO:0044346" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.05263157894736842, "significant": true, "source": "GO:BP", "term_size": 19, "source_order": 23730, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 20914, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "IMP" ], [], [], [], [], [] ], "name": "negative regulation of fatty acid biosynthetic process", "native": "GO:0045717", "p_value": 0.021341753417092095, "parents": [ "GO:0006633", "GO:0042304", "GO:0045922", "GO:0051055" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.05263157894736842, "significant": true, "source": "GO:BP", "term_size": 19, "source_order": 10791, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis.\" [GOC:mtg_apoptosis, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 29304, "intersection_size": 1, "intersections": [ [ "IMP" ], [], [], [], [], [], [], [], [], [], [] ], "name": "positive regulation of execution phase of apoptosis", "native": "GO:1900119", "p_value": 0.021341753417092095, "parents": [ "GO:0043065", "GO:0097194", "GO:1900117" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.05263157894736842, "significant": true, "source": "GO:BP", "term_size": 19, "source_order": 19181, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 13535, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "response to salt stress", "native": "GO:0009651", "p_value": 0.021341753417092095, "parents": [ "GO:0006970" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.05263157894736842, "significant": true, "source": "GO:BP", "term_size": 19, "source_order": 3412, "group_id": 20 }, { "description": "\"The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).\" [GOC:jl, GOC:txnOH, ISBN:0321000382]", "effective_domain_size": 20972, "goshv": 12156, "intersection_size": 5, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "IEA" ], [ "ISS", "IEA" ], [], [], [], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [], [], [], [ "IMP" ], [ "IDA" ] ], "name": "transcription by RNA polymerase II", "native": "GO:0006366", "p_value": 0.021705608312303067, "parents": [ "GO:0006351" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.0017686593562079944, "significant": true, "source": "GO:BP", "term_size": 2827, "source_order": 2033, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of vasculature development.\" [GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 30136, "intersection_size": 2, "intersections": [ [], [], [], [], [], [ "IMP" ], [], [], [], [ "IEA" ], [] ], "name": "regulation of vasculature development", "native": "GO:1901342", "p_value": 0.021931908710332047, "parents": [ "GO:0001944", "GO:2000026" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.006688963210702341, "significant": true, "source": "GO:BP", "term_size": 299, "source_order": 20013, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress.\" [PMID:26653712]", "effective_domain_size": 20972, "goshv": 24878, "intersection_size": 2, "intersections": [ [ "IMP" ], [ "IDA" ], [], [], [], [], [], [], [], [], [] ], "name": "cellular response to chemical stress", "native": "GO:0062197", "p_value": 0.022032434515171617, "parents": [ "GO:0033554", "GO:0070887" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.006666666666666667, "significant": true, "source": "GO:BP", "term_size": 300, "source_order": 14755, "group_id": 1 }, { "description": "\"The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate).\" [GOC:pde, ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]", "effective_domain_size": 20972, "goshv": 11980, "intersection_size": 1, "intersections": [ [ "IMP" ], [], [], [], [], [], [], [], [], [], [] ], "name": "pentose-phosphate shunt", "native": "GO:0006098", "p_value": 0.02219947938310534, "parents": [ "GO:0006740", "GO:0051156" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.05, "significant": true, "source": "GO:BP", "term_size": 20, "source_order": 1857, "group_id": 1 }, { "description": "\"Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 14229, "intersection_size": 4, "intersections": [ [ "IMP", "ISS" ], [ "IMP" ], [ "IMP" ], [], [], [], [], [], [], [ "IDA" ], [] ], "name": "positive regulation of cell communication", "native": "GO:0010647", "p_value": 0.02219947938310534, "parents": [ "GO:0007154", "GO:0010646", "GO:0048522" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.0022497187851518562, "significant": true, "source": "GO:BP", "term_size": 1778, "source_order": 4106, "group_id": 1 }, { "description": "\"A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters a specialized resting state known as G0 or quiescence.\" [GOC:mah, GOC:mtg_cell_cycle, ISBN:0815316194]", "effective_domain_size": 20972, "goshv": 25069, "intersection_size": 1, "intersections": [ [ "IDA", "IMP" ], [], [], [], [], [], [], [], [], [], [] ], "name": "G1 to G0 transition", "native": "GO:0070314", "p_value": 0.02219947938310534, "parents": [ "GO:0022402" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.05, "significant": true, "source": "GO:BP", "term_size": 20, "source_order": 14946, "group_id": 1 }, { "description": "\"The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures.\" [GOC:dph, GOC:isa_complete, GOC:jid]", "effective_domain_size": 20972, "goshv": 22143, "intersection_size": 2, "intersections": [ [], [ "IEA" ], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "reproductive structure development", "native": "GO:0048608", "p_value": 0.02219947938310534, "parents": [ "GO:0003006", "GO:0048856", "GO:0061458" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.006622516556291391, "significant": true, "source": "GO:BP", "term_size": 302, "source_order": 12020, "group_id": 1 }, { "description": "\"Any process that activates, maintains or increases the frequency, rate or extent of a signaling process.\" [GOC:mtg_signal]", "effective_domain_size": 20972, "goshv": 16329, "intersection_size": 4, "intersections": [ [ "IMP", "ISS" ], [ "IMP" ], [ "IMP" ], [], [], [], [], [], [], [ "IDA" ], [] ], "name": "positive regulation of signaling", "native": "GO:0023056", "p_value": 0.022202965655673857, "parents": [ "GO:0023051", "GO:0023052", "GO:0048518" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.0022484541877459247, "significant": true, "source": "GO:BP", "term_size": 1779, "source_order": 6206, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22734, "intersection_size": 3, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [ "ISS", "IEA" ], [ "IEA" ], [] ], "name": "negative regulation of developmental process", "native": "GO:0051093", "p_value": 0.022280350464877613, "parents": [ "GO:0032502", "GO:0048519", "GO:0050793" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.0032751091703056767, "significant": true, "source": "GO:BP", "term_size": 916, "source_order": 12611, "group_id": 1 }, { "description": "Pexophagy", "effective_domain_size": 11056, "goshv": 41123, "intersection_size": 1, "intersections": [ [], [ "REAC" ], [], [], [], [], [], [], [], [], [] ], "name": "Pexophagy", "native": "REAC:R-HSA-9664873", "p_value": 0.0223238742349851, "parents": [ "REAC:R-HSA-9663891" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.09090909090909091, "significant": true, "source": "REAC", "term_size": 11, "source_order": 1799, "group_id": 40 }, { "description": "\"The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction.\" [GOC:dph]", "effective_domain_size": 20972, "goshv": 24528, "intersection_size": 2, "intersections": [ [], [ "IEA" ], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "reproductive system development", "native": "GO:0061458", "p_value": 0.02259557438095111, "parents": [ "GO:0048731" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.006535947712418301, "significant": true, "source": "GO:BP", "term_size": 306, "source_order": 14405, "group_id": 1 }, { "description": "\"Any process in which a macromolecule is transported to, or maintained in, a specific location.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17603, "intersection_size": 5, "intersections": [ [ "IDA", "IEA" ], [ "IMP" ], [ "IMP", "IC" ], [], [], [], [], [], [ "IEA" ], [], [ "IDA" ] ], "name": "macromolecule localization", "native": "GO:0033036", "p_value": 0.022930710822881627, "parents": [ "GO:0051179" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.0017385257301808068, "significant": true, "source": "GO:BP", "term_size": 2876, "source_order": 7480, "group_id": 2 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm.\" [GOC:tb]", "effective_domain_size": 20972, "goshv": 13958, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "ISS", "IEA" ], [], [] ], "name": "response to UV-B", "native": "GO:0010224", "p_value": 0.02298547896342178, "parents": [ "GO:0009411" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.047619047619047616, "significant": true, "source": "GO:BP", "term_size": 21, "source_order": 3835, "group_id": 1 }, { "description": "\"The chemical reactions and pathways involving mitochondrial DNA.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 16983, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "mitochondrial DNA metabolic process", "native": "GO:0032042", "p_value": 0.02298547896342178, "parents": [ "GO:0006259" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.047619047619047616, "significant": true, "source": "GO:BP", "term_size": 21, "source_order": 6860, "group_id": 1 }, { "description": "\"Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.\" [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]", "effective_domain_size": 20972, "goshv": 27025, "intersection_size": 1, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "positive regulation of release of cytochrome c from mitochondria", "native": "GO:0090200", "p_value": 0.02298547896342178, "parents": [ "GO:0001836", "GO:0010638", "GO:0090199" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.047619047619047616, "significant": true, "source": "GO:BP", "term_size": 21, "source_order": 16902, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.\" [GOC:go_curators, GOC:txnOH]", "effective_domain_size": 20972, "goshv": 10170, "intersection_size": 3, "intersections": [ [ "IDA", "ISS", "IEA" ], [], [], [], [], [], [], [], [], [ "IMP" ], [ "IDA" ] ], "name": "negative regulation of transcription by RNA polymerase II", "native": "GO:0000122", "p_value": 0.023177772406178285, "parents": [ "GO:0006357", "GO:0006366", "GO:0045892" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.003215434083601286, "significant": true, "source": "GO:BP", "term_size": 933, "source_order": 47, "group_id": 1 }, { "description": "\"Any process that modulates the rate, frequency or extent of a small molecule metabolic process.\" [GOC:vw]", "effective_domain_size": 20972, "goshv": 24802, "intersection_size": 2, "intersections": [ [ "IMP", "IEA" ], [], [], [], [], [ "IMP" ], [], [], [], [], [] ], "name": "regulation of small molecule metabolic process", "native": "GO:0062012", "p_value": 0.023342806190291325, "parents": [ "GO:0019222", "GO:0044281" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.006389776357827476, "significant": true, "source": "GO:BP", "term_size": 313, "source_order": 14679, "group_id": 1 }, { "description": "\"The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position.\" [GOC:al, GOC:vw]", "effective_domain_size": 20972, "goshv": 18943, "intersection_size": 1, "intersections": [ [], [ "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "phosphatidylinositol-3-phosphate biosynthetic process", "native": "GO:0036092", "p_value": 0.02369215821696677, "parents": [ "GO:0046854" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.045454545454545456, "significant": true, "source": "GO:BP", "term_size": 22, "source_order": 8820, "group_id": 12 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.\" [GOC:BHF, GOC:mah]", "effective_domain_size": 20972, "goshv": 25153, "intersection_size": 2, "intersections": [ [ "IEP", "IEA" ], [], [], [], [], [], [], [], [], [], [ "IEP" ] ], "name": "response to oxygen levels", "native": "GO:0070482", "p_value": 0.02369215821696677, "parents": [ "GO:0009628" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.006309148264984227, "significant": true, "source": "GO:BP", "term_size": 317, "source_order": 15030, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17041, "intersection_size": 1, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of telomere maintenance via telomerase", "native": "GO:0032211", "p_value": 0.02369215821696677, "parents": [ "GO:0007004", "GO:0032210", "GO:1904357", "GO:2000279" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.045454545454545456, "significant": true, "source": "GO:BP", "term_size": 22, "source_order": 6918, "group_id": 1 }, { "description": "\"The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang.\" [PMID:10357855]", "effective_domain_size": 20972, "goshv": 10326, "intersection_size": 1, "intersections": [ [], [ "IDA" ], [], [], [], [], [], [], [], [], [] ], "name": "DNA double-strand break processing", "native": "GO:0000729", "p_value": 0.02369215821696677, "parents": [ "GO:0006259", "GO:0006302" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.045454545454545456, "significant": true, "source": "GO:BP", "term_size": 22, "source_order": 203, "group_id": 1 }, { "description": "\"The directed movement of a protein to a specific location on a chromosome.\" [GOC:BHF, GOC:mah]", "effective_domain_size": 20972, "goshv": 24998, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [ "IDA", "IEA" ], [], [], [], [] ], "name": "establishment of protein localization to chromosome", "native": "GO:0070199", "p_value": 0.02369215821696677, "parents": [ "GO:0072594" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.045454545454545456, "significant": true, "source": "GO:BP", "term_size": 22, "source_order": 14875, "group_id": 2 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator.\" [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871]", "effective_domain_size": 20972, "goshv": 30771, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [], [ "IMP" ] ], "name": "negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "native": "GO:1902254", "p_value": 0.02369215821696677, "parents": [ "GO:0072332", "GO:1901797", "GO:1902253", "GO:2001243" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.045454545454545456, "significant": true, "source": "GO:BP", "term_size": 22, "source_order": 20648, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation.\" [GO_REF:0000058, GOC:TermGenie, PMID:23246467]", "effective_domain_size": 20972, "goshv": 32433, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "IMP" ], [], [] ], "name": "negative regulation of vascular associated smooth muscle cell proliferation", "native": "GO:1904706", "p_value": 0.02369215821696677, "parents": [ "GO:0048662", "GO:1904705", "GO:1990874" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.045454545454545456, "significant": true, "source": "GO:BP", "term_size": 22, "source_order": 22310, "group_id": 1 }, { "description": "TP53 Regulates Transcription of Death Receptors and Ligands", "effective_domain_size": 11056, "goshv": 41878, "intersection_size": 1, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [], [], [] ], "name": "TP53 Regulates Transcription of Death Receptors and Ligands", "native": "REAC:R-HSA-6803211", "p_value": 0.023874191321777583, "parents": [ "REAC:R-HSA-5633008" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.08333333333333333, "significant": true, "source": "REAC", "term_size": 12, "source_order": 2554, "group_id": 25 }, { "description": "HDR through MMEJ (alt-NHEJ)", "effective_domain_size": 11056, "goshv": 40472, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [ "REAC" ], [], [], [], [] ], "name": "HDR through MMEJ (alt-NHEJ)", "native": "REAC:R-HSA-5685939", "p_value": 0.023874191321777583, "parents": [ "REAC:R-HSA-5693538" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.08333333333333333, "significant": true, "source": "REAC", "term_size": 12, "source_order": 1148, "group_id": 28 }, { "description": "\"A metabolic process that generates a pool of NADPH by the reduction of NADP+.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 12437, "intersection_size": 1, "intersections": [ [ "IMP" ], [], [], [], [], [], [], [], [], [], [] ], "name": "NADPH regeneration", "native": "GO:0006740", "p_value": 0.02450387461321731, "parents": [ "GO:0006091", "GO:0006739" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.043478260869565216, "significant": true, "source": "GO:BP", "term_size": 23, "source_order": 2314, "group_id": 1 }, { "description": "\"The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 20014, "intersection_size": 1, "intersections": [ [ "ISS", "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "entrainment of circadian clock by photoperiod", "native": "GO:0043153", "p_value": 0.02450387461321731, "parents": [ "GO:0009648", "GO:0009649" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.043478260869565216, "significant": true, "source": "GO:BP", "term_size": 23, "source_order": 9891, "group_id": 1 }, { "description": "\"The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.