{ "generated_at": "2026-09-28T06:21:13.862Z", "requested_genes": [ "TP53", "ATM", "ATR", "CHEK1", "CHEK2", "BRCA1", "BRCA2", "RAD51", "CDKN1A", "GADD45A", "MDM2" ], "enrichr_library_listing_response": { "organism": "human", "n_libraries": 228, "libraries": [ { "name": "Genome_Browser_PWMs", "gene_coverage": 13362, "genes_per_term": 275, "num_terms": 615, "link": "http://hgdownload.cse.ucsc.edu/goldenPath/hg18/database/", "category_id": 1, "appyter": "ea115789fcbf12797fd692cec6df0ab4dbc79c6a" }, { "name": "TRANSFAC_and_JASPAR_PWMs", "gene_coverage": 27884, "genes_per_term": 1284, "num_terms": 326, "link": "http://jaspar.genereg.net/html/DOWNLOAD/", "category_id": 1, "appyter": "7d42eb43a64a4e3b20d721fc7148f685b53b6b30" }, { "name": "Transcription_Factor_PPIs", "gene_coverage": 6002, "genes_per_term": 77, "num_terms": 290, "link": "", "category_id": 1, "appyter": "849f222220618e2599d925b6b51868cf1dab3763" }, { "name": "ChEA_2013", "gene_coverage": 47172, "genes_per_term": 1370, "num_terms": 353, "link": "http://amp.pharm.mssm.edu/lib/cheadownload.jsp", "category_id": 7, "appyter": "7ebe772afb55b63b41b79dd8d06ea0fdd9fa2630" }, { "name": "Drug_Perturbations_from_GEO_2014", "gene_coverage": 47107, "genes_per_term": 509, "num_terms": 701, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 7, "appyter": "ad270a6876534b7cb063e004289dcd4d3164f342" }, { "name": "ENCODE_TF_ChIP-seq_2014", "gene_coverage": 21493, "genes_per_term": 3713, "num_terms": 498, "link": "http://genome.ucsc.edu/ENCODE/downloads.html", "category_id": 7, "appyter": "497787ebc418d308045efb63b8586f10c526af51" }, { "name": "BioCarta_2013", "gene_coverage": 1295, "genes_per_term": 18, "num_terms": 249, "link": "https://cgap.nci.nih.gov/Pathways/BioCarta_Pathways", "category_id": 7, "appyter": "4a293326037a5229aedb1ad7b2867283573d8bcd" }, { "name": "WikiPathways_2013", "gene_coverage": 2854, "genes_per_term": 34, "num_terms": 199, "link": "http://www.wikipathways.org/index.php/Download_Pathways", "category_id": 7, "appyter": "5c307674c8b97e098f8399c92f451c0ff21cbf68" }, { "name": "Disease_Signatures_from_GEO_up_2014", "gene_coverage": 15057, "genes_per_term": 300, "num_terms": 142, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 7, "appyter": "248c4ed8ea28352795190214713c86a39fd7afab" }, { "name": "KEGG_2013", "gene_coverage": 4128, "genes_per_term": 48, "num_terms": 200, "link": "http://www.kegg.jp/kegg/download/", "category_id": 7, "appyter": "eb26f55d3904cb0ea471998b6a932a9bf65d8e50" }, { "name": "TF-LOF_Expression_from_GEO", "gene_coverage": 34061, "genes_per_term": 641, "num_terms": 269, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 1, "appyter": "" }, { "name": "TargetScan_microRNA", "gene_coverage": 7504, "genes_per_term": 155, "num_terms": 222, "link": "http://www.targetscan.org/cgi-bin/targetscan/data_download.cgi?db=vert_61", "category_id": 7, "appyter": "f4029bf6a62c91ab29401348e51df23b8c44c90f" }, { "name": "PPI_Hub_Proteins", "gene_coverage": 16399, "genes_per_term": 247, "num_terms": 385, "link": "http://amp.pharm.mssm.edu/X2K", "category_id": 2, "appyter": "69c0cfe07d86f230a7ef01b365abcc7f6e52f138" }, { "name": "GeneSigDB", "gene_coverage": 23726, "genes_per_term": 127, "num_terms": 2139, "link": "https://pubmed.ncbi.nlm.nih.gov/22110038/", "category_id": 4, "appyter": "6d655e0aa3408a7accb3311fbda9b108681a8486" }, { "name": "Chromosome_Location", "gene_coverage": 32740, "genes_per_term": 85, "num_terms": 386, "link": "http://software.broadinstitute.org/gsea/msigdb/index.jsp", "category_id": 7, "appyter": "8dab0f96078977223646ff63eb6187e0813f1433" }, { "name": "Human_Gene_Atlas", "gene_coverage": 13373, "genes_per_term": 258, "num_terms": 84, "link": "http://biogps.org/downloads/", "category_id": 5, "appyter": "0741451470203d7c40a06274442f25f74b345c9c" }, { "name": "Mouse_Gene_Atlas", "gene_coverage": 19270, "genes_per_term": 388, "num_terms": 96, "link": "http://biogps.org/downloads/", "category_id": 5, "appyter": "31191bfadded5f96983f93b2a113cf2110ff5ddb" }, { "name": "Human_Phenotype_Ontology", "gene_coverage": 3096, "genes_per_term": 31, "num_terms": 1779, "link": "http://www.human-phenotype-ontology.org/", "category_id": 3, "appyter": "17a138b0b70aa0e143fe63c14f82afb70bc3ed0a" }, { "name": "Epigenomics_Roadmap_HM_ChIP-seq", "gene_coverage": 22288, "genes_per_term": 4368, "num_terms": 383, "link": "http://www.roadmapepigenomics.org/", "category_id": 1, "appyter": "e1bc8a398e9b21f9675fb11bef18087eda21b1bf" }, { "name": "KEA_2013", "gene_coverage": 4533, "genes_per_term": 37, "num_terms": 474, "link": "http://amp.pharm.mssm.edu/lib/keacommandline.jsp", "category_id": 7, "appyter": "462045609440fa1e628a75716b81a1baa5bd9145" }, { "name": "NURSA_Human_Endogenous_Complexome", "gene_coverage": 10231, "genes_per_term": 158, "num_terms": 1796, "link": "https://www.nursa.org/nursa/index.jsf", "category_id": 2, "appyter": "7d3566b12ebc23dd23d9ca9bb97650f826377b16" }, { "name": "CORUM", "gene_coverage": 2741, "genes_per_term": 5, "num_terms": 1658, "link": "http://mips.helmholtz-muenchen.de/genre/proj/corum/", "category_id": 2, "appyter": "d047f6ead7831b00566d5da7a3b027ed9196e104" }, { "name": "SILAC_Phosphoproteomics", "gene_coverage": 5655, "genes_per_term": 342, "num_terms": 84, "link": "http://amp.pharm.mssm.edu/lib/keacommandline.jsp", "category_id": 2, "appyter": "54dcd9438b33301deb219866e162b0f9da7e63a0" }, { "name": "Old_CMAP_up", "gene_coverage": 11251, "genes_per_term": 100, "num_terms": 6100, "link": "http://www.broadinstitute.org/cmap/", "category_id": 7, "appyter": "9041f90cccbc18479138330228b336265e09021c" }, { "name": "Old_CMAP_down", "gene_coverage": 8695, "genes_per_term": 100, "num_terms": 6100, "link": "http://www.broadinstitute.org/cmap/", "category_id": 7, "appyter": "ebc0d905b3b3142f936d400c5f2a4ff926c81c37" }, { "name": "OMIM_Disease", "gene_coverage": 1759, "genes_per_term": 25, "num_terms": 90, "link": "http://www.omim.org/downloads", "category_id": 4, "appyter": "cb2b92578a91e023d0498a334923ee84add34eca" }, { "name": "OMIM_Expanded", "gene_coverage": 2178, "genes_per_term": 89, "num_terms": 187, "link": "http://www.omim.org/downloads", "category_id": 4, "appyter": "27eca242904d8e12a38cf8881395bc50d57a03e1" }, { "name": "VirusMINT", "gene_coverage": 851, "genes_per_term": 15, "num_terms": 85, "link": "http://mint.bio.uniroma2.it/download.html", "category_id": 4, "appyter": "5abad1fc36216222b0420cadcd9be805a0dda63e" }, { "name": "MSigDB_Computational", "gene_coverage": 10061, "genes_per_term": 106, "num_terms": 858, "link": "http://www.broadinstitute.org/gsea/msigdb/collections.jsp", "category_id": 4, "appyter": "e4cdcc7e259788fdf9b25586cce3403255637064" }, { "name": "MSigDB_Oncogenic_Signatures", "gene_coverage": 11250, "genes_per_term": 166, "num_terms": 189, "link": "http://www.broadinstitute.org/gsea/msigdb/collections.jsp", "category_id": 4, "appyter": "c76f5319c33c4833c71db86a30d7e33cd63ff8cf" }, { "name": "Disease_Signatures_from_GEO_down_2014", "gene_coverage": 15406, "genes_per_term": 300, "num_terms": 142, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 7, "appyter": "aabdf7017ae55ae75a004270924bcd336653b986" }, { "name": "Virus_Perturbations_from_GEO_up", "gene_coverage": 17711, "genes_per_term": 300, "num_terms": 323, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 4, "appyter": "45268b7fc680d05dd9a29743c2f2b2840a7620bf" }, { "name": "Virus_Perturbations_from_GEO_down", "gene_coverage": 17576, "genes_per_term": 300, "num_terms": 323, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 4, "appyter": "5f531580ccd168ee4acc18b02c6bdf8200e19d08" }, { "name": "Cancer_Cell_Line_Encyclopedia", "gene_coverage": 15797, "genes_per_term": 176, "num_terms": 967, "link": "https://portals.broadinstitute.org/ccle/home\n", "category_id": 5, "appyter": "eb38dbc3fb20adafa9d6f9f0b0e36f378e75284f" }, { "name": "NCI-60_Cancer_Cell_Lines", "gene_coverage": 12232, "genes_per_term": 343, "num_terms": 93, "link": "http://biogps.org/downloads/", "category_id": 5, "appyter": "75c81676d8d6d99d262c9660edc024b78cfb07c9" }, { "name": "Tissue_Protein_Expression_from_ProteomicsDB", "gene_coverage": 13572, "genes_per_term": 301, "num_terms": 207, "link": "https://www.proteomicsdb.org/", "category_id": 7, "appyter": "" }, { "name": "Tissue_Protein_Expression_from_Human_Proteome_Map", "gene_coverage": 6454, "genes_per_term": 301, "num_terms": 30, "link": "http://www.humanproteomemap.org/index.php", "category_id": 5, "appyter": "49351dc989f9e6ca97c55f8aca7778aa3bfb84b9" }, { "name": "HMDB_Metabolites", "gene_coverage": 3723, "genes_per_term": 47, "num_terms": 3906, "link": "http://www.hmdb.ca/downloads", "category_id": 6, "appyter": "1905132115d22e4119bce543bdacaab074edb363" }, { "name": "Pfam_InterPro_Domains", "gene_coverage": 7588, "genes_per_term": 35, "num_terms": 311, "link": "ftp://ftp.ebi.ac.uk/pub/databases/interpro/", "category_id": 6, "appyter": "e2b4912cfb799b70d87977808c54501544e4cdc9" }, { "name": "Allen_Brain_Atlas_up", "gene_coverage": 13121, "genes_per_term": 305, "num_terms": 2192, "link": "http://www.brain-map.org/", "category_id": 5, "appyter": "3804715a63a308570e47aa1a7877f01147ca6202" }, { "name": "ENCODE_TF_ChIP-seq_2015", "gene_coverage": 26382, "genes_per_term": 1811, "num_terms": 816, "link": "http://genome.ucsc.edu/ENCODE/downloads.html", "category_id": 1, "appyter": "56b6adb4dc8a2f540357ef992d6cd93dfa2907e5" }, { "name": "ENCODE_Histone_Modifications_2015", "gene_coverage": 29065, "genes_per_term": 2123, "num_terms": 412, "link": "http://genome.ucsc.edu/ENCODE/downloads.html", "category_id": 1, "appyter": "55b56cd8cf2ff04b26a09b9f92904008b82f3a6f" }, { "name": "Phosphatase_Substrates_from_DEPOD", "gene_coverage": 280, "genes_per_term": 9, "num_terms": 59, "link": "http://www.koehn.embl.de/depod/", "category_id": 2, "appyter": "d40701e21092b999f4720d1d2b644dd0257b6259" }, { "name": "Allen_Brain_Atlas_down", "gene_coverage": 13877, "genes_per_term": 304, "num_terms": 2192, "link": "http://www.brain-map.org/", "category_id": 5, "appyter": "ea67371adec290599ddf484ced2658cfae259304" }, { "name": "ENCODE_Histone_Modifications_2013", "gene_coverage": 15852, "genes_per_term": 912, "num_terms": 109, "link": "http://genome.ucsc.edu/ENCODE/downloads.html", "category_id": 7, "appyter": "c209ae527bc8e98e4ccd27a668d36cd2c80b35b4" }, { "name": "Achilles_fitness_increase", "gene_coverage": 4320, "genes_per_term": 129, "num_terms": 216, "link": "http://www.broadinstitute.org/achilles", "category_id": 4, "appyter": "98366496a75f163164106e72439fb2bf2f77de4e" }, { "name": "Achilles_fitness_decrease", "gene_coverage": 4271, "genes_per_term": 128, "num_terms": 216, "link": "http://www.broadinstitute.org/achilles", "category_id": 4, "appyter": "83a710c1ff67fd6b8af0d80fa6148c40dbd9bc64" }, { "name": "BioCarta_2015", "gene_coverage": 1678, "genes_per_term": 21, "num_terms": 239, "link": "https://cgap.nci.nih.gov/Pathways/BioCarta_Pathways", "category_id": 7, "appyter": "70e4eb538daa7688691acfe5d9c3c19022be832b" }, { "name": "HumanCyc_2015", "gene_coverage": 756, "genes_per_term": 12, "num_terms": 125, "link": "http://humancyc.org/", "category_id": 7, "appyter": "711f0c02b23f5e02a01207174943cfeee9d3ea9c" }, { "name": "KEGG_2015", "gene_coverage": 3800, "genes_per_term": 48, "num_terms": 179, "link": "http://www.kegg.jp/kegg/download/", "category_id": 7, "appyter": "e80d25c56de53c704791ddfdc6ab5eec28ae7243" }, { "name": "Panther_2015", "gene_coverage": 1918, "genes_per_term": 39, "num_terms": 104, "link": "http://www.pantherdb.org/", "category_id": 7, "appyter": "ab824aeeff0712bab61f372e43aebb870d1677a9" }, { "name": "WikiPathways_2015", "gene_coverage": 5863, "genes_per_term": 51, "num_terms": 404, "link": "http://www.wikipathways.org/index.php/Download_Pathways", "category_id": 7, "appyter": "1f7eea2f339f37856522c1f1c70ec74c7b25325f" }, { "name": "ESCAPE", "gene_coverage": 25651, "genes_per_term": 807, "num_terms": 315, "link": "http://www.maayanlab.net/ESCAPE/", "category_id": 5, "appyter": "a7acc741440264717ff77751a7e5fed723307835" }, { "name": "HomoloGene", "gene_coverage": 19129, "genes_per_term": 1594, "num_terms": 12, "link": "http://www.ncbi.nlm.nih.gov/homologene", "category_id": 6, "appyter": "663b665b75a804ef98add689f838b68e612f0d2a" }, { "name": "Disease_Perturbations_from_GEO_down", "gene_coverage": 23939, "genes_per_term": 293, "num_terms": 839, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 8, "appyter": "0f412e0802d76efa0374504c2c9f5e0624ff7f09" }, { "name": "Disease_Perturbations_from_GEO_up", "gene_coverage": 23561, "genes_per_term": 307, "num_terms": 839, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 8, "appyter": "9ddc3902fb01fb9eaf1a2a7c2ff3acacbb48d37e" }, { "name": "Drug_Perturbations_from_GEO_down", "gene_coverage": 23877, "genes_per_term": 302, "num_terms": 906, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 8, "appyter": "068623a05ecef3e4a5e0b4f8db64bb8faa3c897f" }, { "name": "Genes_Associated_with_NIH_Grants", "gene_coverage": 15886, "genes_per_term": 9, "num_terms": 32876, "link": "https://grants.nih.gov/grants/oer.htm\n", "category_id": 6, "appyter": "76fc5ec6735130e287e62bae6770a3c5ee068645" }, { "name": "Drug_Perturbations_from_GEO_up", "gene_coverage": 24350, "genes_per_term": 299, "num_terms": 906, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 8, "appyter": "c9c2155b5ac81ac496854fa61ba566dcae06cc80" }, { "name": "KEA_2015", "gene_coverage": 3102, "genes_per_term": 25, "num_terms": 428, "link": "http://amp.pharm.mssm.edu/Enrichr", "category_id": 2, "appyter": "18a081774e6e0aaf60b1a4be7fd20afcf9e08399" }, { "name": "Gene_Perturbations_from_GEO_up", "gene_coverage": 31132, "genes_per_term": 298, "num_terms": 2460, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 8, "appyter": "53dedc29ce3100930d68e506f941ef59de05dc6b" }, { "name": "Gene_Perturbations_from_GEO_down", "gene_coverage": 30832, "genes_per_term": 302, "num_terms": 2460, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 8, "appyter": "499882af09c62dd6da545c15cb51c1dc5e234f78" }, { "name": "ChEA_2015", "gene_coverage": 48230, "genes_per_term": 1429, "num_terms": 395, "link": "http://amp.pharm.mssm.edu/Enrichr", "category_id": 7, "appyter": "712eb7b6edab04658df153605ec6079fa89fb5c7" }, { "name": "dbGaP", "gene_coverage": 5613, "genes_per_term": 36, "num_terms": 345, "link": "http://www.ncbi.nlm.nih.gov/gap", "category_id": 4, "appyter": "010f1267055b1a1cb036e560ea525911c007a666" }, { "name": "LINCS_L1000_Chem_Pert_up", "gene_coverage": 9559, "genes_per_term": 73, "num_terms": 33132, "link": "https://clue.io/", "category_id": 7, "appyter": "5e678b3debe8d8ea95187d0cd35c914017af5eb3" }, { "name": "LINCS_L1000_Chem_Pert_down", "gene_coverage": 9448, "genes_per_term": 63, "num_terms": 33132, "link": "https://clue.io/", "category_id": 7, "appyter": "fedbf5e221f45ee60ebd944f92569b5eda7f2330" }, { "name": "GTEx_Tissue_Expression_Down", "gene_coverage": 16725, "genes_per_term": 1443, "num_terms": 2918, "link": "http://www.gtexportal.org/", "category_id": 5, "appyter": "74b818bd299a9c42c1750ffe43616aa9f7929f02" }, { "name": "GTEx_Tissue_Expression_Up", "gene_coverage": 19249, "genes_per_term": 1443, "num_terms": 2918, "link": "http://www.gtexportal.org/", "category_id": 5, "appyter": "103738763d89cae894bec9f145ac28167a90e611" }, { "name": "Ligand_Perturbations_from_GEO_down", "gene_coverage": 15090, "genes_per_term": 282, "num_terms": 261, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 8, "appyter": "1eb3c0426140340527155fd0ef67029db2a72191" }, { "name": "Aging_Perturbations_from_GEO_down", "gene_coverage": 16129, "genes_per_term": 292, "num_terms": 286, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 8, "appyter": "cd95fe1b505ba6f28cd722cfba50fdea979d3b4c" }, { "name": "Aging_Perturbations_from_GEO_up", "gene_coverage": 15309, "genes_per_term": 308, "num_terms": 286, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 8, "appyter": "74c4f0a0447777005b2a5c00c9882a56dfc62d7c" }, { "name": "Ligand_Perturbations_from_GEO_up", "gene_coverage": 15103, "genes_per_term": 318, "num_terms": 261, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 8, "appyter": "31baa39da2931ddd5f7aedf2d0bbba77d2ba7b46" }, { "name": "MCF7_Perturbations_from_GEO_down", "gene_coverage": 15022, "genes_per_term": 290, "num_terms": 401, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 8, "appyter": "555f68aef0a29a67b614a0d7e20b6303df9069c6" }, { "name": "MCF7_Perturbations_from_GEO_up", "gene_coverage": 15676, "genes_per_term": 310, "num_terms": 401, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 8, "appyter": "1bc2ba607f1ff0dda44e2a15f32a2c04767da18c" }, { "name": "Microbe_Perturbations_from_GEO_down", "gene_coverage": 15854, "genes_per_term": 279, "num_terms": 312, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 8, "appyter": "9e613dba78ef7e60676b13493a9dc49ccd3c8b3f" }, { "name": "Microbe_Perturbations_from_GEO_up", "gene_coverage": 15015, "genes_per_term": 321, "num_terms": 312, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 8, "appyter": "d0c3e2a68e8c611c669098df2c87b530cec3e132" }, { "name": "LINCS_L1000_Ligand_Perturbations_down", "gene_coverage": 3788, "genes_per_term": 159, "num_terms": 96, "link": "https://clue.io/", "category_id": 7, "appyter": "957846cb05ef31fc8514120516b73cc65af7980e" }, { "name": "LINCS_L1000_Ligand_Perturbations_up", "gene_coverage": 3357, "genes_per_term": 153, "num_terms": 96, "link": "https://clue.io/", "category_id": 7, "appyter": "3bd494146c98d8189898a947f5ef5710f1b7c4b2" }, { "name": "L1000_Kinase_and_GPCR_Perturbations_down", "gene_coverage": 12668, "genes_per_term": 300, "num_terms": 3644, "link": "https://clue.io/", "category_id": 7, "appyter": "1ccc5bce553e0c2279f8e3f4ddcfbabcf566623b" }, { "name": "L1000_Kinase_and_GPCR_Perturbations_up", "gene_coverage": 12638, "genes_per_term": 300, "num_terms": 3644, "link": "https://clue.io/", "category_id": 7, "appyter": "b54a0d4ba525eac4055c7314ca9d9312adcb220c" }, { "name": "KEGG_2016", "gene_coverage": 