Spatial Immune Organization and Breast Cancer Prognosis

Archived study

Examines whether spatial immune organization adds prognostic information beyond clinical variables and cell composition in 278 patients from the public Basel breast-cancer cohort. In patient-level internal validation, adding spatial features increased concordance by 0.0127 and reduced 60-month Brier error by 0.00163; both paired 95% intervals included zero.

Interpretation and limits

Incremental prognostic value remains inconclusive; this does not demonstrate that spatial biology has no prognostic value. The analysis uses one retrospective cohort and fixed public cell annotations. Uncertainty intervals hold fitted models and validation splits fixed, rather than capturing full retraining uncertainty. The results do not establish external validation or clinical utility.

Package and provenance

The unchanged research package comes from upstream Case 28. It includes the conversation, source inputs, analysis code, results, and figures. The poster uses an illustrative microscope photograph, not an actual study image or experimental record. This introduction summarizes archived findings; the analysis was not rerun for this presentation.

Import provenance

This case was added to the Academic Research category on 2026-10-13, with the archived upstream case recorded as its source. The supplied session export and poster were uploaded without changing their contents. This introduction summarizes the archived findings and was standardized for the repository. The study, external data sources, and scientific results were not rerun or independently reverified for this import.

This GitHub catalog imports the case from the verified Hugging Face snapshot. The session export is referenced through that fixed revision; the cover and introduction are stored in this repository.

Case files

• Session export
• Case poster