\" [GOC:dos]", "effective_domain_size": 20972, "goshv": 27783, "intersection_size": 2, "intersections": [ [], [ "IMP", "IEA" ], [], [], [ "IMP" ], [], [], [], [], [], [] ], "name": "nuclear chromosome segregation", "native": "GO:0098813", "p_value": 0.02450387461321731, "parents": [ "GO:0007059" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.006172839506172839, "significant": true, "source": "GO:BP", "term_size": 324, "source_order": 17660, "group_id": 1 }, { "description": "\"The progression of the atrial septum over time, from its initial formation to the mature structure.\" [GOC:mtg_heart]", "effective_domain_size": 20972, "goshv": 11763, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [], [ "IEA" ] ], "name": "atrial septum development", "native": "GO:0003283", "p_value": 0.02450387461321731, "parents": [ "GO:0003230", "GO:0003279" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.043478260869565216, "significant": true, "source": "GO:BP", "term_size": 23, "source_order": 1640, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation.\" [GOC:dph]", "effective_domain_size": 20972, "goshv": 34162, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of stem cell proliferation", "native": "GO:2000647", "p_value": 0.02450387461321731, "parents": [ "GO:0008285", "GO:0072089", "GO:0072091" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.043478260869565216, "significant": true, "source": "GO:BP", "term_size": 23, "source_order": 24039, "group_id": 1 }, { "description": "\"Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by heterochromatin formation leading to a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex.\" [GOC:jl, GOC:mr, GOC:pr, PMID:11498577, PMID:20622855, Wikipedia:XY_sex-determination_system]", "effective_domain_size": 20972, "goshv": 13211, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "IEA" ], [], [], [], [], [] ], "name": "dosage compensation by inactivation of X chromosome", "native": "GO:0009048", "p_value": 0.02450387461321731, "parents": [ "GO:0007549", "GO:0031507" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.043478260869565216, "significant": true, "source": "GO:BP", "term_size": 23, "source_order": 3088, "group_id": 1 }, { "description": "\"A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation.\" [GOC:go_curators, ISBN:0198547684]", "effective_domain_size": 20972, "goshv": 13108, "intersection_size": 11, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "NAS", "IEA" ], [ "IDA", "IMP", "IGI", "ISS", "IBA", "TAS", "IC", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "ISS", "TAS", "IEA" ], [ "IDA", "IMP", "TAS", "IEA" ], [ "IDA", "IMP", "IBA", "TAS", "NAS", "IEA" ], [ "IDA", "IMP", "IBA", "IEA" ], [ "IDA", "IMP", "ISS", "IBA", "TAS", "IEA" ], [ "IDA", "IMP", "TAS", "IEA" ], [ "IMP", "TAS" ], [ "IDA", "IMP", "IGI", "IBA", "TAS", "IEA" ] ], "name": "metabolic process", "native": "GO:0008152", "p_value": 0.02454759992210242, "parents": [ "GO:0009987" ], "precision": 1, "query": "query_1", "query_size": 11, "recall": 0.0007837548984681154, "significant": true, "source": "GO:BP", "term_size": 14035, "source_order": 2985, "group_id": 1 }, { "description": "\"Any biological process, occurring at the level of a multicellular organism, pertinent to its function.\" [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]", "effective_domain_size": 20972, "goshv": 17239, "intersection_size": 8, "intersections": [ [ "IMP", "ISS", "IEA" ], [ "IMP", "ISS", "IEA" ], [], [ "IEA" ], [], [ "IMP", "IBA", "IEA" ], [ "IDA", "IEA" ], [], [ "ISS", "IEA" ], [ "IEA" ], [ "IEA" ] ], "name": "multicellular organismal process", "native": "GO:0032501", "p_value": 0.024798616422467286, "parents": [ "GO:0008150" ], "precision": 0.7272727272727273, "query": "query_1", "query_size": 11, "recall": 0.0010903639089546136, "significant": true, "source": "GO:BP", "term_size": 7337, "source_order": 7116, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of protein kinase activity.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 21021, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [], [], [ "IDA", "IMP", "TAS" ], [ "IMP", "TAS" ], [] ], "name": "regulation of protein kinase activity", "native": "GO:0045859", "p_value": 0.025064788274529723, "parents": [ "GO:0001932", "GO:0043549" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.006060606060606061, "significant": true, "source": "GO:BP", "term_size": 330, "source_order": 10898, "group_id": 1 }, { "description": "\"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.\" [GOC:dgh, ISBN:0198506732]", "effective_domain_size": 20972, "goshv": 16363, "intersection_size": 3, "intersections": [ [ "IMP", "IEA" ], [ "ISS", "IEA" ], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "hemopoiesis", "native": "GO:0030097", "p_value": 0.025064788274529723, "parents": [ "GO:0048468" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.003089598352214212, "significant": true, "source": "GO:BP", "term_size": 971, "source_order": 6240, "group_id": 1 }, { "description": "\"The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes.\" [GOC:txnOH-2018, PMID:25934543, PMID:31580950]", "effective_domain_size": 20972, "goshv": 14099, "intersection_size": 9, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "NAS", "IEA" ], [ "IDA", "IMP", "ISS", "IEA" ], [], [ "ISS", "IEA" ], [ "IDA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IBA" ], [], [ "IEA" ], [ "IMP" ], [ "IDA", "IMP", "IEA" ] ], "name": "gene expression", "native": "GO:0010467", "p_value": 0.02508167246444903, "parents": [ "GO:0009059" ], "precision": 0.8181818181818182, "query": "query_1", "query_size": 11, "recall": 0.0009748700173310225, "significant": true, "source": "GO:BP", "term_size": 9232, "source_order": 3976, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of execution phase of apoptosis.\" [GOC:mtg_apoptosis, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 29302, "intersection_size": 1, "intersections": [ [ "IMP" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of execution phase of apoptosis", "native": "GO:1900117", "p_value": 0.02508167246444903, "parents": [ "GO:0050794", "GO:0097194" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.041666666666666664, "significant": true, "source": "GO:BP", "term_size": 24, "source_order": 19179, "group_id": 1 }, { "description": "\"The directed movement of a protein to a specific location.\" [GOC:bf]", "effective_domain_size": 20972, "goshv": 20675, "intersection_size": 4, "intersections": [ [ "IEA" ], [], [], [], [], [], [ "IDA", "IEA" ], [], [ "IEA" ], [], [ "IDA" ] ], "name": "establishment of protein localization", "native": "GO:0045184", "p_value": 0.02508167246444903, "parents": [ "GO:0051234" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.002140181915462814, "significant": true, "source": "GO:BP", "term_size": 1869, "source_order": 10552, "group_id": 2 }, { "description": "\"A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.\" [GOC:add]", "effective_domain_size": 20972, "goshv": 20710, "intersection_size": 3, "intersections": [ [ "IEA" ], [ "IMP", "ISS", "IEA" ], [], [], [], [], [], [], [ "IEA" ], [], [] ], "name": "leukocyte activation", "native": "GO:0045321", "p_value": 0.02508167246444903, "parents": [ "GO:0001775", "GO:0002376" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.003076923076923077, "significant": true, "source": "GO:BP", "term_size": 975, "source_order": 10587, "group_id": 1 }, { "description": "\"The chemical reactions and pathways involving an mRNA encoding a histone.\" [GOC:krc, GOC:mah, PMID:17855393]", "effective_domain_size": 20972, "goshv": 13148, "intersection_size": 1, "intersections": [ [], [ "IDA" ], [], [], [], [], [], [], [], [], [] ], "name": "histone mRNA metabolic process", "native": "GO:0008334", "p_value": 0.02508167246444903, "parents": [ "GO:0016071" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.041666666666666664, "significant": true, "source": "GO:BP", "term_size": 24, "source_order": 3025, "group_id": 10 }, { "description": "\"The directed movement of substances into, out of, or within the nucleus.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22784, "intersection_size": 2, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [ "IMP", "IEA" ], [], [] ], "name": "nuclear transport", "native": "GO:0051169", "p_value": 0.02508167246444903, "parents": [ "GO:0046907" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.006024096385542169, "significant": true, "source": "GO:BP", "term_size": 332, "source_order": 12661, "group_id": 2 }, { "description": "\"The directed movement of molecules between the nucleus and the cytoplasm.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 12554, "intersection_size": 2, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [ "IMP", "IEA" ], [], [] ], "name": "nucleocytoplasmic transport", "native": "GO:0006913", "p_value": 0.02508167246444903, "parents": [ "GO:0051169" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.006024096385542169, "significant": true, "source": "GO:BP", "term_size": 332, "source_order": 2431, "group_id": 2 }, { "description": "\"Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 21534, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "NAS" ], [], [], [], [], [] ], "name": "regulation of centriole replication", "native": "GO:0046599", "p_value": 0.0259870247549534, "parents": [ "GO:0007099", "GO:0010824", "GO:1902115" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.04, "significant": true, "source": "GO:BP", "term_size": 25, "source_order": 11411, "group_id": 1 }, { "description": "\"Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.\" [CL:0000057, GOC:jl, GOC:mtg_apoptosis, GOC:yaf]", "effective_domain_size": 20972, "goshv": 20386, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "fibroblast apoptotic process", "native": "GO:0044346", "p_value": 0.0259870247549534, "parents": [ "GO:0006915" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.04, "significant": true, "source": "GO:BP", "term_size": 25, "source_order": 10263, "group_id": 1 }, { "description": "\"Compensating for the variation in the unpaired sex chromosome:autosome chromosome ratios between sexes by activation or inactivation of genes on one or both of the sex chromosomes.\" [GOC:ems, PMID:11498577, PMID:30049999, PMID:35306885]", "effective_domain_size": 20972, "goshv": 13014, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "IBA", "IEA" ], [], [], [], [], [] ], "name": "sex-chromosome dosage compensation", "native": "GO:0007549", "p_value": 0.0259870247549534, "parents": [ "GO:0040029" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.04, "significant": true, "source": "GO:BP", "term_size": 25, "source_order": 2891, "group_id": 1 }, { "description": "\"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.\" [GOC:dph, GOC:jid]", "effective_domain_size": 20972, "goshv": 22072, "intersection_size": 5, "intersections": [ [ "IMP", "IEA" ], [ "IEA" ], [], [], [], [], [ "IDA", "IEA" ], [], [ "ISS", "IEA" ], [], [ "IEA" ] ], "name": "animal organ development", "native": "GO:0048513", "p_value": 0.02653229997893135, "parents": [ "GO:0048856" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.0016567263088137839, "significant": true, "source": "GO:BP", "term_size": 3018, "source_order": 11949, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species.\" [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]", "effective_domain_size": 20972, "goshv": 13532, "intersection_size": 1, "intersections": [ [ "ISS", "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "photoperiodism", "native": "GO:0009648", "p_value": 0.026701651033040157, "parents": [ "GO:0009416" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.038461538461538464, "significant": true, "source": "GO:BP", "term_size": 26, "source_order": 3409, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of p38MAPK cascade.\" [GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 29754, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [ "IDA" ], [] ], "name": "positive regulation of p38MAPK cascade", "native": "GO:1900745", "p_value": 0.026701651033040157, "parents": [ "GO:0038066", "GO:0043410", "GO:1900744" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.038461538461538464, "significant": true, "source": "GO:BP", "term_size": 26, "source_order": 19631, "group_id": 6 }, { "description": "\"Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death.\" [GOC:dph, GOC:mtg_apoptosis, GOC:tb]", "effective_domain_size": 20972, "goshv": 14242, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "positive regulation of muscle cell apoptotic process", "native": "GO:0010661", "p_value": 0.026701651033040157, "parents": [ "GO:0010657", "GO:0010660", "GO:0043065" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.038461538461538464, "significant": true, "source": "GO:BP", "term_size": 26, "source_order": 4119, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of anoikis.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 33800, "intersection_size": 1, "intersections": [ [], [], [], [], [ "IEA" ], [], [], [], [], [], [] ], "name": "regulation of anoikis", "native": "GO:2000209", "p_value": 0.026701651033040157, "parents": [ "GO:0042981", "GO:0043276" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.038461538461538464, "significant": true, "source": "GO:BP", "term_size": 26, "source_order": 23677, "group_id": 1 }, { "description": "\"The process in which the structure of the atrioventricular valve is generated and organized.\" [GOC:mtg_heart]", "effective_domain_size": 20972, "goshv": 11677, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [], [ "IEA" ] ], "name": "atrioventricular valve morphogenesis", "native": "GO:0003181", "p_value": 0.026701651033040157, "parents": [ "GO:0003171", "GO:0003179" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.038461538461538464, "significant": true, "source": "GO:BP", "term_size": 26, "source_order": 1554, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation.\" [GOC:dph, GOC:yaf]", "effective_domain_size": 20972, "goshv": 33772, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of neural precursor cell proliferation", "native": "GO:2000178", "p_value": 0.026701651033040157, "parents": [ "GO:0008285", "GO:0061351", "GO:2000177" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.038461538461538464, "significant": true, "source": "GO:BP", "term_size": 26, "source_order": 23649, "group_id": 1 }, { "description": "Regulation of TP53 Activity through Association with Co-factors", "effective_domain_size": 11056, "goshv": 41422, "intersection_size": 1, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [], [], [] ], "name": "Regulation of TP53 Activity through Association with Co-factors", "native": "REAC:R-HSA-6804759", "p_value": 0.02730300230682964, "parents": [ "REAC:R-HSA-5633007" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.07142857142857142, "significant": true, "source": "REAC", "term_size": 14, "source_order": 2098, "group_id": 25 }, { "description": "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "effective_domain_size": 11056, "goshv": 41883, "intersection_size": 1, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [], [], [] ], "name": "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "native": "REAC:R-HSA-6803205", "p_value": 0.02730300230682964, "parents": [ "REAC:R-HSA-5633008" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.07142857142857142, "significant": true, "source": "REAC", "term_size": 14, "source_order": 2559, "group_id": 25 }, { "description": "\"The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 11914, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "glucose catabolic process", "native": "GO:0006007", "p_value": 0.0273991487372534, "parents": [ "GO:0006006", "GO:0019320" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.037037037037037035, "significant": true, "source": "GO:BP", "term_size": 27, "source_order": 1791, "group_id": 1 }, { "description": "\"A process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs).\" [GOC:aruk, GOC:bc, GOC:dph, GOC:rl, GOC:tb, PMID:23985560, PMID:28379604]", "effective_domain_size": 20972, "goshv": 24164, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of miRNA-mediated gene silencing", "native": "GO:0060964", "p_value": 0.0273991487372534, "parents": [ "GO:0035195", "GO:1900368" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.037037037037037035, "significant": true, "source": "GO:BP", "term_size": 27, "source_order": 14041, "group_id": 1 }, { "description": "\"The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.