7010, "genes_per_term": 87, "num_terms": 293, "link": "http://www.kegg.jp/kegg/download/", "category_id": 7, "appyter": "43f56da7540195ba3c94eb6e34c522a699b36da9" }, { "name": "WikiPathways_2016", "gene_coverage": 5966, "genes_per_term": 51, "num_terms": 437, "link": "http://www.wikipathways.org/index.php/Download_Pathways", "category_id": 7, "appyter": "340be98b444cad50bb974df69018fd598e23e5e1" }, { "name": "ENCODE_and_ChEA_Consensus_TFs_from_ChIP-X", "gene_coverage": 15562, "genes_per_term": 887, "num_terms": 104, "link": "", "category_id": 1, "appyter": "5426f7747965c23ef32cff46fabf906e2cd76bfa" }, { "name": "Kinase_Perturbations_from_GEO_down", "gene_coverage": 17850, "genes_per_term": 300, "num_terms": 285, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 2, "appyter": "bb9682d78b8fc43be842455e076166fcd02cefc3" }, { "name": "Kinase_Perturbations_from_GEO_up", "gene_coverage": 17660, "genes_per_term": 300, "num_terms": 285, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 2, "appyter": "78618915009cac3a0663d6f99d359e39a31b6660" }, { "name": "BioCarta_2016", "gene_coverage": 1348, "genes_per_term": 19, "num_terms": 237, "link": "http://cgap.nci.nih.gov/Pathways/BioCarta_Pathways", "category_id": 2, "appyter": "13d9ab18921d5314a5b2b366f6142b78ab0ff6aa" }, { "name": "HumanCyc_2016", "gene_coverage": 934, "genes_per_term": 13, "num_terms": 152, "link": "http://humancyc.org/", "category_id": 2, "appyter": "d6a502ef9b4c789ed5e73ca5a8de372796e5c72a" }, { "name": "NCI-Nature_2016", "gene_coverage": 2541, "genes_per_term": 39, "num_terms": 209, "link": "https://www.ndexbio.org/index.html#/networkset/7bc65b82-2a2f-11ed-ac45-0ac135e8bacf", "category_id": 2, "appyter": "3c1e1f7d1a651d9aaa198e73704030716fc09431" }, { "name": "Panther_2016", "gene_coverage": 2041, "genes_per_term": 42, "num_terms": 112, "link": "http://www.pantherdb.org/pathway/", "category_id": 2, "appyter": "ca5f6abf7f75d9baae03396e84d07300bf1fd051" }, { "name": "DrugMatrix", "gene_coverage": 5209, "genes_per_term": 300, "num_terms": 7876, "link": "https://ntp.niehs.nih.gov/drugmatrix/", "category_id": 4, "appyter": "255c3db820d612f34310f22a6985dad50e9fe1fe" }, { "name": "ChEA_2016", "gene_coverage": 49238, "genes_per_term": 1550, "num_terms": 645, "link": "http://amp.pharm.mssm.edu/Enrichr", "category_id": 7, "appyter": "af271913344aa08e6a755af1d433ef15768d749a" }, { "name": "huMAP", "gene_coverage": 2243, "genes_per_term": 19, "num_terms": 995, "link": "http://proteincomplexes.org/", "category_id": 2, "appyter": "249247d2f686d3eb4b9e4eb976c51159fac80a89" }, { "name": "Jensen_TISSUES", "gene_coverage": 19586, "genes_per_term": 545, "num_terms": 1842, "link": "http://tissues.jensenlab.org/", "category_id": 7, "appyter": "e8879ab9534794721614d78fe2883e9e564d7759" }, { "name": "RNA-Seq_Disease_Gene_and_Drug_Signatures_from_GEO", "gene_coverage": 22440, "genes_per_term": 505, "num_terms": 1302, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 8, "appyter": "f0752e4d7f5198f86446678966b260c530d19d78" }, { "name": "Jensen_COMPARTMENTS", "gene_coverage": 18329, "genes_per_term": 161, "num_terms": 2283, "link": "http://compartments.jensenlab.org/", "category_id": 7, "appyter": "56ec68c32d4e83edc2ee83bea0e9f6a3829b2279" }, { "name": "Jensen_DISEASES", "gene_coverage": 15755, "genes_per_term": 28, "num_terms": 1811, "link": "http://diseases.jensenlab.org/", "category_id": 7, "appyter": "3045dff8181367c1421627bb8e4c5a32c6d67f98" }, { "name": "BioPlex_2017", "gene_coverage": 10271, "genes_per_term": 22, "num_terms": 3915, "link": "http://bioplex.hms.harvard.edu/", "category_id": 2, "appyter": "b8620b1a9d0d271d1a2747d8cfc63589dba39991" }, { "name": "ARCHS4_Tissues", "gene_coverage": 21809, "genes_per_term": 2316, "num_terms": 108, "link": "http://amp.pharm.mssm.edu/archs4", "category_id": 5, "appyter": "4126374338235650ab158ba2c61cd2e2383b70df" }, { "name": "ARCHS4_Cell-lines", "gene_coverage": 23601, "genes_per_term": 2395, "num_terms": 125, "link": "http://amp.pharm.mssm.edu/archs4", "category_id": 5, "appyter": "5496ef9c9ae9429184d0b9485c23ba468ee522a8" }, { "name": "ARCHS4_IDG_Coexp", "gene_coverage": 20883, "genes_per_term": 299, "num_terms": 352, "link": "http://amp.pharm.mssm.edu/archs4", "category_id": 4, "appyter": "ce60be284fdd5a9fc6240a355421a9e12b1ee84a" }, { "name": "ARCHS4_Kinases_Coexp", "gene_coverage": 19612, "genes_per_term": 299, "num_terms": 498, "link": "http://amp.pharm.mssm.edu/archs4", "category_id": 2, "appyter": "6721c5ed97b7772e4a19fdc3f797110df0164b75" }, { "name": "ARCHS4_TFs_Coexp", "gene_coverage": 25983, "genes_per_term": 299, "num_terms": 1724, "link": "http://amp.pharm.mssm.edu/archs4", "category_id": 1, "appyter": "8a468c3ae29fa68724f744cbef018f4f3b61c5ab" }, { "name": "SysMyo_Muscle_Gene_Sets", "gene_coverage": 19500, "genes_per_term": 137, "num_terms": 1135, "link": "http://sys-myo.rhcloud.com/", "category_id": 8, "appyter": "" }, { "name": "miRTarBase_2017", "gene_coverage": 14893, "genes_per_term": 128, "num_terms": 3240, "link": "http://mirtarbase.mbc.nctu.edu.tw/", "category_id": 1, "appyter": "6b7c7fe2a97b19aecbfba12d8644af6875ad99c4" }, { "name": "TargetScan_microRNA_2017", "gene_coverage": 17598, "genes_per_term": 1208, "num_terms": 683, "link": "http://www.targetscan.org/", "category_id": 1, "appyter": "79d13fb03d2fa6403f9be45c90eeda0f6822e269" }, { "name": "Enrichr_Libraries_Most_Popular_Genes", "gene_coverage": 5902, "genes_per_term": 109, "num_terms": 121, "link": "http://amp.pharm.mssm.edu/Enrichr", "category_id": 6, "appyter": "e9b7d8ee237d0a690bd79d970a23a9fa849901ed" }, { "name": "Enrichr_Submissions_TF-Gene_Coocurrence", "gene_coverage": 12486, "genes_per_term": 299, "num_terms": 1722, "link": "http://amp.pharm.mssm.edu/Enrichr", "category_id": 1, "appyter": "be2ca8ef5a8c8e17d7e7bd290e7cbfe0951396c0" }, { "name": "Data_Acquisition_Method_Most_Popular_Genes", "gene_coverage": 1073, "genes_per_term": 100, "num_terms": 12, "link": "http://amp.pharm.mssm.edu/Enrichr", "category_id": 6, "appyter": "17ce5192b9eba7d109b6d228772ea8ab222e01ef" }, { "name": "DSigDB", "gene_coverage": 19513, "genes_per_term": 117, "num_terms": 4026, "link": "http://tanlab.ucdenver.edu/DSigDB/DSigDBv1.0/", "category_id": 4, "appyter": "287476538ab98337dbe727b3985a436feb6d192a" }, { "name": "TF_Perturbations_Followed_by_Expression", "gene_coverage": 19741, "genes_per_term": 270, "num_terms": 1958, "link": "http://www.ncbi.nlm.nih.gov/geo/", "category_id": 1, "appyter": "34d08a4878c19584aaf180377f2ea96faa6a6eb1" }, { "name": "Chromosome_Location_hg19", "gene_coverage": 27360, "genes_per_term": 802, "num_terms": 36, "link": "http://hgdownload.cse.ucsc.edu/downloads.html", "category_id": 6, "appyter": "fdab39c467ba6b0fb0288df1176d7dfddd7196d5" }, { "name": "Rare_Diseases_AutoRIF_ARCHS4_Predictions", "gene_coverage": 13787, "genes_per_term": 200, "num_terms": 3725, "link": "https://amp.pharm.mssm.edu/geneshot/", "category_id": 4, "appyter": "375ff8cdd64275a916fa24707a67968a910329bb" }, { "name": "Rare_Diseases_GeneRIF_ARCHS4_Predictions", "gene_coverage": 13929, "genes_per_term": 200, "num_terms": 2244, "link": "https://www.ncbi.nlm.nih.gov/gene/about-generif", "category_id": 4, "appyter": "0f7fb7f347534779ecc6c87498e96b5460a8d652" }, { "name": "Rare_Diseases_GeneRIF_Gene_Lists", "gene_coverage": 10352, "genes_per_term": 58, "num_terms": 2244, "link": "https://www.ncbi.nlm.nih.gov/gene/about-generif", "category_id": 4, "appyter": "0fb9ac92dbe52024661c088f71a1134f00567a8b" }, { "name": "Rare_Diseases_AutoRIF_Gene_Lists", "gene_coverage": 10471, "genes_per_term": 76, "num_terms": 3725, "link": "https://amp.pharm.mssm.edu/geneshot/", "category_id": 4, "appyter": "ee3adbac2da389959410260b280e7df1fd3730df" }, { "name": "SubCell_BarCode", "gene_coverage": 12419, "genes_per_term": 491, "num_terms": 104, "link": "http://www.subcellbarcode.org/", "category_id": 2, "appyter": "b50bb9480d8a77103fb75b331fd9dd927246939a" }, { "name": "GWAS_Catalog_2019", "gene_coverage": 19378, "genes_per_term": 37, "num_terms": 1737, "link": "https://www.ebi.ac.uk/gwas", "category_id": 7, "appyter": "fef3864bcb5dd9e60cee27357eff30226116c49b" }, { "name": "WikiPathways_2019_Human", "gene_coverage": 6201, "genes_per_term": 45, "num_terms": 472, "link": "https://www.wikipathways.org/", "category_id": 7, "appyter": "b0c9e9ebb9014f14561e896008087725a2db24b7" }, { "name": "WikiPathways_2019_Mouse", "gene_coverage": 4558, "genes_per_term": 54, "num_terms": 176, "link": "https://www.wikipathways.org/", "category_id": 7, "appyter": "e7750958da20f585c8b6d5bc4451a5a4305514ba" }, { "name": "TRRUST_Transcription_Factors_2019", "gene_coverage": 3264, "genes_per_term": 22, "num_terms": 571, "link": "https://www.grnpedia.org/trrust/", "category_id": 1, "appyter": "5f8cf93e193d2bcefa5a37ccdf0eefac576861b0" }, { "name": "KEGG_2019_Human", "gene_coverage": 7802, "genes_per_term": 92, "num_terms": 308, "link": "https://www.kegg.jp/", "category_id": 7, "appyter": "3477bc578c4ea5d851dcb934fe2a41e9fd789bb4" }, { "name": "KEGG_2019_Mouse", "gene_coverage": 8551, "genes_per_term": 98, "num_terms": 303, "link": "https://www.kegg.jp/", "category_id": 7, "appyter": "187eb44b2d6fa154ebf628eba1f18537f64e797c" }, { "name": "InterPro_Domains_2019", "gene_coverage": 12444, "genes_per_term": 23, "num_terms": 1071, "link": "https://www.ebi.ac.uk/interpro/", "category_id": 6, "appyter": "18dd5ec520fdf589a93d6a7911289c205e1ddf22" }, { "name": "Pfam_Domains_2019", "gene_coverage": 9000, "genes_per_term": 20, "num_terms": 608, "link": "https://pfam.xfam.org/", "category_id": 6, "appyter": "a6325ed264f9ac9e6518796076c46a1d885cca7a" }, { "name": "DepMap_WG_CRISPR_Screens_Broad_CellLines_2019", "gene_coverage": 7744, "genes_per_term": 363, "num_terms": 558, "link": "https://depmap.org/", "category_id": 7, "appyter": "0b08b32b20854ac8a738458728a9ea50c2e04800" }, { "name": "DepMap_WG_CRISPR_Screens_Sanger_CellLines_2019", "gene_coverage": 6204, "genes_per_term": 387, "num_terms": 325, "link": "https://depmap.org/", "category_id": 4, "appyter": "b7c4ead26d0eb64f1697c030d31682b581c8bb56" }, { "name": "UK_Biobank_GWAS_v1", "gene_coverage": 14148, "genes_per_term": 122, "num_terms": 857, "link": "https://www.ukbiobank.ac.uk/tag/gwas/", "category_id": 4, "appyter": "958fb52e6215626673a5acf6e9289a1b84d11b4a" }, { "name": "BioPlanet_2019", "gene_coverage": 9813, "genes_per_term": 49, "num_terms": 1510, "link": "https://tripod.nih.gov/bioplanet/", "category_id": 2, "appyter": "e110851dfc763d30946f2abedcc2cd571ac357a0" }, { "name": "ClinVar_2019", "gene_coverage": 1397, "genes_per_term": 13, "num_terms": 182, "link": "https://www.ncbi.nlm.nih.gov/clinvar/", "category_id": 7, "appyter": "0a95303f8059bec08836ecfe02ce3da951150547" }, { "name": "PheWeb_2019", "gene_coverage": 9116, "genes_per_term": 22, "num_terms": 1161, "link": "http://pheweb.sph.umich.edu/", "category_id": 4, "appyter": "6a7c7321b6b72c5285b722f7902d26a2611117cb" }, { "name": "DisGeNET", "gene_coverage": 17464, "genes_per_term": 63, "num_terms": 9828, "link": "https://www.disgenet.org", "category_id": 4, "appyter": "3c261626478ce9e6bf2c7f0a8014c5e901d43dc0" }, { "name": "HMS_LINCS_KinomeScan", "gene_coverage": 394, "genes_per_term": 73, "num_terms": 148, "link": "http://lincs.hms.harvard.edu/kinomescan/", "category_id": 2, "appyter": "47ba06cdc92469ac79400fc57acd84ba343ba616" }, { "name": "CCLE_Proteomics_2020", "gene_coverage": 11851, "genes_per_term": 586, "num_terms": 378, "link": "https://portals.broadinstitute.org/ccle", "category_id": 5, "appyter": "7094b097ae2301a1d6a5bd856a193b084cca993d" }, { "name": "ProteomicsDB_2020", "gene_coverage": 8189, "genes_per_term": 421, "num_terms": 913, "link": "https://www.proteomicsdb.org/", "category_id": 5, "appyter": "8c87c8346167bac2ba68195a32458aba9b1acfd1" }, { "name": "lncHUB_lncRNA_Co-Expression", "gene_coverage": 18704, "genes_per_term": 100, "num_terms": 3729, "link": "https://amp.pharm.mssm.edu/lnchub/", "category_id": 1, "appyter": "45b597d7efa5693b7e4172b09c0ed2dda3305582" }, { "name": "Virus-Host_PPI_P-HIPSTer_2020", "gene_coverage": 5605, "genes_per_term": 39, "num_terms": 6715, "link": "http://phipster.org/", "category_id": 2, "appyter": "a592eed13e8e9496aedbab63003b965574e46a65" }, { "name": "Elsevier_Pathway_Collection", "gene_coverage": 5718, "genes_per_term": 31, "num_terms": 1721, "link": "http://www.transgene.ru/disease-pathways/", "category_id": 2, "appyter": "9196c760e3bcae9c9de1e3f87ad81f96bde24325" }, { "name": "Table_Mining_of_CRISPR_Studies", "gene_coverage": 14156, "genes_per_term": 40, "num_terms": 802, "link": "", "category_id": 6, "appyter": "ad580f3864fa8ff69eaca11f6d2e7f9b86378d08" }, { "name": "COVID-19_Related_Gene_Sets", "gene_coverage": 16979, "genes_per_term": 295, "num_terms": 205, "link": "https://amp.pharm.mssm.edu/covid19", "category_id": 7, "appyter": "72b0346849570f66a77a6856722601e711596cb4" }, { "name": "MSigDB_Hallmark_2020", "gene_coverage": 4383, "genes_per_term": 146, "num_terms": 50, "link": "https://www.gsea-msigdb.org/gsea/msigdb/collections.jsp ", "category_id": 2, "appyter": "6952efda94663d4bd8db09bf6eeb4e67d21ef58c" }, { "name": "Enrichr_Users_Contributed_Lists_2020", "gene_coverage": 54974, "genes_per_term": 483, "num_terms": 1482, "link": "https://maayanlab.cloud/Enrichr", "category_id": 6, "appyter": "8dc362703b38b30ac3b68b6401a9b20a58e7d3ef" }, { "name": "TG_GATES_2020", "gene_coverage": 12118, "genes_per_term": 448, "num_terms": 1190, "link": "https://toxico.nibiohn.go.jp/english/", "category_id": 4, "appyter": "9e32560437b11b4628b00ccf3d584360f7f7daee" }, { "name": "Allen_Brain_Atlas_10x_scRNA_2021", "gene_coverage": 12361, "genes_per_term": 124, "num_terms": 766, "link": "https://portal.brain-map.org/", "category_id": 5, "appyter": "46f8235cb585829331799a71aec3f7c082170219" }, { "name": "Descartes_Cell_Types_and_Tissue_2021", "gene_coverage": 9763, "genes_per_term": 139, "num_terms": 172, "link": "https://descartes.brotmanbaty.org/bbi/human-gene-expression-during-development/", "category_id": 5, "appyter": "" }, { "name": "KEGG_2021_Human", "gene_coverage": 8078, "genes_per_term": 102, "num_terms": 320, "link": "https://www.kegg.jp/", "category_id": 7, "appyter": "" }, { "name": "WikiPathway_2021_Human", "gene_coverage": 7173, "genes_per_term": 43, "num_terms": 622, "link": "https://www.wikipathways.org/", "category_id": 7, "appyter": "" }, { "name": "HuBMAP_ASCT_plus_B_augmented_w_RNAseq_Coexpression", "gene_coverage": 5833, "genes_per_term": 100, "num_terms": 344, "link": "https://hubmapconsortium.github.io/ccf-asct-reporter/", "category_id": 5, "appyter": "" }, { "name": "GO_Biological_Process_2021", "gene_coverage": 14937, "genes_per_term": 33, "num_terms": 6036, "link": "http://www.geneontology.org/", "category_id": 7, "appyter": "" }, { "name": "GO_Cellular_Component_2021", "gene_coverage": 11497, "genes_per_term": 80, "num_terms": 511, "link": "http://www.geneontology.org/", "category_id": 7, "appyter": "" }, { "name": "GO_Molecular_Function_2021", "gene_coverage": 11936, "genes_per_term": 34, "num_terms": 1274, "link": "http://www.geneontology.org/", "category_id": 7, "appyter": "" }, { "name": "MGI_Mammalian_Phenotype_Level_4_2021", "gene_coverage": 9767, "genes_per_term": 33, "num_terms": 4601, "link": "http://www.informatics.jax.org/", "category_id": 7, "appyter": "" }, { "name": "CellMarker_Augmented_2021", "gene_coverage": 14167, "genes_per_term": 80, "num_terms": 1097, "link": "http://biocc.hrbmu.edu.cn/CellMarker/", "category_id": 5, "appyter": "" }, { "name": "Orphanet_Augmented_2021", "gene_coverage": 17851, "genes_per_term": 102, "num_terms": 3774, "link": "http://www.orphadata.org/", "category_id": 4, "appyter": "" }, { "name": "COVID-19_Related_Gene_Sets_2021", "gene_coverage": 16853, "genes_per_term": 360, "num_terms": 478, "link": "https://maayanlab.cloud/covid19/", "category_id": 4, "appyter": "" }, { "name": "PanglaoDB_Augmented_2021", "gene_coverage": 6654, "genes_per_term": 136, "num_terms": 178, "link": "https://panglaodb.se/", "category_id": 5, "appyter": "" }, { "name": "Azimuth_Cell_Types_2021", "gene_coverage": 1683, "genes_per_term": 10, "num_terms": 341, "link": "https://azimuth.hubmapconsortium.org/", "category_id": 5, "appyter": "" }, { "name": "PhenGenI_Association_2021", "gene_coverage": 20414, "genes_per_term": 112, "num_terms": 950, "link": "https://www.ncbi.nlm.nih.gov/gap/phegeni", "category_id": 4, "appyter": "" }, { "name": "GTEx_Aging_Signatures_2021", "gene_coverage": 11980, "genes_per_term": 250, "num_terms": 270, "link": "https://gtexportal.org/", "category_id": 4, "appyter": "" }, { "name": "HDSigDB_Human_2021", "gene_coverage": 31158, "genes_per_term": 805, "num_terms": 2564, "link": "https://www.hdinhd.org/", "category_id": 4, "appyter": "" }, { "name": "HDSigDB_Mouse_2021", "gene_coverage": 30006, "genes_per_term": 815, "num_terms": 2579, "link": "https://www.hdinhd.org/", "category_id": 4, "appyter": "" }, { "name": "HuBMAP_ASCTplusB_augmented_2022", "gene_coverage": 13366, "genes_per_term": 103, "num_terms": 777, "link": "https://hubmapconsortium.github.io/ccf-asct-reporter/", "category_id": 5, "appyter": "" }, { "name": "FANTOM6_lncRNA_KD_DEGs", "gene_coverage": 13697, "genes_per_term": 343, "num_terms": 350, "link": "https://fantom.gsc.riken.jp/6/", "category_id": 1, "appyter": "" }, { "name": "MAGMA_Drugs_and_Diseases", "gene_coverage": 2183, "genes_per_term": 18, "num_terms": 1395, "link": "https://github.com/nybell/drugsets/tree/main/DATA/GENESETS", "category_id": 4, "appyter": "" }, { "name": "Tabula_Sapiens", "gene_coverage": 1509, "genes_per_term": 100, "num_terms": 469, "link": "https://tabula-sapiens-portal.ds.czbiohub.org/", "category_id": 5, "appyter": "" }, { "name": "ChEA_2022", "gene_coverage": 18365, "genes_per_term": 1214, "num_terms": 757, "link": "https://maayanlab.cloud/chea3/", "category_id": 1, "appyter": "" }, { "name": "Diabetes_Perturbations_GEO_2022", "gene_coverage": 13525, "genes_per_term": 175, "num_terms": 