\" [GOC:dph, GOC:mah]", "effective_domain_size": 20972, "goshv": 17870, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [ "IDA" ], [], [], [], [] ], "name": "mammary gland epithelial cell proliferation", "native": "GO:0033598", "p_value": 0.0273991487372534, "parents": [ "GO:0050673", "GO:0061180" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.037037037037037035, "significant": true, "source": "GO:BP", "term_size": 27, "source_order": 7747, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of purine nucleotide metabolic process.\" [GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 29589, "intersection_size": 1, "intersections": [ [ "IMP" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of purine nucleotide metabolic process", "native": "GO:1900543", "p_value": 0.0273991487372534, "parents": [ "GO:0006163", "GO:0045980", "GO:1900542" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.037037037037037035, "significant": true, "source": "GO:BP", "term_size": 27, "source_order": 19466, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.\" [GOC:bf]", "effective_domain_size": 20972, "goshv": 20206, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [], [], [ "IDA", "IMP", "TAS" ], [ "IMP", "TAS" ], [] ], "name": "regulation of kinase activity", "native": "GO:0043549", "p_value": 0.0273991487372534, "parents": [ "GO:0042325", "GO:0051338" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.0056657223796034, "significant": true, "source": "GO:BP", "term_size": 353, "source_order": 10083, "group_id": 1 }, { "description": "\"The series of molecular signals initiated by interferon-gamma binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.\" [GOC:add, GOC:dph, GOC:signaling, PMID:28901902]", "effective_domain_size": 20972, "goshv": 23677, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "type II interferon-mediated signaling pathway", "native": "GO:0060333", "p_value": 0.0273991487372534, "parents": [ "GO:0071346", "GO:0140888" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.037037037037037035, "significant": true, "source": "GO:BP", "term_size": 27, "source_order": 13554, "group_id": 21 }, { "description": "\"A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins.\" [GOC:mah, GOC:rn, PMID:11349150, PMID:11352055]", "effective_domain_size": 20972, "goshv": 15053, "intersection_size": 1, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [], [], [] ], "name": "telomere capping", "native": "GO:0016233", "p_value": 0.0273991487372534, "parents": [ "GO:0000723" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.037037037037037035, "significant": true, "source": "GO:BP", "term_size": 27, "source_order": 4930, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 21114, "intersection_size": 1, "intersections": [ [ "IMP" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of nucleotide metabolic process", "native": "GO:0045980", "p_value": 0.02821934989743346, "parents": [ "GO:0006140", "GO:0009117", "GO:0045934", "GO:0045936", "GO:0062014" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.03571428571428571, "significant": true, "source": "GO:BP", "term_size": 28, "source_order": 10991, "group_id": 1 }, { "description": "\"The synchronization of a circadian rhythm to environmental time cues such as light.\" [GOC:jid]", "effective_domain_size": 20972, "goshv": 13533, "intersection_size": 1, "intersections": [ [ "ISS", "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "entrainment of circadian clock", "native": "GO:0009649", "p_value": 0.02821934989743346, "parents": [ "GO:0009605", "GO:0042752" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.03571428571428571, "significant": true, "source": "GO:BP", "term_size": 28, "source_order": 3410, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of post-transcriptional gene silencing by a non-coding RNA.\" [GOC:kmv, GOC:TermGenie, PMID:22412382]", "effective_domain_size": 20972, "goshv": 29483, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of post-transcriptional gene silencing by regulatory ncRNA", "native": "GO:1900368", "p_value": 0.02821934989743346, "parents": [ "GO:0035194", "GO:0060147", "GO:0060966" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.03571428571428571, "significant": true, "source": "GO:BP", "term_size": 28, "source_order": 19360, "group_id": 1 }, { "description": "\"A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline.\" [GOC:dph, GOC:mah]", "effective_domain_size": 20972, "goshv": 12701, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "male meiosis I", "native": "GO:0007141", "p_value": 0.02821934989743346, "parents": [ "GO:0007127", "GO:0007140" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.03571428571428571, "significant": true, "source": "GO:BP", "term_size": 28, "source_order": 2578, "group_id": 1 }, { "description": "\"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.\" [GOC:bf, GOC:jid, ISBN:0582227089]", "effective_domain_size": 20972, "goshv": 12899, "intersection_size": 3, "intersections": [ [ "IEA" ], [ "IEA" ], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "central nervous system development", "native": "GO:0007417", "p_value": 0.0283415322401317, "parents": [ "GO:0007399", "GO:0048731" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.002898550724637681, "significant": true, "source": "GO:BP", "term_size": 1035, "source_order": 2776, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 14119, "intersection_size": 2, "intersections": [ [ "IEA" ], [ "IMP", "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "regulation of autophagy", "native": "GO:0010506", "p_value": 0.028716086246364257, "parents": [ "GO:0006914", "GO:0009894" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.005494505494505495, "significant": true, "source": "GO:BP", "term_size": 364, "source_order": 3996, "group_id": 1 }, { "description": "\"The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22776, "intersection_size": 1, "intersections": [ [ "IMP" ], [], [], [], [], [], [], [], [], [], [] ], "name": "glucose 6-phosphate metabolic process", "native": "GO:0051156", "p_value": 0.028886006092405807, "parents": [ "GO:0006796", "GO:0019637", "GO:1901135" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.034482758620689655, "significant": true, "source": "GO:BP", "term_size": 29, "source_order": 12653, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.\" [GOC:hjd, ISBN:0721662544]", "effective_domain_size": 20972, "goshv": 21601, "intersection_size": 1, "intersections": [ [], [], [ "IEA" ], [], [], [], [], [], [], [], [] ], "name": "response to arsenic-containing substance", "native": "GO:0046685", "p_value": 0.028886006092405807, "parents": [ "GO:0042221" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.034482758620689655, "significant": true, "source": "GO:BP", "term_size": 29, "source_order": 11478, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism.\" [GOC:dph]", "effective_domain_size": 20972, "goshv": 23531, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of post-transcriptional gene silencing", "native": "GO:0060147", "p_value": 0.028886006092405807, "parents": [ "GO:0010468", "GO:0016441" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.034482758620689655, "significant": true, "source": "GO:BP", "term_size": 29, "source_order": 13408, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process.\" [GOC:BHF, GOC:mtg_apoptosis]", "effective_domain_size": 20972, "goshv": 33728, "intersection_size": 1, "intersections": [ [ "ISS", "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "positive regulation of leukocyte apoptotic process", "native": "GO:2000108", "p_value": 0.028886006092405807, "parents": [ "GO:0043065", "GO:0071887", "GO:2000106" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.034482758620689655, "significant": true, "source": "GO:BP", "term_size": 29, "source_order": 23605, "group_id": 1 }, { "description": "\"The progression of the atrioventricular valve over time, from its formation to the mature structure.\" [GOC:mtg_heart]", "effective_domain_size": 20972, "goshv": 11667, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [], [ "IEA" ] ], "name": "atrioventricular valve development", "native": "GO:0003171", "p_value": 0.028886006092405807, "parents": [ "GO:0003170" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.034482758620689655, "significant": true, "source": "GO:BP", "term_size": 29, "source_order": 1544, "group_id": 1 }, { "description": "Signaling by FLT3 ITD and TKD mutants", "effective_domain_size": 11056, "goshv": 41675, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "REAC" ], [], [] ], "name": "Signaling by FLT3 ITD and TKD mutants", "native": "REAC:R-HSA-9703648", "p_value": 0.028966730559226987, "parents": [ "REAC:R-HSA-9682385" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.06666666666666667, "significant": true, "source": "REAC", "term_size": 15, "source_order": 2351, "group_id": 26 }, { "description": "Zygotic genome activation (ZGA)", "effective_domain_size": 11056, "goshv": 42104, "intersection_size": 1, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [], [], [] ], "name": "Zygotic genome activation (ZGA)", "native": "REAC:R-HSA-9819196", "p_value": 0.0295051440356277, "parents": [ "REAC:R-HSA-9816359" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0625, "significant": true, "source": "REAC", "term_size": 16, "source_order": 2780, "group_id": 41 }, { "description": "Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "effective_domain_size": 11056, "goshv": 40315, "intersection_size": 1, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [], [], [] ], "name": "Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "native": "REAC:R-HSA-2559584", "p_value": 0.0295051440356277, "parents": [ "REAC:R-HSA-2559586" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0625, "significant": true, "source": "REAC", "term_size": 16, "source_order": 991, "group_id": 29 }, { "description": "Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "effective_domain_size": 11056, "goshv": 41392, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "REAC" ], [], [] ], "name": "Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "native": "REAC:R-HSA-9825892", "p_value": 0.0295051440356277, "parents": [ "REAC:R-HSA-9856651" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0625, "significant": true, "source": "REAC", "term_size": 16, "source_order": 2068, "group_id": 42 }, { "description": "Mitotic G2-G2/M phases", "effective_domain_size": 11056, "goshv": 40870, "intersection_size": 2, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [ "REAC" ], [], [] ], "name": "Mitotic G2-G2/M phases", "native": "REAC:R-HSA-453274", "p_value": 0.0295051440356277, "parents": [ "REAC:R-HSA-69278" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.010101010101010102, "significant": true, "source": "REAC", "term_size": 198, "source_order": 1546, "group_id": 33 }, { "description": "G2/M Transition", "effective_domain_size": 11056, "goshv": 40378, "intersection_size": 2, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [ "REAC" ], [], [] ], "name": "G2/M Transition", "native": "REAC:R-HSA-69275", "p_value": 0.0295051440356277, "parents": [ "REAC:R-HSA-453274" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.01020408163265306, "significant": true, "source": "REAC", "term_size": 196, "source_order": 1054, "group_id": 33 }, { "description": "\"The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25369, "intersection_size": 3, "intersections": [ [], [ "IC" ], [], [], [ "IDA", "IMP" ], [ "NAS" ], [], [], [], [], [] ], "name": "organelle assembly", "native": "GO:0070925", "p_value": 0.02960548612000715, "parents": [ "GO:0006996", "GO:0022607" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.002838221381267739, "significant": true, "source": "GO:BP", "term_size": 1057, "source_order": 15246, "group_id": 1 }, { "description": "\"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 16379, "intersection_size": 3, "intersections": [ [], [ "IEA" ], [], [], [ "IMP" ], [], [], [], [], [], [ "IDA", "IMP", "IGI", "IBA", "TAS", "IEA" ] ], "name": "protein catabolic process", "native": "GO:0030163", "p_value": 0.02960548612000715, "parents": [ "GO:0009057", "GO:0019538" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.002838221381267739, "significant": true, "source": "GO:BP", "term_size": 1057, "source_order": 6256, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening.\" [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]", "effective_domain_size": 20972, "goshv": 32168, "intersection_size": 1, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of telomere maintenance via telomere lengthening", "native": "GO:1904357", "p_value": 0.02963286164863645, "parents": [ "GO:0010833", "GO:0032205", "GO:1904356" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.03333333333333333, "significant": true, "source": "GO:BP", "term_size": 30, "source_order": 22045, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.\" [GOC:TermGenie, PMID:17245429]", "effective_domain_size": 20972, "goshv": 30608, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "IMP" ], [], [], [], [], [] ], "name": "negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "native": "GO:1902042", "p_value": 0.02963286164863645, "parents": [ "GO:0008625", "GO:1902041", "GO:2001237" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.03333333333333333, "significant": true, "source": "GO:BP", "term_size": 30, "source_order": 20485, "group_id": 13 }, { "description": "\"Any process that regulates the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 24166, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of gene silencing by regulatory ncRNA", "native": "GO:0060966", "p_value": 0.02963286164863645, "parents": [ "GO:0010468", "GO:0031047" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.03333333333333333, "significant": true, "source": "GO:BP", "term_size": 30, "source_order": 14043, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.\" [GOC:jl, PMID:12115731]", "effective_domain_size": 20972, "goshv": 12594, "intersection_size": 2, "intersections": [ [ "IMP", "IEA" ], [ "IDA" ], [], [], [], [], [], [], [], [], [] ], "name": "response to oxidative stress", "native": "GO:0006979", "p_value": 0.02969310181604441, "parents": [ "GO:0006950" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.0053475935828877, "significant": true, "source": "GO:BP", "term_size": 374, "source_order": 2471, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.\" [GOC:isa_complete]", "effective_domain_size": 20972, "goshv": 24909, "intersection_size": 3, "intersections": [ [ "TAS" ], [], [], [], [], [], [], [], [ "IDA", "IMP", "TAS" ], [ "IMP", "TAS" ], [] ], "name": "regulation of molecular function", "native": "GO:0065009", "p_value": 0.030349030130627192, "parents": [ "GO:0065007" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.002803738317757009, "significant": true, "source": "GO:BP", "term_size": 1070, "source_order": 14786, "group_id": 1 }, { "description": "\"Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor.\" [GOC:BHF, GOC:rl]", "effective_domain_size": 20972, "goshv": 14165, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "IMP" ], [], [], [], [], [] ], "name": "positive regulation of vascular endothelial growth factor production", "native": "GO:0010575", "p_value": 0.030465204093827067, "parents": [ "GO:0001819", "GO:0010573", "GO:0010574" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.03225806451612903, "significant": true, "source": "GO:BP", "term_size": 31, "source_order": 4042, "group_id": 7 }, { "description": "Signaling by FLT3 fusion proteins", "effective_domain_size": 11056, "goshv": 41676, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "REAC" ], [], [] ], "name": "Signaling by FLT3 fusion proteins", "native": "REAC:R-HSA-9703465", "p_value": 0.030517619848552207, "parents": [ "REAC:R-HSA-9682385" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.058823529411764705, "significant": true, "source": "REAC", "term_size": 17, "source_order": 2352, "group_id": 26 }, { "description": "Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects", "effective_domain_size": 11056, "goshv": 39375, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "REAC" ], [], [] ], "name": "Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects", "native": "REAC:R-HSA-9659787", "p_value": 0.030517619848552207, "parents": [ "REAC:R-HSA-9687139" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.058823529411764705, "significant": true, "source": "REAC", "term_size": 17, "source_order": 51, "group_id": 36 }, { "description": "Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)", "effective_domain_size": 11056, "goshv": 40033, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "REAC" ], [], [] ], "name": "Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)", "native": "REAC:R-HSA-9661069", "p_value": 0.030517619848552207, "parents": [ "REAC:R-HSA-9659787" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.058823529411764705, "significant": true, "source": "REAC", "term_size": 17, "source_order": 709, "group_id": 36 }, { "description": "Cellular response to chemical stress", "effective_domain_size": 11056, "goshv": 39674, "intersection_size": 2, "intersections": [ [], [], [], [], [], [ "REAC" ], [], [], [ "REAC" ], [], [] ], "name": "Cellular response to chemical stress", "native": "REAC:R-HSA-9711123", "p_value": 0.03064926061804409, "parents": [ "REAC:R-HSA-2262752" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.009708737864077669, "significant": true, "source": "REAC", "term_size": 206, "source_order": 350, "group_id": 29 }, { "description": "\"Any process that modulates the frequency, rate or extent of programmed necrotic cell death.