601, "link": "https://appyters.maayanlab.cloud/#/Gene_Expression_T2D_Signatures", "category_id": 4, "appyter": "" }, { "name": "LINCS_L1000_Chem_Pert_Consensus_Sigs", "gene_coverage": 9525, "genes_per_term": 245, "num_terms": 10850, "link": "https://maayanlab.cloud/sigcom-lincs/#/Download", "category_id": 4, "appyter": "" }, { "name": "LINCS_L1000_CRISPR_KO_Consensus_Sigs", "gene_coverage": 9440, "genes_per_term": 245, "num_terms": 10424, "link": "https://maayanlab.cloud/sigcom-lincs/#/Download", "category_id": 4, "appyter": "" }, { "name": "Tabula_Muris", "gene_coverage": 3857, "genes_per_term": 80, "num_terms": 106, "link": "https://tabula-muris.ds.czbiohub.org/", "category_id": 5, "appyter": "" }, { "name": "Reactome_2022", "gene_coverage": 10489, "genes_per_term": 61, "num_terms": 1818, "link": "https://reactome.org/download-data", "category_id": 7, "appyter": "" }, { "name": "SynGO_2022", "gene_coverage": 1198, "genes_per_term": 23, "num_terms": 118, "link": "https://www.syngoportal.org/", "category_id": 7, "appyter": "" }, { "name": "GlyGen_Glycosylated_Proteins_2022", "gene_coverage": 1882, "genes_per_term": 47, "num_terms": 338, "link": "https://www.glygen.org/", "category_id": 2, "appyter": "" }, { "name": "IDG_Drug_Targets_2022", "gene_coverage": 1552, "genes_per_term": 16, "num_terms": 888, "link": "https://drugcentral.org/", "category_id": 4, "appyter": "" }, { "name": "KOMP2_Mouse_Phenotypes_2022", "gene_coverage": 6713, "genes_per_term": 68, "num_terms": 529, "link": "https://www.mousephenotype.org/", "category_id": 3, "appyter": "" }, { "name": "Metabolomics_Workbench_Metabolites_2022", "gene_coverage": 936, "genes_per_term": 15, "num_terms": 233, "link": "https://www.metabolomicsworkbench.org/", "category_id": 2, "appyter": "" }, { "name": "Proteomics_Drug_Atlas_2023", "gene_coverage": 8220, "genes_per_term": 146, "num_terms": 1748, "link": "https://www.nature.com/articles/s41587-022-01539-0", "category_id": 4, "appyter": "" }, { "name": "The_Kinase_Library_2023", "gene_coverage": 9021, "genes_per_term": 793, "num_terms": 303, "link": "https://kinase-library.phosphosite.org/site", "category_id": 7, "appyter": "" }, { "name": "GTEx_Tissues_V8_2023", "gene_coverage": 8076, "genes_per_term": 96, "num_terms": 511, "link": "https://gtexportal.org/home/", "category_id": 5, "appyter": "" }, { "name": "GO_Biological_Process_2023", "gene_coverage": 14698, "genes_per_term": 33, "num_terms": 5407, "link": "http://www.geneontology.org/", "category_id": 7, "appyter": "" }, { "name": "GO_Cellular_Component_2023", "gene_coverage": 10972, "genes_per_term": 85, "num_terms": 474, "link": "http://www.geneontology.org/", "category_id": 7, "appyter": "" }, { "name": "GO_Molecular_Function_2023", "gene_coverage": 12126, "genes_per_term": 38, "num_terms": 1147, "link": "http://www.geneontology.org/", "category_id": 7, "appyter": "" }, { "name": "PFOCR_Pathways_2023", "gene_coverage": 13662, "genes_per_term": 12, "num_terms": 21845, "link": "https://pfocr.wikipathways.org/", "category_id": 2, "appyter": "" }, { "name": "GWAS_Catalog_2023", "gene_coverage": 18290, "genes_per_term": 34, "num_terms": 5271, "link": "https://www.ebi.ac.uk/gwas", "category_id": 7, "appyter": "" }, { "name": "GeDiPNet_2023", "gene_coverage": 12081, "genes_per_term": 50, "num_terms": 2388, "link": "http://gedipnet.bicnirrh.res.in/", "category_id": 4, "appyter": "" }, { "name": "MAGNET_2023", "gene_coverage": 12853, "genes_per_term": 485, "num_terms": 72, "link": "https://magnet-winterlab.herokuapp.com/", "category_id": 5, "appyter": "" }, { "name": "Azimuth_2023", "gene_coverage": 3712, "genes_per_term": 9, "num_terms": 1425, "link": "https://azimuth.hubmapconsortium.org/", "category_id": 5, "appyter": "" }, { "name": "Rummagene_kinases", "gene_coverage": 19178, "genes_per_term": 218, "num_terms": 3810, "link": "https://rummagene.com/", "category_id": 2, "appyter": "" }, { "name": "Rummagene_signatures", "gene_coverage": 19434, "genes_per_term": 369, "num_terms": 11130, "link": "https://rummagene.com/", "category_id": 8, "appyter": "" }, { "name": "Rummagene_transcription_factors", "gene_coverage": 19379, "genes_per_term": 250, "num_terms": 7244, "link": "https://rummagene.com/", "category_id": 1, "appyter": "" }, { "name": "MoTrPAC_2023", "gene_coverage": 10428, "genes_per_term": 115, "num_terms": 225, "link": "https://motrpac-data.org/", "category_id": 4, "appyter": "" }, { "name": "WikiPathway_2023_Human", "gene_coverage": 8044, "genes_per_term": 42, "num_terms": 801, "link": "https://www.wikipathways.org/", "category_id": 7, "appyter": "" }, { "name": "DepMap_CRISPR_GeneDependency_CellLines_2023", "gene_coverage": 9711, "genes_per_term": 414, "num_terms": 1093, "link": "https://depmap.org/", "category_id": 4, "appyter": "" }, { "name": "SynGO_2024", "gene_coverage": 1555, "genes_per_term": 27, "num_terms": 134, "link": "https://www.syngoportal.org/", "category_id": 3, "appyter": "" }, { "name": "CellMarker_2024", "gene_coverage": 12642, "genes_per_term": 30, "num_terms": 1692, "link": "http://bio-bigdata.hrbmu.edu.cn/CellMarker/", "category_id": 5, "appyter": "" }, { "name": "DGIdb_Drug_Targets_2024", "gene_coverage": 2513, "genes_per_term": 20, "num_terms": 659, "link": "https://dgidb.org/", "category_id": 4, "appyter": "" }, { "name": "MGI_Mammalian_Phenotype_Level_4_2024", "gene_coverage": 11625, "genes_per_term": 36, "num_terms": 5003, "link": "http://www.informatics.jax.org/", "category_id": 3, "appyter": "" }, { "name": "WikiPathways_2024_Mouse", "gene_coverage": 4494, "genes_per_term": 51, "num_terms": 188, "link": "https://www.wikipathways.org/", "category_id": 2, "appyter": "" }, { "name": "WikiPathways_2024_Human", "gene_coverage": 8281, "genes_per_term": 43, "num_terms": 829, "link": "https://www.wikipathways.org/", "category_id": 2, "appyter": "" }, { "name": "The_Kinase_Library_2024", "gene_coverage": 9122, "genes_per_term": 627, "num_terms": 392, "link": "https://kinase-library.phosphosite.org/site", "category_id": 2, "appyter": "" }, { "name": "PerturbAtlas", "gene_coverage": 16971, "genes_per_term": 76, "num_terms": 12841, "link": "https://perturbatlas.kratoss.site/#/", "category_id": 4, "appyter": "" }, { "name": "Reactome_Pathways_2024", "gene_coverage": 11671, "genes_per_term": 62, "num_terms": 2105, "link": "https://reactome.org/download-data", "category_id": 2, "appyter": "" }, { "name": "GO_Biological_Process_2025", "gene_coverage": 14674, "genes_per_term": 32, "num_terms": 5343, "link": "http://www.geneontology.org/", "category_id": 7, "appyter": "" }, { "name": "GO_Cellular_Component_2025", "gene_coverage": 11501, "genes_per_term": 90, "num_terms": 468, "link": "http://www.geneontology.org/", "category_id": 7, "appyter": "" }, { "name": "GO_Molecular_Function_2025", "gene_coverage": 11484, "genes_per_term": 36, "num_terms": 1174, "link": "http://www.geneontology.org/", "category_id": 7, "appyter": "" }, { "name": "NIBR_DRUGseq_2025_up", "gene_coverage": 12033, "genes_per_term": 158, "num_terms": 5412, "link": "", "category_id": 4, "appyter": "" }, { "name": "NIBR_DRUGseq_2025_down", "gene_coverage": 10641, "genes_per_term": 201, "num_terms": 4503, "link": "", "category_id": 4, "appyter": "" }, { "name": "Jensen_DISEASES_Curated_2025", "gene_coverage": 3741, "genes_per_term": 63, "num_terms": 574, "link": "http://diseases.jensenlab.org/", "category_id": 3, "appyter": "" }, { "name": "Jensen_DISEASES_Experimental_2025", "gene_coverage": 10631, "genes_per_term": 343, "num_terms": 500, "link": "http://diseases.jensenlab.org/", "category_id": 3, "appyter": "" }, { "name": "COMPARTMENTS_Curated_2025", "gene_coverage": 12865, "genes_per_term": 116, "num_terms": 1015, "link": "https://compartments.jensenlab.org/Search", "category_id": 3, "appyter": "" }, { "name": "PerturbAtlas_MouseGenePerturbationSigs", "gene_coverage": 15733, "genes_per_term": 68, "num_terms": 10729, "link": "https://perturbatlas.kratoss.site/#/", "category_id": 4, "appyter": "" }, { "name": "PerturbSeq_ReplogleK562", "gene_coverage": 7724, "genes_per_term": 83, "num_terms": 4102, "link": "https://gwps.wi.mit.edu/", "category_id": 4, "appyter": "" }, { "name": "TISSUES_Experimental_2025", "gene_coverage": 14528, "genes_per_term": 1232, "num_terms": 218, "link": "https://tissues.jensenlab.org/Search", "category_id": 3, "appyter": "" }, { "name": "COMPARTMENTS_Experimental_2025", "gene_coverage": 5961, "genes_per_term": 643, "num_terms": 48, "link": "https://compartments.jensenlab.org/Search", "category_id": 3, "appyter": "" }, { "name": "PerturbSeq_ReplogleRPE1", "gene_coverage": 6999, "genes_per_term": 68, "num_terms": 2708, "link": "https://gwps.wi.mit.edu/", "category_id": 4, "appyter": "" }, { "name": "TISSUES_Curated_2025", "gene_coverage": 16211, "genes_per_term": 737, "num_terms": 417, "link": "https://tissues.jensenlab.org/Search", "category_id": 3, "appyter": "" }, { "name": "RummaGEO_DrugPerturbations_2025", "gene_coverage": 18936, "genes_per_term": 752, "num_terms": 5344, "link": "https://rummageo.com/", "category_id": 4, "appyter": "" }, { "name": "RummaGEO_GenePerturbations_2025", "gene_coverage": 18872, "genes_per_term": 704, "num_terms": 4312, "link": "https://rummageo.com/", "category_id": 4, "appyter": "" }, { "name": "GWAS_Catalog_2025", "gene_coverage": 15030, "genes_per_term": 43, "num_terms": 2369, "link": "https://www.ebi.ac.uk/gwas", "category_id": 4, "appyter": "" }, { "name": "ClinVar_2025", "gene_coverage": 3481, "genes_per_term": 17, "num_terms": 609, "link": "https://www.ncbi.nlm.nih.gov/clinvar/", "category_id": 4, "appyter": "" }, { "name": "CM4AI_U2OS_Protein_Localization_Assemblies", "gene_coverage": 4776, "genes_per_term": 42, "num_terms": 209, "link": "https://cm4ai.org/", "category_id": 2, "appyter": "" }, { "name": "JASPAR_PWM_Human_2025", "gene_coverage": 18518, "genes_per_term": 2144, "num_terms": 675, "link": "https://jaspar.elixir.no/", "category_id": 2, "appyter": "" }, { "name": "JASPAR_PWM_Mouse_2025", "gene_coverage": 16389, "genes_per_term": 2108, "num_terms": 146, "link": "https://jaspar.elixir.no/", "category_id": 2, "appyter": "" }, { "name": "Sciplex_Drug_Perturbation_Signatures_2025", "gene_coverage": 10257, "genes_per_term": 499, "num_terms": 4604, "link": "https://jaspar.elixir.no/", "category_id": 4, "appyter": "" }, { "name": "Carcinogenome", "gene_coverage": 11974, "genes_per_term": 131, "num_terms": 11748, "link": "https://carcinogenome.org/", "category_id": 4, "appyter": "" }, { "name": "KEGG_2026", "gene_coverage": 8110, "genes_per_term": 99, "num_terms": 352, "link": "https://www.kegg.jp/", "category_id": 2, "appyter": "" }, { "name": "GO_Biological_Process_2026", "gene_coverage": 15557, "genes_per_term": 31, "num_terms": 5954, "link": "http://www.geneontology.org/", "category_id": 3, "appyter": "" }, { "name": "GO_Cellular_Component_2026", "gene_coverage": 12491, "genes_per_term": 93, "num_terms": 510, "link": "http://www.geneontology.org/", "category_id": 3, "appyter": "" }, { "name": "GO_Molecular_Function_2026", "gene_coverage": 12297, "genes_per_term": 32, "num_terms": 1394, "link": "http://www.geneontology.org/", "category_id": 3, "appyter": "" } ] }, "enrichr_enrichment_response": { "tool": "enrich_gene_set_enrichr", "organism": "human", "mapping_status": "not_reported_by_enrichr", "input_genes": [ "TP53", "ATM", "ATR", "CHEK1", "CHEK2", "BRCA1", "BRCA2", "RAD51", "CDKN1A", "GADD45A", "MDM2" ], "n_input": 11, "n_unique_input": 11, "duplicate_genes": [], "background_size": null, "user_list_id": 138675808, "short_id": "d28111fcfb8ed46f0b44f4bf071fd1f4", "background_id": null, "libraries": [ { "name": "GO_Biological_Process_2025", "n_results": 305, "n_total_results": 305, "truncated": false, "results": [ { "rank": 1, "term": "Cellular Response to Ionizing Radiation (GO:0071479)", "p_value": 1.1816288855494013e-13, "odds_ratio": 509.15744680851066, "combined_score": 15155.943240078142, "overlapping_genes": [ "RAD51", "GADD45A", "MDM2", "BRCA1", "BRCA2", "TP53" ], "adjusted_p_value": 3.603968100925674e-11, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 2, "term": "DNA Repair (GO:0006281)", "p_value": 3.9083512086853106e-13, "odds_ratio": 178.63945578231292, "combined_score": 5103.81689393584, "overlapping_genes": [ "RAD51", "GADD45A", "CHEK2", "CHEK1", "ATM", "BRCA1", "BRCA2", "TP53" ], "adjusted_p_value": 5.960235593245099e-11, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 3, "term": "Response to Ionizing Radiation (GO:0010212)", "p_value": 7.343444707531991e-13, "odds_ratio": 367.8276923076923, "combined_score": 10277.031484480956, "overlapping_genes": [ "RAD51", "GADD45A", "ATM", "BRCA1", "BRCA2", "TP53" ], "adjusted_p_value": 7.465835452657525e-11, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 4, "term": "Signal Transduction in Response to DNA Damage (GO:0042770)", "p_value": 1.5378436926629978e-12, "odds_ratio": 322.94594594594594, "combined_score": 8784.336376468147, "overlapping_genes": [ "GADD45A", "CHEK2", "CHEK1", "MDM2", "ATM", "TP53" ], "adjusted_p_value": 1.1726058156555358e-10, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 5, "term": "Cellular Response to Radiation (GO:0071478)", "p_value": 2.6303302590230175e-11, "odds_ratio": 395.7738095238095, "combined_score": 9641.575037832055, "overlapping_genes": [ "RAD51", "GADD45A", "BRCA1", "BRCA2", "TP53" ], "adjusted_p_value": 1.6045014580040408e-9, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 6, "term": "Mitotic DNA Damage Checkpoint Signaling (GO:0044773)", "p_value": 8.559187143520137e-11, "odds_ratio": 307.6388888888889, "combined_score": 7131.509613292655, "overlapping_genes": [ "CHEK2", "CHEK1", "ATM", "BRCA1", "TP53" ], "adjusted_p_value": 4.3509201312894034e-9, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 7, "term": "DNA Damage Response (GO:0006974)", "p_value": 5.347021562149261e-10, "odds_ratio": 82.7445652173913, "combined_score": 1766.5394763614388, "overlapping_genes": [ "RAD51", "GADD45A", "CHEK2", "CHEK1", "ATM", "BRCA1", "TP53" ], "adjusted_p_value": 2.3297736806507493e-8, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 8, "term": "Regulation of Cell Cycle (GO:0051726)", "p_value": 6.659559878454712e-9, "odds_ratio": 75.68076923076923, "combined_score": 1424.8579198465961, "overlapping_genes": [ "GADD45A", "CHEK1", "MDM2", "ATM", "BRCA1", "TP53" ], "adjusted_p_value": 2.538957203660859e-7, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 9, "term": "Intrinsic Apoptotic Signaling Pathway in Response to DNA Damage (GO:0008630)", "p_value": 1.3223684847507812e-8, "odds_ratio": 237.39285714285714, "combined_score": 4306.604667252272, "overlapping_genes": [ "CHEK2", "ATM", "BRCA1", "TP53" ], "adjusted_p_value": 4.481359864988758e-7, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 10, "term": "Regulation of Signal Transduction by P53 Class Mediator (GO:1901796)", "p_value": 1.543880021409923e-8, "odds_ratio": 227.87428571428572, "combined_score": 4098.633951223905, "overlapping_genes": [ "CHEK2", "CHEK1", "MDM2", "ATM" ], "adjusted_p_value": 4.7088340653002654e-7, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 11, "term": "Regulation of Cell Cycle Checkpoint (GO:1901976)", "p_value": 2.0369792464832213e-8, "odds_ratio": 936.609375, "combined_score": 16586.614727699634, "overlapping_genes": [ "RAD51", "BRCA1", "BRCA2" ], "adjusted_p_value": 5.607998506138167e-7, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 12, "term": "Double-Strand Break Repair (GO:0006302)", "p_value": 2.206425641759279e-8, "odds_ratio": 96.57894736842105, "combined_score": 1702.619902698509, "overlapping_genes": [ "RAD51", "CHEK2", "ATM", "BRCA1", "BRCA2" ], "adjusted_p_value": 5.607998506138167e-7, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 13, "term": "Regulation of DNA Damage Checkpoint (GO:2000001)", "p_value": 6.90315364159031e-8, "odds_ratio": 576.2307692307693, "combined_score": 9501.297660227256, "overlapping_genes": [ "RAD51", "BRCA1", "BRCA2" ], "adjusted_p_value": 0.0000016195860466808035, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 14, "term": "Recombinational Repair (GO:0000725)", "p_value": 1.9671649168097368e-7, "odds_ratio": 117.1840942562592, "combined_score": 1809.498457849282, "overlapping_genes": [ "RAD51", "ATM", "BRCA1", "BRCA2" ], "adjusted_p_value": 0.0000042856092830497835, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 15, "term": "Regulation of Cellular Response to Stress (GO:0080135)", "p_value": 2.877440043710024e-7, "odds_ratio": 106.17890520694259, "combined_score": 1599.181156476636, "overlapping_genes": [ "RAD51", "ATM", "BRCA1", "BRCA2" ], "adjusted_p_value": 0.0000056218541555097835, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 16, "term": "Double-Strand Break Repair via Homologous Recombination (GO:0000724)", "p_value": 3.2033117663362717e-7, "odds_ratio": 103.26753246753246, "combined_score": 1544.2534328438196, "overlapping_genes": [ "RAD51", "ATM", "BRCA1", "BRCA2" ], "adjusted_p_value": 0.0000056218541555097835, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 17, "term": "DNA Metabolic Process (GO:0006259)", "p_value": 3.2569769976247145e-7, "odds_ratio": 55.25252525252525, "combined_score": 825.3233347839424, "overlapping_genes": [ "RAD51", "GADD45A", "CHEK1", "ATM", "BRCA1" ], "adjusted_p_value": 0.0000056218541555097835, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 18, "term": "Intrinsic Apoptotic Signaling Pathway (GO:0097193)", "p_value": 3.317815567186102e-7, "odds_ratio": 102.33204633204633, "combined_score": 1526.6702119011975, "overlapping_genes": [ "CHEK2", "ATM", "BRCA1", "TP53" ], "adjusted_p_value": 0.0000056218541555097835, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 19, "term": "Mitotic G2 DNA Damage Checkpoint Signaling (GO:0007095)", "p_value": 4.983940965334791e-7, "odds_ratio": 277.25, "combined_score": 4023.41726456181, "overlapping_genes": [ "CHEK1", "ATM", "BRCA1" ], "adjusted_p_value": 0.00000800053681277427, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 