\" [GOC:aruk, GOC:rph, PMID:27258785]", "effective_domain_size": 20972, "goshv": 24838, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of programmed necrotic cell death", "native": "GO:0062098", "p_value": 0.031339370668253805, "parents": [ "GO:0043067", "GO:0097300" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.03125, "significant": true, "source": "GO:BP", "term_size": 32, "source_order": 14715, "group_id": 1 }, { "description": "\"A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.\" [GOC:devbiol, https://www.ncbi.nlm.nih.gov/books/NBK279054/]", "effective_domain_size": 20972, "goshv": 10458, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "oocyte maturation", "native": "GO:0001556", "p_value": 0.031339370668253805, "parents": [ "GO:0003006", "GO:0048469", "GO:0048599" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.03125, "significant": true, "source": "GO:BP", "term_size": 32, "source_order": 335, "group_id": 1 }, { "description": "\"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 12794, "intersection_size": 2, "intersections": [ [], [ "IEA" ], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "germ cell development", "native": "GO:0007281", "p_value": 0.03142381079277773, "parents": [ "GO:0003006", "GO:0007276", "GO:0022412", "GO:0048468" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.00516795865633075, "significant": true, "source": "GO:BP", "term_size": 387, "source_order": 2671, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22752, "intersection_size": 3, "intersections": [ [ "IDA" ], [ "IMP", "ISS", "IEA" ], [ "IMP", "ISS" ], [], [], [], [], [], [], [], [] ], "name": "positive regulation of cellular component organization", "native": "GO:0051130", "p_value": 0.031720267634796406, "parents": [ "GO:0016043", "GO:0048522", "GO:0051128" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.002749770852428964, "significant": true, "source": "GO:BP", "term_size": 1091, "source_order": 12629, "group_id": 1 }, { "description": "Regulation of NF-kappa B signaling", "effective_domain_size": 11056, "goshv": 41396, "intersection_size": 1, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [], [], [] ], "name": "Regulation of NF-kappa B signaling", "native": "REAC:R-HSA-9758274", "p_value": 0.03174607498382216, "parents": [ "REAC:R-HSA-445989" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.05555555555555555, "significant": true, "source": "REAC", "term_size": 18, "source_order": 2072, "group_id": 43 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22577, "intersection_size": 1, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of B cell activation", "native": "GO:0050869", "p_value": 0.03215593890210454, "parents": [ "GO:0042113", "GO:0050864", "GO:0051250" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.030303030303030304, "significant": true, "source": "GO:BP", "term_size": 33, "source_order": 12454, "group_id": 1 }, { "description": "\"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 24904, "intersection_size": 5, "intersections": [ [ "IDA", "IEA" ], [ "IMP" ], [ "IMP" ], [], [], [], [], [ "IMP", "IBA" ], [], [], [ "IDA" ] ], "name": "protein-containing complex assembly", "native": "GO:0065003", "p_value": 0.03241111627691362, "parents": [ "GO:0022607", "GO:0043933" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.0015556938394523958, "significant": true, "source": "GO:BP", "term_size": 3214, "source_order": 14781, "group_id": 1 }, { "description": "\"The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template.\" [GOC:jl, ISBN:0198506732]", "effective_domain_size": 20972, "goshv": 13417, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "rRNA transcription", "native": "GO:0009303", "p_value": 0.032859597518682615, "parents": [ "GO:0006351", "GO:0016072" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.029411764705882353, "significant": true, "source": "GO:BP", "term_size": 34, "source_order": 3294, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor.\" [GOC:rl]", "effective_domain_size": 20972, "goshv": 14164, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "IMP" ], [], [], [], [], [] ], "name": "regulation of vascular endothelial growth factor production", "native": "GO:0010574", "p_value": 0.032859597518682615, "parents": [ "GO:0001817", "GO:0010573" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.029411764705882353, "significant": true, "source": "GO:BP", "term_size": 34, "source_order": 4041, "group_id": 7 }, { "description": "\"Any process that modulates the frequency, rate or extent of glial cell proliferation.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 23606, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of glial cell proliferation", "native": "GO:0060251", "p_value": 0.032859597518682615, "parents": [ "GO:0014009", "GO:0042127" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.029411764705882353, "significant": true, "source": "GO:BP", "term_size": 34, "source_order": 13483, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25555, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [ "IDA", "IEA" ], [], [], [] ], "name": "cellular response to alkaloid", "native": "GO:0071312", "p_value": 0.032859597518682615, "parents": [ "GO:0043279", "GO:1901699" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.029411764705882353, "significant": true, "source": "GO:BP", "term_size": 34, "source_order": 15432, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.\" [GOC:go_curators, GOC:jl]", "effective_domain_size": 20972, "goshv": 19485, "intersection_size": 2, "intersections": [ [], [], [], [], [ "IMP" ], [], [], [], [], [], [ "IDA" ] ], "name": "regulation of protein catabolic process", "native": "GO:0042176", "p_value": 0.033180618302826634, "parents": [ "GO:0009894", "GO:0030163", "GO:0051246" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.004987531172069825, "significant": true, "source": "GO:BP", "term_size": 401, "source_order": 9362, "group_id": 1 }, { "description": "\"The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop.\" [CL:0000037, GOC:add, GOC:BHF, GOC:mah, GOC:rl]", "effective_domain_size": 20972, "goshv": 25661, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "hematopoietic stem cell proliferation", "native": "GO:0071425", "p_value": 0.03355172054895339, "parents": [ "GO:0030097", "GO:0072089" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02857142857142857, "significant": true, "source": "GO:BP", "term_size": 35, "source_order": 15538, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17648, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [ "IMP" ], [] ], "name": "regulation of peptidyl-serine phosphorylation", "native": "GO:0033135", "p_value": 0.03355172054895339, "parents": [ "GO:0001932", "GO:0018105" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02857142857142857, "significant": true, "source": "GO:BP", "term_size": 35, "source_order": 7525, "group_id": 1 }, { "description": "\"Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.\" [GOC:dph, GOC:mtg_apoptosis, GOC:tb]", "effective_domain_size": 20972, "goshv": 14246, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of cardiac muscle cell apoptotic process", "native": "GO:0010665", "p_value": 0.03355172054895339, "parents": [ "GO:0010659", "GO:0010662" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02857142857142857, "significant": true, "source": "GO:BP", "term_size": 35, "source_order": 4123, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.\" [GOC:jid]", "effective_domain_size": 20972, "goshv": 21826, "intersection_size": 1, "intersections": [ [ "IMP", "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of fibroblast proliferation", "native": "GO:0048147", "p_value": 0.03355172054895339, "parents": [ "GO:0008285", "GO:0048144", "GO:0048145" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02857142857142857, "significant": true, "source": "GO:BP", "term_size": 35, "source_order": 11703, "group_id": 1 }, { "description": "\"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell.\" [GOC:mgi_curators]", "effective_domain_size": 20972, "goshv": 10550, "intersection_size": 3, "intersections": [ [ "IEA" ], [ "IMP", "ISS", "IEA" ], [], [], [], [], [], [], [ "IEA" ], [], [] ], "name": "cell activation", "native": "GO:0001775", "p_value": 0.033628514329943945, "parents": [ "GO:0009987", "GO:0032501" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.0026714158504007124, "significant": true, "source": "GO:BP", "term_size": 1123, "source_order": 427, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction by p53 class mediator.\" [GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 30431, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [], [ "IDA", "IMP", "TAS" ] ], "name": "negative regulation of signal transduction by p53 class mediator", "native": "GO:1901797", "p_value": 0.03391462890600894, "parents": [ "GO:0072331", "GO:1901796", "GO:1902532" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.027777777777777776, "significant": true, "source": "GO:BP", "term_size": 36, "source_order": 20308, "group_id": 1 }, { "description": "\"A cell cycle process that modulates the rate or extent of the transition from the G0 quiescent state to the G1 phase.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25071, "intersection_size": 1, "intersections": [ [], [], [], [ "TAS" ], [], [], [], [], [], [], [] ], "name": "regulation of G0 to G1 transition", "native": "GO:0070316", "p_value": 0.03391462890600894, "parents": [ "GO:0010564", "GO:0045023" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.027777777777777776, "significant": true, "source": "GO:BP", "term_size": 36, "source_order": 14948, "group_id": 1 }, { "description": "\"The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.\" [GOC:bf, GOC:BHF, GOC:dph, GOC:rl, PMID:15378083]", "effective_domain_size": 20972, "goshv": 23584, "intersection_size": 1, "intersections": [ [ "IMP" ], [], [], [], [], [], [], [], [], [], [] ], "name": "hematopoietic stem cell differentiation", "native": "GO:0060218", "p_value": 0.03391462890600894, "parents": [ "GO:0002244", "GO:0048863" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.027777777777777776, "significant": true, "source": "GO:BP", "term_size": 36, "source_order": 13461, "group_id": 22 }, { "description": "\"Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22886, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [], [], [ "IDA", "IMP", "TAS" ], [ "IMP", "TAS" ], [] ], "name": "regulation of transferase activity", "native": "GO:0051338", "p_value": 0.03391462890600894, "parents": [ "GO:0050790" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.004901960784313725, "significant": true, "source": "GO:BP", "term_size": 408, "source_order": 12763, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17657, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "IMP" ], [], [], [], [], [] ], "name": "regulation of intracellular estrogen receptor signaling pathway", "native": "GO:0033146", "p_value": 0.03391462890600894, "parents": [ "GO:0030520", "GO:0033143" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.027777777777777776, "significant": true, "source": "GO:BP", "term_size": 36, "source_order": 7534, "group_id": 1 }, { "description": "\"Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix.\" [GOC:jl, PMID:37667281]", "effective_domain_size": 20972, "goshv": 20051, "intersection_size": 1, "intersections": [ [], [], [], [], [ "IEA" ], [], [], [], [], [], [] ], "name": "anoikis", "native": "GO:0043276", "p_value": 0.03391462890600894, "parents": [ "GO:0006915" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.027777777777777776, "significant": true, "source": "GO:BP", "term_size": 36, "source_order": 9928, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 20201, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [ "IMP", "IEA" ], [] ], "name": "negative regulation of blood vessel endothelial cell migration", "native": "GO:0043537", "p_value": 0.03391462890600894, "parents": [ "GO:0010596", "GO:0043534", "GO:0043535" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.027777777777777776, "significant": true, "source": "GO:BP", "term_size": 36, "source_order": 10078, "group_id": 14 }, { "description": "\"The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.\" [GOC:mtg_heart]", "effective_domain_size": 20972, "goshv": 11724, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [], [ "IEA" ] ], "name": "cardiac atrium development", "native": "GO:0003230", "p_value": 0.03391462890600894, "parents": [ "GO:0003205" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.027777777777777776, "significant": true, "source": "GO:BP", "term_size": 36, "source_order": 1601, "group_id": 1 }, { "description": "\"A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid).\" [Wikipedia:Sexual_reproduction]", "effective_domain_size": 20972, "goshv": 15788, "intersection_size": 3, "intersections": [ [], [ "TAS", "IEA" ], [], [], [], [], [ "IEA" ], [ "ISS", "IBA", "TAS", "IEA" ], [], [], [] ], "name": "sexual reproduction", "native": "GO:0019953", "p_value": 0.03391462890600894, "parents": [ "GO:0022414" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.0026595744680851063, "significant": true, "source": "GO:BP", "term_size": 1128, "source_order": 5665, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17655, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "IMP" ], [], [], [], [], [] ], "name": "negative regulation of intracellular steroid hormone receptor signaling pathway", "native": "GO:0033144", "p_value": 0.03391462890600894, "parents": [ "GO:0030518", "GO:0033143", "GO:1902532" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.027777777777777776, "significant": true, "source": "GO:BP", "term_size": 36, "source_order": 7532, "group_id": 1 }, { "description": "Ub-specific processing proteases", "effective_domain_size": 11056, "goshv": 42036, "intersection_size": 2, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [], [], [ "REAC" ] ], "name": "Ub-specific processing proteases", "native": "REAC:R-HSA-5689880", "p_value": 0.03440761378420907, "parents": [ "REAC:R-HSA-5688426" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.00904977375565611, "significant": true, "source": "REAC", "term_size": 221, "source_order": 2712, "group_id": 35 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 21062, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "IMP" ], [], [], [], [], [] ], "name": "negative regulation of fatty acid metabolic process", "native": "GO:0045922", "p_value": 0.034687318543653235, "parents": [ "GO:0006631", "GO:0019217", "GO:0045833", "GO:0062014" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02702702702702703, "significant": true, "source": "GO:BP", "term_size": 37, "source_order": 10939, "group_id": 1 }, { "description": "\"A process that promotes the bypass of single-stranded DNA lesions encountered by DNA polymerases during DNA replication, thereby preventing replication fork stalling and allowing completion of DNA replication without removing the damage.\" [PMID:18157158, PMID:26322163, PMID:31251805]", "effective_domain_size": 20972, "goshv": 12123, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "IDA" ], [], [], [], [], [] ], "name": "DNA damage tolerance", "native": "GO:0006301", "p_value": 0.034687318543653235, "parents": [ "GO:0006259", "GO:0006260", "GO:0006974" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02702702702702703, "significant": true, "source": "GO:BP", "term_size": 37, "source_order": 2000, "group_id": 1 }, { "description": "\"The appearance of vascular endothelial growth factor production due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.