20, "term": "DNA Damage Checkpoint Signaling (GO:0000077)", "p_value": 0.0000010331048943235618, "odds_ratio": 213.79285714285714, "combined_score": 2946.6945135819124, "overlapping_genes": [ "CHEK2", "CHEK1", "ATM" ], "adjusted_p_value": 0.000015754849638434317, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 21, "term": "DNA Integrity Checkpoint Signaling (GO:0031570)", "p_value": 0.000001980407412520879, "odds_ratio": 169.98579545454547, "combined_score": 2232.2888179441948, "overlapping_genes": [ "CHEK2", "CHEK1", "ATM" ], "adjusted_p_value": 0.000028004329193556585, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 22, "term": "Replication Fork Processing (GO:0031297)", "p_value": 0.000002111801873612464, "odds_ratio": 166.2, "combined_score": 2171.896448857574, "overlapping_genes": [ "RAD51", "BRCA1", "BRCA2" ], "adjusted_p_value": 0.000028004329193556585, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 23, "term": "Mitotic G2/M Transition Checkpoint (GO:0044818)", "p_value": 0.000002111801873612464, "odds_ratio": 166.2, "combined_score": 2171.896448857574, "overlapping_genes": [ "CHEK1", "ATM", "BRCA1" ], "adjusted_p_value": 0.000028004329193556585, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 24, "term": "Regulation of Reactive Oxygen Species Metabolic Process (GO:2000377)", "p_value": 0.000004377207796268003, "odds_ratio": 128.86422413793105, "combined_score": 1590.0684870167483, "overlapping_genes": [ "GADD45A", "BRCA1", "TP53" ], "adjusted_p_value": 0.000055627015744239206, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 25, "term": "Regulation of Catabolic Process (GO:0009894)", "p_value": 0.000010314787736795368, "odds_ratio": 95.72596153846153, "combined_score": 1099.118980039264, "overlapping_genes": [ "CHEK2", "MDM2", "ATM" ], "adjusted_p_value": 0.00012584041038890347, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 26, "term": "Regulation of Double-Strand Break Repair (GO:2000779)", "p_value": 0.000014642941013790878, "odds_ratio": 84.80539772727273, "combined_score": 944.015710005004, "overlapping_genes": [ "RAD51", "CHEK1", "ATM" ], "adjusted_p_value": 0.0001717729618925468, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 27, "term": "Cellular Response to Gamma Radiation (GO:0071480)", "p_value": 0.00003286162327694617, "odds_ratio": 317.06349206349205, "combined_score": 3273.1114414226845, "overlapping_genes": [ "MDM2", "TP53" ], "adjusted_p_value": 0.00037121463331365117, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 28, "term": "Regulation of Vacuole Organization (GO:0044088)", "p_value": 0.0000574219267049387, "odds_ratio": 233.5672514619883, "combined_score": 2280.8039070745754, "overlapping_genes": [ "CHEK2", "ATM" ], "adjusted_p_value": 0.0006039202636209071, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 29, "term": "Response to Gamma Radiation (GO:0010332)", "p_value": 0.0000574219267049387, "odds_ratio": 233.5672514619883, "combined_score": 2280.8039070745754, "overlapping_genes": [ "MDM2", "TP53" ], "adjusted_p_value": 0.0006039202636209071, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 30, "term": "Mitotic Cell Cycle Checkpoint Signaling (GO:0007093)", "p_value": 0.00008873438171949139, "odds_ratio": 184.86111111111111, "combined_score": 1724.7288639352953, "overlapping_genes": [ "CHEK1", "BRCA1" ], "adjusted_p_value": 0.0009021328808148291, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 31, "term": "Cellular Response to Nitrogen Compound (GO:1901699)", "p_value": 0.00009304295133509273, "odds_ratio": 44.7808734939759, "combined_score": 415.6761891213192, "overlapping_genes": [ "MDM2", "BRCA1", "TP53" ], "adjusted_p_value": 0.0009154225857162349, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 32, "term": "DNA Damage Response, Signal Transduction by P53 Class Mediator (GO:0030330)", "p_value": 0.00013517920606612052, "odds_ratio": 147.84444444444443, "combined_score": 1317.1327323844173, "overlapping_genes": [ "MDM2", "TP53" ], "adjusted_p_value": 0.0012884268078177112, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 33, "term": "Negative Regulation of G2/M Transition of Mitotic Cell Cycle (GO:0010972)", "p_value": 0.00014385734571119708, "odds_ratio": 143.06810035842295, "combined_score": 1265.67890445098, "overlapping_genes": [ "CHEK1", "BRCA1" ], "adjusted_p_value": 0.001329590619451973, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 34, "term": "Regulation of DNA Damage Response, Signal Transduction by P53 Class Mediator (GO:0043516)", "p_value": 0.00015280264738462226, "odds_ratio": 138.59027777777777, "combined_score": 1217.7045381044284, "overlapping_genes": [ "MDM2", "ATM" ], "adjusted_p_value": 0.001370729630950288, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 35, "term": "Positive Regulation of RNA Biosynthetic Process (GO:1902680)", "p_value": 0.00016572762876068288, "odds_ratio": 20.158672543427535, "combined_score": 175.48456881241668, "overlapping_genes": [ "CHEK2", "BRCA1", "BRCA2", "TP53" ], "adjusted_p_value": 0.0014441979077716648, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 36, "term": "Negative Regulation of Cell Cycle Process (GO:0010948)", "p_value": 0.0001714937660463913, "odds_ratio": 130.4248366013072, "combined_score": 1130.9090161319034, "overlapping_genes": [ "CHEK1", "TP53" ], "adjusted_p_value": 0.001452933295670815, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 37, "term": "Regulation of Gene Expression (GO:0010468)", "p_value": 0.0001954803791669372, "odds_ratio": 14.012923351158646, "combined_score": 119.67107371461837, "overlapping_genes": [ "CHEK2", "ATM", "BRCA1", "BRCA2", "TP53" ], "adjusted_p_value": 0.0016113923147544826, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 38, "term": "Regulation of DNA Recombination (GO:0000018)", "p_value": 0.000212071277436947, "odds_ratio": 116.67251461988305, "combined_score": 986.8847467329822, "overlapping_genes": [ "RAD51", "CHEK1" ], "adjusted_p_value": 0.001702151042586022, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 39, "term": "Apoptotic Process (GO:0006915)", "p_value": 0.00023733376360016633, "odds_ratio": 32.35807860262009, "combined_score": 270.0619193722403, "overlapping_genes": [ "GADD45A", "CHEK1", "MDM2" ], "adjusted_p_value": 0.0018221710531276308, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 40, "term": "DNA Recombination (GO:0006310)", "p_value": 0.00024529265118944116, "odds_ratio": 108.11924119241192, "combined_score": 898.8015841018229, "overlapping_genes": [ "RAD51", "BRCA1" ], "adjusted_p_value": 0.0018221710531276308, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 41, "term": "Positive Regulation of Cellular Process (GO:0048522)", "p_value": 0.0002568031969686043, "odds_ratio": 17.91123439667129, "combined_score": 148.07576662197917, "overlapping_genes": [ "CHEK1", "MDM2", "ATM", "TP53" ], "adjusted_p_value": 0.0018221710531276308, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 42, "term": "Regulation of Telomere Maintenance via Telomerase (GO:0032210)", "p_value": 0.0002568962468343873, "odds_ratio": 105.53968253968254, "combined_score": 872.4794859258211, "overlapping_genes": [ "ATM", "TP53" ], "adjusted_p_value": 0.0018221710531276308, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 43, "term": "Regulation of Autophagosome Assembly (GO:2000785)", "p_value": 0.0002568962468343873, "odds_ratio": 105.53968253968254, "combined_score": 872.4794859258211, "overlapping_genes": [ "CHEK2", "ATM" ], "adjusted_p_value": 0.0018221710531276308, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 44, "term": "Positive Regulation of Programmed Cell Death (GO:0043068)", "p_value": 0.0002887494334416459, "odds_ratio": 30.220408163265308, "combined_score": 246.29485353464128, "overlapping_genes": [ "GADD45A", "ATM", "TP53" ], "adjusted_p_value": 0.0020015585727205, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 45, "term": "Positive Regulation of DNA-templated Transcription (GO:0045893)", "p_value": 0.00034762444730636517, "odds_ratio": 12.293144208037825, "combined_score": 97.9073681883897, "overlapping_genes": [ "CHEK2", "ATM", "BRCA1", "BRCA2", "TP53" ], "adjusted_p_value": 0.0023229932557919477, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 46, "term": "Positive Regulation of Reactive Oxygen Species Metabolic Process (GO:2000379)", "p_value": 0.00035922676978951407, "odds_ratio": 88.61777777777777, "combined_score": 702.8769289105478, "overlapping_genes": [ "GADD45A", "TP53" ], "adjusted_p_value": 0.0023229932557919477, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 47, "term": "Signal Transduction by P53 Class Mediator (GO:0072331)", "p_value": 0.00035922676978951407, "odds_ratio": 88.61777777777777, "combined_score": 702.8769289105478, "overlapping_genes": [ "MDM2", "TP53" ], "adjusted_p_value": 0.0023229932557919477, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 48, "term": "Nucleotide-Excision Repair (GO:0006289)", "p_value": 0.00037320219519280473, "odds_ratio": 86.87581699346406, "combined_score": 685.744723074984, "overlapping_genes": [ "BRCA2", "TP53" ], "adjusted_p_value": 0.0023229932557919477, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 49, "term": "Cellular Response to Mechanical Stimulus (GO:0071260)", "p_value": 0.00037320219519280473, "odds_ratio": 86.87581699346406, "combined_score": 685.744723074984, "overlapping_genes": [ "GADD45A", "CHEK1" ], "adjusted_p_value": 0.0023229932557919477, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 50, "term": "Regulation of Apoptotic Process (GO:0042981)", "p_value": 0.0004121433110256471, "odds_ratio": 15.746122448979591, "combined_score": 122.72747379885324, "overlapping_genes": [ "GADD45A", "MDM2", "ATM", "TP53" ], "adjusted_p_value": 0.002492038504157485, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 51, "term": "Cellular Response to Alcohol (GO:0097306)", "p_value": 0.00041670152036731717, "odds_ratio": 82.03703703703704, "combined_score": 638.505774876317, "overlapping_genes": [ "RAD51", "BRCA1" ], "adjusted_p_value": 0.002492038504157485, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 52, "term": "Positive Regulation of Cell Cycle (GO:0045787)", "p_value": 0.00047836212312948043, "odds_ratio": 76.3639846743295, "combined_score": 583.8135471866307, "overlapping_genes": [ "CHEK1", "MDM2" ], "adjusted_p_value": 0.0028057778375863754, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 53, "term": "Phosphorylation (GO:0016310)", "p_value": 0.0004944843358391435, "odds_ratio": 25.034745762711864, "combined_score": 190.5643616791926, "overlapping_genes": [ "CHEK2", "CHEK1", "ATM" ], "adjusted_p_value": 0.0028456174043573353, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 54, "term": "Regulation of Intracellular Signal Transduction (GO:1902531)", "p_value": 0.000514112985760696, "odds_ratio": 24.694816053511705, "combined_score": 187.01550887357962, "overlapping_genes": [ "CHEK2", "CHEK1", "ATM" ], "adjusted_p_value": 0.00290378630846319, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 55, "term": "Epigenetic Regulation of Gene Expression (GO:0040029)", "p_value": 0.0005441932684144313, "odds_ratio": 71.42293906810036, "combined_score": 536.8295304023001, "overlapping_genes": [ "CHEK1", "BRCA1" ], "adjusted_p_value": 0.0030177990339345737, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 56, "term": "Protein Autoubiquitination (GO:0051865)", "p_value": 0.0005613009114282874, "odds_ratio": 70.28571428571429, "combined_score": 526.1063826886168, "overlapping_genes": [ "MDM2", "BRCA1" ], "adjusted_p_value": 0.0030535590463887413, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 57, "term": "Positive Regulation of Apoptotic Process (GO:0043065)", "p_value": 0.0005706651332595353, "odds_ratio": 23.80524193548387, "combined_score": 177.79440033747562, "overlapping_genes": [ "GADD45A", "ATM", "TP53" ], "adjusted_p_value": 0.0030535590463887413, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 58, "term": "Telomere Maintenance (GO:0000723)", "p_value": 0.0006883061323478026, "odds_ratio": 63.234920634920634, "combined_score": 460.4309643116587, "overlapping_genes": [ "RAD51", "ATM" ], "adjusted_p_value": 0.0036195408683806865, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 59, "term": "Cellular Response to Hypoxia (GO:0071456)", "p_value": 0.000786762964181551, "odds_ratio": 59.004444444444445, "combined_score": 421.73919613452125, "overlapping_genes": [ "MDM2", "TP53" ], "adjusted_p_value": 0.004067164475853781, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 60, "term": "Cellular Response to Decreased Oxygen Levels (GO:0036294)", "p_value": 0.0008072251304274173, "odds_ratio": 58.22514619883041, "combined_score": 414.67413198594653, "overlapping_genes": [ "MDM2", "TP53" ], "adjusted_p_value": 0.004103394413006038, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 61, "term": "Positive Regulation of Macromolecule Biosynthetic Process (GO:0010557)", "p_value": 0.0008230384224842788, "odds_ratio": 20.920099431818183, "combined_score": 148.58516672375978, "overlapping_genes": [ "ATM", "BRCA1", "TP53" ], "adjusted_p_value": 0.0041151921124213935, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 62, "term": "Regulation of Double-Strand Break Repair via Homologous Recombination (GO:0010569)", "p_value": 0.0008489183706752518, "odds_ratio": 56.72649572649573, "combined_score": 401.1441103936546, "overlapping_genes": [ "RAD51", "CHEK1" ], "adjusted_p_value": 0.0041761306944508355, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 63, "term": "Protein Phosphorylation (GO:0006468)", "p_value": 0.0009498989141878284, "odds_ratio": 19.88412162162162, "combined_score": 138.37668410842298, "overlapping_genes": [ "CHEK2", "CHEK1", "ATM" ], "adjusted_p_value": 0.0045987169655125025, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 64, "term": "Regulation of Organelle Assembly (GO:1902115)", "p_value": 0.0009801323593554442, "odds_ratio": 52.65873015873016, "combined_score": 364.81035851387213, "overlapping_genes": [ "CHEK2", "ATM" ], "adjusted_p_value": 0.004670943275053289, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 65, "term": "Cellular Response to Tumor Necrosis Factor (GO:0071356)", "p_value": 0.001002893463632885, "odds_ratio": 52.03660130718954, "combined_score": 359.30575877593174, "overlapping_genes": [ "BRCA1", "TP53" ], "adjusted_p_value": 0.004705884713969692, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 66, "term": "Cellular Response to Oxygen-Containing Compound (GO:1901701)", "p_value": 0.0010332398906773167, "odds_ratio": 19.299212598425196, "combined_score": 132.68316522062563, "overlapping_genes": [ "MDM2", "ATM", "TP53" ], "adjusted_p_value": 0.004774820706917903, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 67, "term": "Positive Regulation of DNA Repair (GO:0045739)", "p_value": 0.0011447913297592018, "odds_ratio": 48.59096459096459, "combined_score": 329.08390649715756, "overlapping_genes": [ "ATM", "BRCA1" ], "adjusted_p_value": 0.005134725817302302, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 68, "term": "Regulation of Protein Metabolic Process (GO:0051246)", "p_value": 0.0011447913297592018, "odds_ratio": 48.59096459096459, "combined_score": 329.08390649715756, "overlapping_genes": [ "CHEK2", "MDM2" ], "adjusted_p_value": 0.005134725817302302, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 69, "term": "Positive Regulation of Protein-Containing Complex Assembly (GO:0031334)", "p_value": 0.0014558446451528107, "odds_ratio": 42.903991370010786, "combined_score": 280.25612389042504, "overlapping_genes": [ "ATM", "TP53" ], "adjusted_p_value": 0.00643525531553054, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 70, "term": "Positive Regulation of Gene Expression (GO:0010628)", "p_value": 0.001490195790165633, "odds_ratio": 16.9364896073903, "combined_score": 110.23703252566465, "overlapping_genes": [ "ATM", "BRCA1", "TP53" ], "adjusted_p_value": 0.006491768038909022, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 71, "term": "Protein Catabolic Process (GO:0030163)", "p_value": 0.0015111984615165264, "odds_ratio": 42.08253968253968, "combined_score": 273.3198779565988, "overlapping_genes": [ "CHEK2", "MDM2" ], "adjusted_p_value": 0.006491768038909022, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 72, "term": "Negative Regulation of DNA-templated Transcription (GO:0045892)", "p_value": 0.0015797571153999793, "odds_ratio": 10.828058169375534, "combined_score": 69.84621779380232, "overlapping_genes": [ "GADD45A", "MDM2", "BRCA1", "TP53" ], "adjusted_p_value": 0.00666863911428307, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 73, "term": "Negative Regulation of Gene Expression, Epigenetic (GO:0045814)", "p_value": 0.00159610050932021, "odds_ratio": 40.907407407407405, "combined_score": 263.4515499969604, "overlapping_genes": [ "CHEK1", "BRCA1" ], "adjusted_p_value": 0.00666863911428307, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 74, "term": "Negative Regulation of Growth (GO:0045926)", "p_value": 0.0017425786577592239, "odds_ratio": 39.087512291052114, "combined_score": 248.29909388744773, "overlapping_genes": [ "BRCA1", "TP53" ], "adjusted_p_value": 0.007182249873196801, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 75, "term": "Regulation of RNA Biosynthetic Process (GO:2001141)", "p_value": 0.001792741944453392, "odds_ratio": 15.849837662337663, "combined_score": 100.23451632018777, "overlapping_genes": [ "CHEK2", "BRCA2", "TP53" ], "adjusted_p_value": 0.007290483907443794, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 76, "term": "Negative Regulation of RNA Biosynthetic Process (GO:1902679)", "p_value": 0.001848523399047443, "odds_ratio": 15.67612419700214, "combined_score": 98.6556202864886, "overlapping_genes": [ "MDM2", "BRCA1", "TP53" ], "adjusted_p_value": 0.007418416272493029, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 77, "term": "Cellular