\" [GOC:rl]", "effective_domain_size": 20972, "goshv": 14163, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "IMP" ], [], [], [], [], [] ], "name": "vascular endothelial growth factor production", "native": "GO:0010573", "p_value": 0.034687318543653235, "parents": [ "GO:0001816" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02702702702702703, "significant": true, "source": "GO:BP", "term_size": 37, "source_order": 4040, "group_id": 7 }, { "description": "\"The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.\" [GOC:dph, GOC:isa_complete]", "effective_domain_size": 20972, "goshv": 11530, "intersection_size": 2, "intersections": [ [ "IEA" ], [ "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "regionalization", "native": "GO:0003002", "p_value": 0.03539816394664313, "parents": [ "GO:0007389" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.004739336492890996, "significant": true, "source": "GO:BP", "term_size": 422, "source_order": 1407, "group_id": 1 }, { "description": "\"The mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression.\" [GOC:mtg_cell_cycle, ISBN:0716731363]", "effective_domain_size": 20972, "goshv": 20599, "intersection_size": 1, "intersections": [ [], [], [], [ "TAS" ], [], [], [], [], [], [], [] ], "name": "G0 to G1 transition", "native": "GO:0045023", "p_value": 0.03539816394664313, "parents": [ "GO:0022402" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02631578947368421, "significant": true, "source": "GO:BP", "term_size": 38, "source_order": 10476, "group_id": 1 }, { "description": "\"A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.\" [CL:0000746, GOC:dph, GOC:mtg_apoptosis, GOC:tb]", "effective_domain_size": 20972, "goshv": 14240, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "cardiac muscle cell apoptotic process", "native": "GO:0010659", "p_value": 0.03539816394664313, "parents": [ "GO:0010658" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02631578947368421, "significant": true, "source": "GO:BP", "term_size": 38, "source_order": 4117, "group_id": 1 }, { "description": "\"Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.\" [GOC:dph, GOC:mtg_apoptosis, GOC:tb]", "effective_domain_size": 20972, "goshv": 14243, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of striated muscle cell apoptotic process", "native": "GO:0010662", "p_value": 0.03539816394664313, "parents": [ "GO:0010658", "GO:0010660" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02631578947368421, "significant": true, "source": "GO:BP", "term_size": 38, "source_order": 4120, "group_id": 1 }, { "description": "\"A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism.\" [GOC:isa_complete]", "effective_domain_size": 20972, "goshv": 16292, "intersection_size": 2, "intersections": [ [], [ "IEA" ], [], [], [], [], [ "IEA" ], [], [], [], [] ], "name": "cellular process involved in reproduction in multicellular organism", "native": "GO:0022412", "p_value": 0.035561566044468175, "parents": [ "GO:0009987", "GO:0048609" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.0047169811320754715, "significant": true, "source": "GO:BP", "term_size": 424, "source_order": 6169, "group_id": 1 }, { "description": "\"The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion.\" [GOC:jid]", "effective_domain_size": 20972, "goshv": 22262, "intersection_size": 2, "intersections": [ [], [ "IEA" ], [], [], [], [], [ "IDA" ], [], [], [], [] ], "name": "gland development", "native": "GO:0048732", "p_value": 0.03566495432657828, "parents": [ "GO:0048513" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.004705882352941176, "significant": true, "source": "GO:BP", "term_size": 425, "source_order": 12139, "group_id": 1 }, { "description": "\"The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.\" [CL:0000542, GOC:go_curators]", "effective_domain_size": 20972, "goshv": 16364, "intersection_size": 2, "intersections": [ [ "IEA" ], [ "ISS", "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "lymphocyte differentiation", "native": "GO:0030098", "p_value": 0.03592637407540565, "parents": [ "GO:0046649", "GO:1903131" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.00468384074941452, "significant": true, "source": "GO:BP", "term_size": 427, "source_order": 6241, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia.\" [GOC:ef]", "effective_domain_size": 20972, "goshv": 14494, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of gliogenesis", "native": "GO:0014014", "p_value": 0.03604505222513744, "parents": [ "GO:0014013", "GO:0042063", "GO:0050768" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02564102564102564, "significant": true, "source": "GO:BP", "term_size": 39, "source_order": 4371, "group_id": 1 }, { "description": "\"Any apoptotic process that is involved in anatomical structure development.\" [GO_REF:0000060, GOC:mtg_apoptosis, GOC:pg, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 31049, "intersection_size": 1, "intersections": [ [], [], [], [ "IEA" ], [], [], [], [], [], [], [] ], "name": "apoptotic process involved in development", "native": "GO:1902742", "p_value": 0.03604505222513744, "parents": [ "GO:0006915", "GO:0048856" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02564102564102564, "significant": true, "source": "GO:BP", "term_size": 39, "source_order": 20926, "group_id": 1 }, { "description": "NPAS4 regulates expression of target genes", "effective_domain_size": 11056, "goshv": 40928, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [], [ "REAC" ] ], "name": "NPAS4 regulates expression of target genes", "native": "REAC:R-HSA-9768919", "p_value": 0.036062264979341764, "parents": [ "REAC:R-HSA-9634815" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.047619047619047616, "significant": true, "source": "REAC", "term_size": 21, "source_order": 1604, "group_id": 44 }, { "description": "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "effective_domain_size": 11056, "goshv": 41882, "intersection_size": 1, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [], [], [] ], "name": "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "native": "REAC:R-HSA-6804115", "p_value": 0.036062264979341764, "parents": [ "REAC:R-HSA-6791312" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.047619047619047616, "significant": true, "source": "REAC", "term_size": 21, "source_order": 2558, "group_id": 25 }, { "description": "\"Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.\" [GOC:dph, GOC:mtg_apoptosis, GOC:tb]", "effective_domain_size": 20972, "goshv": 27024, "intersection_size": 1, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of release of cytochrome c from mitochondria", "native": "GO:0090199", "p_value": 0.03668174929051046, "parents": [ "GO:0001836", "GO:0010821" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.025, "significant": true, "source": "GO:BP", "term_size": 40, "source_order": 16901, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 15059, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of macroautophagy", "native": "GO:0016242", "p_value": 0.03668174929051046, "parents": [ "GO:0010507", "GO:0016236", "GO:0016241" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.025, "significant": true, "source": "GO:BP", "term_size": 40, "source_order": 4936, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of p38MAPK cascade.\" [GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 29753, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [ "IDA" ], [] ], "name": "regulation of p38MAPK cascade", "native": "GO:1900744", "p_value": 0.03668174929051046, "parents": [ "GO:0038066", "GO:0043408" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.025, "significant": true, "source": "GO:BP", "term_size": 40, "source_order": 19630, "group_id": 6 }, { "description": "\"A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.\" [GOC:BHF, GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, PMID:18846107, PMID:20823910, PMID:21737330, PMID:21760595, PMID:21876153]", "effective_domain_size": 20972, "goshv": 25043, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "necroptotic process", "native": "GO:0070266", "p_value": 0.03668174929051046, "parents": [ "GO:0097300" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.025, "significant": true, "source": "GO:BP", "term_size": 40, "source_order": 14920, "group_id": 1 }, { "description": "\"The chemical reactions and pathways involving nicotinamide adenine dinucleotide phosphate (NADP+), a coenzyme that interconverts with its reduced form, NADPH, in many redox and biosynthetic reactions.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 12436, "intersection_size": 1, "intersections": [ [ "IMP" ], [], [], [], [], [], [], [], [], [], [] ], "name": "NADP+ metabolic process", "native": "GO:0006739", "p_value": 0.03668174929051046, "parents": [ "GO:0006163", "GO:0046496" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.025, "significant": true, "source": "GO:BP", "term_size": 40, "source_order": 2313, "group_id": 1 }, { "description": "\"The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances.\" [ISBN:0721662544]", "effective_domain_size": 20972, "goshv": 22471, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [ "IDA" ], [], [ "IEA" ], [], [] ], "name": "epithelial cell proliferation", "native": "GO:0050673", "p_value": 0.036753350915231485, "parents": [ "GO:0008283" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.004597701149425287, "significant": true, "source": "GO:BP", "term_size": 435, "source_order": 12348, "group_id": 1 }, { "description": "\"The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle.\" [PMID:28225081]", "effective_domain_size": 20972, "goshv": 28738, "intersection_size": 2, "intersections": [ [], [], [], [], [ "IMP" ], [ "NAS" ], [], [], [], [], [] ], "name": "membraneless organelle assembly", "native": "GO:0140694", "p_value": 0.03685665535053134, "parents": [ "GO:0070925" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.0045871559633027525, "significant": true, "source": "GO:BP", "term_size": 436, "source_order": 18615, "group_id": 1 }, { "description": "\"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).\" [GOC:txnOH-2018]", "effective_domain_size": 20972, "goshv": 14210, "intersection_size": 3, "intersections": [ [ "IDA", "IMP", "ISS", "IEA" ], [ "IMP" ], [], [], [], [ "IMP" ], [], [], [], [], [] ], "name": "positive regulation of gene expression", "native": "GO:0010628", "p_value": 0.036976789676783285, "parents": [ "GO:0010467", "GO:0010468", "GO:0010557" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.002533783783783784, "significant": true, "source": "GO:BP", "term_size": 1184, "source_order": 4087, "group_id": 1 }, { "description": "\"The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.\" [GOC:mtg_heart]", "effective_domain_size": 20972, "goshv": 11697, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [], [ "IEA" ] ], "name": "endocardial cushion morphogenesis", "native": "GO:0003203", "p_value": 0.0371971155632025, "parents": [ "GO:0003007", "GO:0003197", "GO:0072132" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.024390243902439025, "significant": true, "source": "GO:BP", "term_size": 41, "source_order": 1574, "group_id": 1 }, { "description": "\"A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations.\" [CL:0000737, GOC:dph, GOC:mtg_apoptosis, GOC:tb]", "effective_domain_size": 20972, "goshv": 14239, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "striated muscle cell apoptotic process", "native": "GO:0010658", "p_value": 0.0371971155632025, "parents": [ "GO:0010657" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.024390243902439025, "significant": true, "source": "GO:BP", "term_size": 41, "source_order": 4116, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of DNA replication.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 20934, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "TAS" ], [], [] ], "name": "positive regulation of DNA replication", "native": "GO:0045740", "p_value": 0.0371971155632025, "parents": [ "GO:0006260", "GO:0006275", "GO:0051054" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.024390243902439025, "significant": true, "source": "GO:BP", "term_size": 41, "source_order": 10811, "group_id": 1 }, { "description": "\"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline.\" [GOC:dph, GOC:ems, GOC:mah, GOC:vw]", "effective_domain_size": 20972, "goshv": 12703, "intersection_size": 1, "intersections": [ [], [ "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "female meiotic nuclear division", "native": "GO:0007143", "p_value": 0.0371971155632025, "parents": [ "GO:0007292", "GO:0140013" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.024390243902439025, "significant": true, "source": "GO:BP", "term_size": 41, "source_order": 2580, "group_id": 1 }, { "description": "\"Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.\" [GOC:bf, PMID:12546810]", "effective_domain_size": 20972, "goshv": 18779, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "positive regulation of mitochondrial membrane permeability", "native": "GO:0035794", "p_value": 0.037925479095224715, "parents": [ "GO:0046902", "GO:1905710" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.023809523809523808, "significant": true, "source": "GO:BP", "term_size": 42, "source_order": 8656, "group_id": 3 }, { "description": "\"The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell.\" [GOC:add, ISBN:0781735149]", "effective_domain_size": 20972, "goshv": 10976, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "T cell lineage commitment", "native": "GO:0002360", "p_value": 0.037925479095224715, "parents": [ "GO:0030217", "GO:0045165" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.023809523809523808, "significant": true, "source": "GO:BP", "term_size": 42, "source_order": 853, "group_id": 23 }, { "description": "\"Any process that modulates the occurrence or rate of T cell death by apoptotic process.\" [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]", "effective_domain_size": 20972, "goshv": 25018, "intersection_size": 1, "intersections": [ [ "ISS", "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of T cell apoptotic process", "native": "GO:0070232", "p_value": 0.037925479095224715, "parents": [ "GO:0070228", "GO:0070231" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.023809523809523808, "significant": true, "source": "GO:BP", "term_size": 42, "source_order": 14895, "group_id": 1 }, { "description": "\"Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 20292, "intersection_size": 5, "intersections": [ [ "IDA", "IEA" ], [ "IMP" ], [ "IMP" ], [], [], [], [], [ "IMP", "IBA" ], [], [], [ "IDA", "IEA" ] ], "name": "protein-containing complex organization", "native": "GO:0043933", "p_value": 0.03850440271225197, "parents": [ "GO:0016043" ], "precision": 0.45454545454545453, "query": "query_1", "query_size": 11, "recall": 0.0014654161781946073, "significant": true, "source": "GO:BP", "term_size": 3412, "source_order": 10169, "group_id": 1 }, { "description": "\"The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins.\" [GOC:cvs, GOC:jj, GOC:ppm, GOC:sj, PMID:21148556, PMID:22817896, PMID:28937655, PMID:29654159]", "effective_domain_size": 20972, "goshv": 33333, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [], [ "IMP" ] ], "name": "amyloid fibril formation", "native": "GO:1990000", "p_value": 0.03858986693429708, "parents": [ "GO:0019538", "GO:0097435" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.023255813953488372, "significant": true, "source": "GO:BP", "term_size": 43, "source_order": 23210, "group_id": 1 }, { "description": "\"The specific behavior of an organism that recurs with a regularity of approximately 24 hours.\" [GOC:bf, GOC:go_curators, GOC:pr]", "effective_domain_size": 20972, "goshv": 22071, "intersection_size": 1, "intersections": [ [ "ISS", "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "circadian behavior", "native": "GO:0048512", "p_value": 0.03858986693429708, "parents": [ "GO:0007622", "GO:0007623" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.023255813953488372, "significant": true, "source": "GO:BP", "term_size": 43, "source_order": 11948, "group_id": 15 }, { "description": "\"A process leading to the generation of a functional miRNA. Includes the cleavage of stem-loop RNA precursors into microRNAs (miRNAs). miRNAs are a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein, or by increasing the degradation of non-protein-coding RNA transcripts.\" [GOC:aruk, GOC:bc, GOC:dph, GOC:rl, GOC:tb, PMID:15066275, PMID:15066283, PMID:23985560, PMID:28379604]", "effective_domain_size": 20972, "goshv": 18432, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "miRNA processing", "native": "GO:0035196", "p_value": 0.03858986693429708, "parents": [ "GO:0070918" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.023255813953488372, "significant": true, "source": "GO:BP", "term_size": 43, "source_order": 8309, "group_id": 1 }, { "description": "\"Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.\" [GOC:ai, GOC:dos]", "effective_domain_size": 20972, "goshv": 22810, "intersection_size": 6, "intersections": [ [ "IEA" ], [ "IMP" ], [ "IMP", "IC" ], [], [], [], [ "IDA", "IEA" ], [], [ "IMP", "IEA" ], [], [ "IDA" ] ], "name": "establishment of localization", "native": "GO:0051234", "p_value": 0.03906286453646223, "parents": [ "GO:0051179" ], "precision": 0.5454545454545454, "query": "query_1", "query_size": 11, "recall": 0.0012489592006661116, "significant": true, "source": "GO:BP", "term_size": 4804, "source_order": 12687, "group_id": 2 }, { "description": "\"Any signaling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.\" [GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 29282, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [], [ "IEA" ] ], "name": "positive regulation of G1/S transition of mitotic cell cycle", "native": "GO:1900087", "p_value": 0.03918848240657818, "parents": [ "GO:0000082", "GO:1901992", "GO:1902808", "GO:2000045" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.022727272727272728, "significant": true, "source": "GO:BP", "term_size": 44, "source_order": 19159, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of neuroblast proliferation.\" [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:21168496]", "effective_domain_size": 20972, "goshv": 31029, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of neuroblast proliferation", "native": "GO:1902692", "p_value": 0.03918848240657818, "parents": [ "GO:0007405", "GO:2000177" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.022727272727272728, "significant": true, "source": "GO:BP", "term_size": 44, "source_order": 20906, "group_id": 1 }, { "description": "\"Any regulation of mitochondrial membrane permeability that is involved in apoptotic process.\" [GOC:mtg_apoptosis, GOC:pm, GOC:TermGenie, PMID:19168129]", "effective_domain_size": 20972, "goshv": 30658, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of mitochondrial membrane permeability involved in apoptotic process", "native": "GO:1902108", "p_value": 0.03918848240657818, "parents": [ "GO:0008637", "GO:0046902" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.022727272727272728, "significant": true, "source": "GO:BP", "term_size": 44, "source_order": 20535, "group_id": 3 }, { "description": "\"Any process that modulates the frequency, rate or extent of cellular senescence.\" [GOC:BHF]", "effective_domain_size": 20972, "goshv": 34251, "intersection_size": 1, "intersections": [ [ "IDA", "ISS", "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of cellular senescence", "native": "GO:2000772", "p_value": 0.03918848240657818, "parents": [ "GO:0050794", "GO:0090398" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.022727272727272728, "significant": true, "source": "GO:BP", "term_size": 44, "source_order": 24128, "group_id": 1 }, { "description": "\"The reorganization or renovation of existing blood vessels.\" [GOC:hjd]", "effective_domain_size": 20972, "goshv": 10689, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [], [ "IEA" ] ], "name": "blood vessel remodeling", "native": "GO:0001974", "p_value": 0.03989410629924097, "parents": [ "GO:0048771" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.022222222222222223, "significant": true, "source": "GO:BP", "term_size": 45, "source_order": 566, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils.\" [GOC:go_curators, GOC:jl]", "effective_domain_size": 20972, "goshv": 19551, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "IMP" ], [], [], [], [], [] ], "name": "regulation of fatty acid biosynthetic process", "native": "GO:0042304", "p_value": 0.03989410629924097, "parents": [ "GO:0006633", "GO:0019217", "GO:0046890" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.022222222222222223, "significant": true, "source": "GO:BP", "term_size": 45, "source_order": 9428, "group_id": 1 }, { "description": "\"The specific behavior of an organism that recur with measured regularity.\" [GOC:jl, GOC:pr]", "effective_domain_size": 20972, "goshv": 13062, "intersection_size": 1, "intersections": [ [ "ISS", "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "rhythmic behavior", "native": "GO:0007622", "p_value": 0.03989410629924097, "parents": [ "GO:0007610" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.022222222222222223, "significant": true, "source": "GO:BP", "term_size": 45, "source_order": 2939, "group_id": 15 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.\" [GOC:go_curators, GOC:txnOH]", "effective_domain_size": 20972, "goshv": 21081, "intersection_size": 3, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IEA" ], [ "ISS", "IEA" ], [], [], [], [ "IDA", "IMP", "IBA", "IEA" ], [], [], [], [], [] ], "name": "positive regulation of transcription by RNA polymerase II", "native": "GO:0045944", "p_value": 0.04031363940436722, "parents": [ "GO:0006357", "GO:0006366", "GO:0045893" ], "precision": 0.2727272727272727, "query": "query_1", "query_size": 11, "recall": 0.002425222312045271, "significant": true, "source": "GO:BP", "term_size": 1237, "source_order": 10958, "group_id": 1 }, { "description": "Neddylation", "effective_domain_size": 11056, "goshv": 40946, "intersection_size": 2, "intersections": [ [], [], [], [], [], [ "REAC" ], [], [], [ "REAC" ], [], [] ], "name": "Neddylation", "native": "REAC:R-HSA-8951664", "p_value": 0.04041215503289587, "parents": [ "REAC:R-HSA-597592" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.00819672131147541, "significant": true, "source": "REAC", "term_size": 244, "source_order": 1622, "group_id": 45 }, { "description": "Defective Intrinsic Pathway for Apoptosis", "effective_domain_size": 11056, "goshv": 39918, "intersection_size": 1, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [], [], [] ], "name": "Defective Intrinsic Pathway for Apoptosis", "native": "REAC:R-HSA-9734009", "p_value": 0.04048350265932144, "parents": [ "REAC:R-HSA-9645723" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.041666666666666664, "significant": true, "source": "REAC", "term_size": 24, "source_order": 594, "group_id": 32 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of the passage or uptake of molecules by a membrane.\" [PMID:27482894]", "effective_domain_size": 20972, "goshv": 33159, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "positive regulation of membrane permeability", "native": "GO:1905710", "p_value": 0.040534243075685636, "parents": [ "GO:0090559" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.021739130434782608, "significant": true, "source": "GO:BP", "term_size": 46, "source_order": 23036, "group_id": 3 }, { "description": "\"Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.\" [CL:0000192, GOC:ebc]", "effective_domain_size": 20972, "goshv": 22194, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "IMP" ], [], [] ], "name": "negative regulation of smooth muscle cell proliferation", "native": "GO:0048662", "p_value": 0.040534243075685636, "parents": [ "GO:0008285", "GO:0048659", "GO:0048660" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.021739130434782608, "significant": true, "source": "GO:BP", "term_size": 46, "source_order": 12071, "group_id": 1 }, { "description": "\"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0.\" [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124]", "effective_domain_size": 20972, "goshv": 12671, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "NAS" ], [], [], [], [], [] ], "name": "centriole replication", "native": "GO:0007099", "p_value": 0.040534243075685636, "parents": [ "GO:0022402", "GO:0051298", "GO:0098534" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.021739130434782608, "significant": true, "source": "GO:BP", "term_size": 46, "source_order": 2548, "group_id": 1 }, { "description": "\"Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.\" [GOC:go_curators, GOC:isa_complete, ISBN:0521436125]", "effective_domain_size": 20972, "goshv": 12876, "intersection_size": 2, "intersections": [ [ "IEA" ], [ "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "pattern specification process", "native": "GO:0007389", "p_value": 0.04056026641953763, "parents": [ "GO:0007275", "GO:0032501" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.004273504273504274, "significant": true, "source": "GO:BP", "term_size": 468, "source_order": 2753, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.\" [GOC:TermGenie, PMID:17245429]", "effective_domain_size": 20972, "goshv": 30607, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "IMP" ], [], [], [], [], [] ], "name": "regulation of extrinsic apoptotic signaling pathway via death domain receptors", "native": "GO:1902041", "p_value": 0.04122606519839354, "parents": [ "GO:0008625", "GO:2001236" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02127659574468085, "significant": true, "source": "GO:BP", "term_size": 47, "source_order": 20484, "group_id": 13 }, { "description": "\"Any process that activates or increases the rate or extent of B cell proliferation.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 16631, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "IEA" ], [], [] ], "name": "positive regulation of B cell proliferation", "native": "GO:0030890", "p_value": 0.04122606519839354, "parents": [ "GO:0030888", "GO:0042100", "GO:0050671", "GO:0050871" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02127659574468085, "significant": true, "source": "GO:BP", "term_size": 47, "source_order": 6508, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 16931, "intersection_size": 2, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [], [ "IMP", "IEA" ], [], [] ], "name": "response to nutrient levels", "native": "GO:0031667", "p_value": 0.041519915339110966, "parents": [ "GO:0050896" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.004210526315789474, "significant": true, "source": "GO:BP", "term_size": 475, "source_order": 6808, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of macromitophagy.\" [GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 30257, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of mitophagy", "native": "GO:1901524", "p_value": 0.04197189315973183, "parents": [ "GO:0000423", "GO:0016241", "GO:1903146" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.020833333333333332, "significant": true, "source": "GO:BP", "term_size": 48, "source_order": 20134, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 19473, "intersection_size": 1, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "cellular response to glucose starvation", "native": "GO:0042149", "p_value": 0.042287715233640305, "parents": [ "GO:0009267" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02040816326530612, "significant": true, "source": "GO:BP", "term_size": 49, "source_order": 9350, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.\" [GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 14351, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "NAS" ], [], [], [], [], [] ], "name": "regulation of centrosome duplication", "native": "GO:0010824", "p_value": 0.042287715233640305, "parents": [ "GO:0046605", "GO:0051298" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02040816326530612, "significant": true, "source": "GO:BP", "term_size": 49, "source_order": 4228, "group_id": 1 }, { "description": "\"The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.\" [RESID:AA0038]", "effective_domain_size": 20972, "goshv": 15194, "intersection_size": 1, "intersections": [ [], [], [], [ "IDA" ], [], [], [], [], [], [], [] ], "name": "peptidyl-threonine phosphorylation", "native": "GO:0018107", "p_value": 0.042287715233640305, "parents": [ "GO:0006468", "GO:0018210" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02040816326530612, "significant": true, "source": "GO:BP", "term_size": 49, "source_order": 5071, "group_id": 1 }, { "description": "\"The modification of peptidyl-threonine.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 15235, "intersection_size": 1, "intersections": [ [], [], [], [ "IDA" ], [], [], [], [], [], [], [] ], "name": "peptidyl-threonine modification", "native": "GO:0018210", "p_value": 0.042287715233640305, "parents": [ "GO:0018193" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02040816326530612, "significant": true, "source": "GO:BP", "term_size": 49, "source_order": 5112, "group_id": 1 }, { "description": "\"A signaling process that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25458, "intersection_size": 1, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [], [], [] ], "name": "spindle assembly checkpoint signaling", "native": "GO:0071173", "p_value": 0.042287715233640305, "parents": [ "GO:0031577" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02040816326530612, "significant": true, "source": "GO:BP", "term_size": 49, "source_order": 15335, "group_id": 1 }, { "description": "\"A signaling process that contributes to a mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, the completion of anaphase until chromosomes are attached to the spindle, or mitotic exit and cytokinesis when the spindle does not form.\" [GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 25459, "intersection_size": 1, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [], [], [] ], "name": "mitotic spindle checkpoint signaling", "native": "GO:0071174", "p_value": 0.042287715233640305, "parents": [ "GO:0007093", "GO:0031577" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02040816326530612, "significant": true, "source": "GO:BP", "term_size": 49, "source_order": 15336, "group_id": 1 }, { "description": "\"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 25875, "intersection_size": 1, "intersections": [ [], [], [ "IDA" ], [], [], [], [], [], [], [], [] ], "name": "nuclear membrane organization", "native": "GO:0071763", "p_value": 0.042287715233640305, "parents": [ "GO:0006998", "GO:0061024" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02040816326530612, "significant": true, "source": "GO:BP", "term_size": 49, "source_order": 15752, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly.\" [GOC:pr, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 30665, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "NAS" ], [], [], [], [], [] ], "name": "negative regulation of organelle assembly", "native": "GO:1902116", "p_value": 0.042287715233640305, "parents": [ "GO:0010639", "GO:0070925", "GO:1902115" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02040816326530612, "significant": true, "source": "GO:BP", "term_size": 49, "source_order": 20542, "group_id": 1 }, { "description": "\"A mitotic cell cycle checkpoint that delays mitotic sister chromatid separation and consequently the mitotic metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle. Spindle assembly checkpoint signaling begins with the activated Mph family kinase, and results in the inhibition of the Anaphase Promoting Complex and its activator Sleepy/Cdc20 by the mitotic checkpoint complex (MCC).\" [GOC:mtg_cell_cycle, PMID:12360190]", "effective_domain_size": 20972, "goshv": 12666, "intersection_size": 1, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [], [], [] ], "name": "mitotic spindle assembly checkpoint signaling", "native": "GO:0007094", "p_value": 0.042287715233640305, "parents": [ "GO:0045841", "GO:0071173", "GO:0071174" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02040816326530612, "significant": true, "source": "GO:BP", "term_size": 49, "source_order": 2543, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling.\" [GO_REF:0000058, GOC:TermGenie, PMID:25366275]", "effective_domain_size": 20972, "goshv": 32087, "intersection_size": 1, "intersections": [ [], [ "IMP", "IBA", "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of TORC1 signaling", "native": "GO:1904262", "p_value": 0.04295714888078276, "parents": [ "GO:0032007", "GO:0038202", "GO:1903432" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02, "significant": true, "source": "GO:BP", "term_size": 50, "source_order": 21964, "group_id": 24 }, { "description": "\"The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule.\" [ISBN:0198506732]", "effective_domain_size": 20972, "goshv": 15472, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "hexose catabolic process", "native": "GO:0019320", "p_value": 0.04295714888078276, "parents": [ "GO:0019318", "GO:0046365" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02, "significant": true, "source": "GO:BP", "term_size": 50, "source_order": 5349, "group_id": 1 }, { "description": "\"A signaling process that that controls a cell cycle checkpoint that originates from the mitotic or meiotic spindle.