Response to Oxidative Stress (GO:0034599)", "p_value": 0.0019265251216805841, "odds_ratio": 37.105508870214756, "combined_score": 231.98502749281076, "overlapping_genes": [ "ATM", "TP53" ], "adjusted_p_value": 0.007533207206571514, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 78, "term": "Negative Regulation of Cell Growth (GO:0030308)", "p_value": 0.0019265251216805841, "odds_ratio": 37.105508870214756, "combined_score": 231.98502749281076, "overlapping_genes": [ "BRCA1", "TP53" ], "adjusted_p_value": 0.007533207206571514, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 79, "term": "Protein-Containing Complex Organization (GO:0043933)", "p_value": 0.001989813866519725, "odds_ratio": 36.48852157943067, "combined_score": 226.94817503952012, "overlapping_genes": [ "MDM2", "TP53" ], "adjusted_p_value": 0.007682192775804002, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 80, "term": "Regulation of Protein Catabolic Process (GO:0042176)", "p_value": 0.002185574097671191, "odds_ratio": 34.75415573053368, "combined_score": 212.8996742085833, "overlapping_genes": [ "CHEK2", "MDM2" ], "adjusted_p_value": 0.008332501247371416, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 81, "term": "Protein Autophosphorylation (GO:0046777)", "p_value": 0.002567294135666666, "odds_ratio": 31.966183574879228, "combined_score": 190.67517791835434, "overlapping_genes": [ "CHEK2", "ATM" ], "adjusted_p_value": 0.00966697174541152, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 82, "term": "Establishment of Protein Localization to Telomere (GO:0070200)", "p_value": 0.002747205358336921, "odds_ratio": 499.625, "combined_score": 2946.3741195064317, "overlapping_genes": [ "BRCA2" ], "adjusted_p_value": 0.009974971836818582, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 83, "term": "Regulation of Pentose-Phosphate Shunt (GO:0043456)", "p_value": 0.002747205358336921, "odds_ratio": 499.625, "combined_score": 2946.3741195064317, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.009974971836818582, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 84, "term": "Double-Strand Break Repair via Synthesis-Dependent Strand Annealing (GO:0045003)", "p_value": 0.002747205358336921, "odds_ratio": 499.625, "combined_score": 2946.3741195064317, "overlapping_genes": [ "RAD51" ], "adjusted_p_value": 0.009974971836818582, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 85, "term": "Protein Modification Process (GO:0036211)", "p_value": 0.0028199035403468444, "odds_ratio": 13.455027675276753, "combined_score": 78.99517521826468, "overlapping_genes": [ "CHEK2", "CHEK1", "ATM" ], "adjusted_p_value": 0.010020569591274656, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 86, "term": "Positive Regulation of Metabolic Process (GO:0009893)", "p_value": 0.0028254720814741654, "odds_ratio": 30.412260536398467, "combined_score": 178.49198459045135, "overlapping_genes": [ "GADD45A", "TP53" ], "adjusted_p_value": 0.010020569591274656, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 87, "term": "Negative Regulation of Telomere Capping (GO:1904354)", "p_value": 0.0032958256764104633, "odds_ratio": 399.68, "combined_score": 2284.210591570385, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.011554331394312544, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 88, "term": "Regulation of DNA-templated Transcription (GO:0006355)", "p_value": 0.0036965859436465117, "odds_ratio": 6.972430490471727, "combined_score": 39.04802044115113, "overlapping_genes": [ "CHEK2", "MDM2", "BRCA1", "BRCA2", "TP53" ], "adjusted_p_value": 0.012812030827411206, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 89, "term": "DNA Strand Resection Involved in Replication Fork Processing (GO:0110025)", "p_value": 0.00384417200458596, "odds_ratio": 333.05, "combined_score": 1852.1566750462314, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.012884312762623272, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 90, "term": "ER Overload Response (GO:0006983)", "p_value": 0.00384417200458596, "odds_ratio": 333.05, "combined_score": 1852.1566750462314, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.012884312762623272, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 91, "term": "Regulation of Thymocyte Apoptotic Process (GO:0070243)", "p_value": 0.00384417200458596, "odds_ratio": 333.05, "combined_score": 1852.1566750462314, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.012884312762623272, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 92, "term": "Negative Regulation of Mitotic Nuclear Division (GO:0045839)", "p_value": 0.004392244396163033, "odds_ratio": 285.45714285714286, "combined_score": 1549.43708775113, "overlapping_genes": [ "CHEK1" ], "adjusted_p_value": 0.014251431285422608, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 93, "term": "Regulation of Intrinsic Apoptotic Signaling Pathway by P53 Class Mediator (GO:1902253)", "p_value": 0.004392244396163033, "odds_ratio": 285.45714285714286, "combined_score": 1549.43708775113, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.014251431285422608, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 94, "term": "Regulation of Mitotic Centrosome Separation (GO:0046602)", "p_value": 0.004392244396163033, "odds_ratio": 285.45714285714286, "combined_score": 1549.43708775113, "overlapping_genes": [ "CHEK1" ], "adjusted_p_value": 0.014251431285422608, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 95, "term": "Regulation of Transcription by RNA Polymerase II (GO:0006357)", "p_value": 0.004620734826335185, "odds_ratio": 6.58648849294729, "combined_score": 35.416876022791136, "overlapping_genes": [ "GADD45A", "MDM2", "ATM", "BRCA1", "TP53" ], "adjusted_p_value": 0.014834990758234015, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 96, "term": "Regulation of Programmed Cell Death (GO:0043067)", "p_value": 0.004909118939983431, "odds_ratio": 22.793321819228556, "combined_score": 121.18436050948773, "overlapping_genes": [ "ATM", "TP53" ], "adjusted_p_value": 0.015374623382635089, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 97, "term": "Negative Regulation of Peptidyl-Serine Phosphorylation (GO:0033137)", "p_value": 0.0049400429229450454, "odds_ratio": 249.7625, "combined_score": 1326.3340991921912, "overlapping_genes": [ "GADD45A" ], "adjusted_p_value": 0.015374623382635089, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 98, "term": "Hematopoietic Stem Cell Differentiation (GO:0060218)", "p_value": 0.0049400429229450454, "odds_ratio": 249.7625, "combined_score": 1326.3340991921912, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.015374623382635089, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 99, "term": "Telomere Maintenance via Recombination (GO:0000722)", "p_value": 0.005487567669022947, "odds_ratio": 222, "combined_score": 1155.5699775561973, "overlapping_genes": [ "RAD51" ], "adjusted_p_value": 0.016249593583029114, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 100, "term": "Regulation of Telomere Capping (GO:1904353)", "p_value": 0.005487567669022947, "odds_ratio": 222, "combined_score": 1155.5699775561973, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.016249593583029114, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 101, "term": "Negative Regulation of Nuclear Division (GO:0051784)", "p_value": 0.005487567669022947, "odds_ratio": 222, "combined_score": 1155.5699775561973, "overlapping_genes": [ "CHEK1" ], "adjusted_p_value": 0.016249593583029114, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 102, "term": "Homologous Recombination (GO:0035825)", "p_value": 0.005487567669022947, "odds_ratio": 222, "combined_score": 1155.5699775561973, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.016249593583029114, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 103, "term": "Positive Regulation of Cellular Senescence (GO:2000774)", "p_value": 0.005487567669022947, "odds_ratio": 222, "combined_score": 1155.5699775561973, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.016249593583029114, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 104, "term": "Positive Regulation of T Cell Apoptotic Process (GO:0070234)", "p_value": 0.006034818727760455, "odds_ratio": 199.79, "combined_score": 1020.9687483548147, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.017529711542542275, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 105, "term": "Positive Regulation of Execution Phase of Apoptosis (GO:1900119)", "p_value": 0.006034818727760455, "odds_ratio": 199.79, "combined_score": 1020.9687483548147, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.017529711542542275, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 106, "term": "Regulation of Cell Growth (GO:0001558)", "p_value": 0.006315311534254596, "odds_ratio": 19.96868686868687, "combined_score": 101.136969774862, "overlapping_genes": [ "BRCA1", "TP53" ], "adjusted_p_value": 0.018171415263657092, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 107, "term": "Negative Regulation of Transcription by RNA Polymerase II (GO:0000122)", "p_value": 0.00646431128364294, "odds_ratio": 9.907407407407407, "combined_score": 49.94778628322193, "overlapping_genes": [ "GADD45A", "MDM2", "TP53" ], "adjusted_p_value": 0.01842630786458969, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 108, "term": "Protein Polyubiquitination (GO:0000209)", "p_value": 0.0066501054637537966, "odds_ratio": 19.432645034414946, "combined_score": 97.41823132411149, "overlapping_genes": [ "MDM2", "BRCA1" ], "adjusted_p_value": 0.018780390430045445, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 109, "term": "Mitotic DNA Integrity Checkpoint Signaling (GO:0044774)", "p_value": 0.00712850018242009, "odds_ratio": 166.475, "combined_score": 822.994869532877, "overlapping_genes": [ "CHEK2" ], "adjusted_p_value": 0.01941243353248328, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 110, "term": "Mitotic G1 DNA Damage Checkpoint Signaling (GO:0031571)", "p_value": 0.00712850018242009, "odds_ratio": 166.475, "combined_score": 822.994869532877, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.01941243353248328, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 111, "term": "Negative Regulation of DNA Damage Response, Signal Transduction by P53 Class Mediator (GO:0043518)", "p_value": 0.00712850018242009, "odds_ratio": 166.475, "combined_score": 822.994869532877, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.01941243353248328, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 112, "term": "Lipid Droplet Formation (GO:0140042)", "p_value": 0.00712850018242009, "odds_ratio": 166.475, "combined_score": 822.994869532877, "overlapping_genes": [ "CHEK2" ], "adjusted_p_value": 0.01941243353248328, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 113, "term": "Negative Regulation of Fatty Acid Biosynthetic Process (GO:0045717)", "p_value": 0.007674930787541144, "odds_ratio": 153.66153846153847, "combined_score": 748.3003458854362, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.020007298206838026, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 114, "term": "Protein Localization to Chromosome, Telomeric Region (GO:0070198)", "p_value": 0.007674930787541144, "odds_ratio": 153.66153846153847, "combined_score": 748.3003458854362, "overlapping_genes": [ "BRCA2" ], "adjusted_p_value": 0.020007298206838026, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 115, "term": "Establishment of Protein Localization to Chromosome (GO:0070199)", "p_value": 0.007674930787541144, "odds_ratio": 153.66153846153847, "combined_score": 748.3003458854362, "overlapping_genes": [ "BRCA2" ], "adjusted_p_value": 0.020007298206838026, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 116, "term": "Mitotic G1/S Transition Checkpoint Signaling (GO:0044819)", "p_value": 0.007674930787541144, "odds_ratio": 153.66153846153847, "combined_score": 748.3003458854362, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.020007298206838026, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 117, "term": "Negative Regulation of ATP-dependent Activity (GO:0032780)", "p_value": 0.007674930787541144, "odds_ratio": 153.66153846153847, "combined_score": 748.3003458854362, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.020007298206838026, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 118, "term": "Regulation of Execution Phase of Apoptosis (GO:1900117)", "p_value": 0.008221088123671455, "odds_ratio": 142.67857142857142, "combined_score": 685.0073410932765, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.020552720309178638, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 119, "term": "Pexophagy (GO:0000425)", "p_value": 0.008221088123671455, "odds_ratio": 142.67857142857142, "combined_score": 685.0073410932765, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.020552720309178638, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 120, "term": "Mitotic Recombination (GO:0006312)", "p_value": 0.008221088123671455, "odds_ratio": 142.67857142857142, "combined_score": 685.0073410932765, "overlapping_genes": [ "RAD51" ], "adjusted_p_value": 0.020552720309178638, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 121, "term": "Autophagy of Peroxisome (GO:0030242)", "p_value": 0.008221088123671455, "odds_ratio": 142.67857142857142, "combined_score": 685.0073410932765, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.020552720309178638, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 122, "term": "Protein K6-linked Ubiquitination (GO:0085020)", "p_value": 0.008221088123671455, "odds_ratio": 142.67857142857142, "combined_score": 685.0073410932765, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.020552720309178638, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 123, "term": "Chromatin Remodeling (GO:0006338)", "p_value": 0.008697211729449362, "odds_ratio": 16.86239316239316, "combined_score": 80.00788709705736, "overlapping_genes": [ "CHEK1", "BRCA1" ], "adjusted_p_value": 0.021054539777890128, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 124, "term": "DNA Double-Strand Break Processing (GO:0000729)", "p_value": 0.008766972300957528, "odds_ratio": 133.16, "combined_score": 630.7474630602054, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.021054539777890128, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 125, "term": "Negative Regulation of Intrinsic Apoptotic Signaling Pathway by P53 Class Mediator (GO:1902254)", "p_value": 0.008766972300957528, "odds_ratio": 133.16, "combined_score": 630.7474630602054, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.021054539777890128, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 126, "term": "Cellular Response to Alkaloid (GO:0071312)", "p_value": 0.008766972300957528, "odds_ratio": 133.16, "combined_score": 630.7474630602054, "overlapping_genes": [ "RAD51" ], "adjusted_p_value": 0.021054539777890128, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 127, "term": "Positive Regulation of DNA Damage Response, Signal Transduction by P53 Class Mediator (GO:0043517)", "p_value": 0.008766972300957528, "odds_ratio": 133.16, "combined_score": 630.7474630602054, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.021054539777890128, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 128, "term": "Negative Regulation of Fibroblast Proliferation (GO:0048147)", "p_value": 0.009312583434128836, "odds_ratio": 124.83125, "combined_score": 583.7594513941907, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.02201812362332787, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 129, "term": "Negative Regulation of Telomere Maintenance (GO:0032205)", "p_value": 0.009312583434128836, "odds_ratio": 124.83125, "combined_score": 583.7594513941907, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.02201812362332787, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 130, "term": "Cellular Component Assembly (GO:0022607)", "p_value": 0.00967994549428526, "odds_ratio": 15.930505050505051, "combined_score": 73.88088747707648, "overlapping_genes": [ "MDM2", "TP53" ], "adjusted_p_value": 0.022710641351976958, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 131, "term": "Negative Regulation of Reactive Oxygen Species Metabolic Process (GO:2000378)", "p_value": 0.010402987018789436, "odds_ratio": 110.95, "combined_score": 506.5602322657193, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.024037204854021044, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 132, "term": "Regulation of Centriole Replication (GO:0046599)", "p_value": 0.010402987018789436, "odds_ratio": 110.95, "combined_score": 506.5602322657193, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.024037204854021044, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 133, "term": "Positive Regulation of Release of Cytochrome C From Mitochondria (GO:0090200)", "p_value": 0.010947779702855981, "odds_ratio": 105.10526315789474, "combined_score": 474.5101770765117, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.024918453801276674, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 134, "term": "Regulation of Cell Cycle G2/M Phase Transition (GO:1902749)", "p_value": 0.010947779702855981, "odds_ratio": 105.10526315789474, "combined_score": 474.5101770765117, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.024918453801276674, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 135, "term": "Entrainment of Circadian Clock by Photoperiod (GO:0043153)", "p_value": 0.011492299803033998, "odds_ratio": 99.845, "combined_score": 445.91556292503236, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.025399648115401227, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 136, "term": "Negative Regulation of Signal Transduction by P53 Class Mediator (GO:1901797)", "p_value": 0.011492299803033998, "odds_ratio": 99.845, "combined_score": 445.91556292503236, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.025399648115401227, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 