\" [GOC:mtg_cell_cycle]", "effective_domain_size": 20972, "goshv": 16887, "intersection_size": 1, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [], [], [] ], "name": "spindle checkpoint signaling", "native": "GO:0031577", "p_value": 0.04295714888078276, "parents": [ "GO:0000075" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.02, "significant": true, "source": "GO:BP", "term_size": 50, "source_order": 6764, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of mitotic sister chromatid separation.\" [GOC:obol]", "effective_domain_size": 20972, "goshv": 34286, "intersection_size": 1, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of mitotic sister chromatid separation", "native": "GO:2000816", "p_value": 0.0433150474480582, "parents": [ "GO:0010965", "GO:0033048", "GO:0051306", "GO:1905819" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0196078431372549, "significant": true, "source": "GO:BP", "term_size": 51, "source_order": 24163, "group_id": 1 }, { "description": "\"Any process that modulates the rate of an ATP-dependent activity.\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 20157, "intersection_size": 1, "intersections": [ [ "TAS" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of ATP-dependent activity", "native": "GO:0043462", "p_value": 0.0433150474480582, "parents": [ "GO:0065009" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0196078431372549, "significant": true, "source": "GO:BP", "term_size": 51, "source_order": 10034, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17610, "intersection_size": 1, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of mitotic sister chromatid segregation", "native": "GO:0033048", "p_value": 0.0433150474480582, "parents": [ "GO:0000070", "GO:0033046", "GO:0033047" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0196078431372549, "significant": true, "source": "GO:BP", "term_size": 51, "source_order": 7487, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 21007, "intersection_size": 1, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of mitotic metaphase/anaphase transition", "native": "GO:0045841", "p_value": 0.0433150474480582, "parents": [ "GO:0007091", "GO:0030071", "GO:0045839", "GO:1901991", "GO:1902100", "GO:2000816" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0196078431372549, "significant": true, "source": "GO:BP", "term_size": 51, "source_order": 10884, "group_id": 1 }, { "description": "\"An intracellular signaling cassette in which a small monomeric GTPase relays a signal.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 12779, "intersection_size": 2, "intersections": [ [ "IEP" ], [], [], [], [], [], [], [], [ "IEP" ], [], [] ], "name": "small GTPase-mediated signal transduction", "native": "GO:0007264", "p_value": 0.0433150474480582, "parents": [ "GO:0141124" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.004056795131845842, "significant": true, "source": "GO:BP", "term_size": 493, "source_order": 2656, "group_id": 8 }, { "description": "\"A cellular process that results in the assembly of one or more centrioles.\" [GOC:dos, PMID:24075808]", "effective_domain_size": 20972, "goshv": 27680, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "NAS" ], [], [], [], [], [] ], "name": "centriole assembly", "native": "GO:0098534", "p_value": 0.0433150474480582, "parents": [ "GO:0031023", "GO:0140694" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0196078431372549, "significant": true, "source": "GO:BP", "term_size": 51, "source_order": 17557, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17608, "intersection_size": 1, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of sister chromatid segregation", "native": "GO:0033046", "p_value": 0.0433150474480582, "parents": [ "GO:0000819", "GO:0033045", "GO:0051985", "GO:2001251" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0196078431372549, "significant": true, "source": "GO:BP", "term_size": 51, "source_order": 7485, "group_id": 1 }, { "description": "\"The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components.\" [GOC:add, ISBN:0781735149]", "effective_domain_size": 20972, "goshv": 22093, "intersection_size": 1, "intersections": [ [], [ "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "thymus development", "native": "GO:0048538", "p_value": 0.0433150474480582, "parents": [ "GO:0048534", "GO:0048732" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.0196078431372549, "significant": true, "source": "GO:BP", "term_size": 51, "source_order": 11970, "group_id": 1 }, { "description": "\"A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.\" [GOC:mtg_apoptosis, PMID:21760595]", "effective_domain_size": 20972, "goshv": 27485, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "programmed necrotic cell death", "native": "GO:0097300", "p_value": 0.043785908662160616, "parents": [ "GO:0012501" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.019230769230769232, "significant": true, "source": "GO:BP", "term_size": 52, "source_order": 17362, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.\" [GOC:jid]", "effective_domain_size": 20972, "goshv": 21825, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "IMP" ], [], [] ], "name": "positive regulation of fibroblast proliferation", "native": "GO:0048146", "p_value": 0.043785908662160616, "parents": [ "GO:0008284", "GO:0048144", "GO:0048145" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.019230769230769232, "significant": true, "source": "GO:BP", "term_size": 52, "source_order": 11702, "group_id": 1 }, { "description": "\"Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 16918, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [], [ "IDA", "IMP" ] ], "name": "protein destabilization", "native": "GO:0031648", "p_value": 0.043785908662160616, "parents": [ "GO:0031647" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.019230769230769232, "significant": true, "source": "GO:BP", "term_size": 52, "source_order": 6795, "group_id": 4 }, { "description": "\"The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.\" [GOC:mtg_heart]", "effective_domain_size": 20972, "goshv": 11693, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [], [ "IEA" ] ], "name": "endocardial cushion development", "native": "GO:0003197", "p_value": 0.043785908662160616, "parents": [ "GO:0007507", "GO:0060485" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.019230769230769232, "significant": true, "source": "GO:BP", "term_size": 52, "source_order": 1570, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate.\" [GOC:go_curators]", "effective_domain_size": 20972, "goshv": 21054, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of carbohydrate metabolic process", "native": "GO:0045912", "p_value": 0.043785908662160616, "parents": [ "GO:0005975", "GO:0006109", "GO:0009892" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.019230769230769232, "significant": true, "source": "GO:BP", "term_size": 52, "source_order": 10931, "group_id": 1 }, { "description": "\"The cellular synthesis of messenger RNA (mRNA) from a DNA template.\" [GOC:jl]", "effective_domain_size": 20972, "goshv": 13413, "intersection_size": 1, "intersections": [ [ "IMP" ], [], [], [], [], [], [], [], [], [], [] ], "name": "mRNA transcription", "native": "GO:0009299", "p_value": 0.043785908662160616, "parents": [ "GO:0006351", "GO:0016071" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.019230769230769232, "significant": true, "source": "GO:BP", "term_size": 52, "source_order": 3290, "group_id": 1 }, { "description": "\"The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others.\" [GOC:ef, ISBN:0878932585]", "effective_domain_size": 20972, "goshv": 14490, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "glial cell proliferation", "native": "GO:0014009", "p_value": 0.04395387915226433, "parents": [ "GO:0008283", "GO:0042063" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.018867924528301886, "significant": true, "source": "GO:BP", "term_size": 53, "source_order": 4367, "group_id": 1 }, { "description": "\"Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity.\" [GOC:BHF, GOC:mah]", "effective_domain_size": 20972, "goshv": 25950, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [ "IMP" ], [] ], "name": "negative regulation of protein serine/threonine kinase activity", "native": "GO:0071901", "p_value": 0.04395387915226433, "parents": [ "GO:0006469", "GO:0071900" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.018867924528301886, "significant": true, "source": "GO:BP", "term_size": 53, "source_order": 15827, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.\" [GOC:bf]", "effective_domain_size": 20972, "goshv": 21711, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of mitochondrial membrane permeability", "native": "GO:0046902", "p_value": 0.04395387915226433, "parents": [ "GO:0090559" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.018867924528301886, "significant": true, "source": "GO:BP", "term_size": 53, "source_order": 11588, "group_id": 3 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of cell cycle.\" [GOC:mtg_cell_cycle, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 30650, "intersection_size": 1, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of metaphase/anaphase transition of cell cycle", "native": "GO:1902100", "p_value": 0.04395387915226433, "parents": [ "GO:0044784", "GO:1901988", "GO:1902099" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.018867924528301886, "significant": true, "source": "GO:BP", "term_size": 53, "source_order": 20527, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of mitochondrion degradation by an autophagic process.\" [GO_REF:0000058, GOC:autophagy, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24600391]", "effective_domain_size": 20972, "goshv": 31337, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of autophagy of mitochondrion", "native": "GO:1903146", "p_value": 0.04395387915226433, "parents": [ "GO:0000422", "GO:0010506" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.018867924528301886, "significant": true, "source": "GO:BP", "term_size": 53, "source_order": 21214, "group_id": 1 }, { "description": "\"The series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 12597, "intersection_size": 1, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "ER-nucleus signaling pathway", "native": "GO:0006984", "p_value": 0.04395387915226433, "parents": [ "GO:0035556" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.018867924528301886, "significant": true, "source": "GO:BP", "term_size": 53, "source_order": 2474, "group_id": 1 }, { "description": "\"Any process that stops, prevents or reduces the frequency, rate or extent of chromosome separation.\" [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:21795393]", "effective_domain_size": 20972, "goshv": 33228, "intersection_size": 1, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of chromosome separation", "native": "GO:1905819", "p_value": 0.04395387915226433, "parents": [ "GO:0051304", "GO:0051985", "GO:1905818" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.018867924528301886, "significant": true, "source": "GO:BP", "term_size": 53, "source_order": 23105, "group_id": 1 }, { "description": "\"The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.\" [GOC:add, GOC:mah, GOC:mtg_apoptosis, ISBN:0721639976, PMID:12925707, PMID:9560217]", "effective_domain_size": 20972, "goshv": 10603, "intersection_size": 1, "intersections": [ [ "IDA", "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "release of cytochrome c from mitochondria", "native": "GO:0001836", "p_value": 0.04395387915226433, "parents": [ "GO:0008637", "GO:0097190" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.018867924528301886, "significant": true, "source": "GO:BP", "term_size": 53, "source_order": 480, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.\" [GOC:ecd]", "effective_domain_size": 20972, "goshv": 18058, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "IMP", "IEA" ], [], [] ], "name": "cellular response to amino acid starvation", "native": "GO:0034198", "p_value": 0.04395387915226433, "parents": [ "GO:0009267", "GO:1990928" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.018867924528301886, "significant": true, "source": "GO:BP", "term_size": 53, "source_order": 7935, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.\" [GOC:hjd]", "effective_domain_size": 20972, "goshv": 10656, "intersection_size": 2, "intersections": [ [], [], [], [], [], [], [], [], [ "IDA", "IMP", "TAS" ], [ "IMP", "TAS" ], [] ], "name": "regulation of protein phosphorylation", "native": "GO:0001932", "p_value": 0.04395387915226433, "parents": [ "GO:0006468", "GO:0031399", "GO:0042325" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.003968253968253968, "significant": true, "source": "GO:BP", "term_size": 504, "source_order": 533, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 23228, "intersection_size": 1, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [], [], [] ], "name": "negative regulation of chromosome segregation", "native": "GO:0051985", "p_value": 0.04395387915226433, "parents": [ "GO:0007059", "GO:0010948", "GO:0051983" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.018867924528301886, "significant": true, "source": "GO:BP", "term_size": 53, "source_order": 13105, "group_id": 1 }, { "description": "Glutamate binding, activation of AMPA receptors and synaptic plasticity", "effective_domain_size": 11056, "goshv": 40429, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [], [ "REAC" ] ], "name": "Glutamate binding, activation of AMPA receptors and synaptic plasticity", "native": "REAC:R-HSA-399721", "p_value": 0.044038424018599, "parents": [ "REAC:R-HSA-112314" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.037037037037037035, "significant": true, "source": "REAC", "term_size": 27, "source_order": 1105, "group_id": 37 }, { "description": "Pyroptosis", "effective_domain_size": 11056, "goshv": 41228, "intersection_size": 1, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [], [], [] ], "name": "Pyroptosis", "native": "REAC:R-HSA-5620971", "p_value": 0.044038424018599, "parents": [ "REAC:R-HSA-5218859" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.037037037037037035, "significant": true, "source": "REAC", "term_size": 27, "source_order": 1904, "group_id": 46 }, { "description": "FLT3 signaling in disease", "effective_domain_size": 11056, "goshv": 40285, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "REAC" ], [], [] ], "name": "FLT3 signaling in disease", "native": "REAC:R-HSA-9682385", "p_value": 0.044038424018599, "parents": [ "REAC:R-HSA-5663202" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.037037037037037035, "significant": true, "source": "REAC", "term_size": 27, "source_order": 961, "group_id": 26 }, { "description": "Trafficking of AMPA receptors", "effective_domain_size": 11056, "goshv": 41954, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [], [ "REAC" ] ], "name": "Trafficking of AMPA receptors", "native": "REAC:R-HSA-399719", "p_value": 0.044038424018599, "parents": [ "REAC:R-HSA-399721" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.037037037037037035, "significant": true, "source": "REAC", "term_size": 27, "source_order": 2630, "group_id": 37 }, { "description": "\"Any process that modulates the frequency, rate or extent of lymphocyte activation.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22821, "intersection_size": 2, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [ "IEA" ], [], [] ], "name": "regulation of lymphocyte activation", "native": "GO:0051249", "p_value": 0.04421793923021992, "parents": [ "GO:0002694", "GO:0046649" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.003952569169960474, "significant": true, "source": "GO:BP", "term_size": 506, "source_order": 12698, "group_id": 1 }, { "description": "\"The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.\" [ISBN:0198506732]", "effective_domain_size": 20972, "goshv": 21687, "intersection_size": 1, "intersections": [ [], [ "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "phosphatidylinositol phosphate biosynthetic process", "native": "GO:0046854", "p_value": 0.044520838393935516, "parents": [ "GO:0006661" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.018518518518518517, "significant": true, "source": "GO:BP", "term_size": 54, "source_order": 11564, "group_id": 12 }, { "description": "\"Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.