137, "term": "Negative Regulation of Telomere Maintenance via Telomerase (GO:0032211)", "p_value": 0.011492299803033998, "odds_ratio": 99.845, "combined_score": 445.91556292503236, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.025399648115401227, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 138, "term": "Intrinsic Apoptotic Signaling Pathway in Response to DNA Damage by P53 Class Mediator (GO:0042771)", "p_value": 0.011492299803033998, "odds_ratio": 99.845, "combined_score": 445.91556292503236, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.025399648115401227, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 139, "term": "Photoperiodism (GO:0009648)", "p_value": 0.012036547438812547, "odds_ratio": 95.08571428571429, "combined_score": 420.26056624547704, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.02622247834884162, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 140, "term": "Positive Regulation of p38MAPK Cascade (GO:1900745)", "p_value": 0.012036547438812547, "odds_ratio": 95.08571428571429, "combined_score": 420.26056624547704, "overlapping_genes": [ "GADD45A" ], "adjusted_p_value": 0.02622247834884162, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 141, "term": "Protein Modification by Small Protein Conjugation (GO:0032446)", "p_value": 0.012456642309167971, "odds_ratio": 13.924274593064402, "combined_score": 61.06492404445706, "overlapping_genes": [ "MDM2", "BRCA1" ], "adjusted_p_value": 0.026945219179405892, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 142, "term": "Postreplication Repair (GO:0006301)", "p_value": 0.012580522725551224, "odds_ratio": 90.75909090909092, "combined_score": 397.1259752205777, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.02702154529079664, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 143, "term": "Protein-Containing Complex Assembly (GO:0065003)", "p_value": 0.012988226728069676, "odds_ratio": 13.615784008307372, "combined_score": 59.143043952756074, "overlapping_genes": [ "MDM2", "TP53" ], "adjusted_p_value": 0.027509785778203132, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 144, "term": "Chromatin Organization (GO:0006325)", "p_value": 0.012988226728069676, "odds_ratio": 13.615784008307372, "combined_score": 59.143043952756074, "overlapping_genes": [ "CHEK1", "BRCA1" ], "adjusted_p_value": 0.027509785778203132, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 145, "term": "Negative Regulation of Extrinsic Apoptotic Signaling Pathway via Death Domain Receptors (GO:1902042)", "p_value": 0.013124225781325726, "odds_ratio": 86.80869565217391, "combined_score": 376.1677267870623, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.027606130091754114, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 146, "term": "Negative Regulation of Catalytic Activity (GO:0043086)", "p_value": 0.013667656724254873, "odds_ratio": 83.1875, "combined_score": 357.1008995813401, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.028515123562307437, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 147, "term": "Negative Regulation of Fatty Acid Metabolic Process (GO:0045922)", "p_value": 0.014210815676953212, "odds_ratio": 79.856, "combined_score": 339.6876146735057, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.028515123562307437, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 148, "term": "Regulation of Fatty Acid Biosynthetic Process (GO:0042304)", "p_value": 0.014210815676953212, "odds_ratio": 79.856, "combined_score": 339.6876146735057, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.028515123562307437, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 149, "term": "Negative Regulation of Lipid Biosynthetic Process (GO:0051055)", "p_value": 0.014210815676953212, "odds_ratio": 79.856, "combined_score": 339.6876146735057, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.028515123562307437, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 150, "term": "Cellular Response to Xenobiotic Stimulus (GO:0071466)", "p_value": 0.014210815676953212, "odds_ratio": 79.856, "combined_score": 339.6876146735057, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.028515123562307437, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 151, "term": "Negative Regulation of DNA Biosynthetic Process (GO:2000279)", "p_value": 0.014210815676953212, "odds_ratio": 79.856, "combined_score": 339.6876146735057, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.028515123562307437, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 152, "term": "Amyloid Fibril Formation (GO:1990000)", "p_value": 0.014210815676953212, "odds_ratio": 79.856, "combined_score": 339.6876146735057, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.028515123562307437, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 153, "term": "Positive Regulation of Transcription by RNA Polymerase II (GO:0045944)", "p_value": 0.014516526301213818, "odds_ratio": 7.273852040816327, "combined_score": 30.78634260740489, "overlapping_genes": [ "ATM", "BRCA1", "TP53" ], "adjusted_p_value": 0.02893817334555696, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 154, "term": "ER-nucleus Signaling Pathway (GO:0006984)", "p_value": 0.01475370275603204, "odds_ratio": 76.78076923076924, "combined_score": 323.7277777065472, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.02897749698481564, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 155, "term": "Positive Regulation of Vascular Endothelial Growth Factor Production (GO:0010575)", "p_value": 0.01475370275603204, "odds_ratio": 76.78076923076924, "combined_score": 323.7277777065472, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.02897749698481564, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 156, "term": "Telomere Maintenance via Telomere Lengthening (GO:0010833)", "p_value": 0.015296318080509241, "odds_ratio": 73.93333333333334, "combined_score": 309.05191525436794, "overlapping_genes": [ "RAD51" ], "adjusted_p_value": 0.02897749698481564, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 157, "term": "Positive Regulation of Mitotic Cell Cycle (GO:0045931)", "p_value": 0.015296318080509241, "odds_ratio": 73.93333333333334, "combined_score": 309.05191525436794, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.02897749698481564, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 158, "term": "Regulation of DNA Biosynthetic Process (GO:2000278)", "p_value": 0.015296318080509241, "odds_ratio": 73.93333333333334, "combined_score": 309.05191525436794, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.02897749698481564, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 159, "term": "Hematopoietic Progenitor Cell Differentiation (GO:0002244)", "p_value": 0.015296318080509241, "odds_ratio": 73.93333333333334, "combined_score": 309.05191525436794, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.02897749698481564, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 160, "term": "Positive Regulation of Signal Transduction by P53 Class Mediator (GO:1901798)", "p_value": 0.015296318080509241, "odds_ratio": 73.93333333333334, "combined_score": 309.05191525436794, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.02897749698481564, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 161, "term": "Negative Regulation of Telomere Maintenance via Telomere Lengthening (GO:1904357)", "p_value": 0.015296318080509241, "odds_ratio": 73.93333333333334, "combined_score": 309.05191525436794, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.02897749698481564, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 162, "term": "Regulation of Vascular Endothelial Growth Factor Production (GO:0010574)", "p_value": 0.01583866177167553, "odds_ratio": 71.28928571428571, "combined_score": 295.5155744703354, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.029819702718278003, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 163, "term": "Negative Regulation of Mitotic Cell Cycle (GO:0045930)", "p_value": 0.01638073395054089, "odds_ratio": 68.82758620689656, "combined_score": 282.994903106762, "overlapping_genes": [ "CHEK1" ], "adjusted_p_value": 0.03065106659457038, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 164, "term": "Protein Ubiquitination (GO:0016567)", "p_value": 0.016725284286301073, "odds_ratio": 11.881320012110203, "combined_score": 48.60450401405494, "overlapping_genes": [ "MDM2", "BRCA1" ], "adjusted_p_value": 0.031104949434889194, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 165, "term": "Negative Regulation of Intracellular Steroid Hormone Receptor Signaling Pathway (GO:0033144)", "p_value": 0.016922534733464, "odds_ratio": 66.53, "combined_score": 271.3831303578043, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.03128104905276679, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 166, "term": "Regulation of Extrinsic Apoptotic Signaling Pathway via Death Domain Receptors (GO:1902041)", "p_value": 0.017464064240814415, "odds_ratio": 64.38064516129032, "combined_score": 260.5877419554691, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.03189544666735567, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 167, "term": "Lipid Droplet Organization (GO:0034389)", "p_value": 0.017464064240814415, "odds_ratio": 64.38064516129032, "combined_score": 260.5877419554691, "overlapping_genes": [ "CHEK2" ], "adjusted_p_value": 0.03189544666735567, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 168, "term": "Negative Regulation of Programmed Cell Death (GO:0043069)", "p_value": 0.017856417315062642, "odds_ratio": 11.467251461988305, "combined_score": 46.16018598858009, "overlapping_genes": [ "MDM2", "TP53" ], "adjusted_p_value": 0.03241790048270301, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 169, "term": "Regulation of G0 to G1 Transition (GO:0070316)", "p_value": 0.01800532259639319, "odds_ratio": 62.365625, "combined_score": 250.52819538044852, "overlapping_genes": [ "CHEK1" ], "adjusted_p_value": 0.032494812969822026, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 170, "term": "Tumor Necrosis Factor-Mediated Signaling Pathway (GO:0033209)", "p_value": 0.018546309917010683, "odds_ratio": 60.472727272727276, "combined_score": 241.13405880391542, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.03288735188772243, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 171, "term": "Negative Regulation of Blood Vessel Endothelial Cell Migration (GO:0043537)", "p_value": 0.018546309917010683, "odds_ratio": 60.472727272727276, "combined_score": 241.13405880391542, "overlapping_genes": [ "GADD45A" ], "adjusted_p_value": 0.03288735188772243, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 172, "term": "Regulation of Cell Cycle Phase Transition (GO:1901987)", "p_value": 0.018546309917010683, "odds_ratio": 60.472727272727276, "combined_score": 241.13405880391542, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.03288735188772243, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 173, "term": "Regulation of p38MAPK Cascade (GO:1900744)", "p_value": 0.01908702632439229, "odds_ratio": 58.69117647058823, "combined_score": 232.34348501767582, "overlapping_genes": [ "GADD45A" ], "adjusted_p_value": 0.03345714384448074, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 174, "term": "Regulation of Cellular Senescence (GO:2000772)", "p_value": 0.01908702632439229, "odds_ratio": 58.69117647058823, "combined_score": 232.34348501767582, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.03345714384448074, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 175, "term": "Peptidyl-Threonine Phosphorylation (GO:0018107)", "p_value": 0.01962747193991364, "odds_ratio": 57.011428571428574, "combined_score": 224.10195239289595, "overlapping_genes": [ "CHEK1" ], "adjusted_p_value": 0.03420787966670663, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 176, "term": "Regulation of Release of Cytochrome C From Mitochondria (GO:0090199)", "p_value": 0.020167646885642113, "odds_ratio": 55.425, "combined_score": 216.36122001333428, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.03455692303438677, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 177, "term": "Negative Regulation of Endothelial Cell Migration (GO:0010596)", "p_value": 0.020167646885642113, "odds_ratio": 55.425, "combined_score": 216.36122001333428, "overlapping_genes": [ "GADD45A" ], "adjusted_p_value": 0.03455692303438677, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 178, "term": "Intrinsic Apoptotic Signaling Pathway by P53 Class Mediator (GO:0072332)", "p_value": 0.020167646885642113, "odds_ratio": 55.425, "combined_score": 216.36122001333428, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.03455692303438677, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 179, "term": "Positive Regulation of Intrinsic Apoptotic Signaling Pathway (GO:2001244)", "p_value": 0.021247185233602552, "odds_ratio": 52.502631578947366, "combined_score": 202.2155053364779, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.03600217497915988, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 180, "term": "Interstrand Cross-Link Repair (GO:0036297)", "p_value": 0.021247185233602552, "odds_ratio": 52.502631578947366, "combined_score": 202.2155053364779, "overlapping_genes": [ "RAD51" ], "adjusted_p_value": 0.03600217497915988, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 181, "term": "G2/M Transition of Mitotic Cell Cycle (GO:0000086)", "p_value": 0.02178654888216798, "odds_ratio": 51.15384615384615, "combined_score": 195.7382752343542, "overlapping_genes": [ "CHEK2" ], "adjusted_p_value": 0.03671214038155378, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 182, "term": "Protein Destabilization (GO:0031648)", "p_value": 0.022864465733773234, "odds_ratio": 48.65365853658537, "combined_score": 183.82185575175376, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.03796766408794022, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 183, "term": "Cellular Response to Retinoic Acid (GO:0071300)", "p_value": 0.022864465733773234, "odds_ratio": 48.65365853658537, "combined_score": 183.82185575175376, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.03796766408794022, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 184, "term": "Positive Regulation of Gene Expression, Epigenetic (GO:0141137)", "p_value": 0.02340301917551725, "odds_ratio": 47.49285714285714, "combined_score": 178.33046577189359, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.03796766408794022, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 185, "term": "mRNA Transcription (GO:0009299)", "p_value": 0.02340301917551725, "odds_ratio": 47.49285714285714, "combined_score": 178.33046577189359, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.03796766408794022, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 186, "term": "Cell Cycle G2/M Phase Transition (GO:0044839)", "p_value": 0.02340301917551725, "odds_ratio": 47.49285714285714, "combined_score": 178.33046577189359, "overlapping_genes": [ "CHEK2" ], "adjusted_p_value": 0.03796766408794022, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 187, "term": "Cellular Response to Glucose Starvation (GO:0042149)", "p_value": 0.02340301917551725, "odds_ratio": 47.49285714285714, "combined_score": 178.33046577189359, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.03796766408794022, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 188, "term": "Negative Regulation of Organelle Assembly (GO:1902116)", "p_value": 0.02340301917551725, "odds_ratio": 47.49285714285714, "combined_score": 178.33046577189359, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.03796766408794022, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 189, "term": "DNA-templated DNA Replication Maintenance of Fidelity (GO:0045005)", "p_value": 0.023941302793523297, "odds_ratio": 46.38604651162791, "combined_score": 173.11969096681065, "overlapping_genes": [ "RAD51" ], "adjusted_p_value": 0.038031757041794824, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 190, "term": "Peptidyl-Threonine Modification (GO:0018210)", "p_value": 0.023941302793523297, "odds_ratio": 46.38604651162791, "combined_score": 173.11969096681065, "overlapping_genes": [ "CHEK1" ], "adjusted_p_value": 0.038031757041794824, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 191, "term": "Protein Sumoylation (GO:0016925)", "p_value": 0.023941302793523297, "odds_ratio": 46.38604651162791, "combined_score": 173.11969096681065, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.038031757041794824, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 192, "term": "Bone Development (GO:0060348)", "p_value": 0.023941302793523297, "odds_ratio": 46.38604651162791, "combined_score": 173.11969096681065, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.038031757041794824, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 193, "term": "Regulation of B Cell Proliferation (GO:0030888)", "p_value": 0.02447931669919003, "odds_ratio": 45.32954545454545, "combined_score": 168.16929253740548, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.03853638187769057, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 194, "term": "Regulation of Cyclin-Dependent Protein Serine/Threonine Kinase Activity (GO:0000079)", "p_value": 0.025017061022238465, "odds_ratio": 44.32, "combined_score": 163.46090194189088, "overlapping_genes": [ "GADD45A" ], "adjusted_p_value": 0.03853638187769057, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 195, "term": "Macromolecule Catabolic Process (GO:0009057)", "p_value": 0.025017061022238465, "odds_ratio": 44.32, "combined_score": 163.46090194189088, "overlapping_genes": [ "CHEK2" ], "adjusted_p_value": 0.03853638187769057, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 196, "term": "Regulation of Fibroblast Proliferation (GO:0048145)", "p_value": 0.025017061022238465, "odds_ratio": 44.32, "combined_score": 