\" [GOC:BHF, GOC:dph, GOC:tb]", "effective_domain_size": 20972, "goshv": 14181, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [ "IMP", "IEA" ], [] ], "name": "negative regulation of endothelial cell migration", "native": "GO:0010596", "p_value": 0.044520838393935516, "parents": [ "GO:0010594", "GO:0030336", "GO:0043542" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.018518518518518517, "significant": true, "source": "GO:BP", "term_size": 54, "source_order": 4058, "group_id": 14 }, { "description": "\"The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms.\" [ISBN:0198506732]", "effective_domain_size": 20972, "goshv": 21421, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "monosaccharide catabolic process", "native": "GO:0046365", "p_value": 0.044520838393935516, "parents": [ "GO:0005996", "GO:0016052", "GO:0044282" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.018518518518518517, "significant": true, "source": "GO:BP", "term_size": 54, "source_order": 11298, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.\" [PMID:7765311]", "effective_domain_size": 20972, "goshv": 33615, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "IMP", "IEA" ], [], [] ], "name": "response to amino acid starvation", "native": "GO:1990928", "p_value": 0.04527291860024185, "parents": [ "GO:0042594" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.01818181818181818, "significant": true, "source": "GO:BP", "term_size": 55, "source_order": 23492, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 21540, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "NAS" ], [], [], [], [], [] ], "name": "regulation of centrosome cycle", "native": "GO:0046605", "p_value": 0.04565092065054784, "parents": [ "GO:0007098", "GO:0010564", "GO:0032886", "GO:0051128" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.017857142857142856, "significant": true, "source": "GO:BP", "term_size": 56, "source_order": 11417, "group_id": 1 }, { "description": "\"An epigenetic mechanism of regulation of gene expression that involves chromatin remodeling to capacitate gene expression by either modifying the chromatin fiber, the nucleosomal histones, or the DNA.\" [PMID:34414474]", "effective_domain_size": 20972, "goshv": 20988, "intersection_size": 1, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "transcription initiation-coupled chromatin remodeling", "native": "GO:0045815", "p_value": 0.04565092065054784, "parents": [ "GO:0006367", "GO:0141137" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.017857142857142856, "significant": true, "source": "GO:BP", "term_size": 56, "source_order": 10865, "group_id": 1 }, { "description": "\"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 22717, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "IMP" ], [], [], [], [], [] ], "name": "negative regulation of lipid biosynthetic process", "native": "GO:0051055", "p_value": 0.04565092065054784, "parents": [ "GO:0008610", "GO:0009890", "GO:0045833", "GO:0046890" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.017857142857142856, "significant": true, "source": "GO:BP", "term_size": 56, "source_order": 12594, "group_id": 1 }, { "description": "\"A nuclear receptor-mediated signaling pathway initiated by an estrogen binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.\" [GOC:signaling]", "effective_domain_size": 20972, "goshv": 16513, "intersection_size": 1, "intersections": [ [], [], [], [], [], [ "IMP" ], [], [], [], [], [] ], "name": "estrogen receptor signaling pathway", "native": "GO:0030520", "p_value": 0.04565092065054784, "parents": [ "GO:0030518" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.017857142857142856, "significant": true, "source": "GO:BP", "term_size": 56, "source_order": 6390, "group_id": 1 }, { "description": "\"The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication.\" [GOC:mah, GOC:txnOH]", "effective_domain_size": 20972, "goshv": 17437, "intersection_size": 7, "intersections": [ [ "IDA", "IMP", "IGI", "ISS", "IBA", "NAS", "IEA" ], [ "ISS", "IEA" ], [], [], [ "IDA" ], [ "IDA", "IMP", "IBA", "TAS", "IEA" ], [ "IDA", "IBA" ], [], [], [ "IMP" ], [ "IDA", "IMP" ] ], "name": "RNA biosynthetic process", "native": "GO:0032774", "p_value": 0.04565092065054784, "parents": [ "GO:0016070", "GO:0141187" ], "precision": 0.6363636363636364, "query": "query_1", "query_size": 11, "recall": 0.0010562848951259998, "significant": true, "source": "GO:BP", "term_size": 6627, "source_order": 7314, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.\" [GOC:hjd]", "effective_domain_size": 20972, "goshv": 11516, "intersection_size": 1, "intersections": [ [ "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "response to ischemia", "native": "GO:0002931", "p_value": 0.04565092065054784, "parents": [ "GO:0006950" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.017857142857142856, "significant": true, "source": "GO:BP", "term_size": 56, "source_order": 1393, "group_id": 1 }, { "description": "\"A MAPK cascade containing at least the p38MAPK (MAPK14) MAP kinase, or Hog1 in yeast. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of p38MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The p38MAPK cascade is activated by stress signals, including hyperosmolarity, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation.\" [PMID:20811974, PMID:23125017, PMID:32794416]", "effective_domain_size": 20972, "goshv": 19182, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [ "IDA" ], [] ], "name": "p38MAPK cascade", "native": "GO:0038066", "p_value": 0.04565092065054784, "parents": [ "GO:0000165" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.017857142857142856, "significant": true, "source": "GO:BP", "term_size": 56, "source_order": 9059, "group_id": 6 }, { "description": "\"Any process in which a protein is transported to, or maintained in, a specific location.\" [GOC:ai]", "effective_domain_size": 20972, "goshv": 13106, "intersection_size": 4, "intersections": [ [ "IDA", "IEA" ], [], [ "IMP" ], [], [], [], [], [], [ "IEA" ], [], [ "IDA" ] ], "name": "intracellular protein localization", "native": "GO:0008104", "p_value": 0.04587233972787558, "parents": [ "GO:0033036" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.001665972511453561, "significant": true, "source": "GO:BP", "term_size": 2401, "source_order": 2983, "group_id": 2 }, { "description": "\"The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell.\" [CL:0000842, GO_REF:0000086, GOC:TermGenie, PMID:24759906]", "effective_domain_size": 20972, "goshv": 31328, "intersection_size": 2, "intersections": [ [ "IEA" ], [ "ISS", "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "mononuclear cell differentiation", "native": "GO:1903131", "p_value": 0.046144537704956315, "parents": [ "GO:0002521" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.0038240917782026767, "significant": true, "source": "GO:BP", "term_size": 523, "source_order": 21205, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation.\" [GO_REF:0000058, GOC:TermGenie, PMID:23246467]", "effective_domain_size": 20972, "goshv": 32432, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "IMP" ], [], [] ], "name": "regulation of vascular associated smooth muscle cell proliferation", "native": "GO:1904705", "p_value": 0.046144537704956315, "parents": [ "GO:0048660", "GO:1990874" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.017543859649122806, "significant": true, "source": "GO:BP", "term_size": 57, "source_order": 22309, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis.\" [GOC:mah]", "effective_domain_size": 20972, "goshv": 17609, "intersection_size": 1, "intersections": [ [], [ "IMP" ], [], [], [], [], [], [], [], [], [] ], "name": "regulation of mitotic sister chromatid segregation", "native": "GO:0033047", "p_value": 0.046144537704956315, "parents": [ "GO:0000070", "GO:0033045" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.017543859649122806, "significant": true, "source": "GO:BP", "term_size": 57, "source_order": 7486, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription.\" [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545]", "effective_domain_size": 20972, "goshv": 31167, "intersection_size": 1, "intersections": [ [ "IDA", "IMP", "IGI" ], [], [], [], [], [], [], [], [], [], [] ], "name": "positive regulation of miRNA transcription", "native": "GO:1902895", "p_value": 0.046144537704956315, "parents": [ "GO:0045893", "GO:0061614", "GO:1902893", "GO:2000630" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.017543859649122806, "significant": true, "source": "GO:BP", "term_size": 57, "source_order": 21044, "group_id": 1 }, { "description": "\"The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.\" [PMID:23246467]", "effective_domain_size": 20972, "goshv": 33599, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "IMP" ], [], [] ], "name": "vascular associated smooth muscle cell proliferation", "native": "GO:1990874", "p_value": 0.046755404384300626, "parents": [ "GO:0048659" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.017241379310344827, "significant": true, "source": "GO:BP", "term_size": 58, "source_order": 23476, "group_id": 1 }, { "description": "\"The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin.\" [CL:0000311]", "effective_domain_size": 20972, "goshv": 20244, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [ "IEA" ], [], [] ], "name": "keratinocyte proliferation", "native": "GO:0043616", "p_value": 0.046755404384300626, "parents": [ "GO:0050673" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.017241379310344827, "significant": true, "source": "GO:BP", "term_size": 58, "source_order": 10121, "group_id": 1 }, { "description": "\"The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells.\" [GOC:mtg_kidney_jan10]", "effective_domain_size": 20972, "goshv": 26129, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [], [ "IEA" ] ], "name": "mesenchyme morphogenesis", "native": "GO:0072132", "p_value": 0.046755404384300626, "parents": [ "GO:0009887", "GO:0048729", "GO:0060485" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.017241379310344827, "significant": true, "source": "GO:BP", "term_size": 58, "source_order": 16006, "group_id": 1 }, { "description": "\"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.\" [GOC:hb]", "effective_domain_size": 20972, "goshv": 13499, "intersection_size": 4, "intersections": [ [ "ISS", "IEA" ], [], [ "IDA" ], [ "IEP" ], [], [], [], [], [], [ "IEP" ], [] ], "name": "response to external stimulus", "native": "GO:0009605", "p_value": 0.04703312629368623, "parents": [ "GO:0050896" ], "precision": 0.36363636363636365, "query": "query_1", "query_size": 11, "recall": 0.0016481252575195715, "significant": true, "source": "GO:BP", "term_size": 2427, "source_order": 3376, "group_id": 1 }, { "description": "\"Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway.\" [GOC:mtg_apoptosis]", "effective_domain_size": 20972, "goshv": 34608, "intersection_size": 1, "intersections": [ [ "IMP", "ISS" ], [], [], [], [], [], [], [], [], [], [] ], "name": "positive regulation of intrinsic apoptotic signaling pathway", "native": "GO:2001244", "p_value": 0.047298301502249764, "parents": [ "GO:0097193", "GO:1902533", "GO:2001235", "GO:2001242" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.01694915254237288, "significant": true, "source": "GO:BP", "term_size": 59, "source_order": 24485, "group_id": 1 }, { "description": "\"An epigenetic process that increases gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA demethylation.\" [PMID:36618446]", "effective_domain_size": 20972, "goshv": 28913, "intersection_size": 1, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "positive regulation of gene expression, epigenetic", "native": "GO:0141137", "p_value": 0.047298301502249764, "parents": [ "GO:0010628", "GO:0040029" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.01694915254237288, "significant": true, "source": "GO:BP", "term_size": 59, "source_order": 18790, "group_id": 1 }, { "description": "\"Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.\" [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]", "effective_domain_size": 20972, "goshv": 31101, "intersection_size": 1, "intersections": [ [], [], [], [], [], [], [], [], [], [], [ "IEA" ] ], "name": "positive regulation of cell cycle G1/S phase transition", "native": "GO:1902808", "p_value": 0.047298301502249764, "parents": [ "GO:0044843", "GO:1901989", "GO:1902806" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.01694915254237288, "significant": true, "source": "GO:BP", "term_size": 59, "source_order": 20978, "group_id": 1 }, { "description": "\"The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.\" [https://www.ncbi.nlm.nih.gov/books/NBK279054/]", "effective_domain_size": 20972, "goshv": 10443, "intersection_size": 1, "intersections": [ [], [ "IEA" ], [], [], [], [], [], [], [], [], [] ], "name": "ovarian follicle development", "native": "GO:0001541", "p_value": 0.04796148104486025, "parents": [ "GO:0008585", "GO:0048856" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.016666666666666666, "significant": true, "source": "GO:BP", "term_size": 60, "source_order": 320, "group_id": 1 }, { "description": "\"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.\" [GOC:dph, GOC:ems, GOC:jl, GOC:mah]", "effective_domain_size": 20972, "goshv": 12603, "intersection_size": 1, "intersections": [ [], [], [ "IDA" ], [], [], [], [], [], [], [], [] ], "name": "nuclear envelope organization", "native": "GO:0006998", "p_value": 0.04796148104486025, "parents": [ "GO:0006997", "GO:0010256", "GO:0061024" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.016666666666666666, "significant": true, "source": "GO:BP", "term_size": 60, "source_order": 2480, "group_id": 1 }, { "description": "Regulation of TP53 Activity through Acetylation", "effective_domain_size": 11056, "goshv": 41421, "intersection_size": 1, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [], [], [] ], "name": "Regulation of TP53 Activity through Acetylation", "native": "REAC:R-HSA-6804758", "p_value": 0.0481018606787004, "parents": [ "REAC:R-HSA-5633007" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.03333333333333333, "significant": true, "source": "REAC", "term_size": 30, "source_order": 2097, "group_id": 25 }, { "description": "Activation of BH3-only proteins", "effective_domain_size": 11056, "goshv": 39407, "intersection_size": 1, "intersections": [ [ "REAC" ], [], [], [], [], [], [], [], [], [], [] ], "name": "Activation of BH3-only proteins", "native": "REAC:R-HSA-114452", "p_value": 0.0481018606787004, "parents": [ "REAC:R-HSA-109606" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.03333333333333333, "significant": true, "source": "REAC", "term_size": 30, "source_order": 83, "group_id": 34 }, { "description": "\"Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process.\" [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]", "effective_domain_size": 20972, "goshv": 25014, "intersection_size": 1, "intersections": [ [ "ISS", "IEA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "regulation of lymphocyte apoptotic process", "native": "GO:0070228", "p_value": 0.048684933200175244, "parents": [ "GO:0070227", "GO:2000106" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.01639344262295082, "significant": true, "source": "GO:BP", "term_size": 61, "source_order": 14891, "group_id": 1 }, { "description": "\"Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.\" [ISBN:0878932453]", "effective_domain_size": 20972, "goshv": 10441, "intersection_size": 2, "intersections": [ [], [], [], [], [], [ "IMP" ], [], [], [], [ "IEA" ], [] ], "name": "angiogenesis", "native": "GO:0001525", "p_value": 0.04909618542623278, "parents": [ "GO:0048514", "GO:0048646" ], "precision": 0.18181818181818182, "query": "query_1", "query_size": 11, "recall": 0.003663003663003663, "significant": true, "source": "GO:BP", "term_size": 546, "source_order": 318, "group_id": 1 }, { "description": "\"Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter.\" [GOC:dph, GOC:tb, GOC:txnOH]", "effective_domain_size": 20972, "goshv": 23616, "intersection_size": 1, "intersections": [ [ "IDA" ], [], [], [], [], [], [], [], [], [], [] ], "name": "positive regulation of transcription initiation by RNA polymerase II", "native": "GO:0060261", "p_value": 0.049276258083194864, "parents": [ "GO:0006367", "GO:0045944", "GO:0060260", "GO:2000144" ], "precision": 0.09090909090909091, "query": "query_1", "query_size": 11, "recall": 0.016129032258064516, "significant": true, "source": "GO:BP", "term_size": 62, "source_order": 13493, "group_id": 1 }, { "description": "\"Any process that modulates the frequency, rate or extent of mitotic sister chromatid separation. 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