163.46090194189088, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.03853638187769057, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 197, "term": "Regulation of Intrinsic Apoptotic Signaling Pathway (GO:2001242)", "p_value": 0.025017061022238465, "odds_ratio": 44.32, "combined_score": 163.46090194189088, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.03853638187769057, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 198, "term": "Negative Regulation of Protein Serine/Threonine Kinase Activity (GO:0071901)", "p_value": 0.025017061022238465, "odds_ratio": 44.32, "combined_score": 163.46090194189088, "overlapping_genes": [ "GADD45A" ], "adjusted_p_value": 0.03853638187769057, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 199, "term": "Positive Regulation of miRNA Transcription (GO:1902895)", "p_value": 0.02555453587694348, "odds_ratio": 43.35434782608696, "combined_score": 158.97781166869382, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.03858481902211763, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 200, "term": "Mitotic Spindle Assembly (GO:0090307)", "p_value": 0.02555453587694348, "odds_ratio": 43.35434782608696, "combined_score": 158.97781166869382, "overlapping_genes": [ "CHEK2" ], "adjusted_p_value": 0.03858481902211763, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 201, "term": "Double-Strand Break Repair via Nonhomologous End Joining (GO:0006303)", "p_value": 0.02555453587694348, "odds_ratio": 43.35434782608696, "combined_score": 158.97781166869382, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.03858481902211763, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 202, "term": "Stem Cell Differentiation (GO:0048863)", "p_value": 0.02555453587694348, "odds_ratio": 43.35434782608696, "combined_score": 158.97781166869382, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.03858481902211763, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 203, "term": "Negative Regulation of TORC1 Signaling (GO:1904262)", "p_value": 0.02662867767591582, "odds_ratio": 41.54375, "combined_score": 150.62793852241148, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.040008604389922785, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 204, "term": "Negative Regulation of Apoptotic Process (GO:0043066)", "p_value": 0.026863684936389024, "odds_ratio": 9.168898285177354, "combined_score": 33.16372086510065, "overlapping_genes": [ "MDM2", "TP53" ], "adjusted_p_value": 0.0401638426745032, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 205, "term": "Positive Regulation of Fat Cell Differentiation (GO:0045600)", "p_value": 0.027165344857992397, "odds_ratio": 40.69387755102041, "combined_score": 146.73452100035948, "overlapping_genes": [ "CHEK2" ], "adjusted_p_value": 0.040416732593598445, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 206, "term": "Transcription Initiation-Coupled Chromatin Remodeling (GO:0045815)", "p_value": 0.027701743059261864, "odds_ratio": 39.878, "combined_score": 143.01287394480332, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.04101471666541198, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 207, "term": "Positive Regulation of miRNA Metabolic Process (GO:2000630)", "p_value": 0.02877373299362358, "odds_ratio": 38.340384615384615, "combined_score": 136.0428936891653, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.042396080014759384, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 208, "term": "Positive Regulation of Transcription Initiation by RNA Polymerase II (GO:0060261)", "p_value": 0.02930932497110778, "odds_ratio": 37.615094339622644, "combined_score": 132.7756240232595, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.04297761594321092, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 209, "term": "Positive Regulation of Telomere Maintenance (GO:0032206)", "p_value": 0.029844648447595826, "odds_ratio": 36.916666666666664, "combined_score": 129.64209444665414, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.043553195102950845, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 210, "term": "Regulation of Blood Vessel Endothelial Cell Migration (GO:0043535)", "p_value": 0.030914490381785415, "odds_ratio": 35.59464285714286, "combined_score": 123.7458530082544, "overlapping_genes": [ "GADD45A" ], "adjusted_p_value": 0.04489961698306929, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 211, "term": "Regulation of Mitotic Nuclear Division (GO:0007088)", "p_value": 0.03144900907971979, "odds_ratio": 34.96842105263158, "combined_score": 120.96932931919562, "overlapping_genes": [ "CHEK1" ], "adjusted_p_value": 0.04545946810101676, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 212, "term": "Negative Regulation of Intrinsic Apoptotic Signaling Pathway (GO:2001243)", "p_value": 0.03251724254582002, "odds_ratio": 33.779661016949156, "combined_score": 115.72860487101575, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.04612911151848887, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 213, "term": "Negative Regulation of Protein Kinase Activity (GO:0006469)", "p_value": 0.03251724254582002, "odds_ratio": 33.779661016949156, "combined_score": 115.72860487101575, "overlapping_genes": [ "GADD45A" ], "adjusted_p_value": 0.04612911151848887, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 214, "term": "Response to Reactive Oxygen Species (GO:0000302)", "p_value": 0.03251724254582002, "odds_ratio": 33.779661016949156, "combined_score": 115.72860487101575, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.04612911151848887, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 215, "term": "Response to Retinoic Acid (GO:0032526)", "p_value": 0.03251724254582002, "odds_ratio": 33.779661016949156, "combined_score": 115.72860487101575, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.04612911151848887, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 216, "term": "Negative Regulation of Cellular Process (GO:0048523)", "p_value": 0.03301961897968829, "odds_ratio": 8.17475320310859, "combined_score": 27.881249639851298, "overlapping_genes": [ "BRCA1", "TP53" ], "adjusted_p_value": 0.04645411085057256, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 217, "term": "Telomere Organization (GO:0032200)", "p_value": 0.03305095755598113, "odds_ratio": 33.215, "combined_score": 113.25334294423654, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.04645411085057256, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 218, "term": "protein-DNA Complex Assembly (GO:0065004)", "p_value": 0.03358440490598319, "odds_ratio": 32.66885245901639, "combined_score": 110.86807091829407, "overlapping_genes": [ "RAD51" ], "adjusted_p_value": 0.046772801353081615, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 219, "term": "Cellular Response to Light Stimulus (GO:0071482)", "p_value": 0.03358440490598319, "odds_ratio": 32.66885245901639, "combined_score": 110.86807091829407, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.046772801353081615, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 220, "term": "Negative Regulation of Metabolic Process (GO:0009892)", "p_value": 0.03411758472221407, "odds_ratio": 32.14032258064516, "combined_score": 108.56815667877291, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.04729937881943315, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 221, "term": "Regulation of miRNA Transcription (GO:1902893)", "p_value": 0.03571552014502453, "odds_ratio": 30.65230769230769, "combined_score": 102.13869848967185, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.04929064997390263, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 222, "term": "Chordate Embryonic Development (GO:0043009)", "p_value": 0.03624763101785663, "odds_ratio": 30.186363636363637, "combined_score": 100.13967676460433, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.049576356324871174, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 223, "term": "Regulation of Protein Serine/Threonine Kinase Activity (GO:0071900)", "p_value": 0.03624763101785663, "odds_ratio": 30.186363636363637, "combined_score": 100.13967676460433, "overlapping_genes": [ "GADD45A" ], "adjusted_p_value": 0.049576356324871174, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 224, "term": "Ras Protein Signal Transduction (GO:0007265)", "p_value": 0.036779474955290804, "odds_ratio": 29.734328358208955, "combined_score": 98.20699568293153, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.05007919580965935, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 225, "term": "Phosphatidylinositol Metabolic Process (GO:0046488)", "p_value": 0.03731105207809084, "odds_ratio": 29.29558823529412, "combined_score": 96.33753689320037, "overlapping_genes": [ "CHEK2" ], "adjusted_p_value": 0.05057720392807869, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 226, "term": "Peptidyl-Serine Phosphorylation (GO:0018105)", "p_value": 0.037842362503763806, "odds_ratio": 28.869565217391305, "combined_score": 94.52837096535384, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.05062245861249106, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 227, "term": "Positive Regulation of Apoptotic Signaling Pathway (GO:2001235)", "p_value": 0.037842362503763806, "odds_ratio": 28.869565217391305, "combined_score": 94.52837096535384, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.05062245861249106, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 228, "term": "Negative Regulation of TOR Signaling (GO:0032007)", "p_value": 0.037842362503763806, "odds_ratio": 28.869565217391305, "combined_score": 94.52837096535384, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.05062245861249106, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 229, "term": "Cellular Response to Reactive Oxygen Species (GO:0034614)", "p_value": 0.038373406353793084, "odds_ratio": 28.455714285714286, "combined_score": 92.77674343537714, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.050886473643073436, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 230, "term": "Positive Regulation of Proteasomal Ubiquitin-Dependent Protein Catabolic Process (GO:0032436)", "p_value": 0.038373406353793084, "odds_ratio": 28.455714285714286, "combined_score": 92.77674343537714, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.050886473643073436, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 231, "term": "Negative Regulation of Extrinsic Apoptotic Signaling Pathway (GO:2001237)", "p_value": 0.03890418375818435, "odds_ratio": 28.053521126760565, "combined_score": 91.0800620630536, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.05136699587119579, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 232, "term": "Negative Regulation of Epithelial Cell Proliferation (GO:0050680)", "p_value": 0.039434694821538385, "odds_ratio": 27.6625, "combined_score": 89.43588520720674, "overlapping_genes": [ "BRCA2" ], "adjusted_p_value": 0.05139992273747525, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 233, "term": "DNA Replication (GO:0006260)", "p_value": 0.039434694821538385, "odds_ratio": 27.6625, "combined_score": 89.43588520720674, "overlapping_genes": [ "CHEK1" ], "adjusted_p_value": 0.05139992273747525, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 234, "term": "Spindle Assembly (GO:0051225)", "p_value": 0.039434694821538385, "odds_ratio": 27.6625, "combined_score": 89.43588520720674, "overlapping_genes": [ "CHEK2" ], "adjusted_p_value": 0.05139992273747525, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 235, "term": "Peptidyl-Serine Modification (GO:0018209)", "p_value": 0.04049491842710541, "odds_ratio": 26.91216216216216, "combined_score": 86.2959682120762, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.05233453440791166, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 236, "term": "Regulation of Fat Cell Differentiation (GO:0045598)", "p_value": 0.04049491842710541, "odds_ratio": 26.91216216216216, "combined_score": 86.2959682120762, "overlapping_genes": [ "CHEK2" ], "adjusted_p_value": 0.05233453440791166, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 237, "term": "Cellular Response to UV (GO:0034644)", "p_value": 0.0415540781399269, "odds_ratio": 26.201315789473686, "combined_score": 83.34008705275691, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.053476767226488205, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 238, "term": "Protein Metabolic Process (GO:0019538)", "p_value": 0.0430749975965744, "odds_ratio": 7.0359477124183005, "combined_score": 22.126736683792974, "overlapping_genes": [ "CHEK2", "MDM2" ], "adjusted_p_value": 0.05481114797990065, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 239, "term": "Proteolysis Involved in Protein Catabolic Process (GO:0051603)", "p_value": 0.04314082499469826, "odds_ratio": 25.20253164556962, "combined_score": 79.21875265135186, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.05481114797990065, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 240, "term": "Response to Tumor Necrosis Factor (GO:0034612)", "p_value": 0.04314082499469826, "odds_ratio": 25.20253164556962, "combined_score": 79.21875265135186, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.05481114797990065, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 241, "term": "Positive Regulation of Organelle Organization (GO:0010638)", "p_value": 0.04366920970201921, "odds_ratio": 24.88625, "combined_score": 77.92163622636126, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.05481114797990065, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 242, "term": "Positive Regulation of JNK Cascade (GO:0046330)", "p_value": 0.04366920970201921, "odds_ratio": 24.88625, "combined_score": 77.92163622636126, "overlapping_genes": [ "GADD45A" ], "adjusted_p_value": 0.05481114797990065, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 243, "term": "Negative Regulation of Cell Cycle (GO:0045786)", "p_value": 0.04366920970201921, "odds_ratio": 24.88625, "combined_score": 77.92163622636126, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.05481114797990065, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 244, "term": "Peptidyl-Lysine Modification (GO:0018205)", "p_value": 0.0457800971719973, "odds_ratio": 23.696428571428573, "combined_score": 73.07755450297252, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.05722512146499662, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 245, "term": "Positive Regulation of Ubiquitin-Dependent Protein Catabolic Process (GO:2000060)", "p_value": 0.04736048219236788, "odds_ratio": 22.875862068965517, "combined_score": 69.77062685533508, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.05895896762723349, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 246, "term": "Nuclear-Transcribed mRNA Catabolic Process (GO:0000956)", "p_value": 0.04788674820170976, "odds_ratio": 22.614772727272726, "combined_score": 68.72440526863295, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.05937178130699787, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 247, "term": "Mitotic Spindle Organization (GO:0007052)", "p_value": 0.04841274991635465, "odds_ratio": 22.359550561797754, "combined_score": 67.70454183296923, "overlapping_genes": [ "CHEK2" ], "adjusted_p_value": 0.05978092601007356, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 248, "term": "Phosphatidylinositol Biosynthetic Process (GO:0006661)", "p_value": 0.048938487444328285, "odds_ratio": 22.11, "combined_score": 66.71009583505662, "overlapping_genes": [ "CHEK2" ], "adjusted_p_value": 0.060186446252097285, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 249, "term": "Positive Regulation of Response to Stimulus (GO:0048584)", "p_value": 0.04946396091014192, "odds_ratio": 21.865934065934066, "combined_score": 65.74016991684287, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.060346032310373145, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 250, "term": "Positive Regulation of Cell Adhesion (GO:0045785)", "p_value": 0.04946396091014192, "odds_ratio": 21.865934065934066, "combined_score": 65.74016991684287, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.060346032310373145, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 251, "term": "Positive Regulation of Double-Strand Break Repair (GO:2000781)", "p_value": 0.05051411613720297, "odds_ratio": 21.393548387096775, "combined_score": 63.87049121569168, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.0613816949077566, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 252, "term": "Regulation of TORC1 Signaling (GO:1903432)", "p_value": 0.052087371500602615, "odds_ratio": 20.721875, "combined_score": 61.22967487540231, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.06304225518922142, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 253, "term": "Positive Regulation of Proteasomal Protein Catabolic Process (GO:1901800)", "p_value": 0.052611263106800116, "odds_ratio": 20.507216494845363, "combined_score": 60.390164935250596, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.0634246452473282, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 254, "term": "Cellular Response to Chemical Stress (GO:0062197)", "p_value": 0.05365825675086383, "odds_ratio": 20.09090909090909, "combined_score": 58.768318421882675, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.0641794835647587, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 255, "term": "Response to UV (GO:0009411)", "p_value": 0.05365825675086383, "odds_ratio": 20.09090909090909, "combined_score": 58.768318421882675, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.0641794835647587, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 256, "term": "mRNA Metabolic Process (GO:0016071)", "p_value": 0.054181359025060244, "odds_ratio": 19.889, "combined_score": 57.98475574455278, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.0643008346406357, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 257, "term": "Hemopoiesis (GO:0030097)", "p_value": 0.054181359025060244, "odds_ratio": 19.889, "combined_score": 57.98475574455278, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.0643008346406357, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 258, "term": "Positive Regulation of DNA Metabolic Process (GO:0051054)", "p_value": 0.057835721217223385, "odds_ratio": 18.581308411214952, "combined_score": 52.959491641957904, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.06837168593508966, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 259, "term": "Positive Regulation of Vasculature Development (GO:1904018)", "p_value": 0.05835672384406997, "odds_ratio": 18.408333333333335, "combined_score": 52.30140127379555, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.06845692604785132, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 260, "term": "Regulation of Proteasomal Ubiquitin-Dependent Protein Catabolic Process (GO:0032434)", "p_value": 0.05835672384406997, "odds_ratio": 18.408333333333335, "combined_score": 52.30140127379555, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.06845692604785132, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 261, "term": "Glycerophospholipid Biosynthetic Process (GO:0046474)", "p_value": 0.058877464556040184, "odds_ratio": 18.238532110091743, "combined_score": 51.65693734856973, "overlapping_genes": [ "CHEK2" ], "adjusted_p_value": 0.06880316739307378, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 262, "term": "Mitotic Cell Cycle Phase Transition (GO:0044772)", "p_value": 0.06043811633234245, "odds_ratio": 17.74732142857143, "combined_score": 49.80138528268159, "overlapping_genes": [ "CHEK2" ], "adjusted_p_value": 0.07035734916551317, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 263, "term": "Regulation of JNK Cascade (GO:0046328)", "p_value": 0.061477243410223426, "odds_ratio": 17.43421052631579, "combined_score": 48.62555082904469, "overlapping_genes": [ "GADD45A" ], "adjusted_p_value": 0.07129490205368116, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 264, "term": "Regulation of DNA Metabolic Process (GO:0051052)", "p_value": 0.06199641507314463, "odds_ratio": 17.281739130434783, "combined_score": 48.05496419291303, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.07162464620192845, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 265, "term": "Mitotic Sister Chromatid Segregation (GO:0000070)", "p_value": 0.06407049195104964, "odds_ratio": 16.69747899159664, "combined_score": 45.88085464119431, "overlapping_genes": [ "CHEK2" ], "adjusted_p_value": 0.07374150960403826, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 266, "term": "Regulation of Cell Population Proliferation (GO:0042127)", "p_value": 0.06452308325141567, "odds_ratio": 5.569172823410112, "combined_score": 15.263611503560814, "overlapping_genes": [ "MDM2", "TP53" ], "adjusted_p_value": 0.07398323455519466, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 267, "term": "Transcription Initiation at RNA Polymerase II Promoter (GO:0006367)", "p_value": 0.06562331267019857, "odds_ratio": 16.284426229508195, "combined_score": 44.3559153884753, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.0749629601663317, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 268, "term": "Regulation of Mitotic Cell Cycle (GO:0007346)", "p_value": 0.06614039888187752, "odds_ratio": 16.151219512195123, "combined_score": 43.86631714557356, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.07527172260810688, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 269, "term": "Positive Regulation of Angiogenesis (GO:0045766)", "p_value": 0.06717379097360096, "odds_ratio": 15.8912, "combined_score": 42.91374259788014, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.07616359199609031, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 270, "term": "Protein Localization to Nucleus (GO:0034504)", "p_value": 0.0676900970783306, "odds_ratio": 15.764285714285714, "combined_score": 42.45031112549025, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.07646473929218826, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 271, "term": "Regulation of DNA Repair (GO:0006282)", "p_value": 0.06923745710256594, "odds_ratio": 15.395348837209303, "combined_score": 41.1088648413353, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.07792407533683622, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 272, "term": "Membraneless Organelle Assembly (GO:0140694)", "p_value": 0.07386553979752421, "odds_ratio": 14.384782608695652, "combined_score": 37.47967865613064, "overlapping_genes": [ "CHEK2" ], "adjusted_p_value": 0.08282716778766501, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 273, "term": "Cellular Response to Starvation (GO:0009267)", "p_value": 0.0748911573283546, "odds_ratio": 14.177857142857142, "combined_score": 36.7450281891981, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.08366960800420568, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 274, "term": "Regulation of Cell Adhesion (GO:0030155)", "p_value": 0.07540357879431908, "odds_ratio": 14.076595744680851, "combined_score": 36.38659995556786, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.08393464062871284, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 275, "term": "Regulation of Cell Cycle Process (GO:0010564)", "p_value": 0.07745068546971694, "odds_ratio": 13.68551724137931, "combined_score": 35.00911135940426, "overlapping_genes": [ "CHEK1" ], "adjusted_p_value": 0.08589985115732242, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 276, "term": "Protein Localization to Organelle (GO:0033365)", "p_value": 0.0800037743240655, "odds_ratio": 13.226, "combined_score": 33.40466307421403, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.08840996800304339, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 277, "term": "Macroautophagy (GO:0016236)", "p_value": 0.08559797531574136, "odds_ratio": 12.315527950310559, "combined_score": 30.27272103834212, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.0942504782357441, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 278, "term": "Small GTPase-mediated Signal Transduction (GO:0007264)", "p_value": 0.09869791397691897, "odds_ratio": 10.589304812834225, "combined_score": 24.521562804501926, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.10828368260057658, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 279, "term": "Response to Endoplasmic Reticulum Stress (GO:0034976)", "p_value": 0.1026942019426715, "odds_ratio": 10.150769230769232, "combined_score": 23.103146910880294, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.11226427094091328, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 280, "term": "DNA-templated Transcription (GO:0006351)", "p_value": 0.10617773281045749, "odds_ratio": 9.795544554455445, "combined_score": 21.96788850664253, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.11565788752567689, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 281, "term": "Modification-Dependent Protein Catabolic Process (GO:0019941)", "p_value": 0.10865843710367488, "odds_ratio": 9.556521739130435, "combined_score": 21.21113884815151, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.11793887301288554, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 282, "term": "Regulation of Angiogenesis (GO:0045765)", "p_value": 0.11014385369528888, "odds_ratio": 9.418571428571429, "combined_score": 20.77706724022753, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.11912721764915996, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 283, "term": "Protein Stabilization (GO:0050821)", "p_value": 0.11063849224487966, "odds_ratio": 9.373459715639811, "combined_score": 20.635551764562276, "overlapping_genes": [ "CHEK2" ], "adjusted_p_value": 0.11923936443352756, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 284, "term": "Regulation of Autophagy (GO:0010506)", "p_value": 0.11949935173976756, "odds_ratio": 8.62882096069869, "combined_score": 18.331449785225676, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.12833557141066587, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 285, "term": "Cellular Response to Lipid (GO:0071396)", "p_value": 0.1214574995857652, "odds_ratio": 8.478969957081546, "combined_score": 17.875287093283262, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.12998083289002943, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 286, "term": "Negative Regulation of Multicellular Organismal Process (GO:0051241)", "p_value": 0.12584886582350988, "odds_ratio": 8.1599173553719, "combined_score": 16.91284503236191, "overlapping_genes": [ "BRCA2" ], "adjusted_p_value": 0.134209454811785, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 287, "term": "Positive Regulation of Cell Motility (GO:2000147)", "p_value": 0.1287653473428992, "odds_ratio": 7.96008064516129, "combined_score": 16.316283112788998, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.13684122278600785, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 288, "term": "Cytokine-Mediated Signaling Pathway (GO:0019221)", "p_value": 0.1316729803945433, "odds_ratio": 7.769685039370079, "combined_score": 15.752522464585367, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.13944534382061008, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 289, "term": "Cellular Response to Cytokine Stimulus (GO:0071345)", "p_value": 0.1479835926195893, "odds_ratio": 6.840625, "combined_score": 13.070066643437114, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.1561764558788053, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 290, "term": "Negative Regulation of Intracellular Signal Transduction (GO:1902532)", "p_value": 0.15178067642718465, "odds_ratio": 6.65304054054054, "combined_score": 12.543101865269113, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.15908283955426572, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 291, "term": "Positive Regulation of Cell Differentiation (GO:0045597)", "p_value": 0.15178067642718465, "odds_ratio": 6.65304054054054, "combined_score": 12.543101865269113, "overlapping_genes": [ "CHEK2" ], "adjusted_p_value": 0.15908283955426572, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 292, "term": "Proteolysis (GO:0006508)", "p_value": 0.16307981305731142, "odds_ratio": 6.1465625, "combined_score": 11.146886656550206, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.1703402156934246, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 293, "term": "Positive Regulation of Cytokine Production (GO:0001819)", "p_value": 0.16494964260270983, "odds_ratio": 6.069444444444445, "combined_score": 10.93783716639799, "overlapping_genes": [ "BRCA1" ], "adjusted_p_value": 0.17170525936459555, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 294, "term": "Supramolecular Fiber Organization (GO:0097435)", "p_value": 0.17146417814272444, "odds_ratio": 5.813905325443787, "combined_score": 10.252129651787737, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.17775578802497352, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 295, "term": "Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process (GO:0043161)", "p_value": 0.1719277294012039, "odds_ratio": 5.79646017699115, "combined_score": 10.2057176971781, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.17775578802497352, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 296, "term": "Positive Regulation of Cell Migration (GO:0030335)", "p_value": 0.17377957773230082, "odds_ratio": 5.727696793002916, "combined_score": 10.02328368134644, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.17906341624443162, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 297, "term": "Positive Regulation of MAPK Cascade (GO:0043410)", "p_value": 0.18206639491740778, "odds_ratio": 5.437119113573408, "combined_score": 9.261500895072757, "overlapping_genes": [ "GADD45A" ], "adjusted_p_value": 0.18697054023504842, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 298, "term": "Negative Regulation of Gene Expression (GO:0010629)", "p_value": 0.18298247255923147, "odds_ratio": 5.406611570247934, "combined_score": 9.182399368003196, "overlapping_genes": [ "CHEK1" ], "adjusted_p_value": 0.18728071855894496, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 299, "term": "Protein Localization (GO:0008104)", "p_value": 0.18618140399257987, "odds_ratio": 5.302432432432433, "combined_score": 8.913568089557383, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.18974808790267633, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 300, "term": "Proteasomal Protein Catabolic Process (GO:0010498)", "p_value": 0.1866374635108292, "odds_ratio": 5.287870619946092, "combined_score": 8.876152158071937, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.18974808790267633, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 301, "term": "Negative Regulation of Cell Population Proliferation (GO:0008285)", "p_value": 0.18982338029375415, "odds_ratio": 5.188095238095238, "combined_score": 8.6208566449, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.1923459501315449, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 302, "term": "Ubiquitin-Dependent Protein Catabolic Process (GO:0006511)", "p_value": 0.22369049652863826, "odds_ratio": 4.302863436123348, "combined_score": 6.443503118721976, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.22591258755375718, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 303, "term": "Regulation of Cell Migration (GO:0030334)", "p_value": 0.23411482824793828, "odds_ratio": 4.081799163179916, "combined_score": 5.926542028517176, "overlapping_genes": [ "ATM" ], "adjusted_p_value": 0.23566014064561447, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 304, "term": "Positive Regulation of Cell Population Proliferation (GO:0008284)", "p_value": 0.2362704804875858, "odds_ratio": 4.038509316770186, "combined_score": 5.826672501934814, "overlapping_genes": [ "MDM2" ], "adjusted_p_value": 0.23704768601550552, "old_p_value": 0, "old_adjusted_p_value": 0 }, { "rank": 305, "term": "Positive Regulation of Intracellular Signal Transduction (GO:1902533)", "p_value": 0.3055724117579959, "odds_ratio": 2.970506912442396, "combined_score": 3.521739428659527, "overlapping_genes": [ "TP53" ], "adjusted_p_value": 0.3055724117579959, "old_p_value": 0, "old_adjusted_p_value": 0 } ] } ] }, "string_id_mapping_response": { "string_version": { "string_version": "12.0", "stable_address": "https://version-12-0.string-db.org" }, "species": 9606, "mapped": [ { "query": "TP53", "string_id": "9606.ENSP00000269305", "preferred_name": "TP53", "ncbi_taxon_id": 9606 }, { "query": "ATM", "string_id": "9606.ENSP00000278616", "preferred_name": "ATM", "ncbi_taxon_id": 9606 }, { "query": "ATR", "string_id": "9606.ENSP00000343741", "preferred_name": "ATR", "ncbi_taxon_id": 9606 }, { "query": "CHEK1", "string_id": "9606.ENSP00000391090", "preferred_name": "CHEK1", "ncbi_taxon_id": 9606 }, { "query": "CHEK2", "string_id": "9606.ENSP00000372023", "preferred_name": "CHEK2", "ncbi_taxon_id": 9606 }, { "query": "BRCA1", "string_id": "9606.ENSP00000418960", "preferred_name": "BRCA1", "ncbi_taxon_id": 9606 }, { "query": "BRCA2", "string_id": "9606.ENSP00000369497", "preferred_name": "BRCA2", "ncbi_taxon_id": 9606 }, { "query": "RAD51", "string_id": "9606.ENSP00000493712", "preferred_name": "RAD51", "ncbi_taxon_id": 9606 }, { "query": "CDKN1A", "string_id": "9606.ENSP00000384849", "preferred_name": "CDKN1A", "ncbi_taxon_id": 9606 }, { "query": "GADD45A", "string_id": "9606.ENSP00000360025", "preferred_name": "GADD45A", "ncbi_taxon_id": 9606 }, { "query": "MDM2", "string_id": "9606.ENSP00000258149", "preferred_name": "MDM2", "ncbi_taxon_id": 9606 } ], "unmapped": [] }, "string_ppi_enrichment_response": { "tool": "string-ppi-enrichment", "tool_version": "0.1.0", "query": { "symbols": [ "TP53", "ATM", "ATR", "CHEK1", "CHEK2", "BRCA1", "BRCA2", "RAD51", "CDKN1A", "GADD45A", "MDM2" ], "species": 9606, "required_score": 700, "background_string_ids": [] }, "string_version": { "string_version": "12.0", "stable_address": "https://version-12-0.string-db.org" }, "mapped": [ { "query": "TP53", "string_id": "9606.ENSP00000269305", "preferred_name": "TP53", "ncbi_taxon_id": 9606 }, { "query": "ATM", "string_id": "9606.ENSP00000278616", "preferred_name": "ATM", "ncbi_taxon_id": 9606 }, { "query": "ATR", "string_id": "9606.ENSP00000343741", "preferred_name": "ATR", "ncbi_taxon_id": 9606 }, { "query": "CHEK1", "string_id": "9606.ENSP00000391090", "preferred_name": "CHEK1", "ncbi_taxon_id": 9606 }, { "query": "CHEK2", "string_id": "9606.ENSP00000372023", "preferred_name": "CHEK2", "ncbi_taxon_id": 9606 }, { "query": "BRCA1", "string_id": "9606.ENSP00000418960", "preferred_name": "BRCA1", "ncbi_taxon_id": 9606 }, { "query": "BRCA2", "string_id": "9606.ENSP00000369497", "preferred_name": "BRCA2", "ncbi_taxon_id": 9606 }, { "query": "RAD51", "string_id": "9606.ENSP00000493712", "preferred_name": "RAD51", "ncbi_taxon_id": 9606 }, { "query": "CDKN1A", "string_id": "9606.ENSP00000384849", "preferred_name": "CDKN1A", "ncbi_taxon_id": 9606 }, { "query": "GADD45A", "string_id": "9606.ENSP00000360025", "preferred_name": "GADD45A", "ncbi_taxon_id": 9606 }, { "query": "MDM2", "string_id": "9606.ENSP00000258149", "preferred_name": "MDM2", "ncbi_taxon_id": 9606 } ], "unmapped": [], "result": { "number_of_nodes": 11, "number_of_edges": 44, "average_node_degree": 8, "local_clustering_coefficient": 0.873, "expected_number_of_edges": 6, "p_value": 0 }, "provenance": { "api_base_url": "https://version-12-0.string-db.org/api", "caller_identity": "bio-tools-string-network", "endpoints_used": [ "json/version", "json/get_string_ids", "tsv/ppi_enrichment" ], "parameters": { "species": 9606, "required_score": 700, "background_string_identifiers": [] }, "retrieved_at": "2026-09-28T06:11:40.836Z", "n_http_requests": 3, "bytes_downloaded": 8458, "requests": [ { "endpoint": "json/version", "bytes": 84 }, { "endpoint": "json/get_string_ids", "bytes": 8238 }, { "endpoint": "tsv/ppi_enrichment", "bytes": 136 } ] } } }